Article
Evolutionary Biology
Luis Alfonso Yanez Guerra, Meet Zandawala
Summary: In this study, the GnRH and CRZ signaling systems were identified and characterized in the amphioxus Branchiostoma floridae. The discovery of these systems in a close relative of vertebrates provides insight into their roles during the transition from invertebrates to vertebrates.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Paul Saenger, Reiko Horikawa
Summary: This study evaluated the efficacy, safety, and tolerability of once-weekly somapacitan treatment for GH deficiency in children over a three-year period. The results showed sustained efficacy in height-related outcomes with similar safety and tolerability to daily GH treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Jun Mori, Volker Boettcher, Ho-Seong Kim, Rikke Beck Bang, Michel Polak, Reiko Horikawa
Summary: This study evaluated the efficacy and tolerability of somapacitan in children with growth hormone deficiency (GHD) for 2 years and after switching from daily growth hormone treatment. The results showed that somapacitan was effective and well-tolerated during the 2-year period, and patients and caregivers preferred once-weekly somapacitan treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Sebastian Rohrich, Paul Saenger, Reiko Horikawa
Summary: This study aimed to assess the efficacy and safety of somapacitan in treating growth hormone deficiency (GHD) in children, as well as the burden of treatment. The results showed that weekly injections of somapacitan could reduce the burden for patients and their parents/guardians compared to daily GH injections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Rasmus Juul Kildemoes, Jun Mori, Michel Polak, Rikke Beck Bang, Volker Boettcher, Stefano Stagi, Reiko Horikawa
Summary: Similar efficacy and safety were demonstrated for Somapacitan compared to daily GH over 52 weeks of treatment in children with GH deficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Aristides K. Maniatis, Samuel J. Casella, Ulhas M. Nadgir, Paul L. Hofman, Paul Saenger, Elena D. Chertock, Elena M. Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Per Holse Mygind, Alden R. Smith, Steven Chessler, Allison S. Komirenko, Michael Beckert, Aimee D. Shu, Paul S. Thornton
Summary: This trial aims to assess the long-term safety and efficacy of lonapegsomatropin in children with growth hormone deficiency. The results show that lonapegsomatropin treatment can continue to improve height without causing excessive advancement of bone age. Patients using the TransCon hGH Auto-Injector reported fewer local tolerability reactions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Veterinary Sciences
Fengyang Wu, Lijie Gao, Fei Li, Jia Cui, Xinyu Yang, Yanhua Liu, Saijuan Chen, Baojiang Chen
Summary: This experiment aimed to investigate the effects of zearalenone on ovarian development in prepubertal gilts. The results showed that zearalenone promoted the development of ovaries and follicles through the growth hormone axis, and exerted reproductive toxicity by increasing the expression levels of growth hormone receptor and related proteins.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Cheri Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A. Silverman, Moshe Phillip, Ho-Seong Kim, Cheol Woo Ko, Oleg Malievskiy, Jose F. Cara, Carl L. Roland, Carrie Turich Taylor, Srinivas Rao Valluri, Michael P. Wajnrajch, Aleksandra Pastrak, Bradley S. Miller
Summary: This study compared the efficacy and safety of once-weekly somatrogon with once-daily somatropin in prepubertal children with growth hormone deficiency. The results showed that once-weekly somatrogon was noninferior to once-daily somatropin in terms of height velocity and change in height standard deviation score. Both treatments were well tolerated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Chiara Mameli, Massimiliano Orso, Valeria Calcaterra, Malgorzata Gabriela Wasniewska, Tommaso Aversa, Simona Granato, Pietro Bruschini, Liliana Guadagni, Daniela d'Angela, Federico Spandonaro, Barbara Polistena, Gianvincenzo Zuccotti
Summary: This study evaluated the effectiveness, safety, adherence, quality of life, and cost-effectiveness of long-acting growth hormone (LAGH) compared to daily growth hormone (GH) in the treatment of growth hormone deficiency (GHD) in children. The results showed that all LAGH formulations were similar to daily GH in terms of efficacy, safety, adherence, and quality of life. However, more high-quality studies are needed to confirm these findings, and further research on adherence, quality of life, and cost-effectiveness is also necessary.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Hui Jiang, Zhi-Xin Chai, Han-Wen Cao, Cheng-Fu Zhang, Yong Zhu, Qiang Zhang, Jin-Wei Xin
Summary: This study analyzed SNPs in 480 yaks from different breeds and identified potential SNPs associated with body weight, some of which may affect hormone functioning by influencing gene expression, ultimately impacting yak body weight. Further investigation is needed to validate the potential use of SNP AX-174555047 as a biomarker for molecular breeding of yak.
