Article
Pediatrics
Jaylyn Waddell, Nicholas C. Rickman, Min He, Ningfeng Tang, Cynthia F. Bearer
Summary: The study demonstrates that choline supplementation in premature infants can provide neuroprotection against hyperbilirubinemia and significantly affect cerebellar weight.
PEDIATRIC RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Josif Vidimce, Johara Pillay, Nirajan Shrestha, Lan-feng Dong, Jiri Neuzil, Karl-Heinz Wagner, Olivia Jane Holland, Andrew Cameron Bulmer
Summary: This study is the first to comprehensively assess body composition, fat metabolism, and mitochondrial function in hyperbilirubinemic rats. The findings suggest that hyperbilirubinemia is associated with reduced fat mass and increased hepatic mitochondrial biogenesis, specifically in female animals, indicating a dual role of elevated bilirubin and reduced UGT1A1 function in adiposity and body composition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Shinya Abe, Kazumichi Fujioka, Ruka Nakasone, Shutaro Suga, Mariko Ashina, Kosuke Nishida, Ronald J. Wong, Kazumoto Iijima
Summary: The study revealed a stronger correlation between the bilirubin/albumin (B/A) ratio and unbound bilirubin (UB) levels in preterm infants who had not received phototherapy. Even when stratified by gestational age, this correlation remained consistent.
PEDIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Miriam Pettersson, Linda Ryen, Mats Eriksson, Andreas Ohlin
Summary: This study compared the cost-effectiveness of home phototherapy and hospital phototherapy for treating hyperbilirubinemia in neonates more than 36 weeks. Results showed that home phototherapy is as effective as hospital phototherapy and has a significantly lower cost per patient. Sensitivity analysis also confirmed the robustness of the findings. Therefore, home phototherapy is a cost-effective alternative to hospital treatment for neonates with hyperbilirubinemia.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Helvi N. Joel, Deborah N. Mchaile, Rune N. Philemon, Ronald M. Mbwasi, Levina Msuya
Summary: This study compared the effectiveness of different phototherapy methods for neonatal jaundice, finding that fiberoptic phototherapy was comparable to blue light conventional phototherapy in terms of reducing bilirubin rate and treatment duration, but more effective than white light conventional phototherapy in reducing bilirubin rate and shortening treatment duration.
Article
Instruments & Instrumentation
Samaa M. M. Faramawy
Summary: Although bilirubin meters are widely used for neonatal jaundice screening, a metrological calibration method is still needed to evaluate their measurement accuracy. This article describes a new calibration method that establishes a correlation between bilirubin units and irradiance units to achieve calibration. The method was evaluated using statistical parameters x and R control charts, and the results showed that it is a considerably valid technique for evaluating bilirubinometers.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Medicine, General & Internal
Meng Zhang, Yang He, Jun Tang, Wenbin Dong, Yong Zhang, Benjin Zhang, Hong Wan, Quanmin Deng, Lirong Guan, Bin Xia, Zhong Chen, Min Ge, Jing Zhao, Wenxing Li, Jingjun Pei, Yi Qu, Dezhi Mu
Summary: This study compared the effectiveness and complications of intensive phototherapy (IPT) and exchange transfusion (ET) in the treatment of extreme hyperbilirubinemia. The results suggest that IPT is a safe and effective treatment. The indication for ET in patients with hyperbilirubinemia should be stricter, but emergency ET should be planned for infants with risk factors.
CHINESE MEDICAL JOURNAL
(2022)
Article
Pediatrics
Yuan-Li Zhan, Hai-Bo Peng, Zhen-Chao Jin, Jin-Feng Su, Xiang-Yu Tan, Lu Zhao, Lian Zhang
Summary: The study evaluates the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values in predicting phototherapy duration in neonates with significant hyperbilirubinemia. A prospective study was conducted on neonates who received phototherapy for significant hyperbilirubinemia. Measurement of breath ETCOc and serum total bilirubin were taken on admission. The study concludes that ETCOc on admission can help predict the duration of phototherapy in neonates with hyperbilirubinemia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Silvia Gazzin, Matteo Dal Ben, Michele Montrone, Sri Jayanti, Andrea Lorenzon, Alessandra Bramante, Cristina Bottin, Rita Moretti, Claudio Tiribelli
Summary: Curcumin treatment successfully restored cerebellar hypoplasia and behavioral abnormalities in Gunn rats, protecting the central nervous system from bilirubin toxicity. This study suggests the potential of curcumin as an alternative or complementary approach to prevent bilirubin-induced brain damage in the clinical setting, with a multi-target action on bilirubin-induced pathological mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yosi Kristian, Mahendra Tri Arif Sampurna, Evan Kusuma Susanto, Visuddho Visuddho, Kian Djien Liem
Summary: Hyperbilirubinemia is more common in low and middle-income countries like Indonesia, due in part to substandard phototherapy intensity. This study presents the design of a low-cost phototherapy intensity meter called PhotoInMeter, using a microcontroller, light sensor, color sensor, and ND filter. Machine learning is utilized to convert sensor readings into accurate light intensity measurements comparable to Ohmeda Biliblanket. The prototype of PhotoInMeter shows high accuracy and is significantly cheaper to produce compared to the reference meter.
