Journal
ORGANIC LETTERS
Volume 17, Issue 21, Pages 5484-5487Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02851
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Funding
- University of Kansas
- NIH Shared Instrumentation Grants [S10RR024664, S10RR014767]
- NSF Major Research Instrumentation Grant [0320648]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0320648] Funding Source: National Science Foundation
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Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.
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