Article
Chemistry, Applied
Hyun Hee L. Lee, Chang Jun Lee, Sang Yoon Choi, Yoonsook Kim, Jinyoung Hur
Summary: This study demonstrates the inhibitory effect of sea buckthorn leaf and berry extracts on the formation of advanced glycation endproducts (AGEs) and suggests their potential as dietary agents for controlling diseases mediated by AGEs and oxidative stress.
Review
Nutrition & Dietetics
Marco Mouanness, Henry Nava, Christelle Dagher, Zaher Merhi
Summary: Recent studies have found that dietary advanced glycation end products (AGEs) play a significant role in reproductive and metabolic dysfunctions associated with polycystic ovary syndrome (PCOS). AGEs are reactive molecules formed by the non-enzymatic glycation process between reducing sugars and proteins, lipids, or nucleic acids. This review discusses the involvement of AGEs in key elements of the PCOS phenotype and pathophysiology and suggests targeting AGEs as a potential novel approach to treating PCOS symptoms.
Review
Pharmacology & Pharmacy
Edwin R. Miranda, Jacob M. Haus
Summary: The prevalence of obesity in the US has significantly increased over the years, leading to a rise in type 2 diabetes. Obesity contributes to various metabolic disorders, with insulin resistance being a major factor in the development of type 2 diabetes and related diseases. However, the mechanisms behind insulin resistance are complex, making it challenging to find viable interventions.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Orthopedics
Zachary S. Gallate, Danielle N. D'Erminio, Philip Nasser, Damien M. Laudier, James C. Iatridis
Summary: Back and neck pain are major causes of disability, with intervertebral disc degeneration being a contributing factor. Accumulation of advanced glycation endproducts (AGEs) is associated with oxidative stress and collagen damage in the intervertebral disc. The receptors for AGEs (RAGE) and Galectin 3 (Gal3) play important roles in the response to AGEs in the intervertebral disc.
Article
Endocrinology & Metabolism
Mathias D. G. Van den Eynde, Alfons J. H. M. Houben, Jean L. J. M. Scheijen, Armand M. A. Linkens, Petra M. Niessen, Nynke Simons, Nordin M. J. Hanssen, Yvo H. A. M. Kusters, Simone J. M. P. Eussen, Toshio Miyata, Coen D. A. Stehouwer, Casper G. Schalkwijk
Summary: This study found that pyridoxamine (PM), a B6 vitamer and dicarbonyl scavenger, can reduce methylglyoxal (MGO), protein-bound N delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). However, PM does not affect insulin sensitivity and vascular function.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sara Csiha, Istvan Molnar, Sandor Halmi, David Hutkai, Hajnalka Lorincz, Sandor Somodi, Monika Katko, Mariann Harangi, Gyorgy Paragh, Endre V. Nagy, Eszter Berta, Miklos Bodor
Summary: The levels of advanced glycation end products (AGEs) in the serum of patients with Hashimoto thyroiditis (HT) are lower, and soluble RAGE (sRAGE) can reduce the interaction between AGEs and their receptor in a competitive manner, which is beneficial for thyroid function balance in patients. Further research is needed to confirm these results.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Manuel Portero-Otin, M. Pia de la Maza, Jaime Uribarri
Summary: Insulin resistance is commonly observed during aging and is a major factor in chronic nontransmissible diseases. Diet, particularly the intake of advanced glycation end products (AGEs), plays a significant role in causing insulin resistance. Clinical trials and animal studies suggest that reducing dietary AGE intake can improve insulin resistance.
