Article
Public, Environmental & Occupational Health
Anna Olczak-Pienkowska, Waleria Hryniewicz
Summary: This study analyzed the regional antibiotic consumption in primary care in Poland from 2013 to 2017, and found strong correlations with factors such as employment, population mobility, number of outpatient consultations, and number of dentists. Identified risk factors for increased antibiotic consumption should be targeted for interventions promoting rational antibiotic policies.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Marcella Sibani, Lorenzo Maria Canziani, Chiara Tonolli, Maddalena Armellini, Elena Carrara, Fulvia Mazzaferri, Michela Conti, Annarita Mazzariol, Claudio Micheletto, Andrea Dalbeni, Domenico Girelli, Evelina Tacconelli
Summary: Since the emergence of the SARS-CoV-2 pandemic, antimicrobial stewardship (AS) activities have shifted towards COVID-19 management. This study analyzed changes in antibiotic consumption in moderate-to-severe COVID-19 patients to assess the impact of COVID-19 on AS activities. The implementation of calibrated AS activities significantly decreased antibiotic consumption in the intervention units for COVID-19 patients.
Article
Infectious Diseases
Eder Rodriguez-Campos, Ana Belen Guisado-Gil, German Penalva, Beatriz Fernandez-Rubio, Teresa Aldabo, Laura Herrera-Hidalgo, Esperanza Fernandez-Delgado, Marta Mejias-Trueba, Maria Luisa Gascon, Maria Adriaensens, Jose Miguel Cisneros, Maria Victoria Gil-Navarro
Summary: This study assessed the quality of antimicrobial use in ICUs using a bundle of indicators in a teaching hospital in Spain. The indicators were selected based on consumption data and trends were analyzed using segmented regression. The findings showed an increase in the use of certain antimicrobial agents and the detection of patterns that align with local guidelines and antibiogram reports. The use of these novel indicators provides additional information for analysis and improvement within antimicrobial stewardship programs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Lionel Chok, Katharina Kusejko, Nadia Eberhard, Sandra E. Chaudron, Dirk Saleschus, Claudine Kocher, Roger D. Kouyos, Rainer Weber, Stefan P. Kuster
Summary: The study analyzed the impact of a computer-assisted intervention on the use of meropenem, voriconazole, and caspofungin in a tertiary care hospital. The introduction of an electronic alert system was found to decrease prescriptions and days of therapy for voriconazole, but did not have a significant effect on the other two drugs. Additional measures such as face-to-face prompting with infectious disease physicians or audit and feedback are needed to optimize antimicrobial use.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Rebekah W. Moehring, Michael E. Yarrington, Angelina E. Davis, April P. Dyer, Melissa D. Johnson, Travis M. Jones, S. Shaefer Spires, Deverick J. Anderson, Daniel J. Sexton, Elizabeth S. Dodds Ashley
Summary: The study established a collaborative, consultative network to support hospital Antimicrobial Stewardship Programs (ASP). Results showed that participating hospitals increased ASP activities over 42 months, leading to a decline in antimicrobial use. There was significant variation in antimicrobial use among different hospitals.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Pierre-Marie Roger, Anne Espinet, Delphine Ravily, Marie-Jose Meyer, Francine Moll, Eve Montera, Agnes Rancezot, Veronique Dautezac, Olivier Pantaloni
Summary: The study indicates that simplified therapeutic guidelines (STGs) are more likely to improve the rate of optimal antibiotic therapy (OAT) and reduce antibiotic consumption in hospitals compared to other antimicrobial stewardship program tools.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Christian Pallares, Cristhian Hernandez-Gomez, Tobias Manuel Appel, Kevin Escandon, Sergio Reyes, Soraya Salcedo, Lorena Matta, Ernesto Martinez, Sara Cobo, Laura Mora, Adriana Marin, Adriana Correa, Elsa De la Cadena, Jesus Rodriguez-Bano, Maria Virginia Villegas
Summary: This study demonstrated that antimicrobial stewardship programs have a positive impact on antibiotic consumption and resistance.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Sara Y. Tartof, Lie Hong Chen, Yun Tian, Rong Wei, Theresa Im, Kalvin Yu, Gunter Rieg, Zoe Bider-Canfield, Frances Wong, Harpreet S. Takhar, Lei Qian
Summary: This retrospective cohort study examined the impact of an antibiotic stewardship program (ASP) on antibiotic usage and infection rates of drug-resistant organisms in a healthcare setting. Results showed a decrease in overall antibiotic use post-ASP implementation, but an increase in vancomycin-resistant enterococci infections. The study suggests that successful reduction in antibiotic consumption through ASPs may not necessarily lead to a decrease in antibiotic-resistant infections.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Larissa May, Alejandro Martin Quiros, Jaap Ten Oever, Jacobien Hoogerwerf, Teske Schoffelen, Jeroen Schouten
Summary: Emergency departments serve as the entrance gates for patients with infectious diseases and are an important unit for targeted antimicrobial stewardship interventions. Most antimicrobial stewardship programmes are focused on inpatient management, overlooking the equally high rates of inappropriate antibiotic use in the ED setting. Therefore, there is a need to strengthen the focus and intervention on antimicrobial stewardship in the ED.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Education & Educational Research
Wuraola Akande-Sholabi, Amen T. Ajamu
Summary: The study revealed that healthcare students in a Nigerian university have a moderate knowledge of antimicrobial resistance, indicating the necessity for enhanced education and strict policies to regulate the use of antibiotics.
