Journal
JOURNAL OF HYPERTENSION
Volume 29, Issue 10, Pages 1980-1987Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e32834a764e
Keywords
blood pressure; heart rate; hypertension; outcome; stroke; thrombolysis; tissue plasminogen activator
Categories
Funding
- Research Grant for Cardiovascular Diseases [21A-4]
- Ministry of Health, Labour and Welfare, Japan [H20-Junkanki-Ippan-019, H23-Junkanki-Ippan-010]
- Japan Society for the Promotion of Science [20591039]
- National Cerebral and Cardiovascular Center
- Mihara Cerebrovascular Disorder Research Promotion Fund
- Foundation for Biomedical Research and Innovation
- Mitsubishi Tanabe Pharma Corporation
- Kyowa Hakko Kirin Pharma, Inc.
- Hitachi Medical Corporation
- Japan Cardiovascular Research Foundation
- Grants-in-Aid for Scientific Research [20591039] Funding Source: KAKEN
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Background and purpose The present study clarifies associations between stroke outcomes after intravenous tissue plasminogen activator (tPA) and blood pressure (BP) as well as heart rate (HR) profiles. Methods We assessed 125 patients with stroke who received tPA within 3 h of onset. We obtained baseline, mean, maximum, minimum, and coefficient of variation values for BP and HR during the initial 24 h. The primary outcome was independence at 3 months corresponding to a modified Rankin Scale score of 2 or less. The secondary outcomes were early neurological improvement at 24 h and intracerebral hemorrhage (ICH) within 36 h. Results Among the patients, 64 (51%) achieved independence, 66 (53%) early improvement, and 26 (21%) developed ICH. The 24-h time courses of SBP (P = 0.033), pulse pressure (PP, P = 0.007), and HR (P < 0.001) were lower among patients who reached independence than among those who did not. After multivariate adjustment, 24-h mean levels of SBP (odds ratio 0.69, 95% confidence interval 0.48-0.97, per 10-mmHg increase), PP (0.63, 0.41-0.94), and HR (0.59, 0.42-0.80, per 10-bpm increase) were inversely associated with independence, as were their maximum and minimum values. In particular, mean SBP values were inversely associated with independence at 8-16 and 16-24 h (0.73, 0.54-0.97 and 0.66, 0.47-0.91, respectively), but not at 0-8 h (0.79, 0.57-1.07). Baseline and maximum SBP were inversely associated with early improvement. Maximum and coefficient of variation of SBP were associated with ICH. Conclusion Lower SBP, PP, and HR values during the initial 24 h after tPA, especially at 8 h thereafter, were associated with independence at 3 months. J Hypertens 29:1980-1987 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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