Review
Hematology
Nicolas Wenger, Tim Sebastian, Rolf Peter Engelberger, Nils Kucher, David Spirk
Summary: PE and DVT, two clinical manifestations of VTE, have substantial differences in patient characteristics, risk factors, clinical manifestations, and outcomes. However, current guidelines for the management of DVT and PE have strikingly similar recommendations for diagnosis and treatment, with the main difference being the indication for advanced reperfusion therapies. More data is needed to propose evidence-based adjustments in diagnostic and therapeutic strategies to improve prognosis and outcomes for patients with VTE.
THROMBOSIS RESEARCH
(2021)
Article
Medicine, General & Internal
Sang Hyun Jeon, Geon Ho Kwon, Man Soo Kim
Summary: The incidence of VTE after arthroscopic meniscus surgery is low, but can be life-threatening. Risk factors for VTE should be evaluated before and after surgery, and appropriate thromboprophylaxis should be provided when necessary.
Article
Obstetrics & Gynecology
Tsuyoshi Murata, Yuki Yoshimoto, Yoshiaki Shibano, Koji Owada, Masayuki Miyajima, Soichi Nakamura, Ryuji Yamauchi
Summary: Asymptomatic postpartum ovarian vein thrombosis (OVT) can lead to pulmonary thromboembolism (PTE). Future studies should establish universal screening guidelines and optimal treatment strategies for asymptomatic OVT in pregnant and postpartum women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Pharmacology & Pharmacy
Yunshan Cao, Chao Geng, Yahong Li, Yan Zhang
Summary: This article summarizes and compares the risk factors, common and specific pathogenic mechanisms underlying PTE, in situ pulmonary artery thrombosis, and CTEPH at molecular and cellular levels, and suggests therapeutic strategies for these diseases. The aim is to facilitate understanding of pathogenesis, differential diagnosis, and precision therapeutics of the three pulmonary artery thrombotic diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Hematology
Nicolas Wenger, Tim Sebastian, Jurg H. Beer, Lucia Mazzolai, Drahomir Aujesky, Daniel Hayoz, Rolf P. Engelberger, Wolfgang Korte, Davide Voci, Nils Kucher, Stefano Barco, David Spirk
Summary: The study found differences in demographics, risk factors, and clinical outcomes between PE and DVT alone. Management of anticoagulation duration differs between the two manifestations of VTE in routine clinical practice, contrary to recommendations in the current consensus guidelines.
THROMBOSIS RESEARCH
(2022)
Article
Surgery
Atsushi Kainuma, Yuming Ning, Paul A. Kurlansky, Amy S. Wang, Farhana Latif, Maryjane A. Farr, Gabriel T. Sayer, Nir Uriel, Hiroo Takayama, Yoshifumi Naka, Koji Takeda
Summary: VTE after heart transplantation is an important complication that can lead to longer hospital stays, higher in-hospital mortality, and worse long-term survival rates. Patients with a history of DVT/PE and prolonged intubation are more prone to developing in-hospital VTE.
CLINICAL TRANSPLANTATION
(2022)
Article
Hematology
Anjlee Mahajan, Ann Brunson, Joanna Eldredge, Richard H. White, Theresa H. M. Keegan, Ted Wun
Summary: This study aimed to investigate the epidemiology of isolated distal deep venous thrombosis (iDDVT) among cancer patients, including the incidence of recurrent venous thromboembolism (rVTE) and its effect on mortality by cancer type. The findings showed that iDDVT accounted for 11% of cancer-associated thrombosis (CT), and the risk of rVTE after iDDVT was similar to other CT sites. Furthermore, iDDVT was associated with increased mortality, with similar effects to pulmonary embolism or proximal DVT for most cancer types, except lung, colorectal, bladder, uterine, brain, and myeloma.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Keying Xu, Kerstin Wit, Geert-Jan Geersing, Toshihiko Takada, Roger Schutgens, Johan Elf, Clive Kearon, Sameer Parpia
Summary: Current clinical decision rules for excluding deep vein thrombosis (DVT) are complex and underused. A new simplified rule incorporating D-dimer and Wells items has been developed, showing promise in safely excluding DVT in patients with low clinical pretest probability. Prospective validation is needed to confirm these findings.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Aaron F. J. Iding, Alejandro Pallares Robles, Vincent ten Cate, Hugo ten Cate, Philipp S. Wild, Arina J. ten Cate-Hoek
Summary: This study identified 4 distinct phenotypes among patients with DVT, and assessed their relation to various outcomes. Risks were lowest in women using estrogen therapy and highest in patients with a cardiovascular risk profile. These findings have important implications for personalized clinical management.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Aiham Qdaisat, Adriana H. Wechsler, Maria T. Cruz Carreras, Jazmin R. Menendez, Demis Lipe, Emily A. Highsmith, Mona Kamal, Aisha Al-Breiki, Cristhiam M. Rojas Hernandez, Carol C. Wu, Sai-Ching J. Yeung
Summary: Cancer patients have a higher risk of developing venous thromboembolism, with incidental thromboemboli being common. Concomitant deep vein thrombosis (C-DVT) in cancer patients with unsuspected pulmonary embolism (PE) is associated with increased risk of recurrence and poor short- and long-term survival. Therefore, identifying and treating C-DVT is recommended to improve patient outcomes.