BMC MEDICAL EDUCATION
(2021)
Article
Immunology
Adam L. Hersh, Laura M. King, Daniel J. Shapiro, Lauri A. Hicks, Katherine E. Fleming-Dutra
Summary: The percentage of unnecessary antibiotic prescriptions in US physician offices and emergency departments decreased slightly from 30% in 2010-2011 to 28% in 2014-2015. However, there was a greater decrease in children from 32% to 19%, while unnecessary prescribing in adults remained unchanged.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Joanna M. Kimball, Connor R. Deri, Whitney J. Nesbitt, George E. Nelson, Milner B. Staub
Summary: This study investigated successful antimicrobial stewardship interventions at Vanderbilt University Medical Center, identifying key strategies such as continuous provider-level education and the implementation of division and department algorithms to reduce the use of concomitant vancomycin and piperacillin-tazobactam. The TASE framework and ASIR analysis were effective in identifying pivotal interventions for achieving and sustaining change, suggesting potential for wider application in similar settings.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Brigid M. Wilson, Yunyun Jiang, Robin L. P. Jump, Roberto A. Viau, Federico Perez, Robert A. Bonomo, Scott R. Evans
Summary: Antibiotic stewardship must consider effectiveness and spectrum of therapy, proposing the DOOR MAT approach for evaluating desirability of antibiotic selection. The principle is to effectively treat the patient while minimizing future resistance development.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Federico Perez, Roberto Viau Colindres, Brigid M. Wilson, Elie Saade, Robin L. P. Jump, Ritu Banerjee, Robin Patel, Scott R. Evans, Robert A. Bonomo
Summary: The study used the DOOR MAT approach to evaluate antibiotic treatment of E. coli and K. pneumoniae bloodstream infections in VHA patients across a decade. Over the 10-year period, resistance to certain antibiotics increased in E. coli but remained stable in K. pneumoniae. Discrepancy between empiric and definitive treatment desirability narrowed, with no negative impact on patient survival.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Xin Fang, Noleen Bennett, Courtney Ierano, Rodney James, Karin Thursky
Summary: The National Antimicrobial Prescribing Survey (NAPS) is a widely adopted tool in Australian healthcare facilities to evaluate the reasons, quantity, and quality of antimicrobial prescribing. The study shows that inappropriate prescribing of antimicrobials is common in both hospital and aged care settings.
