Article
Cardiac & Cardiovascular Systems
Jin-Seok Kim, Seon Won Kim, Jong Seok Lee, Seung Ku Lee, Robert Abbott, Ki Yeol Lee, Hong Euy Lim, Ki-Chul Sung, Goo-Yeong Cho, Kwang Kon Koh, Sun H. Kim, Chol Shin, Seong Hwan Kim
Summary: The study demonstrates that pericardial adipose tissue is associated with left ventricular structure and function, independently of other markers of general obesity. This association highlights the importance of exploring the risk of cardiovascular disease related to heart fat.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hayati Eren, Muhammed Bahadir Omar, Ulker Kaya, Lutfi Ocal, Mehmet Inanir, Asli Gozek Ocal, Omer Genc, Selin Genc, Ahmet Guner, Mucahit Yetim
Summary: The study found that in hypertensive patients with LVH, EAT thickness and MA prevalence were significantly higher than in other groups, and EAT thickness and left ventricular mass index were determined as independent predictors for MA development in hypertensive patients with LVH.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Elisangela C. P. Lopes, Layde R. Paim, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Eduarda O. Z. Minin, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Licio A. Velloso, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: This study evaluated the relationship between circulating miRNAs and left ventricular hypertrophy (LVH) in hypertensive patients. The results showed that miR-145-5p, miR-451, and let7c were independently associated with LVH and left ventricular mass index. These miRNAs were also found to regulate genes and pathways related to cardiac remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xia Wu, Fei Yang, Lili Sun
Summary: This study evaluated the characteristics and influencing factors of computed tomography myocardial perfusion imaging (CT-MPI) in patients with left ventricular hypertrophy (LVH) caused by hypertension. The results showed that patients with LVH had lower myocardial blood flow but stable myocardial blood volume. In hypertensive patients, decreased myocardial blood flow was significantly correlated with increased left ventricular mass index.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Sukka Santosh Reddy, Heena Agarwal, Anant Jaiswal, Kumaravelu Jagavelu, Madhu Dikshit, Manoj Kumar Barthwal
Summary: The study found that macrophage p47phox plays a role in hypertensive cardiac remodeling, with its deficiency potentially leading to worsened cardiac dysfunction, hypertrophy, and increased interstitial fibrosis. Further experiments revealed elevated expression of M2 macrophage markers in KO mice, suggesting a restrictive role of p47phox in anti-inflammatory signaling during cardiac remodeling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Valeria R. Martinez, Augusto Martins Lima, Nikolaous Stergiopulos, Jorge O. Velez Rueda, Maria S. Islas, Mercedes Griera, Laura Calleros, Manuel Rodriguez Puyol, Carolina Jaquenod de Giusti, Enrique L. Portiansky, Evelina G. Ferrer, Veronica De Giusti, Patricia A. M. Williams
Summary: Hypertension is the main cause of left ventricular hypertrophy and can lead to heart failure. Candesartan, an angiotensin receptor antagonist, is commonly used for hypertension treatment. Our study focused on the structural modification of candesartan using zinc (ZnCand) to enhance its pharmacological properties. The results showed that ZnCand exhibited stronger interaction with the AT1 receptor, reducing oxidative stress and intracellular calcium flux. Additionally, in vivo experiments demonstrated that ZnCand effectively reduced systolic blood pressure and heart hypertrophy in SHR rats, while restoring the redox status.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Yoichi Sunagawa, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Nurmila Sari, Yasufumi Katanasaka, Yusuke Miyazaki, Hideaki Kakeya, Koji Hasegawa, Tatsuya Morimoto
Summary: Curcumin, a p300 histone acetyltransferase (HAT) inhibitor, has been found to prevent hypertension-induced left ventricular hypertrophy (LVH) development, without affecting blood pressure and systolic function.
Article
Veterinary Sciences
Luis Lobo, Joana Esteves-Guimaraes, Pedro Oliveira, Luis Salazar, Andre Pereira, Ana Patricia Fontes-Sousa
Summary: This study evaluated maternal left ventricular systo-diastolic function in pregnant bitches using conventional and TDI echocardiography. The results show increased cardiac output and heart rate in late gestation, with improved systolic function and decreased diastolic function.
VETERINARY SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, So Mi Jemma Cho, Dong-Wook Kim, Sungha Park, Hyeon Chang Kim
Summary: This study found that maintaining blood pressure at SBP <130 mm Hg and DBP <80 mm Hg was associated with the lowest risk for cardiovascular events in adults with hypertension and LVH. Further randomized trials are needed to establish optimal blood pressure-lowering strategies for these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Sheng-Nan Chang, Jou-Wei Lin, Yi-Chih Wang, Cho-Kai Wu, Jun-Jack Cheng, Juey-Jen Hwang, Jiunn-Lee Lin, Fu-Tien Chiang, Yih-Sharng Chen, Ron-Bin Hsu, William Chen, Jin-Jer Chen, Wen-Pin Lien
Summary: This 12-year study compared the longitudinal change in left ventricular diastolic dysfunction (LVDD) among healthy elderly, coronary artery disease (CAD), and hypertension (HTN) patients. The study found that under aggressive treatment, diastolic function was relatively preserved in HTN subjects with aging in comparison with elderly and CAD subjects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nenad Barisic
Summary: This study aims to investigate the Doppler imaging indicators of cardiac performance in premature newborns and their dynamic changes during the first week of life. The results show that the indicators of cardiac function in premature newborns are independent of gestational age and respiratory support.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Emilio Nardi, Giuseppe Mule, Antonina Giammanco, Alessandro Mattina, Giulio Geraci, Chiara Nardi, Maurizio Averna
Summary: This study assessed the prevalence of LVH in hypertensive patients with stage 2-5 CKD, finding a high prevalence of LVH, especially in advanced CKD stages. The association between LVH and CKD was confirmed, with negative effects on diastolic function.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Anett Apitz, Thenral Socrates, Thilo Burkard, Michael Mayr, Annina S. Vischer
Summary: The study aimed to investigate the prevalence of left ventricular hypertrophy (LVH) in patients with arterial hypertension (AHT) and describe patients with severe LVH. The results showed that over half of the AHT patients (52.5%) had abnormal left ventricular geometry, and 7.3% had severe LVH. Patients with severe LVH were more likely to be male, older, have uncontrolled blood pressure (especially during sleep), receive multiple antihypertensive treatments, and have comorbidities compared to those with normal left ventricular geometry.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Su-Hai Fei, Zhen-Feng Liu, Hai-Ning Xie, Jia-Ni Tong, Zheng-Mei Fang, Yan Chen, Ying-Shui Yao
Summary: In this study, miRNA's diagnostic value for hypertension with left ventricular hypertrophy was evaluated through meta-analysis. The results showed that miRNA has high sensitivity and specificity in this diagnosis, making it a better biological marker.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Monika Drozdz, Anna Moczulska, Andrzej Rudzinski, Dorota Drozdz
Summary: This study aimed to identify the most significant risk factors of left ventricular hypertrophy (LVH) in children with chronic kidney disease (CKD). The results showed that metabolic syndrome, hypertension, and CKD stage were the most important risk factors for LVH.
FRONTIERS IN ENDOCRINOLOGY
(2023)