Article
Biochemistry & Molecular Biology
Danyelle Siqueira Miotto, Francine Duchatsch, Aline Dionizio, Marilia Afonso Rabelo Buzalaf, Sandra Lia Amaral
Summary: Arterial stiffness, an important predictor of cardiovascular events, can be reduced by both perindopril and aerobic training in spontaneously hypertensive rats. However, the mechanisms of action may be different, with perindopril increasing the level of EHD2 protein involved in vessel relaxation and aerobic training decreasing the level of COL1 protein that enhances vessel rigidity.
Article
Medicine, Research & Experimental
Vladiana Turi, Stela Iurciuc, Octavian Marius Cretu, Delia Mirela Tit, Simona Bungau, Adrian Apostol, Radu Dumitru Moleriu, Cristiana Bustea, Tapan Behl, Camelia Cristina Diaconu, Izabella Petre
Summary: The study revealed significant differences in hemodynamic and arterial stiffness parameters as well as heart rate between pregnant women with hypertension and those without. Arterial function parameters in women with pregnancy-induced hypertension differed long before the onset of high blood pressure, and body mass index had a deleterious effect, especially in pregnant women with hypertension. The assessment of arterial function parameters and BMI is important for predicting future blood pressure values and outcomes during pregnancy.
Article
Physiology
Danyelle S. Miotto, Aline Dionizio, Andre M. Jacomini, Anderson S. Zago, Marilia Afonso Rabelo Buzalaf, Sandra L. Amaral
Summary: This study showed that treatment with perindopril reduced systolic blood pressure and pulse wave velocity in spontaneously hypertensive rats. It also increased nitrite concentration and upregulated GDP dissociation inhibitors, potentially inhibiting the RhoA/Rho-kinase pathway and contributing to decreased arterial stiffness.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhipeng Yu, Li Wang, Sijia Wu, Wenjun Xue, Wenzhu Zhao, Jianrong Li
Summary: This study used a non-targeted metabolomics approach to investigate the anti-hypertensive effects of RVPSL on SHRs. The results suggested that RVPSL potentially alleviated hypertension in SHRs mainly through integrated regulations of metabolism and production of specific metabolites.
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Lidieli P. P. Tardelli, Francine Duchatsch, Naiara A. A. Herrera, Thalles Fernando R. Ruiz, Luana U. U. Pagan, Carlos A. A. Vicentini, Katashi Okoshi, Sandra L. L. Amaral
Summary: This study aimed to evaluate the mechanisms induced by combined training to attenuate arterial stiffness and hypertension in spontaneously hypertensive rats. The results showed that combined training reduced blood pressure and pulse wave velocity through the reduction of arterial collagen deposition, and also improved autonomic balance to the heart.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Anesthesiology
Kenichi Ueda, David M. Janiczek, Darren P. Casey
Summary: The study found that preoperative measurement of carotid-femoral pulse-wave velocity in patients chronically treated with ACEIs could help identify patients at increased risk of developing hypotension refractory to vasopressors after induction of general anesthesia.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Article
Endocrinology & Metabolism
Zheng-Wei Chen, Chien-Ting Pan, Che-Wei Liao, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Shuo-Meng Wang, Ching-Chu Lu, Jeff S. Chueh, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
Summary: This study compared the reversal of arterial stiffness in surgically and medically treated PA patients and identified predictors of effective medical treatment. The findings showed that adrenalectomy and medically treated PA patients with unsuppressed plasma renin activity (PRA) had an improvement in arterial stiffness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Eun-Woo Jeong, Se-Yeong Park, Yun-Sun Yang, You-Jin Baek, Da-Min Yun, Hyun-Joo Kim, Gwang-Woong Go, Hyeon-Gyu Lee
Summary: The study showed that adzuki bean extracts have stronger antihypertensive potential in spontaneously hypertensive rats, significantly reducing relative liver weight, AST, ALT, triglyceride, total cholesterol, systolic blood pressure, angiotensin-converting-enzyme level, as well as decreasing renin mRNA expression.
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Peripheral Vascular Disease
Ryan J. Pewowaruk, Claudia Korcarz, James H. Stein, David Bluemke, Yacob Tedla, Adam D. Gepner
Summary: This study compared the associations of several arterial stiffness calculations in a large, multiethnic cohort and found that different methods of calculating local arterial stiffness largely gave equivalent results, indicating that the variety of different arterial stiffness calculations in use do not cause inconsistent findings.
JOURNAL OF HYPERTENSION
(2023)
Article
Cell Biology
Klaas F. Franzen, Moritz Meusel, Julia Engel, Tamara Roecker, Daniel Droemann, Friedhelm Sayk
Summary: PE-induced hypertension results in a strong reflex-mediated decrease in cardiac output, and has stronger effects on PWV, AIx, total peripheral resistance, and pulse pressure compared to Ang II at equal mean aortic BP. Furthermore, there are minimal changes in circulating markers of endothelial function in response to both vasoactive infusions.
