Review
Pathology
Jessica Vilarinho Cardoso, Rui Medeiros, Francisca Dias, Isabelle Alves Costa, Renato Ferrari, Plinio Tostes Berardo, Jamila Alessandra Perini
Summary: The study evaluated the association of DROSHA and DICER1 polymorphisms with the development of endometriosis and other diseases, showing that DICER1 rs3742330 A > G polymorphism may be associated with susceptibility to endometriosis. The frequencies of both polymorphisms varied significantly among populations, with discrepancies in the risk associations with the development of diseases.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Arnab Das, Sudarshana Basu, Diptankar Bandyopadhyay, Kamalika Mukherjee, Debduti Datta, Sreemoyee Chakraborty, Sayantan Jana, Moumita Adak, Sarpita Bose, Saikat Chakrabarti, Snehasikta Swarnakar, Partha Chakrabarti, Suvendra N. Bhattacharyya
Summary: miR-122 in the mammalian liver regulates metabolic homeostasis and plays a role in controlling tissue inflammation through intercellular transfer. MMP2 is essential for the transfer of extracellular vesicles and their miRNA content between hepatic and non-hepatic cells.
Review
Biochemistry & Molecular Biology
Jing Shan, Da-Jin Li, Xiao-Qiu Wang
Summary: Endometriosis is the leading cause of infertility, and its mechanisms leading to implantation failure include hormone imbalance, inflammation, and immune regulatory dysfunction. This review provides an overview of current research on endometriosis-related infertility/subfertility, focusing on factors such as genetic, epigenetic, glycosylation, metabolism, and microRNA. The future clinical implications of these factors in the diagnosis and therapy to improve endometrial function are also discussed.
Article
Biochemistry & Molecular Biology
Sarah Brunty, Kristeena Ray Wright, Brenda Mitchell, Nalini Santanam
Summary: Activation of trimethylation of histone 3 lysine 27 (H3K27me3) by EZH2 plays a role in endometriosis, with higher expression of PRC2 complex components like JARID2, miR-155, and FOXP3 noted in patient tissues. MiR-155 affects the PRC2 complex but has minimal impact on JARID2 expression, suggesting alternative pathways may be involved. A novel crosstalk between miR-155, the PRC2 complex, JARID2, and PHF19 has been identified, providing potential epigenetic targets for further study in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Warren B. Nothnick
Summary: Endometriosis is a significant disease characterized by infertility and pelvic pain. Altered responsiveness to progesterone, potentially regulated by miRNAs, may contribute to the pathophysiology of the disease.
Article
Biology
Agata Ocenasova, Ivana Shawkatova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Maria Kralova, Iliana Kiralyova, Iveta Mikolaskova, Vladimira Durmanova
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss. Matrix metalloproteinases (MMPs) play a role in the disruption of the blood-brain barrier in AD patients, leading to neuroinflammation. This study investigated the association between MMP2 gene polymorphisms and AD susceptibility, as well as their interaction with the APOE epsilon 4 risk allele, age at disease onset, and MoCA score. The results showed no significant differences in MMP2 polymorphisms between AD patients and controls, but revealed a correlation between MMP2 rs243866 GG genotype and a later age at disease onset. This suggests that the MMP2 rs243866 promoter polymorphism may influence the age at onset of AD.
Article
Pharmacology & Pharmacy
Qingxin Song, Fan Zhang, Kun Wang, Zhi Chen, Quan Li, Zude Liu, Hongxing Shen
Summary: The study found that the expression level of miR-874-3p was significantly decreased in IDD patients, and it could target and repress MMP2 and MMP3 expression, potentially providing a diagnostic marker and treatment candidate for IDD, as well as direction for future investigations on cancer and inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Review
Biology
Izyan Nabila Ahmad Azam, Norhazlina Abdul Wahab, Mohd Helmy Mokhtar, Mohamad Nasir Shafiee, Norfilza Mohd Mokhtar
Summary: This review focuses on dysregulated miRNAs and their roles in regulating apoptosis in women with endometriosis. Identifying dysregulated miRNAs and their target genes could help identify new therapeutic targets for treating this disease.
