Article
Biochemistry & Molecular Biology
Laura Stein, Nora Brunner, Salah Amasheh
Summary: The epithelial barrier plays a crucial role in gastrointestinal function by preventing the passage of solutes. This study investigates the interaction between claudin-4 and claudin-18.2, two tight junction proteins in the gastric epithelium, and suggests that this interaction is dependent on both mechanical force and pH. The findings highlight the importance of tight junction integrity for proper gastrointestinal function.
Article
Biochemistry & Molecular Biology
Viviana Scalavino, Emanuele Piccinno, Antonio Lacalamita, Angela Tafaro, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino
Summary: This study identified 18 dysregulated miRNAs in intestinal epithelial cells from the ulcerative colitis (UC) mice model. MiR-195-5p, one of the down-regulated miRNAs, was found to be involved in impaired barrier function. The study demonstrated that miR-195-5p can regulate tight junctions by decreasing CLDN2 levels and subsequently affecting CLDN1 expression.
Article
Oncology
Yanni Lv, Xuehan Wu, Jin Chen, Feng Shao
Summary: The study found that ruscogenin can alleviate the tight junction injury in colorectal cancer mice by inhibiting TRAP1, and it can also reduce the number and weight of liver tumor nodules.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Linda Droessler, Valeria Cornelius, Alexander G. Markov, Salah Amasheh
Summary: The study demonstrates the detrimental effects of TNFα on non-transformed intestinal epithelial cells, leading to barrier dysfunction. This is achieved through modulation of tight junction proteins and TNF receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kazuto Tsukita, Manabu Kitamata, Hiroka Kashihara, Tomoki Yano, Ikuko Fujiwara, Timothy F. Day, Tatsuya Katsuno, Jaewon Kim, Fumiko Takenaga, Hiroo Tanaka, Sungsu Park, Makoto Miyata, Hitomi Watanabe, Gen Kondoh, Ryosuke Takahashi, Atsushi Tamura, Sachiko Tsukita
Summary: Liquid-liquid phase separation (LLPS) plays a role in dynamic biological phenomena. In this study, the role of LLPS in the dynamic regulation of junctional actin filaments in epithelial cells was investigated. The researchers identified a multifunctional actin nucleator called cordon bleu (Cobl) as an AJC-enriched microtubule-associated protein and conducted comprehensive in vitro and in vivo analyses. They found that apical microtubules promoted LLPS of Cobl at the AJC, leading to increased Cobl actin assembly activity and spatiotemporal regulation of junctional actin assembly for epithelial morphogenesis and paracellular barriers.
Article
Physiology
Linda Droessler, Valeria Cornelius, Elisa Boehm, Laura Stein, Nora Brunner, Salah Amasheh
Summary: TNF affects the barrier function of follicle-associated epithelium of porcine Peyer's patches, but has no effects on villus epithelium. These findings reveal the differences in epithelial barrier function between the two structures and the importance of Peyer's patches as a primary mucosal immune defense.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Food Science & Technology
Marta Justyna Koziel, Maksymilian Ziaja, Agnieszka Wanda Piastowska-Ciesielska
Summary: The intestinal barrier acts as the main defense against substances entering the body, ensuring balance in the organism; Mycotoxins, toxic fungi metabolites, may disrupt homeostasis by affecting the intestinal barrier; Claudins, proteins involved in tight junction formation between epithelial cells, play a significant role in responding to mycotoxin-induced cytotoxicity.
Article
Oncology
Manabu Kojima, Kotaro Sugimoto, Makoto Kobayashi, Naoki Ichikawa-Tomikawa, Korehito Kashiwagi, Takafumi Watanabe, Shu Soeda, Keiya Fujimori, Hideki Chiba
Summary: Cell adhesion proteins, including the CLDN family, play a crucial role in maintaining tissue integrity and regulating cellular events. Aberrant expression of CLDN6 is associated with accelerated proliferation and migration in endometrial cancer cells, promoting tumor growth and invasion. The CLDN6/SFK/PI3K/AKT and SGK signaling pathways activate ERα in an ERα-independent manner, contributing to tumor progression. Moreover, CLDN6 can also regulate gene expression independently of ERα.