Article
Cardiac & Cardiovascular Systems
Maria Cristina Vedovati, Gregor Tratar, Alenka Mavri, Matteo Mazzetti, Vladimir Salazar Rosa, Lucia Pierpaoli, Marilena Cotugno, Giancarlo Agnelli, Cecilia Becattini
Summary: The study found that the use of DOACs for UEDVT treatment is feasible, effective, and safe, with patients with active cancer being more likely to delay the initiation of DOACs.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmed K. Pasha, Wiktoria Kuczmik, Waldemar E. Wysokinski, Ana I. Casanegra, Damon Houghton, Danielle T. Vlazny, Abigail Mertzig, Yumiko Hirao-Try, Launia White, David Hodge, Robert McBane
Summary: The study compared outcomes between cancer patients with calf DVT and those without cancer. Cancer patients with calf DVT had similar rates of VTE recurrence but higher major bleeding outcomes compared to patients without cancer.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Medicine, General & Internal
Du-Han Kim, Sang-Soo Na, Ui-Jun Park, Chul-Hyun Cho
Summary: The study aimed to investigate the incidence, risk factors, and outcomes of DVT after shoulder arthroplasty in Korean patients. A total of 265 patients were included, with a mean age of 74.6 years and 195 females and 70 males. Ten patients (3.8%) were diagnosed with DVT using postoperative duplex ultrasonography. There were no significant differences between the DVT and no DVT groups, except for a higher Charlson comorbidity index in the DVT group.
Article
Hematology
Eileen Merriman, Sanjeev Chunilal, Tim Brighton, Vivien Chen, Simon McRae, Paul Ockelford, Jennifer Curnow, Huy Tran, Beng Chong, Mark Smith, Gordon Royle, Helen Crowther, Alison Slocombe, Huyen Tran
Summary: A study was conducted to assess the efficacy and safety of two weeks of therapeutic anticoagulation for low-risk patients with isolated symptomatic distal deep vein thrombi (IDDVT). The results showed that it is safe and efficacious to stop therapeutic anticoagulation at two weeks in these patients, if there is resolution of symptoms and no extension of the thrombus on ultrasound. This finding could potentially replace 6-12 weeks of anticoagulation in ambulatory, low-risk IDDVT patients.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Charles Orione, Cecile Tromeur, Raphael Le Mao, Pierre-Yves Le Floch, Philippe Robin, Clement Hoffmann, Luc Bressollette, Michel Nonent, Pierre-Yves Le Roux, Pierre-Yves Salaun, Marie Guegan, Elise Poulhazan, Karine Lacut, Christophe Leroyer, Catherine A. Lemarie, Francis Couturaud
Summary: This study aimed to assess the association between high PVOI at PE diagnosis and the risk of recurrent VTE. The results showed that PVOI >= 40% was an independent risk factor for VTE recurrence in PE patients, even six months after stopping anticoagulation therapy. Further prospective validation studies are needed to confirm these findings.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Jianbo An, Taeko K. Naruse, Kunihiko Hinohara, Yurie Soejima, Motoji Sawabe, Yasuaki Nakagawa, Koichiro Kuwahara, Akinori Kimura
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Hiroshi Ishii, Saori Matsuoka, Noriko Ikeda, Kyoko Kurihara, Takamasa Ueno, Masafumi Takiguchi, Taeko K. Naruse, Akinori Kimura, Masaru Yokoyama, Hironori Sato, Tetsuro Matano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Yuta Higashikuse, Nishant Mittal, Takuro Arimura, Sung Han Yoon, Mayumi Oda, Hirokazu Enomoto, Ruri Kaneda, Fumiyuki Hattori, Takeshi Suzuki, Atsushi Kawakami, Alexander Gasch, Tetsushi Furukawa, Siegfried Labeit, Keiichi Fukuda, Akinori Kimura, Shinji Makino
DISEASE MODELS & MECHANISMS
(2019)
Article
Cardiac & Cardiovascular Systems
Hirokazu Enomoto, Nishant Mittal, Takayuki Inomata, Takuro Arimura, Tohru Izumi, Akinori Kimura, Keiichi Fukuda, Shinji Makino
Summary: This study identified that mutations in HSPD1 caused mitochondrial dysfunction, leading to mitophagy, increased ROS, and cardiac atrophy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yasuteru Nakashima, Toru Kubo, Kenta Sugiura, Yuri Ochi, Asa Takahashi, Yuichi Baba, Takayoshi Hirota, Naohito Yamasaki, Akinori Kimura, Yoshinori L. Doi, Hiroaki Kitaoka
CIRCULATION JOURNAL
(2020)
Article
Virology
Seiichi Kato, Hisatoshi Shida, Tomotaka Okamura, Xianfeng Zhang, Tomoyuki Miura, Tetsu Mukai, Makoto Inoue, Tsugumine Shu, Taeko K. Naruse, Akinori Kimura, Yasuhiro Yasutomi, Kazuhiro Matsuo
Summary: This study developed a urease-deficient bacillus Calmette-Guerin (BCG) and demonstrated its protective efficacy against SIV infection in Asian-origin cynomolgus monkeys. Strong immune responses were observed in some monkeys post-vaccination, leading to protection against SIV infection in a portion of the vaccinated animals.