Article
Immunology
Jessy J. Duran Ramirez, Tala Ballouz, Huyen Nguyen, Katharina Kusejko, Sandra E. Chaudron, Michael Huber, Hans H. Hirsch, Matthieu Perreau, Alban Ramette, Sabine Yerly, Matthias Cavassini, Marcel Stockle, Hansjakob Furrer, Pietro Vernazza, Enos Bernasconi, Huldrych F. Gunthard, Roger D. Kouyos
Summary: The study reveals a significant increase in non-B subtypes of HIV-1 among men who have sex with men (MSM) in Switzerland, with CRF01_AE being the most prevalent subtype. The majority of molecular transmission clusters (MTCs) among MSM were found to be comprised of Europeans.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Fabio Mauri, Sara Cottler-Casanova, Matthias Cavassini, Marcel Stoeckle, Gilles Wandeler, Patrick Schmid, Dominique L. Braun, Alexandra Scherrer, Enos Bernasconi, Alexandra Calmy, Jasmine Abdulcadir
Summary: FGM/C is a harmful practice that involves injury to the female genitalia without medical purpose, and it is prevalent worldwide. There is a lack of knowledge on how to care for women with FGM/C, and improvements in care and prevention are needed.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2023)
Article
Immunology
Alessandra Noto, Madeleine Suffiotti, Victor Joo, Antonio Mancarella, Francesco A. A. Procopio, Guy Cavet, Yvonne Leung, Jean-Marc Corpataux, Matthias Cavassini, Agostino Riva, Leonidas Stamatatos, Raphael Gottardo, Adrian B. B. McDermott, Richard A. A. Koup, Craig Fenwick, Matthieu Perreau, Giuseppe Pantaleo
Summary: The imbalance between Th2 and Th1-like Tfh cells affects B cell responses in viremic HIV infection. The decrease in Th2-like Tfh cells is related to the decrease in HIV-specific B cells, while the increase in Th1-like Tfh cells is associated with the increase in T-bet and CXCR3 expressing HIV-specific B cells. IL-4 and IL-21 cytokines promote efficient maturation of HIV-specific B cells, while IFN-gamma induces the expression of T-bet and CXCR3 in B cells. CXCR3(+) B cells have a lower rate of somatic hypermutation compared to CXCR3(-) B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Marco Labarile, Tom Loosli, Marius Zeeb, Katharina Kusejko, Michael Huber, Hans H. Hirsch, Matthieu Perreau, Alban Ramette, Sabine Yerly, Matthias Cavassini, Manuel Battegay, Andri Rauch, Alexandra Calmy, Julia Notter, Enos Bernasconi, Christoph Fux, Huldrych F. Gunthard, Chloe Pasin, Roger D. Kouyos
Summary: This study investigated and predicted the dynamics of HIV transmission in Switzerland using a network-based clustering method and statistical learning approaches. The study found that network characteristics can capture major heterogeneities in transmission and that cluster structure has the potential for real-time prediction of ongoing transmission.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Alessio Casutt, Matthaios Papadimitriou-Olivgeris, Foteini Ioakeim, John-David Aubert, Oriol Manuel, Angela Koutsokera
Summary: This study investigated the outcomes of COVID-19 infection in lung transplant recipients and found that they are at increased risk for complications. The administration of monoclonal antibodies as early treatment was associated with a lower risk, while age over 60 years was associated with a higher risk.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Editorial Material
Immunology
Eleftheria Kampouri, Oriol Manuel
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Catia Marzolini, Matthias L. Cavassini, Dominique L. Braun, Anna Hachfeld, Enos Bernasconi, Alexandra Calmy, Patrick Schmid, Manuel Battegay, Luigia Elzi
Summary: This study aimed to investigate whether a common single polymorphism could explain the phenomenon of some HIV patients not achieving their lipid targets despite elevated statin concentrations. The study found that individuals carrying the SLCO1B1 c.521T>C polymorphism had smaller changes in lipid levels after statin initiation compared to those without this polymorphism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Infectious Diseases
Paul Thoueille, Susana Alves Saldanha, Vincent Desfontaine, Katharina Kusejko, Perrine Courlet, Pascal Andre, Matthias Cavassini, Laurent A. Decosterd, Thierry Buclin, Monia Guidi
Summary: This study investigated the pharmacokinetics of tenofovir alafenamide (TAF) in people living with HIV (PLWH), and found that renal function significantly affects TAF exposure. The study suggests cautious adjustment of TAF dosage intervals in case of moderate or severe chronic kidney disease (CKD).
