Review
Otorhinolaryngology
Johannes H. A. M. Kaanders, Sven van den Bosch, Jos Kleijnen
Summary: The aim of this study was to investigate if patients with head and neck cancer in randomized clinical trials are representative of the clinically treated population. The study found that patients in the trials had a good performance status and were younger compared to the general population. The recruitment in these trials was also found to be overly restrictive. Critical evaluation of trial population characteristics is recommended before implementing the results in clinical guidelines and general practice.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Health Care Sciences & Services
Vivienne Hanrahan, Linda Biesty, Louisa Lawrie, Eilidh Duncan, Katie Gillies
Summary: This study uses the Theoretical Domains Framework (TDF) to investigate the barriers and enablers to maternity healthcare professionals inviting eligible women to participate in a maternity care trial. The findings provide important guidance for trial designers and lay the foundation for a recruiter-focused behavior change intervention.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Geriatrics & Gerontology
Thomas Buttgereit, Andriko Palmowski, Noah Forsat, Maarten Boers, Miles D. Witham, Nicolas Rodondi, Elisavet Moutzouri, Antonio Jesus Quesada Navidad, Arnoud W. J. van't Hof, Bart van der Worp, Laura Coll-Planas, Marieke Voshaar, Maarten de Wit, Jose da Silva, Sven Stegemann, Johannes W. Bijlsma, Marcus Koeller, Simon Mooijaart, Patricia M. Kearney, Frank Buttgereit
Summary: Older people are underrepresented in clinical trials, but identifying key barriers and discussing solutions based on experience from current European trials have shown ways to improve recruitment and retention. Barriers such as health conditions and cultural beliefs were addressed by increasing recruitment sites, providing extra time, and improving communication. Special recognition and targeted approaches are needed for recruiting and retaining older patients.
Article
Medicine, Research & Experimental
Tooba Alwani, Jennifer N. Shehan, Jessica LeClair, Taylor F. Mahoney, Pratima Agarwal, Salil T. Chaudhry, Judy J. Wang, Jacob P. Noordzij, Lauren F. Tracy, Heather A. Edwards, Gregory Grillone, Andrew R. Salama, Scharukh M. Jalisi, Anand K. Devaiah
Summary: This study explores the impact of social determinants of health on follow-up care in head and neck cancers. Factors such as income, primary language, country of birth, race/ethnicity, insurance status, and markers of educational attainment do not appear to influence follow-up care at a safety-net, tertiary care institution, but distance from hospital remains a significant contributor to care disparities.
Review
Oncology
Yan Ning, Qian Wang, Yongxia Ding, Wenting Zhao, Zehuan Jia, Binquan Wang
Summary: Patients with head and neck cancer have low compliance with physical activity, and the factors influencing their participation and adherence need to be explored.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Robert E. Sobol, Kerstin B. Menander, Sunil Chada, Dora Wiederhold, Beatha Sellman, Max Talbott, John J. Nemunaitis
Summary: Analysis of previous Ad-p53 treatment data in recurrent HNSCC patients revealed that higher Ad-p53 doses above 7 x 10(10) viral particles/cm(3) were associated with better tumor responses. Favorable p53 biomarker profiles and appropriate dosing are essential for the success of future Ad-p53 gene therapy in clinical trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Irma Verdonck-de Leeuw, Camilla Dawson, Lisa Licitra, Jesper Grau Eriksen, Sefik Hosal, Susanne Singer, Dominic P. Laverty, Wojciech Golusinski, Piotr Machczynski, Ana Varges Gomes, Charis Girvalaki, Christian Simon, C. Rene Leemans
Summary: Survivors of head and neck cancer may experience long-term consequences and require support in social, psychological, financial, and emotional aspects in addition to physical symptoms. This review provides recommendations for the long-term management and support needed for survivors of head and neck cancer in the European healthcare setting.
Review
Medicine, Research & Experimental
Sameed Shariq, Alexandra M. Cardoso Pinto, Shyam Sundar Budhathoki, Marie Miller, Suzie Cro
Summary: This study aims to review and map the potential barriers and facilitators to the recruitment of disabled people in clinical trials. A total of five emergent themes were determined across the barriers and facilitators. The findings of this study can improve inclusive practices in clinical trial research.
