Article
Nanoscience & Nanotechnology
Sofia F. Soares, Sara Fateixa, Tito Trindade, Ana L. Daniel-da-Silva
Summary: A versatile synthetic route was reported for the preparation of nearly monodispersed spherical gelatin-silica hybrid nanoparticles. The method is effective for both gelatin type A and B, using different alkoxysilane coupling agents. ICPTES is more suitable for producing uniform nanospheres with narrow size distribution, while GPTMS increases the surface roughness of the particles. The hybrids are thermo-sensitive and can be used for thermally controlled drug-delivery systems.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Lingyang Meng, Zhuang Teng, Shuang Yang, Na Wang, YingHua Guan, Xiguang Chen, Ya Liu
Summary: Cancer immunotherapy, using the immune system to fight cancer, has made breakthroughs in clinical applications. Dendritic cells play a vital role in linking innate and adaptive immunity and triggering immune response against tumors. With the limitations of conventional DC vaccines, researchers are now interested in using nanovaccines for in vitro-generated DCs.
Article
Chemistry, Multidisciplinary
Pierre Moritz, Antoine Gonon, Thomas Blon, Nicolas Ratel-Ramond, Fabrice Mathieu, Pierre Farger, Juan-Manuel Asensio-Revert, Simon Cayez, David Bourrier, Daisuke Saya, Liviu Nicu, Guillaume Viau, Thierry Leichle, Lise-Marie Lacroix
Summary: This study presents a versatile approach for the fabrication and direct integration of nanostructured magnetic materials onto silicon substrates, using magnetophoresis-assisted capillary assembly to create high-performance magnets and supercrystals. Sub-millimeter and self-standing magnets with magnetic properties comparable to NdFeB-based composites were obtained through this cost- and time-efficient process. The proof-of-concept of electromagnetically actuating a MEMS cantilever with these supercrystals highlights their potential as efficient integrated magnetic materials in portable devices.
Article
Biochemistry & Molecular Biology
Steven A. Roberts, Chaebin Lee, Shrishti Singh, Nitin Agrawal
Summary: This study presents an efficient and universal loading strategy for synthesizing therapeutic liposomes. By addressing existing challenges, this approach facilitates the formulation of novel therapeutic and pharmaceutical strategies.
Review
Materials Science, Multidisciplinary
Qing Yu, Wenzhe Wang, Haixia Ji, Luyao Tian, Mingjuan Yang, Juan Wang, Xia Li, Luqi Huang, Lanping Guo, Wenyuan Gao
Summary: This paper reviews the recent progress of membrane coatings on antitumor nanoparticle platforms using cells, synthetic polymers, polyphenols, and polysaccharides. It also explores the challenges of single membrane coating in tumor therapeutic applications and proposes strategies for effective clinical transformation.
ACS MATERIALS LETTERS
(2022)
Article
Pharmacology & Pharmacy
Monica Cerqueira, Efres Belmonte-Reche, Juan Gallo, Fatima Baltazar, Manuel Banobre-Lopez
Summary: Cancer is a leading cause of death worldwide, with a projected increase in global cancer incidence in the next two decades. Nanomedicine formulations have the potential to improve the effectiveness of conventional cancer therapies. However, the targeting efficiency of advanced nanomedicines in oncology is currently one of the major limitations, highlighting the need for more efficient nanoformulation designs.
Review
Chemistry, Inorganic & Nuclear
Sebastian Scharf, Sebastian Notz, Heinrich Lang
Summary: This article introduces the principle and application of twin polymerization (TP) method for the preparation of inorganic-organic hybrid materials. TP method can form interpenetrating phase (nano)domains in a single step, and can be used to prepare hierarchical materials and encapsulate nanoparticles. TP also has a wide range of applications, including coatings, textile functionalization, and battery materials.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xing-Han Li, Shuqi Dai, Xiao-Yun Yan, Huanyu Lei, Xian-You Liu, Yuchu Liu, Weiqi Zhang, Xiaotong Xu, Jia-Fu Yin, Yuean Wu, Feng Ye, Qing-Yun Guo, Stephen Z. D. Cheng
Summary: Precise modifications of cyclic titanium-oxo cluster: We report an efficient thiol-Michael addition approach for the precise modifications of cyclic titanium-oxo cluster (CTOC). This approach can afford high yields of fully functionalized CTOCs, which provides a powerful platform for achieving versatile functionalization of precise transition metal clusters and further applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Medicine, Research & Experimental
Rafaella B. L. Henrique, Rennan R. M. Lima, Camila A. P. Monteiro, Weslley F. Oliveira, Goreti Pereira, Paulo E. Cabral Filho, Adriana Fontes
Summary: Spheroids are three-dimensional multicellular microstructures that can replicate the complexity of the biological microenvironment and tumor architecture. Compared to traditional cell culture methods, spheroids provide more accurate results that resemble in vivo organisms. In addition, inorganic nanoparticles have been proven to be valuable tools for understanding biological processes and have potential applications in diagnostics and therapeutics. This review highlights the versatility of spheroids in studying biological interactions involving inorganic nanoparticles, including penetration profiles, toxicity evaluation, and therapeutical approaches.
