4.8 Article

Total Synthesis of (±)-Goniomitine via Radical Translocation

Journal

ORGANIC LETTERS
Volume 17, Issue 18, Pages 4558-4560

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02277

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Funding

  1. National Science Foundation [1465287]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1465287] Funding Source: National Science Foundation

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The aspidosperma alkaloid goniomitine was synthesized in six steps from 2-ethyl-delta-valerolactam. The convergent strategy features an Ullman coupling to assemble the required carbon atoms. A complexity-generating radical translocation reaction was used to build the indole architecture.

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