Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability

Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery

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Colchicine effect on P-glycoprotein expression and activity: In silico and in vitro studies

(2014) Renata Silva et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis, and the antioxidant, neuroprotective and P-glycoprotein induction activity of 4-arylquinoline-2-carboxylates

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Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs

(2014) Prashant Joshi et al.   MedChemComm

Effect of atorvastatin and methotrexate on solid Ehrlich tumor

(2013) Ahmed M. Kabel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Docking Characterizes Substrate-Binding Sites and Efflux Modulation Mechanisms within P-Glycoprotein.

(2013) Ricardo J. Ferreira et al.   Journal of Chemical Information and Modeling

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties

(2012) Laura Cosentino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

(2012) Michael M. Hann et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and SAR requirements of adamantane–colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities

(2011) Olga N. Zefirova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cytosolic Carboxypeptidase 1 Is Involved in Processing α- and β-Tubulin

(2011) Iryna Berezniuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and tubulin-binding properties of new allocolchicinoids

(2010) François-Didier Boyer et al.   BIOORGANIC CHEMISTRY

Colchicine in clinical medicine. A guide for internists

(2010) Giuseppe Cocco et al.   European Journal of Internal Medicine

Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors

(2009) Jing Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions

(2009) Saskia Preissner et al.   NUCLEIC ACIDS RESEARCH

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Molecular models of human P-glycoprotein in two different catalytic states

(2009) Jean-Paul Becker et al.   BMC STRUCTURAL BIOLOGY

An overview of cancer multidrug resistance: a still unsolved problem

(2008) H. Lage   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure and mechanism of ATP-binding cassette transporters

(2008) K. P Locher   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Colchicine Update: 2008

(2008) Robert A. Terkeltaub   SEMINARS IN ARTHRITIS AND RHEUMATISM

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS