Article
Immunology
Hong Ki Min, Hyun Sik Na, JooYeon Jhun, Seon-Yeong Lee, Sun Shim Choi, Go Eun Park, Jeong Su Lee, In Gyu Um, Seung Yoon Lee, Hochan Seo, Tae-Seop Shin, Yoon-Keun Kim, Jennifer Jooha Lee, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
Summary: In this study, we compared the gut microbiota of axSpA patients and healthy controls and found an association between specific gut microbiota and SpA pathogenesis. The results showed that axSpA patients had lower alpha-diversity and higher abundance of Bacteroides and Streptococcus, while Faecalibacterium prausnitzii, a butyrate-producing bacteria, was more abundant in healthy controls. Further experiments revealed that introducing F. prausnitzii or butyrate can reduce the polarization of CD4(+) IL-17A(+) T cells and the formation of osteoclasts, and decrease inflammation levels. Therefore, the reduced abundance of butyrate-producing microbes, especially F. prausnitzii, may be associated with axSpA pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huili Zheng, Xiaofei Liang, Hongli Zhou, Tong Zhou, Xinhui Liu, Jialun Duan, Jin-ao Duan, Yue Zhu
Summary: In this study, the protective effect of Lycium barbarum polysaccharides (LBPs) on premature ovarian insufficiency (POI) was investigated in mice. LBPs improved ovarian reserve, regulated sex hormone levels, normalized estrous cycle, and increased offspring numbers in POI mice. Furthermore, LBPs had positive effects on gut microbiota and metabolism. These findings provide valuable support for the application of LBPs in the treatment of female ovarian function degeneration.
Article
Multidisciplinary Sciences
Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li
Summary: This study aimed to establish and evaluate a rat model of inflammatory bowel disease (IBD) using antibiotics. The results showed that the antibiotic-induced IBD model was successfully established in SD rats and may serve as a useful model for clinical IBD research.
Article
Multidisciplinary Sciences
Muhammad Tanweer Khan, Chinmay Dwibedi, Daniel Sundh, Meenakshi Pradhan, Jamie D. Kraft, Robert Caesar, Valentina Tremaroli, Mattias Lorentzon, Fredrik Backhed
Summary: This study successfully co-isolated Faecalibacterium prausnitzii and Desulfovibrio piger and identified their symbiotic relationship in growth and butyrate production. By adapting Faecalibacterium prausnitzii to tolerate oxygen exposure, researchers developed a next-generation probiotic formulation.
Article
Immunology
Li-ting Jin, Ming-Zhi Xu
Summary: In obese patients, the connection between the gut microbiota and the onset of non-alcoholic fatty liver (NAFLD) is yet unknown. A study comparing the gut microbiota of obese individuals with and without NAFLD found a lower quantity of Faecalibacterium prausnitzii in the NAFLD group. Bacteroides, Clostridium leptum, and Clostridium butyricum were more prevalent in the NAFLD group, while Bacteroides, Clostridium butyricum, and F. prausnitzii were more prevalent in the simple obesity group. Lymphocytes and F. prausnitzii may play a role in determining the development of NAFLD in obese patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura Sanchis-Artero, Juan Francisco Martinez-Blanch, Sergio Manresa-Vera, Ernesto Cortes-Castell, Marina Valls-Gandia, Marisa Iborra, Jose Maria Paredes-Arquiola, Maia Bosca-Watts, Jose Maria Huguet, Rafael Gil-Borras, Josefa Rodriguez-Morales, Xavier Cortes-Rizo
Summary: Intestinal dysbiosis plays a crucial role in the development of Crohn's disease (CD). A study conducted on CD patients undergoing anti-TNF treatment revealed significant changes in gut microbiota, with partial restoration observed in responders. The F.prausnitzii/E.coli ratio was identified as a reliable indicator of response to anti-TNF therapy in CD.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Sondergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sorensen, Stanislav D. Ehrlich, Oluf Pedersen
Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.
Article
Multidisciplinary Sciences
Helena A. K. Lapatto, Minna Kuusela, Aino Heikkinen, Maheswary Muniandy, Birgitta W. van der Kolk, Swetha Gopalakrishnan, Noora Pollanen, Martin Sandvik, Mark S. Schmidt, Sini Heinonen, Sina Saari, Juho Kuula, Antti Hakkarainen, Janne Tampio, Tuure Saarinen, Marja-Riitta Taskinen, Nina Lundbom, Per-Henrik Groop, Marja Tiirola, Pekka Katajisto, Marko Lehtonen, Charles Brenner, Jaakko Kaprio, Satu Pekkala, Miina Ollikainen, Kirsi H. Pietilainen, Eija Pirinen
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD(+)), has shown promise in improving obesity-associated mitochondrial dysfunction and metabolic syndrome. However, short-term clinical trials have not yielded positive results. This study aimed to investigate the long-term effects of NR supplementation on mitochondrial biogenesis and metabolic health in humans. The results showed that NR improved NAD(+) metabolism, muscle mitochondrial number, myoblast differentiation, gut microbiota composition, and epigenetic control of gene expression. However, it did not improve adiposity or metabolic health.
Review
Medicine, General & Internal
Yilun Wang, Jie Wei, Weiya Zhang, Michael Doherty, Yuqing Zhang, Haibin Xie, Wei Li, Ning Wang, Guanghua Lei, Chao Zeng
Summary: Dysbiosis in gut microbiota may be associated with the occurrence or development of rheumatic diseases. The review of existing evidence suggests that there is a decrease in alpha-diversity indices in rheumatic diseases, but the specific associations with different rheumatic diseases are inconsistent. Alterations in certain microbial populations in the gut may be related to rheumatic diseases.
Article
Immunology
Francine Jotereau, Joudy Alameddine, Raluca Teusan, Annabelle Pedron, Nicolas Jouand, Frederic Altare, Emmanuelle Godefroy
Summary: In this study, a unique subset of Tregs called DP8 alpha Tregs was identified in humans. These Tregs secrete IL-10, co-express CD4 and CD8 alpha, and react against the symbiotic bacterium Faecalibacterium prausnitzii. They exhibit a mixed Tr1-like/cytotoxic CD4(+) T cell-profile and share master genes with mouse gut microbiota-induced Tregs. DP8 alpha Tregs possess potent cytotoxic, chemotactic, and IgA-promoting abilities. The discovery of their complete signature and novel functional properties provides important insights into their physiological roles and clinical applications in inflammatory bowel diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tatiani Uceli Maioli, Esther Borras-Nogues, Licia Torres, Sara Candida Barbosa, Vinicius Dantas Martins, Philippe Langella, Vasco Ariston Azevedo, Jean-Marc Chatel
Summary: Research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. An obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, contributing to chronic inflammation and insulin resistance. Modulating the gut microbiota may be a potential treatment approach for these conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Psychiatry
Viktoriya L. Nikolova, Megan R. B. Smith, Lindsay J. Hall, Anthony J. Cleare, James M. Stone, Allan H. Young
Summary: This meta-analysis found that gut microbiota perturbations were associated with a transdiagnostic pattern with a depletion of certain anti-inflammatory butyrate-producing bacteria and an enrichment of pro-inflammatory bacteria in patients with depression, bipolar disorder, schizophrenia, and anxiety.
Letter
Gastroenterology & Hepatology
Peng Chen, Fuchao Chen
Summary: This article is related to Ikegami et al's papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biology
L. Berbert, A. Santos, D. O. Magro, D. Guadagnini, H. B. Assalin, L. H. Lourenco, C. A. R. Martinez, M. J. A. Saad, C. S. R. Coy
Summary: This study investigated the composition of gut microbiota in Brazilian colorectal adenocarcinoma (CRC) patients compared with a control population. The results showed that CRC patients had increased alpha diversity, higher percentage of Prevotella genus, and decreased proportion of Megamonas and Ruminococcus. Faecalibacterium prausnitzii was associated with a better prognosis in early stages of CRC, while Fusobacterium nucleatum was identified as an important marker of colorectal carcinogenesis and tumor aggressiveness.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lei Liu, Mehdi Sadaghian Sadabad, Giorgio Gabarrini, Paola Lisotto, Julius Z. H. von Martels, Hannah R. R. Wardill, Gerard Dijkstra, Robert E. Steinert, Hermie J. M. Harmsen
Summary: This study investigated the effects of riboflavin supplementation on gut microbiota, short-chain fatty acids, and gut hormones. The results revealed an increase in butyrate production and enhancement of microbial interaction network after riboflavin intervention. However, riboflavin supplementation did not impact the abundance of F. prausnitzii. Additionally, supplementation with 100 mg/d of riboflavin showed a trend of increased plasma insulin and GLP-1 levels.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Gert J. H. Snel, Maaike van den Boomen, Katia Hurtado-Ortiz, Riemer H. J. A. Slart, Vincent M. van Deursen, Christopher T. Nguyen, David E. Sosnovik, Rudi A. J. O. Dierckx, Birgitta K. Velthuis, Ronald J. H. Borra, Niek H. J. Prakken
Summary: This study aimed to investigate the impact of sedentary lifestyle-related risk factors (overweight, hypertension, and type 2 diabetes) on cardiac morphology, function, and tissue characteristics in young adults. The results showed subclinical alterations in cardiac structure and function associated with these risk factors, highlighting the importance of considering these factors in clinical decision making based on cardiac MRI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Adrienne H. Brouwers, Joyce van Sluis, Johannes H. van Snick, Carolina P. Schroder, Inge O. Baas, Ronald Boellaard, Andor W. J. M. Glaudemans, Ronald J. H. Borra, Adriaan A. Lammertsma, Rudi A. J. O. Dierckx, Charalampos Tsoumpas
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Sira Karvinen, Vasco Fachada, Ulla-Maria Sahinaho, Satu Pekkala, Juulia H. Lautaoja, Sakari Mantyselka, Perttu Permi, Juha J. Hulmi, Mika Silvennoinen, Heikki Kainulainen
Summary: Impaired lipid metabolism is a common risk factor for metabolic diseases. This study demonstrates that BCAA deprivation decreases lipid oxidation and lipogenesis, while high BCAA supplementation also decreases lipid oxidation. These findings highlight the importance of maintaining an adequate level of BCAAs for healthy lipid metabolism.