Review
Biochemistry & Molecular Biology
Yong Teng, Lixia Gao, Antti A. Makitie, Ewa Florek, Agata Czarnywojtek, Nabil F. Saba, Alfio Ferlito
Summary: This review discusses the relationship between ferroptosis and head and neck cancer treatment, including its conceptual framework, mechanism, functional aspects, and implications for tumor therapy. In addition, strategies for improving the efficacy of head and neck cancer treatment through modulation of ferroptosis are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Alice Avancini, Anita Borsati, Lorenzo Belluomini, Diana Giannarelli, Riccardo Nocini, Jessica Insolda, Marco Sposito, Federico Schena, Michele Milella, Sara Pilotto
Summary: This study systematically explored the impact of physical exercise as supportive therapy for head and neck cancer. Through analyzing multiple studies, it was found that physical exercise may have positive effects on improving muscle strength, cardiorespiratory fitness, and quality of life.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Otorhinolaryngology
Tuleen Sawaf, Brooke A. Quinton, Gabriel Moss, Noah M. Yaffe, Humzah A. Quereshy, Claudia Cabrera-Aviles, Nicole Fowler, Shawn Li, Jason E. Thuener, Pierre Lavertu, Rod P. Rezaee, Theodoros N. Teknos, Akina Tamaki
Summary: This study evaluated the reporting and rates of loss to follow-up (LTFU) in head and neck cancer (HNC) randomized controlled trials based in the United States. The majority of HNC trials in the United States do not report LTFU, which hinders the evaluation of attrition bias and generalizability of trial results.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Pharmacology & Pharmacy
Amos J. de Jong, Tessa van Rijssel, Mira G. P. Zuidgeest, Ghislaine J. M. W. van Thiel, Scott Askin, Jaime Fons-Martinez, Tim De Smedt, Anthonius de Boer, Yared Santa-Ana-Tellez, Helga Gardarsdottir
Summary: Decentralized clinical trials (DCTs) have the potential to improve accessibility, diversity, and retention in clinical trials, but also face regulatory challenges. Regulators recognize the opportunities of reducing participation burden and improving data representativeness in DCTs, while expressing concerns about investigator oversight and participant safety.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Nursing
Kondwani Joseph Banda, Hsin Chu, Ching-Chiu Kao, Joachim Voss, Huei-Ling Chiu, Pi-Chen Chang, Ruey Chen, Kuei-Ru Chou
Summary: This study conducted a systematic review and meta-analysis of swallowing exercises in head and neck cancer patients, showing significant effectiveness in improving swallowing function and mouth opening. However, the effects on risk of aspiration, performance status, and quality of life were not significant.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Editorial Material
Oncology
Giovana R. Thomas
Summary: Health care disparity in cancer is a recognized issue, especially in outcomes for African Americans with head and neck cancer in the United States. Access to care is a key area of research and interventions to reduce these disparities for vulnerable populations.
Review
Oncology
Kenneth C. W. Wong, David Johnson, Edwin P. Hui, Rachel C. T. Lam, Brigette B. Y. Ma, Anthony T. C. Chan
Summary: The combination of radiotherapy and immune checkpoint inhibitors has potential for improving prognosis in locally advanced and recurrent/metastatic head and neck cancers, but the clinical trials have yielded largely negative results. Further investigation is needed to explore parameters such as dose fractionation, sequencing, irradiated volume, and predictive biomarkers.