Article
Biochemistry & Molecular Biology
Justyna Basak, Danuta Piotrzkowska, Ireneusz Majsterek, Ewa Kucharska
Summary: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system with no cure and unclear etiology. This study aimed to identify SNPs associated with an increased risk of developing MS. The findings suggest that the GG AGO1 rs636832 and AA GEMIN4 rs7813 genotypes are associated with an increased risk of MS.
Article
Cell Biology
Yu-Xiang Yan, Huan-Bo Xiao, Jie Zhang, Shuo Wang, Jing Dong, Li-Juan Wu
Summary: This study found an association between miR-144 SNP rs9279 and increased risk of T2D, with carriers of the GG genotype showing significantly upregulated expression of miRNAs and cortisol. The SNP may contribute to the development of T2D by altering regulation of the stress response.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Lu Li, Bo Sun, Yingpu Sun
Summary: This study investigates the molecular mechanism of endometriosis by analyzing differentially expressed genes and their predicted transcription factors and miRNAs. The findings provide novel insights for clinical diagnosis and treatment of endometriosis.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Shilin Li, Shiyao Yang, Xiaobo Zhang, Yu Zhang, Jie Zhang, Xiao Zhang, Weiping Li, Xiaochen Niu, Wenzhen Shi, Gejuan Zhang, Mingze Chang, Ye Tian
Summary: This study found a significant association between rs243849 and rs14070 in MMP2 and the risk of IS in the Chinese Shaanxi population. Specifically, rs14070 in MMP2 was found to reduce the risk of IS. Subgroup analysis revealed that rs243849 in MMP2 increased the risk of IS among drinkers, while rs14070 in MMP2 reduced IS susceptibility among females, participants aged >55, smokers, and drinkers.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sayantani Das, Soumasree De, Sumita Sengupta
Summary: The study identified miR-20a and Nucleolin as key regulators of MMP2 through post-transcriptional regulation, demonstrating their impact on the invasion potential of breast cancer cells. It was also shown for the first time that MMP2 is a direct target of miR-20a and that Nucleolin binding to MMP2 3' UTR affects MMP2 expression.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Genetics & Heredity
Zixian Wan, Lu Ye, Guange Chen, Chaoyi Xiong, Zhenbo Ouyang, Liangzhi Wu, Jing He, Ping Duan, Youkun Jie, Qiushi Zhang, Wenfeng Hua
Summary: The study found that WTAP gene polymorphisms were associated with susceptibility to ovarian endometriosis among Chinese women.
FRONTIERS IN GENETICS
(2023)
Article
Environmental Sciences
Sun-Wung Hsieh, Szu-Chia Chen, Chun-Hung Chen, Ming-Tsang Wu, Chih-Hsing Hung
Summary: This study aims to investigate the risks of cognition from incense smoke. Data from Taiwan Biobank in the community were obtained. The study found that incense exposure is one of the independent risk factors for cognitive decline.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Environmental Sciences
Chia-Huang Chang, Yen-An Tsai, Yu-Fang Huang, Ming-Song Tsai, Jia-Woei Hou, Ching-Ling Lin, Pei-Wei Wang, Li-Wei Huang, Chih-Yao Chen, Chia-Fang Wu, Chia-Jung Hsieh, Ming-Tsang Wu, Shu-Li Wang, Mei-Lien Chen
Summary: The Taiwan Maternal and Infant Cohort Study aimed to evaluate the effects of prenatal exposure to phthalic acid esters (PAEs) on infant health. The study found an increased risk of small for gestational age (SGA) in male neonates with higher maternal exposure to mono-n-butyl phthalate (MnBP) in the third trimester, while a negative association was observed in female neonates. Exposure to high levels of MnBP during pregnancy may increase the risk of LBW/SGA in male neonates, but an opposite association was observed for LBW or SGA in male and female neonates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Chia-Chu Liu, Chia-Fang Wu, Yung-Chin Lee, Tsung-Yi Huang, Shih-Ting Huang, Hsun-Shuan Wang, Jhen-Hao Jhan, Shu-Pin Huang, Ching-Chia Li, Yung-Shun Juan, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chu-Chih Chen, Ming-Tsang Wu
Summary: Environmental exposure to melamine increases the risk of oxidative stress and early kidney injury. The single-nucleotide polymorphisms (SNPs) of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in patients with calcium urolithiasis.
