4.8 Article

Cyclopentadiene-Phosphine/Palladium-Catalyzed Synthesis of Indolizines from Pyrrole and 1,4-Dibromo-1,3-butadienes

Journal

ORGANIC LETTERS
Volume 17, Issue 22, Pages 5674-5677

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02959

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Funding

  1. 973 Program [2012CB821600]
  2. Natural Science Foundation of China

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The cyclopentadienephosphine ligand (L1) and palladium were found to be an efficient catalyst system to activate the alpha-C(sp(2))H bond of pyrrole and indole derivatives. Various alkenyl or aryl dibromides could be used to react with pyrrole and indole derivatives to afford multisubstituted indolizines in high yields.

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