CANCER TREATMENT REVIEWS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vivian U. Y. Chow, Michael L. M. Cheung, Monica W. K. Kan, Anthony T. C. Chan
Summary: Accurate detection of patient shift is crucial in radiation therapy to ensure optimal dose delivery to the tumor and minimize radiation to surrounding normal tissues. This study evaluated the shift detectability of a newly developed optical surface and thermal tracking system (EXTD) and compared it with image guidance under cone-beam computed tomography (CBCT). The results showed that the EXTD system with thermal mapping capability offered comparable accuracy for shift detection with CBCT on both cranial and pelvis phantoms.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Oncology
Si-Qi Tang, Lei Chen, Wen-Fei Li, Anthony T. C. Chan, Shao Hui Huang, Melvin L. K. Chua, Brian O'Sullivan, Anne W. M. Lee, Nancy Y. Lee, Yuan Zhang, Yu-Pei Chen, Cheng Xu, Ying Sun, Ling-Long Tang, Jun Ma
Summary: By analyzing data from non-metastatic NPC patients, N2-3 or T4 patients were identified as ideal candidates for multicenter clinical trials in locoregionally advanced NPC. Stratification based on pre-treatment EBV DNA can identify high-risk patients, while detectable post-treatment EBV DNA indicates a high risk of progression.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
A. T. C. Chan, V. H. F. Lee, R-L Hong, M. -J. Ahn, W. Q. Chong, S. -B. Kim, G. F. Ho, P. B. Caguioa, N. Ngamphaiboon, C. Ho, M. A. S. A. Aziz, Q. S. Ng, C. -J. Yen, N. Soparattanapaisarn, R. K. -C Ngan, S. K. Kho, M. L. A. Tiambeng, T. Yun, V. Sriuranpong, A. P. Algazi, A. Cheng, E. Massarelli, R. F. Swaby, S. Saraf, J. Yuan, L. L. Siu
Summary: Pembrolizumab showed robust antitumor activity and manageable safety in patients with platinum-pretreated recurrent and/or metastatic nasopharyngeal carcinoma. However, it did not significantly improve overall survival compared with chemotherapy.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
W. K. Jacky Lam, Ann D. King, Jacob A. Miller, Zhiwei Liu, Kelly J. Yu, Melvin L. K. Chua, Brigette B. Y. Ma, Ming Yuan Chen, Benjamin A. Pinsky, Pei-Jen Lou, John K. S. Woo, Wan-Lun Hsu, Julia Simon, Denise L. Doolan, Tim Waterboer, Edwin P. Hui, Hui Li, Raymond K. Tsang, Kenneth C. W. Wong, Julian P. Goh, Alexander C. Vlantis, Qi Yong Ai, Lun M. Wong, Victor Abdullah, Jin Ching Lin, Chien-Jen Chen, Ruth M. Pfeiffer, Quynh-Thu Le, Anne W. M. Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T. C. Chan, K. C. Allen Chan, Allan Hildesheim
Summary: A meeting of experts in November 2021 discussed the performance and cost-effectiveness of EBV-based approaches for screening early stage nasopharyngeal carcinoma. Both serum EBV antibody and plasma EBV DNA testing methods were found to be favorable. Additionally, the use of MRI was recommended to increase the sensitivity of NPC detection without greatly impacting the cost-effectiveness of the screening program.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Biochemistry & Molecular Biology
Lili Li, Xing-sheng Shu, Hua Geng, Jianming Ying, Lei Guo, Jie Luo, Tingxiu Xiang, Longtao Wu, Brigette B. Y. Ma, Anthony T. C. Chan, Xiaofeng Zhu, Richard F. Ambinder, Qian Tao
Summary: Peptides/small proteins encoded by noncanonical open reading frames (ORF) of previously claimed non-coding RNAs have important biological functions but are largely uncharacterized. In this study, we identified and validated a small protein SP0495 as a novel tumor suppressor, frequently inactivated by promoter methylation in multiple tumors. SP0495 functions as a phosphoinositide-binding protein, regulating AKT signaling activation and autophagy. It inhibits tumor cell growth and induces apoptosis, cell cycle arrest, senescence, and autophagy through multiple mechanisms, including the modulation of phosphoinositides turnover and autophagic/proteasomal degradation of autophagy regulators. SP0495 has the potential to be a biomarker for cancer diagnosis and prognosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Ze Zhou, Mary-Jane L. Ma, Rebecca W. Y. Chan, W. K. Jacky Lam, Wenlei Peng, Wanxia Gai, Xi Hu, Spencer C. Ding, Lu Ji, Qing Zhou, Peter P. H. Cheung, Stephanie C. Y. Yu, Jeremy Y. C. Teoh, Cheuk-Chun Szeto, John Wong, Vincent W. S. Wong, Grace L. H. Wong, Stephen L. Chan, Edwin P. Hui, Brigette B. Y. Ma, Anthony T. C. Chan, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo, Peiyong Jiang
Summary: Using a non-negative matrix factorization algorithm, this study identified distinct types of cfDNA cleavage patterns based on different end motifs. These profiles were associated with specific DNA nucleases and could be used to diagnose autoimmune disorders and cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Shweta Mahajan, Hayri E. Balcioglu, Astrid Oostvogels, Willem A. Dik, K. C. Allen Chan, Kwok-Wai Lo, Edwin P. Hui, Anna Tsang, Joanna Tong, Wai Kei Jacky Lam, Kenneth Wong, Anthony T. C. Chan, Brigette B. Y. Ma, Reno Debets
Summary: Post-radiotherapy clearance of plasma EBV DNA is associated with prognosis in NPC patients. T cells, particularly CD8+ T cells expressing CCR1, 4 and/or 5, play a role in this clearance process. Differences in chemo-attractants related to T-cell chemotaxis are also linked to clinical outcome. Validation in larger cohorts is needed to confirm these findings.