Article
Multidisciplinary Sciences
Go Inamori, Umihiro Kamoto, Fumika Nakamura, Yutaka Isoda, Azusa Uozumi, Ryosuke Matsuda, Masaki Shimamura, Yusuke Okubo, Shuichi Ito, Hiroki Ota
Summary: Neonatal jaundice is common but can lead to brain damage in severe cases. Researchers have developed a wearable bilirubinometer that can simultaneously detect bilirubin, oxygen saturation, and heart rate, showing potential for optimizing treatment of neonatal jaundice.
Article
Neurosciences
Sandrine Blondel, Nathalie Strazielle, Amel Amara, Rainui Guy, Christine Bain, Alix Rose, Laurent Guibaud, Claudio Tiribelli, Silvia Gazzin, Jean-Francois Ghersi-Egea
Summary: The study investigates the effect of neonatal hyperbilirubinemia on brain barriers and finds that bilirubin does not directly affect the organization of the vascular system, morphological integrity of brain barriers, and inflammatory response. This provides important clues for understanding the brain dysfunction caused by severe neonatal jaundice.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Biophysics
Katherine M. Satrom, Raghavendra B. Rao, Ivan Tkac
Summary: Neonatal hyperbilirubinemia can cause brain injury in specific regions such as the cerebellum and hippocampus in newborn infants. Extremely preterm infants are more susceptible to bilirubin neurotoxicity, but the exact mechanism and extent of the injury are not well understood. A study using a preterm rat model found that the cerebellum is more severely affected by hyperbilirubinemia than the hippocampus, with significant morphological changes and alterations in neurochemical profiles.
NMR IN BIOMEDICINE
(2023)
Article
Pediatrics
N. K. V. Vigneshwar, Sriparna Basu, Manisha Naithani, N. Vivekanand, Swathi Chacham, Poonam Singh
Summary: The study found that phototherapy significantly reduced serum calcium levels in neonates, but there was no significant correlation with serum melatonin levels.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Irit Shoris, Ayala Gover, Arina Toropine, Adir Iofe, Rasha Zoabi-Safadi, Svetlana Tsuprun, Arieh Riskin
Summary: Neonatal hyperbilirubinemia, a common complication in newborns, can be treated with phototherapy. However, recent evidence suggests that phototherapy may have side effects and unfavorable outcomes. This review explores alternative treatments to phototherapy and calls for further studies to identify the best complementary treatments that can reduce the duration of phototherapy without compromising its effectiveness.
Article
Gastroenterology & Hepatology
Hedayatullah Esmati, Marieke van Rosmalen, Patrick F. van Rheenen, Marieke T. de Boer, Aad P. van den Berg, Hubert P. J. van der Doef, Michel Rayar, Ruben H. J. de Kleine, Robert J. Porte, Vincent E. de Meijer, Henkjan J. Verkade
Summary: The Eurotransplant (ET) allocation prioritization for patients with biliary atresia (BA) younger than 2 years has significantly reduced the waitlist mortality by decreasing the proportion of deceased donor liver transplantations (DDLT) and increasing the proportion of living donor liver transplantations (LDLT). The waitlist mortality decreased from 6.7% to 2.3% after the implementation of the new allocation rule, and the median waitlist duration also decreased.
LIVER TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Katerina Zizalova, Barbora Novakova, Marek Vecka, Jaromir Petrtyl, Vera Lanska, Kveta Pelinkova, Vaclav Smid, Radan Bruha, Libor Vitek, Martin Lenicek
Summary: The study suggests that taurochenodeoxycholic acid (TCDCA) may be a promising noninvasive marker of clinically significant portal hypertension. Its predictive potential may be further enhanced when combined with the AST/ALT ratio and spleen diameter.