MOLECULAR CANCER RESEARCH
(2021)
Article
Immunology
Mitsunobu Ueda, Hidetomo Kobayashi, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka
Summary: Aeromonas sobria, a Gram-negative pathogen causing food-borne illness, opportunistically leads to severe extraintestinal diseases in immunocompromised patients and the elderly. It can disrupt the barrier function of the intestinal epithelium by destroying tight junctions, potentially aiding the invasion of pathogens into deep sites in the human body.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Chao Chen, Yan Qun Liu, Shi Xiang Qiu, Ya Li, Ning Jun Yu, Kang Liu, Li Ming Zhong
Summary: This study aimed to construct a metastasis-related mRNAs prognostic model for hepatocellular carcinoma (HCC) based on analysis of transcriptomic and clinical data. Six mRNAs associated with prognosis were identified, with a 5-gene prognostic signature significantly stratifying HCC patients into high- and low-risk groups. The model showed predictive value for HCC prognosis, with a significant independent prognostic factor identified. Additionally, a nomogram incorporating the 5-gene signature and clinical features was built for prognostic prediction, and functional enrichment analysis showed differences in pathways between high- and low-risk groups.
Review
Oncology
Jian Li
Summary: Claudin proteins play crucial roles in maintaining tissue integrity and human health, and are associated with signal transduction and tumorigenesis. Their diverse roles in tumor biology make them potential targets for treatment or biomarkers for cancer diagnosis and prognosis. Factors such as organ type, environmental context, and genetic confounders need to be considered when studying the biological functions and targeting of claudins in cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Article
Cell Biology
Shaista Anwer, Emily Branchard, Qinghong Dan, Angela Dan, Katalin Szaszi
Summary: Claudins are crucial for tight junction formation and paracellular transport. TNFa can impact epithelial permeability through modulating the expression of specific claudins, including claudin-3. The effect of TNFa on claudin-3 is mediated by ERK-dependent activation of NF-kappa B and PKA-induced activation of CREB1 pathways, both of which are necessary for the upregulation of claudin-3.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Oncology
Yuan Deng, Lei Sun, Heng Liang, Bojing Cui, Caimei Cui, Dan Zhao, Arabella Wan, Guohui Wan
Summary: This study reported a case where circulating tumor cell (CTC) counts successfully predicted the progression of metastatic colon polyps after interventional therapy for hepatocellular carcinoma (HCC), suggesting that CTC counts can be used to monitor disease progression during HCC metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Spyridoula Katsarou, Michael Makris, Efstratios Vakirlis, Stamatios Gregoriou
Summary: This systematic review focuses on the role of tight junctions in atopic dermatitis and their potential impact on therapeutic approaches. The findings suggest that dysfunctional tight junctions are closely associated with the pathogenesis and inflammation in atopic dermatitis, and further investigation into their functionality may lead to improved epidermal barrier function in this condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Timea Szekerczes, Adam Galamb, Adrienn Kocsis, Marta Benczik, Tibor Takacs, Attila Martonos, Balazs Jaray, Andras Kiss, Csaba Jeney, Miklos Nyiri, Zsuzsa Schaff, Gabor Sobel
PATHOLOGY & ONCOLOGY RESEARCH
(2019)
Article
Oncology
