Article
Geriatrics & Gerontology
Jun Cheng, Hong Wu, Cheng Xie, Yangyan He, Rong Mou, Hongkun Zhang, Yan Yang, Qingbo Xu
Summary: Vascular aging and hypertension have a significant impact on cellular composition, artery remodeling, and smooth muscle cell phenotype. In hypertensive aging, Spp1high scar-associated macrophages are involved in oxidative stress and cell migration, while serum OPN levels are significantly elevated in aged hypertensive patients, potentially serving as a marker for vascular remodeling.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yuanyuan Chen, Yuchan Yuan, Yuhan Chen, Xueze Jiang, Xuesheng Hua, Zhiyong Chen, Julie Wang, Hua Liu, Qing Zhou, Ying Yu, Zhenwei Yang, Yi Yu, Yongqin Wang, Qunshan Wang, Yigang Li, Jie Chen, Yuepeng Wang
Summary: Hypertension-induced tunica media thickening (TMT) is a key factor for complications like stroke and cardiovascular diseases. This study found that FHOD1, a protein involved in actin filament assembly in vascular smooth muscle cells (VSMCs), is a key regulator in the pathogenesis of TMT. The activation and upregulation of FHOD1 by angiotensin-II (Ang-II) contributed to actin filament formation and VSMCs hypertrophy. Additionally, the FHOD1-RNF213-collagen-1α/collagen-3α signaling axis played a crucial role in the development of hypertensive TMT.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Xiaoxiang Ma, Yue Zhuo, Yu Huang, Pengming He, Zhaoyi Huang, Li Jiang, Luyao Tong, Xiaoqin Yao, Xueping Wen, Xuemei Zhong, Shihan Yang, Changqiong Li, Yuping Liu, Zhixin Zhang
Summary: This study reveals that abnormal T-cell responses may play important roles in the progression of essential hypertension and its subclinical target organ damage. The TCR beta repertoires of patients with essential hypertension are significantly different, and are correlated with carotid plaque formation.
Article
Peripheral Vascular Disease
Marieke van den Kerkhof, Merel M. van der Thiel, Alida A. Postma, Robert J. van Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Summary: This study found that patients with hypertension have higher pulsatility index (PI) and lower damping factor (DF) in small perforating arteries, which may be due to hypertension-induced arterial stiffening leading to increased blood flow pulsatility and decreased damping. These results highlight the impact of hypertension on cerebral blood vessel structure and function, and provide clues for further investigation into the relationship between hypertension and stroke and cerebral small vessel disease (cSVD).
Article
Peripheral Vascular Disease
Olga Berillo, Ku-Geng Huo, Chantal Richer, Julio C. Fraulob-Aquino, Marie Briet, Mark L. Lipman, Daniel Sinnett, Pierre Paradis, Ernesto L. Schiffrin
Summary: A distinct transcriptomic profile was observed in gluteal subcutaneous small arteries of hypertensive patients with CKD. Down-regulated miR-338-3p could contribute to GPX3 and PTPRS up-regulation via the canonical microRNA targeting machinery in hypertensive patients with CKD.
JOURNAL OF HYPERTENSION
(2022)
Article
Agricultural Engineering
P. Salachna, L. Lopusiewicz, A. Wesolowska, E. Meller, R. Piechocki
Summary: The study found that adding waste mushroom biomass can provide more nutrients to marigold plants, increase fresh weight and flower quantity, enhance chlorophyll content and antioxidant activity. The essential oil content and composition in leaves and petals also differ.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Medicine, General & Internal
Ali Nahardani, Simon Leistikow, Katja Gruen, Martin Kraemer, Karl-Heinz Herrmann, Andrea Schrepper, Christian Jung, Sara Moradi, Paul Christian Schulze, Lars Linsen, Juergen R. Reichenbach, Verena Hoerr, Marcus Franz
Summary: This study identified potential hemodynamic biomarkers for the diagnosis of pulmonary arterial hypertension (PAH) by analyzing pressure gradients and velocity values non-invasively.