Review
Peripheral Vascular Disease
James E. Sharman, Isabella Tan, George S. Stergiou, Carolina Lombardi, Francesca Saladini, Mark Butlin, Raj Padwal, Kei Asayama, Alberto Avolio, Tammy M. Brady, Alan Murray, Gianfranco Parati
Summary: Automated oscillometric blood pressure measuring devices have replaced manual auscultatory blood pressure measurement by mercury sphygmomanometers in clinical settings. These validated devices provide similar blood pressure values to manual measurement, making them the recommended standard for hypertension diagnosis and management globally.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Biwen Tang, Yaya Bai, Jiehui Zhao, Hui Yang, Alberto Avolio, Junli Zuo
Summary: This study investigated the relationship between the severity of obstructive sleep apnea (OSA) and arteriosclerosis and blood pressure in an Asian population. The results showed that the severity of OSA was positively correlated with pulse wave velocity and office blood pressure, and age was an independent risk factor for arteriosclerosis.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Biwen Tang, Weichao Tu, Jiehui Zhao, Xueqing Deng, Isabella Tan, Mark Butlin, Alberto Avolio, Junli Zuo
Summary: This study investigated the relationship between carotid-femoral pulse wave velocity (c-fPWV), as a measure of arterial stiffness, and accepted metrics of renal function. The results showed a negative correlation between c-fPWV and estimated glomerular filtration rate (eGFR) determined by four different equations, with the equation for CKD-EPICysC showing an independent relation with c-fPWV.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yaya Bai, Qian Wang, Di Cheng, Yueliang Hu, Huijuan Chao, Alberto Avolio, Biwen Tang, Junli Zuo
Summary: This study aimed to explore the risk of target organ damage (TOD) based on carotid-femoral pulse wave velocity (cfPWV) and central aortic blood pressure (CBP) in different populations. The study found that individuals with elevated cfPWV and CBP had a higher risk of microalbuminuria.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
George S. Stergiou, Ramakrishna Mukkamala, Alberto Avolio, Konstantinos G. Kyriakoulis, Stephan Mieke, Alan Murray, Gianfranco Parati, Aletta E. Schutte, James E. Sharman, Roland Asmar, Richard J. McManus, Kei Asayama, Alejandro De la Sierra, Geoffrey Head, Kazuomi Kario, Anastasios Kollias, Martin Myers, Teemu Niiranen, Takayoshi Ohkubo, Jiguang Wang, Gregoire Wuerzner, Eoin O'Brien, Reinhold Kreutz, Paolo Palatini
Summary: Cuffless blood pressure devices have the potential to change the diagnosis and management of hypertension, but fundamental questions regarding accuracy, performance, and implementation need to be addressed before recommending them for clinical use.
JOURNAL OF HYPERTENSION
(2022)
Review
Peripheral Vascular Disease
Ramakrishna Mukkamala, Sanjeev G. Shroff, Cederick Landry, Konstantinos G. Kyriakoulis, Alberto P. Avolio, George S. Stergiou
Summary: Conventional blood pressure measurement devices only provide a limited view of continuous blood pressure profile. Wearable cuffless blood pressure devices utilizing pulse wave analysis and pulse arrival time have the potential to significantly improve the assessment and management of hypertension. The Aurora Project, conducted by Microsoft Research, evaluated the accuracy of various cuffless blood pressure devices and found negative results. This article discusses the emerging technologies, summarizes the Aurora Project, and highlights its implications, study methodology, and limitations.
Article
Cardiac & Cardiovascular Systems
Stephen F. Woodford, Mark Butlin, Bai Wei, Wei Chao, Alberto Avolio
Summary: The pressure field method reduces transfusion requirements by decreasing intraoperative fluid loading.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Biology
Shuo Du, Yang Yao, Guozhe Sun, Lu Wang, Jordi Alastruey, Alberto P. Avolio, Lisheng Xu
Summary: This study proposed an adaptive transfer function (ATF) combined with a tube-load model to estimate the aortic pressure waveform (APW) accurately from the brachial pressure waveform (BPW), achieving personalized diagnosis of cardiovascular disease. Compared to the generalized transfer function (GTF), the proposed method performed better in estimating diastolic blood pressure and pulse pressure, providing accurate pulsatile hemodynamic measures for cardiovascular function evaluation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Peripheral Vascular Disease
Jeong Bae Park, Alberto Avolio
Summary: Cardiovascular disease (CVD) is a major health problem globally, especially in Asian countries facing rapid aging. Factors such as aging, hypertension, hypercholesterolemia, diabetes mellitus, and kidney disease contribute to the development of atherosclerosis and arteriosclerosis, leading to various cardiovascular complications. However, there is an ongoing debate about the clinical need for assessing these conditions beyond traditional diagnosis methods. This study aims to address this gap and provide insights for clinical practice.
Meeting Abstract
Peripheral Vascular Disease
James R. Cox, Ahmad Qasem, Isabella Tan, Mark Butlin
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
James R. Cox, Isabella Tan, Alberto P. Avolio, Mark Butlin
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Alberto Avolio, James Cox, Kyrollos Louka, Fatemeh Shirbani, Isabella Tan, Ahmad Qasem, Mark Butlin
Summary: The global health burden caused by hypertension has motivated the development of improved methods for collecting blood pressure (BP) data. Wearable devices that use non-invasive cuffless techniques to provide BP data have become a growing area of research and commercial activity. These devices, particularly wrist-worn and watch-type devices, use sensors to record photoplethysmography (PPG) signals, and sometimes electrocardiography (ECG) signals, to measure BP.
Meeting Abstract
Peripheral Vascular Disease
James Cox, Kyrollos Louka, Alberto P. Avolio, Isabella Tan, Mark Butlin
JOURNAL OF HYPERTENSION
(2022)