Article
Biochemistry & Molecular Biology
Jukka E. Hintikka, Eveliina Munukka, Maarit Valtonen, Raakel Luoto, Johanna K. Ihalainen, Teemu Kallonen, Matti Waris, Olli J. Heinonen, Olli Ruuskanen, Satu Pekkala
Summary: Exercise affects gut microbiome and metabolic health. Elite athletes have distinct gut microbiota and serum metabolome compared to physically-active controls.
Article
Cardiac & Cardiovascular Systems
Manuel A. Morales, Gert J. H. Snel, Maaike van den Boomen, Ronald J. H. Borra, Vincent M. van Deursen, Riemer H. J. A. Slart, David Izquierdo-Garcia, Niek H. J. Prakken, Ciprian Catana
Summary: This study used a fully-automatic deep learning method to detect asymptomatic dysfunction in young adults with cardiac risk factors. The results showed that the automated method provided evidence of left ventricular diastolic and systolic dysfunction in asymptomatic individuals with overweight, hypertension, and type 2 diabetes risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Sara Khosdelazad, Lieke S. Jorna, Rob J. M. Groen, Sandra E. Rakers, Marieke E. Timmerman, Ronald J. H. Borra, Anouk van der Hoorn, Jacoba M. Spikman, Anne M. Buunk
Summary: The ICONS study aims to investigate deficits in cognition, emotion, and behavior, as well as brain damage in patients with subarachnoid hemorrhage. The study includes neuropsychological assessment, magnetic resonance imaging, questionnaires, and interviews. The results of this study are expected to contribute to a better understanding of the consequences of subarachnoid hemorrhage and improve timely treatment and daily functioning for patients.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Immunology
Anna M. Hanttu, Satu Pekkala, Reetta Satokari, Anna K. Hartikainen, Perttu Arkkila, Kirsi H. Pietilainen, Jussi P. Sutinen
Summary: This study investigated gut microbiota before and after a single antiretroviral agent switch in HIV-positive patients. The results showed that switching to raltegravir (RAL) increased microbiota diversity compared to switching to efavirenz or protease inhibitors (EFV/PI). The relative abundance of Prevotella, Phascolarctobacterium, and Bacteroides also changed after switching to RAL. These findings suggest that a single antiretroviral agent switch can alter gut microbiota, which may be associated with reduced inflammation and/or increased weight.
Article
Microbiology
Anastasiia Driuchina, Jukka Hintikka, Marko Lehtonen, Pekka Keski-Rahkonen, Thomas O'Connell, Risto Juvonen, Juho Kuula, Antti Hakkarainen, Jari A. Laukkanen, Elina Maekinen, Sanna Lensu, Kirsi H. Pietilaeinen, Satu Pekkala
Summary: In order to address the diagnostic challenges posed by the high prevalence of nonalcoholic fatty liver disease, it is important to identify new biomarkers that can potentially be used to diagnose high liver fat content. Our findings suggest that increased levels of amino acid degradation products in feces may serve as such biomarkers. Additionally, we identified molecules in the blood that indicate defective hepatic metabolic enzyme activities in individuals with high liver fat content.