Article
Chemistry, Multidisciplinary
Caroline A. S. Ribeiro, Karine Panico, Tamara J. Handajevsky, Fernanda Dias da Silva, Ismael C. Bellettini, Ewa Pavlova, Fernando C. Giacomelli
Summary: The large surface area of metallic nanoparticles provides them with unique optical, chemical, and biological properties, making them useful in various applications. This study demonstrates a facile and fast synthetic approach to produce different types of d-block transition-metal nanoparticles using a one-pot method in aqueous media and mild temperature conditions. Polyethylenimine (PEI) or its derivatives can effectively reduce gold, palladium, and silver ions, acting as both a reducing and stabilizing agent, without the need for any other external agent. The resulting nanoparticles exhibit enhanced catalytic performance and antimicrobial activity, suggesting their potential for practical and ready-to-use manufacturing in a wide range of applications.
Review
Chemistry, Physical
Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu
Summary: Polymer-based nanoparticles customized for size, morphology, and surface properties are gaining attention for drug, biomolecule, and gene delivery. They protect payloads from degradation and sustain controlled drug release, reducing clearance and increasing stability, solubility, and optimal concentration at target sites, especially in vaccine development.
Article
Chemistry, Multidisciplinary
Elena G. Tikhonova, Yulia A. Tereshkina, Lyubov Kostryukova, Yulia Yu Khudoklinova, Maxim A. Sanzhakov, Anna O. Tamarovskaya, Oleksandr I. Ivankov, Mikhail A. Kiselev
Summary: This study investigated the physicochemical properties of the phospholipid composition of indomethacin and the impact of freeze drying on its parameters. The results showed that the drug remained stable after lyophilization, with no significant changes observed in properties such as particle size, light transmission, and phospholipid oxidation index. Small-angle neutron scattering analysis revealed the morphological characteristics of Indolip as a vesicle with a radius approximately five times greater than the bilayer thickness value.
Article
Chemistry, Physical
Yingjie Hu, Jianhua Li, Yi Ju, Zachary H. Houston, Nicholas L. Fletcher, Robert De Rose, Soraia Fernandes, Christoph E. Hagemeyer, Karen Alt, Kristofer J. Thurecht, Christina Cortez-Jugo, Frank Caruso
Summary: The successful clinical application of monoclonal antibody therapy has led to research in understanding antibody-antigen interactions and engineering antibodies with enhanced properties. This study demonstrates the fabrication of therapeutic antibody nanoassemblies with controlled physicochemical properties, providing a versatile platform for therapeutic and diagnostic applications.
CHEMISTRY OF MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Macro D'Auria, Daniele Davino, Roberto Pantani, Luigi Sorrentino
Summary: Research has shown that in the process of preparing polymer foams, by using a time-variable magnetic field technology, the shape of the stress-strain response of the foam can be managed simply and fully adaptably, achieving a composite foam with mechanical anisotropy, homogeneous, and regular cellular morphology.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Babak Kaboudin, Hiroshi Aoyama, Akihiro Sugiyama, Yoko Endo-Takahashi, Yoichi Negishi
Summary: The presented work describes the synthesis and characterization of a novel magnetic cationic phospholipid (MCP) system with a stable dopamine anchor as well as its transfection activity study. The synthesized architectural system increases the biocompatibility of iron oxide and promises applications of magnetic nanoparticles in living cells. The MCP system is soluble in organic solvents and can be easily adapted to prepare magnetic liposomes. We created complexes with liposomes containing MCP and other functional cationic lipids and pDNA as gene delivery tools, which possessed the ability to enhance the efficiency of transfection, particularly the process of interaction with cells by inducing a magnetic field. The MCP is able to create iron oxide nanoparticles and has the potential for the materials to prepare the system for site-specific gene delivery with the application of an external magnetic field.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Natasha Eccles, Flavio della Sala, Bryden A. F. Le Bailly, George F. S. Whitehead, Jonathan Clayden, Simon J. Webb
Article
Chemistry, Multidisciplinary
David P. August, Stefan Borsley, Scott L. Cockroft, Flavio della Sala, David A. Leigh, Simon J. Webb
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Maria Giovanna Lizio, Mario Campana, Matteo De Poli, Damien F. Jefferies, William Cullen, Valery Andrushchenko, Nikola P. Chmel, Petr Bour, Syma Khalid, Jonathan Clayden, Ewan Blanch, Alison Rodger, Simon J. Webb
Summary: This study used various spectroscopic techniques to investigate the mechanism of action of peptides rich in Aib segments in cell membranes. The peptides were found to quickly orient in the membranes, with evidence of chiral interactions. Chiro-optical spectroscopies can help reveal the mechanism of action of antimicrobial peptides.