Article
Cardiac & Cardiovascular Systems
Julio A. Lamprea-Montealegre, Alice M. Arnold, Robyn L. McCLelland, Kenneth J. Mukamal, Luc Djousse, Mary L. Biggs, David S. Siscovick, Russell P. Tracy, Paul J. Beisswenger, Bruce M. Psaty, Joachim H. Ix, Jorge R. Kizer
Summary: This study found that alpha-dicarbonyl-derived AGEs are associated with CVD in an older cohort, but not in a healthier middle-aged/older cohort. The results suggest that AGEs may exert detrimental cardiovascular effects only under conditions of marked dicarbonyl and oxidative stress. Further investigation of alpha-dicarbonyl derivatives could lead to potential new strategies for CVD prevention in high-risk older populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Infectious Diseases
Kyle Haasbroek, Masayuki Yagi, Yoshikazu Yonei
Summary: The study found that several compounds inhibiting glycation and breaking AGE crosslinks can effectively inhibit biofilm formation of Staphylococcus aureus, potentially treating S. aureus dysbiosis and skin infections associated with elevated skin glycation.
Article
Nutrition & Dietetics
Armand M. A. Linkens, Simone J. M. P. Eussen, Alfons J. H. M. Houben, Andrea Mari, Pieter C. Dagnelie, Coen D. A. Stehouwer, Casper G. Schalkwijk
Summary: This study investigated the association between habitual intake of advanced glycation endproducts (AGEs) and glucose metabolism. The results showed that higher habitual intake of AGEs was not associated with worse glucose metabolism or increased incidence of prediabetes or type 2 diabetes. However, higher intake of MG-H1 was associated with better insulin sensitivity and glucose sensitivity.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Raffaella Mastrocola, Federica Dal Bello, Alessia S. Cento, Katrien Gaens, Debora Collotta, Manuela Aragno, Claudio Medana, Massimo Collino, Kristiaan Wouters, Casper G. Schalkwijk
Summary: High levels of sphingolipid intermediates ceramide and sphingosine-1-phosphate are suggested to be involved in the development of insulin resistance. Accumulation of advanced glycation endproducts (AGEs) in the liver may alter sphingolipids metabolism, leading to insulin resistance. Modulating sphingolipids metabolism through preventing AGEs accumulation could potentially reduce the development of insulin resistance.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Physical
Vaishali Rana, Ahana Mukherjee, Yogita Basnal, Deepak Kushwaha, Jaydeep Bhattacharya, Ranjita Ghosh Moulick
Summary: The elevated blood sugar in Type II diabetes leads to the formation of Advanced Glycation Endproducts (AGEs), which cause severe pathogenic complications. Previous research has shown that AGEs generated from Hemoglobin A0 (HbA0) can synthesize gold nanoparticles (AuNPs). In this study, it was found that these AGEs can also reduce silver ions and synthesize silver nanoparticles (AgNPs) with a different plasmonic response. The research demonstrates that AGEs can be detected by deploying metal salts in solution.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
Ana-Lucia Mayen, Elom K. Aglago, Viktoria Knaze, Reynalda Cordova, Casper G. Schalkwijk, Karl-Heinz Wagner, Krasimira Aleksandrova, Veronika Fedirko, Pekka Keski-Rahkonen, Michael F. Leitzmann, Verena Katzke, Bernard Srour, Matthias B. Schulze, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Bas Bueno-de-Mesquita, Magritt Brustad, Antonio Agudo, Maria Dolores Chirlaque Lopez, Pilar Amiano, Bodil Ohlsson, Stina Ramne, Dagfinn Aune, Elisabete Weiderpass, Mazda Jenab, Heinz Freisling
Summary: The study found that higher dietary intake of AGEs was inversely associated with the risk of hepatocellular carcinoma and positively associated with the risk of gallbladder cancer. No associations were observed for cancers of the intra and extrahepatic bile ducts.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Physiology
Xiaoxia Huang, Bingyu Li, Jiaqing Hu, Zhuanhua Liu, Dongping Li, Zhenfeng Chen, Hang Huang, Yanjia Chen, Xiaohua Guo, Yun Cui, Qiaobing Huang
Summary: This study reveals that AGEs mediate kidney injury with characteristic patterns by binding with RAGE and inducing moesin phosphorylation. AGE-BSA stimulation in mice resulted in distinct abnormal angiogenesis, glomerular hypertrophy, mesangial expansion, glomerular atrophy, and fibrosis at different time points. Moesin phosphorylation was accompanied by these AGE-induced alterations, and moesin deficiency attenuated AGE-BSA-induced fibrosis. The phosphorylation of moesin T558 was critical in AGE-induced tube formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Food Science & Technology