LIVER INTERNATIONAL
(2023)
Article
Chemistry, Organic
Marek Martinek, Lucie Ludvikova, Maria Srankova, Rafael Navratil, Lucie Muchova, Jiri Huzlik, Libor Vitek, Petr Klan, Peter Sebej
Summary: Fluorescein, eosin Y, and rose bengal, commonly used dyes in clinical medicine, have been found to release carbon monoxide (CO) and low-mass secondary photoproducts when extensively irradiated with visible light in aqueous solutions. This photochemistry should be taken into consideration in their applications and they could also be used as visible-light activatable CO-releasing molecules with biological implications.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Pediatrics
Valentina Gracchi, Sophie M. van den Belt, Eva Corpeleijn, Dick de Zeeuw, Hiddo J. L. Heerspink, Henkjan J. Verkade
Summary: Mildly increased albuminuria is common in adults and 2-year-old children. This study aims to evaluate the longitudinal persistence of albuminuria from infancy to school age, and found that albuminuria at 2 years of age does not largely persist until the age of 12.
PEDIATRIC NEPHROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Besrat Berhane, Patrick F. van Rheenen, Henkjan J. Verkade
Summary: A decrease of more than 25% in gamma-glutamyl transferase (GGT) within 1 year of diagnosis in pediatric-onset primary sclerosing cholangitis (PSC) is associated with a lower occurrence of complications within 5 years.
HEALTH SCIENCE REPORTS
(2023)
Review
Pediatrics
Lauren E. H. Westenberg, Jasper V. Been, Sten P. Willemsen, Jolande Y. Vis, Andrei N. Tintu, Wichor M. Bramer, Peter H. Dijk, Eric A. P. Steegers, Irwin K. M. Reiss, Christian V. Hulzebos
Summary: Importance quantification of bilirubin in blood is crucial for early diagnosis and timely treatment of neonatal hyperbilirubinemia. Handheld point-of-care devices can address the current issues with conventional laboratory-based bilirubin quantification. The evaluation of diagnostic accuracy shows that point-of-care devices have faster turnaround time and require less blood volume compared to laboratory-based quantification, but the precision of measurement needs improvement.
Article
Microbiology
Nina M. Frerichs, Sofia el Manouni el Hassani, Nancy Deianova, Mirjam M. van Weissenbruch, Anton H. van Kaam, Daniel C. Vijlbrief, Johannes B. van Goudoever, Christian V. Hulzebos, Boris. W. Kramer, Esther J. d'Haens, Veerle Cossey, Willem P. de Boode, Wouter J. de Jonge, Alfian N. Wicaksono, James A. Covington, Marc A. Benninga, Nanne K. H. de Boer, Hendrik J. Niemarkt, Tim G. J. de Meij
Summary: Early detection of late-onset sepsis (LOS) in preterm infants is essential. Fecal volatile organic compounds (VOCs) can serve as a non-invasive biomarker for detecting LOS. The study analyzed fecal samples of LOS infants and matched controls using gas chromatography-ion mobility spectrometry and gas chromatography-time of flight-mass spectrometry. Differences in VOCs were found before the onset of Escherichia coli LOS and gram-negative LOS. This study highlights the potential of VOCs as a non-invasive preclinical diagnostic biomarker for LOS.
Article
Infectious Diseases
Nancy Deianova, Nanne K. de Boer, Hafsa Aoulad Ahajan, Cilla Verbeek, Cornelieke S. H. Aarnoudse-Moens, Aleid G. Leemhuis, Mirjam M. van Weissenbruch, Anton H. van Kaam, Daniel C. Vijbrief, Chris V. Hulzebos, Astrid Giezen, Veerle Cossey, Willem P. de Boode, Wouter J. de Jonge, Marc A. Benninga, Hendrik J. Niemarkt, Tim G. J. de Meij
Summary: Over 90% of preterm neonates are exposed to antibiotics as a potentially life-saving measure. However, there is insufficient research on the long-term outcomes associated with antibiotic exposure after preterm birth. This study investigated the relationship between duration of antibiotic exposure and developmental and health outcomes in preterm-born children, as well as the impact of gestational age (GA) on outcomes.
