Article
Respiratory System
Carlyne M. Averell, Francois Laliberte, Guillaume Germain, Mei Sheng Duh, Matthew D. Rousculp, Sean D. MacKnight, David J. Slade
Summary: This study highlights the importance of adherence to inhaled corticosteroid/long-acting beta 2 agonist treatment in asthma patients. Adherent patients had lower rates of overall and severe exacerbations, reduced rescue medication use, and lower healthcare resource utilization and costs. The findings emphasize the short-term clinical and economic benefits of medication adherence in asthma management.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Medicine, General & Internal
[Anonymous]
Summary: This study analyzed the airway inflammation and remodeling status of patients after ICS-LABA treatment. The results showed that the combination therapy could decrease inflammation and remodeling pathways, but allergen stimulation-related pathways were still upregulated. For asthma treatment, a combination of medication and allergen removal is a complete strategy.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Ya-Ru Liang, I-Shiang Tzeng, Po-Chun Hsieh, Chan-Yen Kuo, Shiang-Yu Huang, Mei-Chen Yang, Yao-Kuang Wu, Chou-Chin Lan
Summary: This study used RNA transcriptome analysis to understand the comprehensive inflammation or airway remodeling status of patients after ICS-LABA treatment. The results showed that the combination of ICS/LABAs decreased airway inflammatory and remodeling pathways, but allergen stimulation-related pathways were still upregulated.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Carlos E. Rodriguez-Martinez, Monica P. Sossa-Briceno, Jefferson Antonio Buendia
Summary: This study compares the cost-effectiveness of using short-acting beta(2)-agonists (SABAs) alone versus using SABAs plus inhaled corticosteroids (ICS) in children with mild intermittent asthma. The results show that using SABAs plus ICS is more cost-effective, resulting in lower treatment costs and a higher probability of not requiring prednisone.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Arnaud Bourdin, Alberto A. Papi, Jonathan Corren, J. Christian Virchow, Megan S. Rice, Yamo Deniz, Michel Djandji, Paul Rowe, Ian D. Pavord
Summary: Dupilumab significantly reduced severe exacerbations and improved lung function and asthma control in patients with type 2-high asthma on high-dose ICS at baseline.
Article
Health Care Sciences & Services
Priyadarshini Kachroo, Joanne E. Sordillo, Sharon M. Lutz, Scott T. Weiss, Rachel S. Kelly, Michael J. McGeachie, Ann Chen Wu, Jessica A. Lasky-Su
Summary: Metabolomic profiles associated with asthma exacerbations during inhaled corticosteroid treatment were analyzed in this study, revealing potential biomarkers of treatment response variability. Sex differences were observed in the levels of fatty acid metabolites during exacerbations, while interactions between age and metabolites on exacerbation were also detected. These findings suggest that plasma metabolites may play a role in elucidating metabolic pathways underlying variability in asthma treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Chemistry, Medicinal
Gang Xing, Zhengxing Zhi, Ce Yi, Jitian Zou, Xuefeng Jing, Anthony Yiu-Ho Woo, Bin Lin, Li Pan, Yuyang Zhang, Maosheng Cheng
Summary: A group of 8-hydroxyquinolin-2(1H)-one analogues were designed and synthesized, among which compounds B05 and C08 were identified as potent and selective beta(2) agonists. They exhibited partial beta(2)-agonist activities in cells and showed rapid smooth muscle relaxation and long duration of action, suggesting their potential applicability in chronic respiratory diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Wenli Shang, Guizuo Wang, Yan Wang, Dong Han
Summary: This study aimed to evaluate the safety of long-term use of ICS in patients with asthma through a systematic review and meta-analysis. The results showed that, apart from mild local adverse events, the long-term use of ICS was safe for patients with asthma.
CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Ahmed Edris, Emmely W. de Roos, Michael J. McGeachie, Katia M. C. Verhamme, Guy G. Brusselle, Kelan G. Tantisira, Carlos Iribarren, Meng Lu, Ann Chen Wu, Bruno H. Stricker, Lies Lahousse
Summary: Genetic variants in CRHR1 and TBXT genes were found to be associated with poor and improved ICS response in adults with asthma, respectively. These associations may indicate specific endotypes that could potentially predict exacerbation risk and response to ICS treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Chemistry, Multidisciplinary
Elzbieta Dembowska, Aleksandra Jaron, Karolina Skoczek-Szlosser, Ewa Gabrysz-Trybek, Joanna Bladowska, Grzegorz Trybek
Summary: Asthma, a common allergic disease, affects both general health and oral health. This study observed the oral health status of 120 adult patients aged 18 to 71, finding significantly deeper pockets in the lateral segments of the dentition in all study groups, especially in the bronchial-only group. However, there was no significant worsening of periodontal status in asthma patients treated with inhalation, regardless of baseline periodontal status. The history of asthma and the use of inhaled corticosteroids (ICS) have an impact on patients' periodontal status.
APPLIED SCIENCES-BASEL
(2022)
Article
Physiology
Sarah Basin, Simon Valentin, Silvia Demoulin-Alexikova, Bruno Demoulin, Laurent Foucaud, Delphine Gerard, Celso Pouget, Edem Allado, Bruno Chenuel, Mathias Poussel
Summary: This study evaluated the impact of inhaled corticosteroids on cough reflex during artificial limb exercise in an animal model of eosinophilic airway inflammation. The results showed that inhaled corticosteroids were able to restore desensitization of the cough reflex, suggesting potential benefits for managing exercise-induced cough in asthma patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Sarah L. O'Beirne, Jacqueline Salit, Robert J. Kaner, Ronald G. Crystal, Yael Strulovici-Barel
Summary: The study found that airway ACE2 expression is increased in asthmatics on long-term treatment with ICS, which should be considered when assessing the use of inhaled corticosteroids during the pandemic.
RESPIRATORY RESEARCH
(2021)
Article
Pediatrics
Bing Wei, Yan-Hong Dang, Xiang-Ping Liu, Miao Li
Summary: This study aimed to investigate the differences in characteristics of Mycoplasma pneumoniae pneumonia (MPP) among children with and without asthma, as well as among children with asthma with and without inhaled corticosteroid (ICS) therapy. The study found that children with asthma had higher chances of wheezing compared to those without asthma. Furthermore, children with asthma who received ICS therapy had fewer and less severe exacerbations of MPP compared to those without ICS therapy. ICS therapy was identified as an independent protective factor against exacerbation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Health Care Sciences & Services
Marielle Slikkerveer, Afke van de Plas, Johanna H. M. Driessen, Robin Wijngaard, Frank de Vries, Renske Olie, Nathalie Meertens, Patricia van den Bemt
Summary: This study aimed to determine the frequency and determinants of in-hospital LMWH-prescribing errors. The results showed a prescribing error rate of 34%, with the most common error being dose adjustment based on body weight and renal function. Prophylactic LMWH prescribing in medical wards was associated with a higher risk of error compared to surgical wards.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Rheumatology
Irene E. M. Bultink, Frank de Vries, Ronald F. van Vollenhoven, Arief Lalmohamed
Summary: Patients with SLE in the UK have a 1.8-fold increased mortality rate compared to the general population, with the highest risk for those aged 18-39 years old; low-dose HCQ reduces the risk of mortality by 45%.
Article
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
Summary: The simultaneous use of oral glucocorticoids (GCs) and proton pump inhibitors (PPIs) increases the risk of osteoporotic fractures in patients with rheumatoid arthritis (RA), whereas the risk is relatively lower when GCs or PPIs are used alone. Among patients using both oral GCs and PPIs, the risk of fractures does not increase with higher PPI daily dose or duration.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
Summary: Low-dose oral glucocorticoid therapy does not increase the overall risk of osteoporotic fractures in patients with RA, but is associated with an increased risk of clinical vertebral fractures.
Article
Endocrinology & Metabolism
Johan Roikjer, Nikki C. C. Werkman, Niels Ejskjaer, Joop P. W. van den Bergh, Peter Vestergaard, Nicolaas C. Schaper, Morten Hasselstrom Jensen, Olaf Klungel, Frank de Vries, Johannes T. H. Nielen, Johanna H. M. Driessen
Summary: The study found a decline in incidence rates, hospitalizations, and mortality for first diabetic foot ulcers in individuals with type 2 diabetes in the UK primary care setting. Conversely, no significant changes were observed for individuals with type 1 diabetes. This suggests improvements in prevention and care for type 2 diabetes patients with diabetic foot ulcers.