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Oriol Manuel, Mirjam Laager, Cedric Hirzel, Dionysios Neofytos, Laura N. Walti, Gideon Hoenger, Isabelle Binet, Aurelia Schnyder, Susanne Stampf, Michael Koller, Matteo Mombelli, Min Jeong Kim, Matthias Hoffmann, Katrin Koenig, Christoph Hess, Anne-Valerie Burgener, Pietro E. Cippa, Kerstin Huebel, Thomas F. Mueller, Daniel Sidler, Suzan Dahdal, Franziska Suter-Riniker, Jean Villard, Andrea Zbinden, Giuseppe Pantaleo, Nasser Semmo, Karine Hadaya, Natalia Enriquez, Pascal R. Meylan, Marc Froissart, Dela Golshayan, Thomas Fehr, Uyen Huynh-Do, Manuel Pascual, Christian van Delden, Hans H. Hirsch, Peter Jueni, Nicolas J. Mueller, Swiss Transplant Cohort Study STCS
Summary: This study examined the use of immune monitoring to individualize the duration of antiviral prophylaxis after transplantation. The results showed that immune monitoring led to a significant reduction in prophylaxis duration, but did not establish noninferiority in terms of the primary outcome of CMV infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Matteo Mombelli, Dionysios Neofytos, Uyen Huynh-Do, Javier Sanchez-Cespedes, Susanne Stampf, Dela Golshayan, Suzan Dahdal, Guido Stirnimann, Aurelia Schnyder, Christian Garzoni, Reto M. Venzin, Lorenzo Magenta, Melanie Schonenberger, Laura Walti, Cedric Hirzel, Aline Munting, Michael Dickenmann, Michael Koller, John-David Aubert, Jurg Steiger, Manuel Pascual, Thomas F. Mueller, Mace Schuurmans, Christoph Berger, Isabelle Binet, Jean Villard, Nicolas J. Mueller, Adrian Egli, Elisa Cordero, Christian van Delden, Oriol Manuel
Summary: The use of MF59-adjuvanted or high-dose influenza vaccine in solid-organ transplant recipients was safe and resulted in a higher vaccine response rate.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Bashkim Jaha, Corinne D. Schenkel, Lisa Jorimann, Michael Huber, Maryam Zaheri, Kathrin Neumann, Christine Leemann, Alexandra Calmy, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Gunthard, Karin J. Metzner, Swiss HIV Cohort Study
Summary: A new method was used to analyze HIV-1 DNA, including the detection of drug resistance. The results showed varying levels of drug resistance mutations, which were associated with the duration of antiretroviral therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Lukas Baumann, Dominique L. Braun, Matthias Cavassini, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, David Haerry, Charles Beguelin, Christoph A. Fux, Gilles Wandeler, Bernard Surial, Andri Rauch
Summary: The study assessed the changes in the prevalence of replicating HCV infection, treatment uptake, and liver-related morbidity and mortality in persons with HIV and hepatitis C. The introduction of direct-acting antiviral therapy was associated with a significant reduction in the prevalence of replicating HCV infection, as well as a decrease in overall mortality and incidence of liver-related events in this population.
LIVER INTERNATIONAL
(2023)
Review
Immunology
Eleftheria Kampouri, Jessica S. Little, Kai Rejeski, Oriol Manuel, Sarah P. Hammond, Joshua A. Hill
Summary: CAR-T-cell therapies have greatly improved the treatment of blood cancers, but they come with unique toxicities, especially infections. Infection incidence is highest in the first month after treatment and gradually decreases afterwards. Different CAR-T-cell therapies also result in different types of infections.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Immunology
Brice Touilloux, Matthaios Papadimitriou-Olivgeris, Cedric Bongard, Nahal Mansouri, Foteini Ioakeim, Oriol Manuel, Angela Koutsokera, John-David Aubert, Alessio Casutt
Summary: This study examines the long-term lung function in lung transplant recipients after their first SARS-CoV-2 infection. The results show a significant decline in lung function at 3 months, but not at 6 and 12 months post-infection.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Geriatrics & Gerontology
Isabella C. Schoepf, Andres Esteban-Cantos, Christian W. Thorball, Berta Rodes, Peter Reiss, Javier Rodriguez-Centeno, Carlotta Riebensahm, Dominique L. Braun, Catia Marzolini, Marco Seneghini, Enos Bernasconi, Matthias Cavassini, Helene Buvelot, Maria Christine Thurnheer, Roger D. Kouyos, Jacques Fellay, Huldrych F. Gunthard, Jose R. Arribas, Bruno Ledergerber, Philip E. Tarr
Summary: In this long-term study, accelerated epigenetic ageing was observed in untreated HIV infection and partial reversal was achieved with effective antiretroviral therapy. It underscores the significance of limiting the duration of untreated HIV infection.
LANCET HEALTHY LONGEVITY
(2023)