Qian Wu, Yingna Feng, Yu Ouyang, Yinggang Liang, Kuoquan Zhao, Ying Wang, Qing Luo, Juan Xiao, Nianjie Feng, Mengzhou Zhou
Summary: The study demonstrated that LSOPC inhibited AGEs formation, alleviated AGEs-induced liver injury by suppressing NF-kappa B nuclear translocation and MAPK signaling pathway activation. Additionally, LSOPC also inhibited the expression of TNF-alpha and IL-6. In conclusion, LSOPC treatment potentially modulated liver injury caused by long-term dietary AGEs by suppressing the RAGE-MAPK-NF-kappa B pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Ludwig Merker, Thomas Ebert, Martina Guthoff, Berend Isermann
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Article
Biochemistry & Molecular Biology
Anja Saalbach, Ulf Anderegg, Ralph Wendt, Joachim Beige, Anette Bachmann, Nora Kloeting, Matthias Blueher, Ming-Zhi Zhang, Raymond C. Harris, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: Kidney fibrosis, a major factor in chronic kidney disease (CKD), leads to irreversible organ function loss. This study investigated the association of the soluble form of Thymocyte differentiation antigen-1 (sThy-1) with clinical parameters in CKD patients receiving hemodialysis. The study also examined Thy-1 tissue expression in a mouse model of diabetic CKD. The results showed that sThy-1 levels increased with worsening renal function, regardless of the presence of diabetes. Serum creatinine was found to be a major predictor of sThy-1 levels. Additionally, sThy-1 was found to be an independent predictor of markers of renal function. The study suggests that Thy-1 may have a role in controlling kidney fibrosis and could potentially be used as a renal antifibrotic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Janine Molder, Esther Guiu-Jurado, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Peter Kovacs, Matthias Blueher, Nora Kloeting
Summary: This study aimed to investigate the influence of SNP rs10487505 on leptin mRNA expression and obesity-related parameters. The researchers found that rs10487505 is associated with lower leptin levels in women and a lower mean BMI in women carrying the C allele. However, no association was found between rs10487505 and leptin mRNA expression in adipose tissue.
Article
Endocrinology & Metabolism
Noa Ofir, Yuval Mizrakli, Yariv Greenshpan, Yftach Gepner, Omri Sharabi, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Uta Ceglarek, Michael Stumvoll, Matthias Blueher, Yoash Chassidim, Assaf Rudich, Anat Reiner-Benaim, Iris Shai, Ilan Shelef, Roi Gazit
Summary: In this study, the researchers found that long-term weight loss can temporarily reduce bone marrow adipose tissue (BMAT) in adults, with more prominent effects in younger adults. The storage and dynamics of BMAT are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
Review
Medicine, General & Internal
Lara Heuft, Jenny Voigt, Lars Selig, Michael Stumvoll, Haiko Schloegl, Thorsten Kaiser
Summary: This study investigates the role of clinical decision support systems (CDSS) in the diagnosis of refeeding syndrome (RFS) and highlights the importance of identifying high-risk patients. The literature review reveals that malnourished patients with RFS have higher mortality rates and an increased risk of ICU admission compared to those without RFS. The use of CDSS significantly improves the detection and diagnosis of RFS.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Thomas Ebert, Linnea Widman, Peter Stenvinkel, Hannes Hagstrom
Summary: Nonalcoholic fatty liver disease (NAFLD) is bidirectionally linked to other cardiometabolic disorders but its long-term risk for microvascular outcomes is unclear. This study used nationwide Swedish patient data to identify individuals with NAFLD and matched them with reference individuals. The study found that NAFLD is independently and positively associated with the development of microvascular diseases. Rating: 8/10.