Article
Medicine, General & Internal
Nancy Y. Lee, Jonathan Harris, John Kim, Adam Garden, James Mechalakos, David G. Pfister, Anthony T. C. Chan, Kenneth Hu, A. Dimitrios Colevas, Steven Frank, George Shenouda, Voichita Bar-Ad, John N. Waldron, Paul M. Harari, Adam Raben, Pedro Torres-Saavedra, Quynh-Thu Le
Summary: The study aimed to assess the long-term toxic effects and clinical outcomes associated with adding bevacizumab, a vascular endothelial growth factor inhibitor, to standard chemoradiation for patients with nasopharyngeal carcinoma (NPC). The results showed favorable long-term outcomes and no severe adverse events when using bevacizumab in combination with chemoradiation. Further investigation may be warranted.
Article
Oncology
W. K. Jacky Lam, Anthony T. C. Chan
Summary: A recent study has identified a new serological biomarker for NPC screening that targets the EBV protein BNLF2b. This biomarker demonstrated higher sensitivity and specificity for NPC detection compared with conventional antibodies.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Oncology
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T. C. Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K. C. Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L. W. Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard
Summary: This study updated the evaluation of chemotherapy for nasopharynx carcinoma through a network meta-analysis. The results showed that the addition of induction chemotherapy or adjuvant chemotherapy to chemoradiotherapy improved overall survival for patients with non-metastatic nasopharyngeal carcinoma compared to chemoradiotherapy alone.
Article
Oncology
D. C. T. Chan, W. K. J. Lam, E. P. Hui, B. B. Y. Ma, C. M. L. Chan, V. C. T. Lee, S. H. Cheng, W. Gai, P. Jiang, K. C. W. Wong, F. Mo, B. Zee, A. D. King, Q. T. Le, A. T. C. Chan, K. C. A. Chan, Y. M. D. Lo
Summary: Sequencing of plasma EBV DNA can enhance the accuracy of prognostication for nasopharyngeal carcinoma patients. It provides better prediction of local and distant recurrences through quantitative and size profiling analysis. It can also further define a subgroup of patients with undetectable EBV DNA on quantitative PCR, resulting in improved survival outcomes.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Michael L. M. Cheung, Monica W. K. Kan, Vanessa T. Y. Yeung, Darren M. C. Poon, Michael K. M. Kam, Louis K. Y. Lee, Anthony T. C. Chan
Summary: The purpose of this study was to investigate the radiobiological effect of using Acuros XB (AXB) vs Analytic Anisotropic Algorithm (AAA) in hepatocellular carcinoma (HCC) stereotactic body radiation therapy (SBRT). Different computational methods may have an impact on tumor control probability (TCP), normal tissue complication probability (NTCP), and uncomplicated tumor control probability (UTCP).
Article
Oncology
Pierre Blanchard, Anne W. M. Lee, Alexandra Carmel, Ng Wai Tong, Jun Ma, Anthony T. C. Chan, Ruey Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Dora L. W. Kwong, Sharon S. X. Poh, Roger Ngan, Hai-Qiang Mai, Camille Ollivier, George Fountzilas, Li Zhang, Jean Bourhis, Anne Auperin, Benjamin Lacas, Jean-Pierre Pignon
Summary: This study provides an update on the meta-analysis of chemotherapy in the treatment of nasopharyngeal carcinoma. The results confirm the benefits of concomitant chemotherapy and concomitant + adjuvant chemotherapy, and suggest that the addition of induction or adjuvant chemotherapy to concomitant chemotherapy improves tumor control and survival. The effectiveness of chemotherapy decreases with increasing patient age.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Darren M. C. Poon, Daisy Lam, Kenneth C. W. Wong, Cheuk-Man Chu, Michael Cheung, Frankie Mo, Joyce Suen, Chi-Fai Ng, Anthony T. C. Chan
Summary: This study compared the effects of stereotactic body radiotherapy (SBRT) and conventional fractionated radiotherapy (CFRT) in Chinese men with localized prostate cancer (PC). The results showed that SBRT had similar patient-reported quality of life (PRQOL) but fewer toxicities compared to CFRT in the first year.
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.