JOURNAL OF VIROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Toshihiro Moriki, Toru Kubo, Kenta Sugiura, Yuri Ochi, Yuichi Baba, Takayoshi Hirota, Naohito Yamasaki, Akinori Kimura, Yoshinori L. Doi, Hiroaki Kitaoka
Summary: A study involving 209 Japanese HCM patients found that the Mayo Clinic HCM genotype predictor score is useful for predicting positive genetic test results. The study showed that there is an incremental increase in genetic testing yield with higher prediction scores.
CIRCULATION JOURNAL
(2021)
Article
Genetics & Heredity
Kousuke Tanimoto, Taeko K. Naruse, Tetsuro Matano, Akinori Kimura
Summary: A new high-throughput NGS-based genotyping method for MHC class I alleles in rhesus macaques and cynomolgus macaques was developed in this study. The method detected 95% and 100% of alleles identified by PCR cloning-based method in rhesus macaques and cynomolgus macaques, respectively, with high correlation to their expression levels. The simulation of new-allele detection using artificial alleles differing by a few nucleotide sequences from a known allele was accurate, and a real novel allele from a rhesus macaque sample was successfully detected, supporting the adaptability of the method for reducing cost and labor in NGS-based MHC genotyping for primate animal models such as macaques.
Article
Cardiac & Cardiovascular Systems
Kayoko Hirayama-Yamada, Natsuko Inagaki, Takeharu Hayashi, Akinori Kimura
Summary: Heart failure is a life-threatening disease often caused by cardiomyopathy, with dilated cardiomyopathy (DCM) being a common type characterized by ventricular enlargement and progressive heart failure. A novel pathogenic TTN truncation variant was discovered in familial DCM patients, and its functional changes were confirmed using a relatively simple cell model.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Virology
Katsutoshi Nagano, Chihiro Tani-Sassa, Yumi Iwasaki, Yuna Takatsuki, Sonoka Yuasa, Yuta Takahashi, Jun Nakajima, Kazunari Sonobe, Naoya Ichimura, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Shuji Tohda
Summary: This study conducted PCR testing on patients who visited the hospital between February and April 2021, revealing a rapid increase in cases with N501Y and E484K mutations from 8% to 46%, with these mutations being associated with R.1 lineage variants. However, there was no evidence of increased disease severity related to the R.1 variants.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biology
Hiroaki Kawano, Koichi Kawamura, Munetake Kanda, Mitsuaki Ishijima, Kuniko Abe, Tomayoshi Hayashi, Yuji Matsumoto, Akinori Kimura, Koji Maemura
Summary: Restrictive cardiomyopathy is a rare primary myocardial disease with unclear pathological features. A 65-year-old Japanese woman was diagnosed with MHY7 mutation-related RCM, with electron microscopy of a myocardial biopsy revealing specific features possibly associated with the pathogenesis of the disease.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Infectious Diseases
Hiromu Tanaka, Ho Lee, Atsuho Morita, Ho Namkoong, Shotaro Chubachi, Hiroki Kabata, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: This study conducted host genome analysis of hospitalized patients with COVID-19 in Japan and found a relatively high number of severe cases but a relatively low case fatality rate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Chihiro Tani-Sassa, Yumi Iwasaki, Naoya Ichimura, Katsutoshi Nagano, Yuna Takatsuki, Sonoka Yuasa, Yuta Takahashi, Jun Nakajima, Kazunari Sonobe, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Shuji Tohda
Summary: In the summer of 2021, the rapid spread of the Delta variant of the SARS-CoV-2 virus raised serious concerns globally. The Delta variant became the most prevalent in July and August, with infected patients in Tokyo being significantly younger, possibly due to vaccination of elderly individuals. Further research is needed to understand factors contributing to the increased infectivity of the Delta variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Sonoka Yuasa, Jun Nakajima, Yuna Takatsuki, Yuta Takahashi, Chihiro Tani-Sassa, Yumi Iwasaki, Katsutoshi Nagano, Kazunari Sonobe, Tomoyo Yoshimoto, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Naoya Ichimura, Shuji Tohda
Summary: The Omicron variant of COVID-19 has spread rapidly worldwide, surpassing the speed of the Delta variant. However, this increased transmissibility is not due to higher viral loads. The study suggests that factors such as increased affinity to cell receptors or immune escape may contribute to the enhanced infectivity of the Omicron variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Genetics & Heredity
Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura
Summary: This study identified a disease-causing gene, RBM20, associated with familial HCM, and confirmed that the p.Arg636His variant could be the causative factor for this particular HCM.
HUMAN GENOME VARIATION
(2022)