Journal
JOURNAL OF HUMAN HYPERTENSION
Volume 23, Issue 8, Pages 546-552Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jhh.2008.155
Keywords
blood pressure; activities of daily living; mortality; population attributable fraction
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Funding
- Ministry of Health, Labour and Welfare and a Health and Labour Sciences Research Grant, Japan [H11-chouju-046, H14-chouju-003, H17-chouju-012, H19-chouju-014]
- Ministry of Health andWelfare under the auspices of the Japanese Association for Cerebro-cardiovascular Disease Control
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Although several studies have reported on the relation between high blood pressure ( BP) and impaired activities of daily living (ADL), only a few studies have reported on the relation of high BP in middle-aged subjects with future impaired ADL. Furthermore, no studies reported an excess impaired ADL due to non-normal BP. Using ADL 1999 data, we compared data from NIPPON DATA80 survivors without impaired ADL (N = 1816) with those with impaired ADL (N = 75) using baseline BP information collected in 1980. We analysed participants who were aged 47-59 years at baseline. Multiple adjusted logistic regression analyses were used to estimate the risk of impaired ADL, according to baseline BP categories using Joint National Committee 7 guidelines ( normal BP, prehypertension, stage 1 hypertension ( HT) and stage 2 HT). Subjects who used antihypertensive medications were classified as having stage 2 HT. We calculated excess impaired ADL due to non-normal BP. Compared with normal BP categories, the adjusted odds ratio ( OR) and 95% confidence interval (CI) of having impaired ADL was higher in subjects with prehypertension (OR = 1.50, 95% CI: 0.55-4.09), stage 1 HT (OR = 1.56, 95% CI: 0.56-4.32) and stage 2 HT (OR = 2.96, 95% CI: 1.09-8.05). Non-normal BP explained 45% (33.7/75) of impaired ADL. A positive relation of BP categories with the composite end point of mortality and impaired ADL was also observed. In conclusion, controlling BP in middle age may prevent deaths and future ADL decline. Journal of Human Hypertension ( 2009) 23, 546-552; doi: 10.1038/jhh.2008.155; published online 18 December 2008
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