4.6 Article

Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 13, Issue 25, Pages 6944-6948

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00915d

Keywords

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Funding

  1. National Natural Science Foundation of China [21172185, 21372187]
  2. Research Fund for the Doctoral Program of Higher Education of China, Ministry of Education of China [20124301110005]
  3. Hunan Provincial Innovative Foundation for Postgraduate [CX2014B258]

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A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an efficient approach for the synthesis of biologically important aromatic amides from readily available coupling partners using molecular oxygen as the oxidant.

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