Article
Endocrinology & Metabolism
Christian Lottspeich, Anton Koehler, Michael Czihal, Daniel A. Heinrich, Holger Schneider, Laura Handgriff, Martin Reincke, Christian Adolf
Summary: This study found that the arterial stiffness and atherosclerotic burden in patients with milder forms of PA are comparable to patients with EH, but after treatment, the arterial stiffness in PA patients significantly decreased. Therefore, there is an argument for a more liberal use of mineralocorticoid receptor antagonists in the treatment of patients with hypertension.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hafiza Iqra Kanwal, Munaza Shahid, Raham Bacha
Summary: This study compared carotid intima-media thickness (cIMT) in patients with hypertension and diabetes mellitus (DM). The results showed significant differences in mean cIMT among different groups.
JOURNAL OF DIAGNOSTIC MEDICAL SONOGRAPHY
(2023)
Review
Cardiac & Cardiovascular Systems
Hafiza Iqra Kanwal, Munaza Shahid, Raham Bacha
Summary: This study conducted a systematic review of literature on carotid arteries using ultrasonography to investigate the association between diabetes, hypertension, and intima-media thickness (IMT). The findings revealed that hypertension and diabetes were the most significant factors contributing to increased IMT, and coronary artery disease was also a common influencing factor.
PAKISTAN HEART JOURNAL
(2022)
Article
Peripheral Vascular Disease
Carolina De Ciuceis, Enzo Porteri, Damiano Rizzoni, Claudia Corbellini, Elisa La Boria, Gianluca E. M. Boari, Annamaria Pilu, Francesco Mittempergher, Ernesto Di Betta, Claudio Casella, Riccardo Nascimbeni, Claudia Agabiti Rosei, Giuseppina Ruggeri, Luigi Caimi, Enrico Agabiti Rosei
Letter
Peripheral Vascular Disease
Rita Rezzani, Enzo Porteri, Carolina De Ciuceis, Francesca Bonomini, Luigi F. Rodella, Gianluca E. M. Boari, Enrico Agabiti Rosei, Damiano Rizzoni
Article
Clinical Neurology
Carolina De Ciuceis, Claudio Cornali, Enzo Porteri, Dikran Mardighian, Chiara Pinardi, Marco M. Fontanella, Luigi F. Rodella, Rita Rezzani, Damiano Rizzoni, Gianluca E. M. Boari, Enrico Agabiti Rosei, Roberto Gasparotti
Article
Biochemistry & Molecular Biology
Gianluca E. M. Boari, Giulia Chiarini, Silvia Bonetti, Paolo Malerba, Gianluca Bianco, Cristina Faustini, Federico Braglia-Orlandini, Daniele Turini, Vittoria Guarinoni, Michele Saottini, Sara Viola, Giulia Ferrari-Toninelli, Giancarlo Pasini, Cristina Mascadri, Bianca Bonzi, Paolo Desenzani, Claudia Tusi, Eros Zanotti, Matteo Nardin, Damiano Rizzoni
BIOSCIENCE REPORTS
(2020)
Correction
Medicine, Research & Experimental
Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Cosimo Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Paolo Malerba, Gianluca E. M. Boari, Matteo Nardin, Cesare Tomasi, Giulia Chiarini, Silvia Bonetti, Gianluca Bianco, Cristina Faustini, Federico Braglia-Orlandini, Carolina De Ciuceis, Damiano Rizzoni
Summary: The aim of this study was to assess the correlation between SARS-CoV-2 gene detection results and clinical outcomes in COVID-19 patients. The results showed that patients with a complete positive gene detection had higher inflammation markers, which can indirectly reflect the viral load in COVID-19 patients.