Review
Health Care Sciences & Services
Shigeo Saito, Chia-Chen Ku, Kenly Wuputra, Jia-Bin Pan, Chang-Shen Lin, Ying-Chu Lin, Deng-Chyang Wu, Kazunari K. Yokoyama
Summary: The use of biomarkers in cancer diagnosis, therapy, and prognosis has proven to be highly effective in identifying cancer stem cells and their microenvironments. However, the plasticity of cancer stem cells can alter their functional phenotype and appearance in response to chemotherapy and radiation therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Jau-Ling Huang, Si-Yun Chen, Chang-Shen Lin
Summary: Cancer stem cells (CSCs) play a critical role in tumor initiation and maintenance, and possess features that allow them to evade immune surveillance. This review explores the roles of epigenetic modifiers in CSC characteristics and discusses the interplay between CSCs and interferon response. The emerging strategy of targeting these modifiers to eliminate CSCs is also discussed.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Tsung-Lin Tsai, Chia-Jung Hsieh, Ming-Tsang Wu, Mei-Lien Chen, Po-Hsiu Kuo, Shu-Li Wang
Summary: Our study found that prenatal exposure to toxic metals and PAEs may contribute to certain DSM-5-oriented problems in children at 4 years of age. Reducing exposure to toxic metals and PAEs during pregnancy is recommended to prevent increased mental health problems in children.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Hsing-Kang Chen, Shu-Li Wang, Yu-Hsun Chang, Chien-Wen Sun, Ming-Tsang Wu, Mei-Lien Chen, Yu-Jie Lin, Chia -Jung Hsieh
Summary: This study examines the associations between prenatal phthalate exposure and neonatal neurobehavioral development. It found that phthalate exposure was negatively associated with neurobehaviors in female infants and positively associated with neurobehaviors in male infants. These findings highlight the gender-specific effects of maternal phthalate exposure on the neurodevelopment of newborns.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Karthikeyan Prakasham, Swapnil Gurrani, Jen-Taie Shiea, Ming-Tsang Wu, Chia-Fang Wu, Yi-Jia Ku, Tseng-Yu Tsai, Hung-Ta Hua, Yu-Jia Lin, Po-Chin Huang, Gangadhar Andaluri, Vinoth Kumar Ponnusamy
Summary: A fast mycotoxin extraction (FaMEx) technique was developed for the rapid identification and quantification of carcinogenic ochratoxin-A (OTA) in food and agricultural soil samples. The method showed excellent linearity, sensitive detection, and low limits of quantification, making it suitable for mycotoxin detection in various samples.