Article
Multidisciplinary Sciences
Helena A. K. Lapatto, Minna Kuusela, Aino Heikkinen, Maheswary Muniandy, Birgitta W. van der Kolk, Swetha Gopalakrishnan, Noora Pollanen, Martin Sandvik, Mark S. Schmidt, Sini Heinonen, Sina Saari, Juho Kuula, Antti Hakkarainen, Janne Tampio, Tuure Saarinen, Marja-Riitta Taskinen, Nina Lundbom, Per-Henrik Groop, Marja Tiirola, Pekka Katajisto, Marko Lehtonen, Charles Brenner, Jaakko Kaprio, Satu Pekkala, Miina Ollikainen, Kirsi H. Pietilainen, Eija Pirinen
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD(+)), has shown promise in improving obesity-associated mitochondrial dysfunction and metabolic syndrome. However, short-term clinical trials have not yielded positive results. This study aimed to investigate the long-term effects of NR supplementation on mitochondrial biogenesis and metabolic health in humans. The results showed that NR improved NAD(+) metabolism, muscle mitochondrial number, myoblast differentiation, gut microbiota composition, and epigenetic control of gene expression. However, it did not improve adiposity or metabolic health.
Review
Cell Biology
J. H. Lautaoja, D. C. Turner, A. P. Sharples, R. Kivela, S. Pekkala, J. J. Hulmi, L. Yla-Outinen
Summary: The number of studies using skeletal muscle cell culture models to study exercise in vitro is increasing rapidly. Omics approaches, such as transcriptomics, proteomics, and metabolomics, have been used to analyze the molecular responses to exercise mimicking stimuli in cultured myotubes. Electrical pulse stimulation and mechanical stretch are the most commonly used methods to mimic exercise in vitro. This mini-review provides an up-to-date overview of the 2-D and 3-D models and the use of omics approaches to study the molecular response to exercise in vitro.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Elina Makinen, Jan Wikgren, Satu Pekkala, Lauren G. Koch, Steven L. Britton, Miriam S. Nokia, Sanna Lensu
Summary: Aerobic fitness is positively associated with cognitive performance and brain health, while low aerobic fitness predisposes individuals to neurodegenerative diseases. This study explored the effects of genotype and exercise on brain and behavior in rats bred for different aerobic fitness levels. The findings indicate that rats with high aerobic capacity exhibit better cognitive performance and behavior than those with low aerobic capacity.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Satu Pekkala
Summary: The frequency of NAFLD has increased, demanding reliable non-invasive diagnostic tools. Gut microbiome plays a key role in NAFLD progression. However, studies present inconsistent findings regarding microbial metabolites and functional genes in NAFLD. Future studies should consider diet as an important factor in gut microbiota metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wejdan M. Arif, Philip H. Elsinga, Roel J. H. M. Steenbakkers, Walter Noordzij, Lara Barazzuol, Kelvin N. G. Wei Siang, Charlotte L. Brouwer, Bruno Lima Giacobbo, Rudi A. J. O. Dierckx, Ronald J. H. Borra, Gert Luurtsema
Summary: This study investigated regional changes in brain [18F]FDG uptake in head and neck cancer patients treated with intensity-modulated proton therapy (IMPT). The findings showed that 3 months after IMPT, there were significant increases in [18F]FDG uptake in several key brain regions, which were correlated with radiation dose. These results may be useful for identifying patients at risk for cognitive effects of radiation doses in non-tumor tissues.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Johan A. den Boer, Erik J. F. de Vries, Ronald J. H. Borra, Aren van Waarde, Adriaan A. Lam-mertsma, Rudi A. Dierckx
Summary: This review discusses translational, diagnostic, and methodological issues in drug development for CNS disorders, with a focus on psychiatry. The role of preclinical models and brain imaging using PET and fMRI in early stages of drug development is critically reviewed. The review emphasizes the importance of collaborations between industry, academia, and phase I units in drug development. Brain imaging has revolutionized the study of psychiatric illnesses, providing insights at different levels of analysis and supporting preclinical and clinical drug development.
CURRENT REVIEWS IN CLINICAL AND EXPERIMENTAL PHARMACOLOGY
(2022)
Article
Oncology
Hiska L. van der Weide, Justyna Klos, Johannes A. Langendijk, Charlotte L. Brouwer, Peter F. Sinnige, Ronald J. H. Borra, Rudi A. J. O. Dierckx, Rients B. Huitema, Sandra E. Rakers, Anne M. Buunk, Jacoba M. Spikman, Ingeborg B. Bosma, Roelien H. Enting, Merethe Blandhol, Roland K. Chiu, Anouk van der Hoorn, Miranda C. A. Kramer
Summary: The study found that radiotherapy has varying effects on cognitive function and brain structure in patients with LGG, with left-sided tumor patients showing weaker language abilities while right-sided tumor patients' memory performance is affected.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