Article
Endocrinology & Metabolism
Ling Hou, Ke Huang, Chunxiu Gong, Feihong Luo, Haiyan Wei, Liyang Liang, Hongwei Du, Jianping Zhang, Yan Zhong, Ruimin Chen, Xinran Chen, Jiayan Pan, Xianjiang Jin, Ting Zeng, Wei Liao, Deyun Liu, Dan Lan, Shunye Zhu, Zhiya Dong, Huamei Ma, Yu Yang, Feng Xiong, Ping Lu, Shengquan Cheng, Xuefan Gu, Runming Jin, Yu Liu, Jinzhun Wu, Xu Xu, Linqi Chen, Qin Dong, Hui Pan, Zhe Su, Lijun Liu, Xiaoming Luo, Shining Ni, Zhihong Chen, Yuhua Hu, Chunlin Wang, Jing Liu, Li Liu, Biao Lu, Xinli Wang, Yunfeng Wang, Fan Yang, Manyan Zhang, Lizhi Cao, GeLi Liu, Hui Yao, Yaqin Zhan, Mingjuan Dai, Guimei Li, Li Li, Yanjie Liu, Kan Wang, Yanfeng Xiao, Xingxing Zhang, Junhua Dong, Zaiyan Gu, Lirong Ying, Feng Huang, Yanling Liu, Zheng Liu, Jin Ye, Dongmei Zhao, Xu Hu, Zhihong Jiang, Kan Ye, Hong Zhu, Shaoke Chen, Xiaobo Chen, Naijun Wan, Zhuangjian Xu, Qingjin Yin, Hongxiao Zhang, Xiaodong Huang, Jianying Yin, Huifeng Zhang, Pin Li, Ping Yin, Junfen Fu, XiaoPing Luo
Summary: This study examined the effectiveness and safety of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric growth hormone deficiency (GHD). The results showed that PEG-rhGH had favorable outcomes and was safe for treating children with GHD. The high-dose subgroup had better treatment outcomes compared to the low-dose subgroup, and a weekly dose of 0.2 mg/kg might have additional benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Gudmundur Johannsson, Oskar Ragnarsson
Summary: GH deficiency is common in patients with hypothalamic-pituitary disorders, and its replacement therapy can improve symptoms and quality of life while maintaining a good safety profile.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Kevin C. J. Yuen, Bradley S. Miller, Cesar L. Boguszewski, Andrew R. Hoffman
Summary: Long-acting Growth Hormone (LAGH) analogs have been developed to reduce injection frequency and improve patient acceptance and therapeutic flexibility. However, potential clinical issues such as unphysiological GH profile, differing molecular structures, dose initiation, therapeutic monitoring, side-effect incidence, and long-term safety may arise with these analogs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Multidisciplinary Sciences
Yingying Li, Xinying Chen, Zhengduo Liu, Jinghua Yang
Summary: The systematic review and meta-analysis on the efficacy of Chinese herbal medicine (CHM) for idiopathic short stature (ISS) indicated that CHM treatment is associated with increased height, growth velocity, IGF-1 level, and growth hormone peak level, suggesting its potential effectiveness in treating ISS. Further high-quality studies are needed to confirm these conclusions due to the limited quality and quantity of current research.
Article
Multidisciplinary Sciences
Yingying Li, Xinying Chen, Zhengduo Liu, Jinghua Yang
Summary: According to the current research, Chinese herbal medicine appears to be effective for children with idiopathic short stature (ISS). More high-quality studies are needed to confirm the above conclusions due to the limited number and quality of studies included.