Article
Urology & Nephrology
J. J. van Raaij, K. H. Hua, F. de Vries, Paddy K. C. Janssen
Summary: This study aimed to investigate the relationship between the His452Tyr polymorphism of the 5-HT2A receptor and the pathogenesis and intravaginal ejaculation latency time (IELT) differences in patients with lifelong premature ejaculation (LPE). The results showed no correlation between the polymorphism and IELT distribution in LPE patients.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Zohreh Safipour, Rogier van Der Zanden, Joop van den Bergh, Paddy Janssen, Peter Vestergaard, Frank de Vries, Johanna H. M. Driessen
Summary: This study found that the use of oral glucocorticoids in patients with myasthenia gravis did not increase the risk of major osteoporotic fractures based on both a case-control study and pooled analysis. Osteoporosis prevention in myasthenia gravis patients according to clinical guidelines is still recommended.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Oncology
Ard van Veelen, Shahab Abtahi, Patrick Souverein, Johanna H. M. Driessen, Olaf H. Klungel, Anne-Marie C. Dingemans, Robin van Geel, Frank de Vries, Sander Croes
Summary: This study compared the characteristics of lung cancer patients from phase III RCTs evaluating TKIs or ICIs with those in a real-world setting in the UK. The results showed that a considerable proportion of lung cancer patients in the real-world setting would have been ineligible for participation in RCTs, and these potentially ineligible patients had shorter overall survival.
CANCER EPIDEMIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sjoerd D. Meenks, Jos L. M. L. le Noble, Norbert A. Foudraine, Frank de Vries, Kees Neef (C Neef), Paddy K. C. Janssen
Summary: This study developed a reliable population PK model for unbound ceftriaxone in critically ill patients, and dosing simulations revealed that 1,000 mg twice daily, 2,000 mg once daily, or continuous infusion of 2,000 mg daily can achieve fT>4 mg/L>=60%.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Shirley Wang, Sushama Kattinakere Sreedhara, Sebastian Schneeweiss
Summary: Studies that analyze digital data collected in clinical practice provide important insights for healthcare decision-makers. In this study, the reproducibility of 150 peer-reviewed studies was tested, showing strong reproducibility. Future original studies could improve reproducibility by providing more complete reporting.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Eleni Domzaridou, Tjeerd Van Staa, Andrew G. Renehan, Natalie Cook, William Welfare, Darren M. Ashcroft, Victoria Palin
Summary: This study examines the association between antibiotic treatment and long-term mortality in cancer patients, finding that antibiotic use shortly before cancer diagnosis may reduce the effectiveness of chemotherapy and immunotherapy.
Meeting Abstract
Endocrinology & Metabolism
Shahab Abtahi, Rene Cordtz, Lene Dreyer, Johanna H. M. Driessen, Frank de Vries, Annelies Boonen, Andrea M. Burden
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Veerle van Hulten, Cindy Sarodnik, Johanna Driessen, Sandrine Bours, Frank de Vries, Caroll Webers, Geertjan Dinant, Hein de Vries, Patricia van Assema, Stef Kremers, Ramon Ottenheijm, Coen Stehouwer, Nicolaas Schaper, Piet Geusens, Joop van den Bergh
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nikki C. C. Werkman, Johannes T. H. Nielen, Joop P. W. van den Bergh, Niels Ejskjaer, Johan Roikjer, Nicolaas C. Schaper, Bernardette Rossi, Olaf Klungel, Peter Vestergaard, Frank de Vries, Johanna H. M. Driessen
Summary: This study found that current use of SGLT2-Is was not associated with an increased risk of lower limb amputations compared to current use of sulphonylureas (SU). Concomitant use of diuretics and signs of hypovolemia were also not associated with an increased risk of lower limb amputations.
CURRENT DRUG SAFETY
(2021)