Gabor Lendvai, Timea Szekerczes, Benedek Gyongyosi, Krisztina Schlachter, Endre Kontsek, Adrian Pesti, Attila Patonai, Klara Werling, Ilona Kovalszky, Zsuzsa Schaff, Andras Kiss
PATHOLOGY & ONCOLOGY RESEARCH
(2019)
Article
Pathology
Jie Zhang, Pin Liu, Junyan Tao, Pan Wang, Yi Zhang, Xinhua Song, Li Che, Pavel Sumazin, Silvia Ribback, Andras Kiss, Zsuzsa Schaff, Antonio Cigliano, Frank Dombrowski, Carla Cossu, Rosa M. Pascale, Diego F. Calvisi, Satdarshan P. Monga, Xin Chen
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Article
Oncology
Irene Coati, Gabor Lotz, Giuseppe Nicolo Fanelli, Stefano Brignola, Cristiano Lanza, Rocco Cappellesso, Antonio Pellino, Salvatore Pucciarelli, Gaya Spolverato, Vincenza Guzzardo, Giada Munari, Giovanni Zaninotto, Marco Scarpa, Luca Mastracci, Fabio Farinati, Stefano Realdon, Pierluigi Pilati, Sara Lonardi, Nicola Valeri, Massimo Rugge, Andras Kiss, Fotios Loupakis, Matteo Fassan
BRITISH JOURNAL OF CANCER
(2019)
Article
Gastroenterology & Hepatology
Eva Kocsmar, Ildiko Kocsmar, Gyorgy Miklos Buzas, Ildiko Szirtes, Judit Wacha, Alajos Takats, Istvan Hritz, Zsuzsa Schaff, Massimo Rugge, Matteo Fassan, Andras Kiss, Gabor Lotz
Article
Oncology
Farkas Sarnyai, Timea Szekerczes, Miklos Csala, Balazs Sumegi, Andras Szarka, Zsuzsa Schaff, Jozsef Mandl
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Medicine, General & Internal
Tibor Szarvas, Michele J. Hoffmann, Csilla Olah, Eszter Szekely, Andras Kiss, Jochen Hess, Stephan Tschirdewahn, Boris Hadaschik, Vera Grotheer, Peter Nyirady, Anita Csizmarik, Melinda Varadi, Henning Reis
Summary: Chemotherapy resistance is a major issue in bladder cancer treatment. MMP-7 tissue and serum levels are associated with poor prognosis in patients undergoing platinum-based chemotherapy. Analysis of MMP-7 may help in optimizing therapeutic decisions for bladder cancer patients.
Article
Oncology
Andrea Reszegi, Katalin Karaszi, Gabor Toth, Kristof Rada, Lorand Vancza, Lilla Turiak, Zsuzsa Schaff, Andras Kiss, Laszlo Szilak, Gabor Szabo, Gabor Petovari, Anna Sebestyen, Katalin Dezso, Eszter Regos, Peter Tatrai, Kornelia Baghy, Ilona Kovalszky
Summary: Syndecan-1 plays a dual role in tumor development, either promoting or inhibiting tumors depending on the cancer type. In the context of liver cancer, transgenic expression of human syndecan-1 delayed tumor formation by downregulating lipid metabolism, inhibiting mTOR and beta-catenin pathways, and activating Foxo1 and p53 transcription factors. This oncoprotective effect was mediated by a beneficial modulation of lipid metabolism and molecular signaling pathways involved in cell cycle regulation and intermediary metabolism.
Article
Genetics & Heredity
Nadina Ortiz-Bruechle, Sophie Wucherpfennig, Michael Rose, Stefan Garczyk, Simone Bertz, Arndt Hartmann, Henning Reis, Tibor Szarvas, Andras Kiss, Felix Bremmer, Reinhard Golz, Ruth Knuechel, Nadine T. Gaisa
Summary: This study characterized the molecular background of Muellerian tumors of the urinary tract and identified various single nucleotide alterations and copy number alterations in these rare tumors. The absence of TERT promoter mutations and PAX8 immunohistochemical positivity were suggested as key diagnostic features for these tumors.
Meeting Abstract
Pathology
E. Kocsmar, I. Kocsmar, M. Kramer, A. Szijarto, G. M. Buzas, L. Bene, I. Szirtes, Z. Kramer, K. Szenas, P. Fadgyas-Freyler, A. Kiss, Z. Schaff, G. Lotz
Meeting Abstract
Pathology
I. Kocsmar, G. Pajor, A. Sziraki, E. Kocsmar, B. Gyongyosi, E. Szekely, I. Kenessey, P. Nyirady, A. Kiss, Z. Schaff, P. Riesz, G. Lotz