Article
Evolutionary Biology
Hugo F. Gante, Ignacio Doadrio, Maria Judite Alves, Thomas E. Dowling
BMC EVOLUTIONARY BIOLOGY
(2015)
Article
Fisheries
C. Gkenas, J. Gago, N. Mesquita, M. J. Alves, F. Ribeiro
JOURNAL OF APPLIED ICHTHYOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Luca Buonerba, Serena Zaccara, Giovanni B. Delmastro, Massimo Lorenzoni, Walter Salzburger, Hugo F. Gante
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2015)
Article
Marine & Freshwater Biology
Rachel K. Spinks, Moritz Muschick, Walter Salzburger, Hugo F. Gante
Article
Biochemistry & Molecular Biology
Hugo F. Gante, Michael Matschiner, Martin Malmstrom, Kjetill S. Jakobsen, Sissel Jentoft, Walter Salzburger
Article
Multidisciplinary Sciences
Catarina Sofia Mateus, Pedro Raposo Almeida, Natacha Mesquita, Bernardo Ruivo Quintella, Maria Judite Alves
Letter
Multidisciplinary Sciences
R. Abila, P. Akoll, C. Albertson, D. Antunes, T. Banda, R. Bills, A. Bulirani, A. Chocha Manda, A. S. Cohen, F. Cunha-Saraiva, S. Derycke, I. Donohue, M. Du, A. M. Dudu, B. Egger, K. Fritzsche, J. G. Frommen, H. F. Gante, M. J. Genner, A. Haerer, H. Hata, K. Irvine, P. Isumbisho Mwapu, L. Janssens de Bisthoven, A. Jungwirth, P. Kaleme, C. Katongo, L. Kever, S. Koblmueller, A. Konings, A. Lamboj, F. Lemmel-Schaedelin, G. Machado Schiaffino, K. Martens, P. Masilya Mulungula, A. Meyer, H. L. More, Z. Musilova, F. Muterezi Bukinga, R. Muzumani, G. Ntakimazi, W. Okello, H. Phiri, L. Pialek, P. D. Plisnier, J. A. M. Raeymaekers, J. Rajkov, O. Rican, R. Roberts, W. Salzburger, I. Schoen, K. M. Sefc, P. Singh, P. Skelton, J. Snoeks, K. Schneider, C. Sturmbauer, H. Svardal, O. Svensson, J. Torres Dowdall, G. F. Turner, A. Tyers, J. C. van Rijssel, M. Van Steenberge, M. P. M. Vanhove, Erik Verheyen, A. -T. Weber, O. Weyl, A. Ziegelbecker, H. Zimmermann
Article
Evolutionary Biology
Anna Skoracka, Luis Filipe Lopes, Maria Judite Alves, Adam Miller, Mariusz Lewandowski, Wiktoria Szydlo, Agnieszka Majer, Elzbieta Rozanska, Lechoslaw Kuczynski
BMC EVOLUTIONARY BIOLOGY
(2018)
Editorial Material
Multidisciplinary Sciences
Hugo F. Gante
Article
Fisheries
Manuel Curto, Miguel Morgado-Santos, Carlos M. Alexandre, Maria Judite Alves, Hugo F. Gante, Christos Gkenas, Joao P. Medeiros, Paulo J. Pinheiro, Pedro R. Almeida, Maria Filomena Magalhaes, Filipe Ribeiro
Summary: Hybridization between the invasive bleak and native chub species has been found to be widespread in Portuguese river basins, potentially causing damage to the genetic integrity of endemic species and altering the reproductive dynamics of hybrid populations. Future studies should focus on assessing the fitness of bleak hybrids and their interactions with native fish to develop effective conservation measures.
Article
Biodiversity Conservation
Joana Martelo, Luis M. da Costa, Diogo Ribeiro, Joao Gago, Maria Filomena Magalhaes, Hugo F. Gante, Maria Judite Alves, Gisela Cheoo, Christos Gkenas, Filipe Banha, Mafalda Gama, Pedro M. Anastacio, Patricia M. Tiago, Filipe Ribeiro
Summary: This study updated the distribution of recently introduced and long-established non-native fish species in Portugal by combining scientific and citizen science data, showing an expansion in distribution range for these species in the last 20 years.
BIOINVASIONS RECORDS
(2021)
Article
Zoology
Armando J. Almeida, Maria Judite Alves
Article
Evolutionary Biology
Judith C. Bachmann, Fabio Cortesi, Matthew D. Hall, N. Justin Marshall, Walter Salzburger, Hugo F. Gante
Article
Zoology
Armando J. Almeida, Maria Judite Alves