Journal
JOURNAL OF HUMAN GENETICS
Volume 53, Issue 2, Pages 185-191Publisher
SPRINGERNATURE
DOI: 10.1007/s10038-007-0228-0
Keywords
methylation; epigenetics; demethylation; genome-wide; profiling
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Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.
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