INFECTIOUS DISEASES IN CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Francesca Leidi, Gianluca Edoardo Mario Boari, Ottavio Scarano, Benedetta Mangili, Giulia Gorla, Andrea Corbani, Beatrice Accordini, Federico Napoli, Chiara Ghidelli, Giulia Archenti, Daniele Turini, Michele Saottini, Vittoria Guarinoni, Giulia Ferrari-Toninelli, Francesca Manzoni, Silvia Bonetti, Giulia Chiarini, Paolo Malerba, Federico Braglia-Orlandini, Gianluca Bianco, Cristina Faustini, Claudia Agabiti-Rosei, Carolina De Ciuceis, Damiano Rizzoni
Summary: This study aimed to understand the determinants of outcome in two different COVID-19 outbreaks. The study found that mortality was significantly higher during the first wave compared to later periods, while the length of hospital stay was shorter during the first wave. The second wave had a higher use of corticosteroids and low-molecular weight heparin, and a lower prescription of antibiotics. Multivariate regression analysis identified C-reactive protein and procalcitonin values, length of hospital stay and duration of symptoms as the strongest predictors of outcome.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
Damiano Rizzoni, Claudia Agabiti-Rosei, Gianluca E. M. Boari, Maria Lorenza Muiesan, Carolina De Ciuceis
Summary: Arterial hypertension is a common condition with various risks and complications. Vascular remodeling is an early step in hypertension-mediated organ damage and can be assessed using non-invasive techniques. Monitoring these structural changes and improving them with antihypertensive treatment is important.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Francesca Salvotti, Riccardo Pellegrinelli, Veronica Geroldi, Francesca Leidi, Vittorio Scipione, Gigliola Flamminio, Antonella Pastori, Claudia Agabiti-Rosei, Carolina De Ciuceis, Damiano Rizzoni, Gianluca E. M. Boari
Summary: This study analyzed the long-term sequelae in patients hospitalized during the acute phase of COVID-19 at Montichiari Hospital in Italy, who required high-flow oxygen treatment. The analysis found that patients who needed high FiO2 support during the acute phase showed long-term pulmonary consequences, with more than half of the patients presenting radiological alterations and persistent dyspnea or DLCO alterations.
ITALIAN JOURNAL OF MEDICINE
(2023)
Review
Peripheral Vascular Disease
Damiano Rizzoni, Claudia Agabiti-Rosei, Carolina De Ciuceis, Gianluca Edoardo Mario Boari
Summary: Calcium plays a crucial role in various processes within the blood vessel wall, such as endothelial permeability, platelet activation and adhesion, smooth muscle proliferation and migration, and synthesis of fibrous connective tissue. The use of coronary artery calcium score (CACS) as a diagnostic tool to assess cardiovascular risk is controversial, with varying recommendations among different guidelines.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Gianluca Bianco, Gianluca E. M. Boari, Silvia Bonetti, Giulia Chiarini, Federico Braglia Orlandini, Cristina Faustini, Paolo Malerba, Damiano Rizzoni
JOURNAL OF HYPERTENSION
(2021)
Meeting Abstract
Peripheral Vascular Disease
Silvia Bonetti, Gianluca E. M. Boari, Giulia Chiarini, Cristina Faustini, Gianluca Bianco, Federico Braglia-Orlandini, Paolo Malerba, Damiano Rizzoni
JOURNAL OF HYPERTENSION
(2021)
Meeting Abstract
Peripheral Vascular Disease
Giulia Chiarini, Gianluca E. M. Boari, Silvia Bonetti, Federico Braglia Orlandini, Paolo Malerba, Gianluca Bianco, Cristina Faustini, Damiano Rizzoni
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Gianluca E. M. Boari, Silvia Bonetti, Federico Braglia-Orlandini, Giulia Chiarini, Cristina Faustini, Gianluca Bianco, Marzia Santagiuliana, Vittoria Guarinoni, Michele Saottini, Sara Viola, Giulia Ferrari-Toninelli, Giancarlo Pasini, Bianca Bonzi, Paolo Desenzani, Claudia Tusi, Paolo Malerba, Eros Zanotti, Daniele Turini, Damiano Rizzoni
Summary: This study aimed to assess the short-term consequences of COVID-19-related pneumonia and its association with risk indices. Findings revealed that a quarter of patients showed evidence of pulmonary fibrosis after 4 months of discharge, with some patients experiencing persistent symptoms. Quality of life and disease severity may provide insights into predicting the clinical outcomes of the disease.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2021)
Article
Cardiac & Cardiovascular Systems
P. Lemkens, G. E. M. Boari, G. E. Fazzi, G. M. J. Janssen, J. E. Murphy-Ullrich, P. M. H. Schiffers, J. G. R. De Mey
OPEN CARDIOVASCULAR MEDICINE JOURNAL
(2012)
