Journal
JOURNAL OF HUMAN GENETICS
Volume 54, Issue 12, Pages 721-726Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jhg.2009.105
Keywords
autism spectrum disorders (ASDs); mixture distribution; prevalence; sibling recurrence risk
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Results of twin studies have shown that autism spectrum disorders (ASDs) are attributable to complex multigenic interactions rather than to a single susceptibility gene. However, the growing number of distinct, individually rare genetic causes of ASDs, mostly copy number variations (CNVs), favors an alternative to the polygenic hypothesis, the two-component model, which suggests that ASDs are caused either by de novo mutation or by dominant inheritance from asymptomatic carriers of such a mutation. To verify this hypothesis, we estimated the distribution of ASD-risk among both catchment area-based families and multiplex families. Our results suggest that the models with more than three risk components are preferable to the two-component model. Our results also suggest that the largest proportion of ASD cases is caused by dominant inheritance. We additionally show that Supplementary information regarding prevalence has a crucial role in analyzing proband-ascertained data. Journal of Human Genetics (2009) 54, 721-726; doi: 10.1038/jhg.2009.105; published online 6 November 2009
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