Article
Medical Laboratory Technology
Hui-Ming Chen, Chou-Cheng Chen, Jia-Jen Chen, Chia-Fang Wu, Sih-Syuan Lee, Fu-Chen Kuo, Chien-Wen Sun, Mei-Lien Chen, Chia-Jung Hsieh, Shu-Li Wang, Ming-Tsang Wu
Summary: This study aims to establish reference intervals for important biochemical parameters in cord blood of newborns in Taiwan and investigate their sex differences. It also examines the correlation between maternal blood levels and neonatal cord blood levels.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Kenly Wuputra, Chia-Chen Ku, Jia-Bin Pan, Chung-Jung Liu, Kohsuke Kato, Ying-Chu Lin, Yi-Chang Liu, Chang-Shen Lin, Michael Hsiao, Ming-Hong Tai, Inn-Wen Chong, Huang-Ming Hu, Chao-Hung Kuo, Deng-Chyang Wu, Kazunari K. Yokoyama
Summary: By preparing three-dimensional organoids of human stomach cancers and studying the correlation between the tumorigenicity and cytotoxicity of Helicobacter pylori (H. pylori), we found that hepatoma-derived growth factor (HDGF) and tumor necrosis factor (TNFa) had effects on the growth and invasion activity of H. pylori-infected gastric cancer organoids. HDGF controlled the growth of organoids in a species-specific manner, while TNFa decreased cell viability in H. pylori-infected organoids. Additionally, HDGF controlled the invasion activity of H. pylori-infected organoids in a species-dependent manner, whereas TNFa decreased invasion activities of most organoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Karthikeyan Prakasham, Swapnil Gurrani, Jentaie Shiea, Ming-Tsang Wu, Reeta Rani Singhania, Anil Kumar Patel, Cheng-Di Dong, Yu-Chia Lin, Bongee Tsai, Po-Chin Huang, Gangadhar Andaluri, Vinoth Kumar Ponnusamy
Summary: This study presents a novel semi-automated in-syringe-based fast mycotoxin extraction (IS-FaMEx) technique coupled with direct-injection electrospray-ionization tandem mass spectrometer (ESI-MS/MS) detection for the quantification of ochratoxin A in coffee and tea samples. The developed method showed remarkable linearity, with a correlation coefficient of > 0.999 and > 92% extraction recovery with a precision of 6%. The detection and quantification limits for ochratoxin A were lower than the European Union regulatory limit, making it a potential methodology for mycotoxin detection in food products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Plant Sciences
Chien-Liang Lin, Chung- Yu, Tzong-Huei Lee, Jimmy Ming -Jung Chuang, Kuang-Fen Han, Chang-Shen Lin, Wan-Ping Huang, Jeff Yi-Fu Chen, Chung-Yi Chen, Mei-Ying Lin, Chien-Hsing Lee
Summary: This study demonstrated that plumbagin (PG), a natural compound isolated from Plumbago zeylanica L, exhibits anticancer effects against drug-resistant oral cancer cells by reducing cell viability, inducing apoptosis, and triggering intracellular and mitochondrial ROS generation, leading to mitochondrial dysfunction and endoplasmic reticulum stress. In addition, the inhibition of ROS abolished the effects of PG on cell viability, apoptosis, and ER stress.
Article
Environmental Sciences
Yi-Chun Tsai, Chia-Fang Wu, Wei-Wen Hung, Ping-Shaou Yu, Chia-Chu Liu, Tusty-Jiuan Hsieh, Chu-Chih Chen, Sih-Syuan Li, Jia-Jen Chen, Yi-Wen Chiu, Shang-Jyh Hwang, Ming-Tsang Wu
Summary: This prospective cohort study investigated the impact of melamine exposure on kidney outcomes in type 2 diabetes mellitus (T2D) patients. The findings showed a significant association between melamine exposure and adverse kidney outcomes in T2D patients, especially in those with male, well sugar control or good baseline kidney function.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Applied
Karthikeyan Prakasham, Swapnil Gurrani, Jentaie Shiea, Ming-Tsang Wu, Chia-Fang Wu, Yu -Chia Lin, Bongee Tsai, Po-Chin Huang, Gangadhar Andaluri, Vinoth Kumar Ponnusamy
Summary: In this study, a novel semi-automated in-syringe-based coagulant-assisted liquid-liquid microextraction (IS-CGA-LLME) technique coupled with UHPLC-MS/MS was developed for the quantification of mycotoxin (OT-A) in coffee and tea samples. The method showed highly sensitive detection and quantification limits for OT-A, excellent extraction recovery and precision. This method provides a simple, highly sensitive, semi-automated, low-matrix effect, and efficient procedure for mycotoxin determination in food samples.
Meeting Abstract
Urology & Nephrology
C-C Liu, T-J Hsieh, C-F Wu, C-H Lee, Y-C Tsai, T-Y Huang, S-C Wen, C-H Lee, T-M Chien, Y-C Lee, Y-H Chou, S-P Huang, Y-S Juan, W-J Wu, M-T Wu
