Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 51, Issue 3, Pages 841-845Publisher
WILEY
DOI: 10.1002/jhet.1116
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Funding
- National Natural Science foundation of China [20802061]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Qing Lan Project of Jiangsu Education Committee [08QLT001, 10QLD008]
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A mild, green, and facile method for the synthesis of 2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazoline-1,5-dione derivatives is described in high yields by using ionic liquids as green media. The method involves the reaction of 2-aminobenzamides with 4-oxopentanoic acid or 4-aryl-4-oxo-butanoic acid catalyzed by iodine and has the advantages of mild reaction conditions, high yields, one-pot, operational simplicity, and environmentally benign.
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