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Robin Schuerfeld, Benjamin Sandner, Annett Hoffmann, Nora Kloeting, Ekaterine Baratashvili, Marcin Nowicki, Sabine Paeschke, Joanna Kosacka, Susan Kralisch, Anette Bachmann, Armin Frille, Anja Dietel, Jens-Uwe Stolzenburg, Matthias Blueher, Ming-Zhi Zhang, Raymond C. Harris, Berend Isermann, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: ObjectiveAcyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has been recently identified as an endocrine factor that affects food intake and lipid metabolism. This study investigated the regulation of ACBP in conditions with impaired kidney function and found that serum ACBP concentrations were significantly increased in kidney failure and acute kidney dysfunction. Further studies are needed to explore the physiological role of ACBP in malnutrition-related diseases such as chronic kidney disease and to consider markers of renal function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Deborah Kreher, Bero Luke Vincent Ernst, Dirk Ziebolz, Rainer Haak, Jonathan de Fallois, Thomas Ebert, Gerhard Schmalz
Summary: Patients on renal replacement therapy (RRT) often experience oral problems, such as dry mouth, periodontal disease, and dental caries. This systematic review aimed to assess the prevalence of caries in RRT patients. A comprehensive literature search was conducted in August 2022 using PubMed, Web of Science, and Scopus databases. Out of the 653 studies identified, 33 clinical investigations were included in the analysis. The majority of the studies focused on hemodialysis patients and used the decayed-(D), missing- and filled-teeth (DMF-T) index to assess caries burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Maximiliane Chiara Hammel, Robert Stein, Juergen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Toenjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blueher, Wieland Kiess, Antje Koerner
Summary: The study aimed to establish reference ranges for fasting insulin indices across all age ranges and evaluate their clinical application in predicting glycemic deterioration in children. The results showed that insulin resistance in children with obesity doubled the risk for future glycemic deterioration, and insulin-based indices were better predictors of dysglycemia than fasting glucose alone.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Medicine, General & Internal
Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blueher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B. Hu, Meir J. Stampfer, Peter Kovacs, Liming Liang, Iris Shai
Summary: This study found that Mediterranean and green-MED diets with increased polyphenols intake are inversely associated with biological aging. To the best of our knowledge, this is the first clinical trial to indicate a potential link between polyphenol intake, urine polyphenols, and biological aging.
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Medicine, General & Internal
Ognian Neytchev, Helen Erlandsson, Anna Witasp, Louise Nordfors, Abdul Rashid Qureshi, Ken Iseri, Hokuto Morohoshi, Colin Selman, Thomas Ebert, Karolina Kublickiene, Peter Stenvinkel, Paul G. Shiels
Summary: Chronic kidney disease patients exhibit an increased biological age compared to the general population, with kidney transplantation partially reducing age acceleration, while dialysis does not have the same effect.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jana Breitfeld, Katrin Horn, Diana Le Duc, Akhil Velluva, Carola Marzi, Harald Grallert, Nele Friedrich, Maik Pietzner, Uwe Voelker, Henry Voelzke, Emma Ahlqvist, Dina Mansour Aly, Tiinamaija Tuomi, Ronny Baber, Juergen Kratzsch, Joachim Thiery, Berend Isermann, Markus Loeffler, Nora Kloeting, Matthias Blueher, Michael Stumvoll, John T. Heiker, Anke Toenjes, Markus Scholz, Peter Kovacs
Summary: This study found a correlation between genetic variants of the Vaspin gene and serum Vaspin levels, and further revealed the causal role of Vaspin in lipid metabolism.
Article
Genetics & Heredity
Dandan Ren, Thomas Ebert, Deborah Kreher, Bero Luke Vincent Ernst, Jonathan de Fallois, Gerhard Schmalz
Summary: This bioinformatics analysis identified potential cross-talk genes and related pathways between periodontitis and chronic kidney failure (CKF). Datasets from NCBI Gene Expression Omnibus (GEO) were used, and differential expression analysis was performed to assess deregulated genes for periodontitis and CKF. Protein-protein interaction (PPI) networks were constructed and analyzed, identifying potential hub cross-talk genes. The five hub cross-talk genes, CCL5, FCGR3B, MMP-9, SAA1, and SELL, were significantly upregulated in diseased samples compared to controls and showed high predictive value.