Article
Oncology
Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Pallavi Mohapatra, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Falak Pahwa, Krushna Chandra Murmu, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Anshuman Dixit, Punit Prasad, Ranjan K. Nanda, Rupesh Dash
Summary: The study identified RRBP1 as a major driver of cisplatin-resistance in oral squamous cell carcinoma, regulating YAP1 expression to mediate chemoresistance, and demonstrated that targeting RRBP1 could reverse cisplatin-induced chemoresistance.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Vladimir O. Pustylnyak, Efim Y. Alekseenok, Alina M. Perevalova, Vadim V. Kozlov, Lyudmila F. Gulyaeva
Summary: This study investigates the expression and regulation of PTEN gene in lung squamous-cell carcinoma (LUSC) tissues, with a focus on the impact of smoking. The results show that PTEN is downregulated in LUSC tissues compared to normal tissues, and this downregulation is associated with smoking exposure. In silico analysis suggests that hsa-mir-301a may play a role in the downregulation of PTEN, and this correlation is confirmed in patient samples.
Article
Oncology
Lijun Li, Li Li, Lian Hu, Ting Li, Dan Xie, Xiaoliu Liu
Summary: This study identified a lncRNA HAND2-AS1/miR-106a/PTEN axis that can sensitize DDP-resistant SKOV3/DDP cells to DDP treatment. Through the axis, HAND2-AS1 overexpression inhibited cell viability and promoted cell apoptosis in DDP-resistant cells, while miR-106a overexpression reversed these effects by downregulating PTEN and upregulating PI3K/AKT signaling.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Gang Deng, Fei Wang, YiSa Song
Summary: This study demonstrates that circSETD3 promotes NPC proliferation and resistance to cisplatin (DDP) by regulating miR-147a and inhibiting the Akt/mTOR pathway. The circSETD3/miR-147a axis may serve as a potential therapeutic target for NPC.
Article
Biology
Zhouyang Cheng, Qingfeng Ni, Lei Qin, Yang Shi
Summary: The study found that miR-92b plays a significant role in mediating sorafenib resistance in hepatocellular carcinoma cells by directly targeting PTEN and activating the PI3K/AKT/mTOR pathway, leading to increased resistance to sorafenib treatment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Peng Ye, Ye Liu, Ye-Jun Cai, Hong Yang, Hong-Tao Xu, Zhi-Yue Lu
Summary: Tongue squamous cell carcinoma patients showed a significant increase in oral microbiotic diversity, with differences in bacterial community structure and decreased levels of specific taxa in cancer samples. The bacterial community in cancer samples appeared more conserved than in normal tissue, suggesting potential carcinogenic mechanisms.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tao Liu, Fei Jiang, Li-Yuan Yu, You-Yang Wu
Summary: This study elucidated the inhibitory effects of lidocaine on cell proliferation and cisplatin resistance in A431 human cutaneous squamous cell carcinoma cells through the miR-30c/SIRT1 pathway. The findings suggest that lidocaine has promising potential as a treatment strategy for cSCC.
Article
Oncology
Mi Zhang, Ling Wu, Xudong Wang, Jiang Chen
Summary: This study identified a novel lncRNA, lncKRT16P6, that is upregulated in TSCC and promotes metastasis and malignancy by regulating miR-3180 and GATAD2A expression. Therefore, lncKRT16P6 may serve as a prognostic biomarker and therapeutic target for TSCC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Feng He, Fenglin Zhang, Yi Liao, Moon-shong Tang, Xue-Ru Wu
Summary: Muscle-invasive bladder cancer (MIBC) exhibits strong inter- and intra-tumor heterogeneity and mutations in RTK-RAS-PI3K and P19-P53-P21 pathways are commonly observed. This study shows that deficiencies of both PTEN and P53 are responsible for driving the basal/squamous subtype MIBC. PTEN is inactivated by hyperphosphorylation of the C-terminus and this modification may serve as a biomarker for subtyping MIBC and predicting tumor progression. Tailless PTEN is a potential molecular therapeutic for accessible tumors like bladder cancer.
Review
Medicine, Research & Experimental
Hanlin Hu, Bo Li, Junke Wang, Ye Tan, Mingjin Xu, Wenhua Xu, Haijun Lu
Summary: Head and neck squamous cell carcinoma (HNSCC) is influenced by various factors and cisplatin resistance is a major concern. This review focuses on the roles of cancer stem cells and autophagy in cisplatin resistance and discusses potential treatment strategies, including nanodrug delivery systems targeting cancer stem cells or autophagy. The review also highlights the prospects and challenges associated with nanodelivery platforms in addressing cisplatin resistance in HNSCC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biophysics
Yang Sun, Wei Nie, Bo Qiu, Xiangjun Guo, Jian Zhang, Jianming Wei
Summary: The study reveals that miR-17 promotes apoptosis and autophagy in cancer cells through the STAT3 signaling pathway, affecting the growth of tongue squamous carcinoma. Inhibition of miR-17 enhances cisplatin-induced cancer cell apoptosis, suggesting a potential treatment target for human tongue squamous carcinoma.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Oncology
Hua Guan, Linlin Deng
Summary: This study found that the Hippo/YAP1 pathway was dysregulated in tongue squamous cell carcinoma (TSCC) and YAP1 was upregulated and dephosphorylated. Knockdown of YAP1 inhibited cell proliferation and migration, and increased sensitivity to DDP.
Article
Pharmacology & Pharmacy
Danfeng Xue, Xiongming Zhou, Jiaxuan Qiu
Summary: The study found that plumbagin has a greater inhibitory effect on drug-resistant cells compared to sensitive cells, inducing apoptosis and protective autophagy in TSCC cells. Mechanistically, plumbagin induces apoptosis and autophagy by generating reactive oxygen species to mediate JNK and AKT/mTOR pathways, and its growth inhibitory effect against drug-resistant TSCC was confirmed in vivo.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Anais Hagege, Damien Ambrosetti, Julien Boyer, Alexandre Bozec, Jerome Doyen, Emmanuel Chamorey, Xingkang He, Isabelle Bourget, Julie Rousset, Esma Saada, Olivia Rastoin, Julien Parola, Frederic Luciano, Yihai Cao, Gilles Pages, Maeva Dufies
Summary: High expression of Plk1 is associated with poor prognosis in HNSCC, while onvansertib shows potential therapeutic effects by inducing apoptosis. Combination of onvansertib with cisplatin and/or radiotherapy synergistically induces tumor cell death.
Article
Biochemistry & Molecular Biology
Jaroslav Nunvar, Lucie Pagacova, Zuzana Vojtechova, Nayara Trevisan Doimo de Azevedo, Jana Smahelova, Martina Salakova, Ruth Tachezy
Summary: Our study found that the degree of miRNA deregulation varies significantly among tumors at different locations, and the deregulated miRNAs are largely tumor-specific, with no miRNA shared by all four types of HPV-positive tumors.
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