Article
Gastroenterology & Hepatology
Antonia Felzen, Daan B. E. van Wessel, Emmanuel Gonzales, Richard J. Thompson, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipinski, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Bjoern Fischler, Jan B. F. Hulscher, Daniele Serranti, Cigdem Arikan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Munoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsofi, Pier Luigi Calvo, Enke Grabhorn, Steffen Hartleif, Wendy J. van der Woerd, Binita M. Kamath, Jian-She Wang, Liting Li, Ozlem Durmaz, Nanda Kerkar, Marianne Horby Jorgensen, Ryan Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Noemie Laverdure, Cristina Targa Ferreira, Felipe Ordonez Guerrero, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey-Ling Chen, Elisa de Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Aglaia Zellos, Estella M. Alonso, Ronald J. Sokol, Frederick J. Suchy, Kathleen M. Loomes, Patrick J. McKiernan, Philip Rosenthal, Yumirle Turmelle, Simon Horslen, Kathleen Schwarz, Jorge A. Bezerra, Kasper Wang, Bettina E. Hansen, Henkjan J. Verkade
Summary: This study aimed to evaluate the relationship between genetic mutations related to BSEP deficiency and clinical features. The results showed that the combination of one relatively mild mutation and one severe mutation resulted in a clinical presentation similar to patients with two severe mutations, and they had a poor response to surgical interruption of the enterohepatic circulation.
Article
Biochemistry & Molecular Biology
Alena Jiraskova, Jan Skrha, Libor Vitek
Summary: This study assessed serum bilirubin concentrations and microsatellite variations in UGT1A1 and HMOX1 genes in patients with type 2 diabetes mellitus (T2DM). Results showed that T2DM patients had lower serum bilirubin concentrations compared to controls, and the prevalence of phenotypic Gilbert syndrome and (TA)(7/7) UGT1A1 genotype was lower in male T2DM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Weihao Li, Reinoud P. H. Bokkers, Rudi A. J. O. Dierckx, Henkjan J. Verkade, Dewey H. Sanders, Ruben de Kleine, Hubert P. J. van der Doef
Summary: This study evaluated the effectiveness of different treatments for hepatic artery thrombosis and stenosis after pediatric liver transplantation. The findings highlight the significant issue of hepatic artery thrombosis and the need for further research on the efficacy of treatment methods.
LIVER TRANSPLANTATION
(2023)
Article
Hematology
C. Heleen van Ommen, Klasien A. Bergman, Marit Boerma, Heleen A. Bouma, Albertine E. Donker, Melissa Gouvernante, Christian Hulzebos, Dalila Khandour, Ronny Knol, Marlou A. Raets, K. Djien Liem, Richard A. van Lingen, Moniek van de Loo, Enrico Lopriore, Mayke van der Putten, Jeanine J. Sol, Monique H. Suijker, Daniel C. Vijlbrief, Remco Visser, Mirjam M. van Weissenbruch
Summary: A national management guideline was developed in the Netherlands to create uniform management for catheter-related venous thromboembolism (CVTE) in critically ill (preterm) neonates. A prospective observational study of 115 infants showed that following the guideline led to a low incidence of recurrent venous thrombotic events and death due to CVTE, but major bleeding occurred in a small percentage of infants.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pediatrics
Valentina Gracchi, Sophie M. van den Belt, Eva Corpeleijn, Hiddo J. L. Heerspink, Henkjan J. Verkade
Summary: This study aims to evaluate albuminuria in a population-based pediatric cohort and investigate its association with cardiovascular risk factors. The results show a lower prevalence of albuminuria in 12-year-olds compared to previous studies, and it is negatively associated with body mass index. Additionally, there is no significant association between albuminuria and antenatal factors.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Sport Sciences
Kyle D. Flack, Libor Vitek, Christopher S. Fry, David E. Stec, Terry D. Hinds Jr
Summary: Exercise performance is influenced by various factors, including muscular strength, cardiovascular capacity, liver health, and metabolic flexibility. Recent studies have shown that exercise training can increase plasma levels of bilirubin, which has generally been considered a marker of liver dysfunction, and elite athletes may have higher levels. It is speculated that this adaptation could be due to the antioxidant properties of bilirubin in response to reactive oxygen species produced during exercise. Current research has redefined bilirubin as a metabolic hormone that interacts with nuclear receptors, potentially contributing to weight reduction. Additionally, bilirubin has been linked to reduced adiposity and improved cardiovascular function. While no studies have directly examined the impact of elevated bilirubin levels on athletic performance, it is an area worthy of exploration in future research.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Barbora Novakova, Katerina Zizalova, Vaclav Smid, Karel Dvorak, Ales Kubena, Libor Vitek, Martin Lenicek, Radan Bruha
JOURNAL OF HEPATOLOGY
(2023)