Article
Chemistry, Applied
Marion Wrackmeyer, Adam P. O'Rourke, Thomas Pugh, Michael L. Turner, Simon J. Webb
Summary: A library of closely related diacetylenes has been synthesized, with color changes analyzed using various analytical techniques. The diacetylenes with cycloalkyl substituents show greater sensitivity to changes in molecular structure and higher stability compared to those with n-alkyl substituents.
Article
Chemistry, Multidisciplinary
David P. Tilly, William Cullen, Heng Zhong, Romain Jamagne, Inigo Vitorica-Yrezabal, Simon J. Webb
Summary: By investigating the effect of remotely induced changes in ligand folding, a potential pathway towards remote conformational control of organometallic catalysts has been discovered. The study on dynamic folding of Aib peptides revealed that the chiral conformational preference of N-terminal residues can be relayed to the axially chiral Rh(NHC) complex in the helical body.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Siyuan Wang, Flavio della Sala, Matthew J. Cliff, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Simon J. Webb
Summary: This study developed a new 19F reporter tag and its attachment to peptide foldamers to investigate their conformation in phospholipid bilayers. The results showed that the conformational preferences of the foldamers were the same in organic solvents and phospholipid bilayers, and phospholipid chirality had little influence on the conformation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
David P. Tilly, Jean-Paul Heeb, Simon J. Webb, Jonathan Clayden
Summary: Molecular biology controls complex reaction networks by translating a chemical input into an orthogonal chemical output, but dynamic foldamers have been limited by stereochenical changes that produce spectroscopic signals. In this study, the authors introduce an artificial molecular translation device that converts a chemical input into an unrelated chemical output. This device modulates the reactivity of an imidazole moiety by the presence of chloride ions through the allosteric remote control of imidazole tautomer states.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Luis Martinez-Crespo, Inigo J. Vitorica-Yrezabal, George F. S. Whitehead, Simon J. Webb
Summary: Relaying conformational change over several nanometers is crucial in allosterically regulated proteins. Scientists have successfully replicated this mechanism using nanometer-sized molecules that can reversibly switch between defined shapes in response to signaling molecules. The study demonstrated that a 1.8 nm long rigid rod molecule can serve as a switchable multi-squaramide hydrogen-bond relay, with each relay adopting different orientations based on proton signals and undergoing reversible changes. Additionally, a chemical fuel acted as a dissipative signal, causing the relay to return to its original orientation when consumed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Hussain A. Al Nasser, Luis Martinez-Crespo, Simon J. Webb, Robert A. W. Dryfe
Summary: Thiourea-based receptors’ binding affinity for anions at the aqueous|organic interface was evaluated using electrochemical measurements. Most anions showed a 1:1 stoichiometry for complexation, except for excess Cl- and Br- anions which exhibited higher stoichiometry. High stability constants were observed at the aqueous|1,2-dichlorobenzene (DCB) interface, possibly due to the less competitive environment of the less polar solvent. Protonation of the receptor at the bridgehead tertiary amine was inferred from potential-dependent voltammetric measurements unrelated to anion:receptor complexation.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Organic
David P. Tilly, Catherine McColl, Mingda Hu, Inigo J. Vitorica-Yrezabal, Simon J. Webb
Summary: This article describes the study of two short pentapeptides rich in alpha-aminoisobutyric acid (Aib) as enantioselective organocatalysts. The findings show that folding into a 310 helical structure allows the peptides to transmit chiral information and promote the enantioselectivity of the reaction. This demonstrates the important role of achiral residues in catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Joana Silva, Reynard Spiess, Andrea Marchesi, Sabine L. Flitsch, Julie E. Gough, Simon J. Webb
Summary: Despite existing as a mixture of isomers, N-acetylglucosamine (GlcNAc) oximes can still be substrates for beta(1,4)-galactosyltransferase (beta 4GalT1). Combining oxime formation with enzymatic elaboration can be a useful method for the high-throughput surface modification of drug delivery vehicles, such as liposomes, with cell-targeting oligosaccharides. The beta-anomer is consumed preferentially but long reaction times allow this isomer to be replenished by equilibration from the remaining isomers.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Phillip R. A. Chivers, Rebecca S. Dookie, Julie E. Gough, Simon J. Webb
CHEMICAL COMMUNICATIONS
(2020)
Correction
Materials Science, Multidisciplinary
Thomas W. Fallows, Thomas P. Coxon, Julie E. Gough, Simon J. Webb
Article
Chemistry, Multidisciplinary
Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Eriko Takano, John Burthem, Scott L. Cockroft, Simon J. Webb
Article
Chemistry, Multidisciplinary
Natasha Eccles, Bryden A. F. Le Bailly, Flavio della Sala, Inigo J. Vitorica-Yrezabal, Jonathan Clayden, Simon J. Webb
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
