Article
Gastroenterology & Hepatology
Lucile Moga, Marie-Angele Robic, Helene Blasco-Perrin, Pauline Cabarrou, Julie Mogno, Maeva Guillaume, Jean Pierre Vinel, Jean-Marie Peron, Christophe Bureau
Summary: This study assessed the prevalence and prognostic value of ICA 2015 AKI criteria in hospitalised patients with cirrhosis. The results showed that AKI was independently associated with mortality in patients with cirrhosis, even at the early stage. Treatment response improved survival and was inversely proportional to the stage of AKI, suggesting that early intervention is important.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Roula Sasso, Ahmad Abou Yassine, Liliane Deeb
Summary: Hepatorenal syndrome (HRS) is a type of acute kidney injury associated with high mortality in patients with decompensated liver cirrhosis. Predictors of HRS include history of ascites, serum creatinine levels, albumin levels, bilirubin levels, and spontaneous bacterial peritonitis. Early diagnosis and targeted management based on these predictors can improve outcomes for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Kapil Gupta, Abhishek Bhurwal, Cindy Law, Scott Ventre, Carlos D. Minacapelli, Savan Kabaria, You Li, Christopher Tait, Carolyn Catalano, Vinod K. Rustgi
Summary: Acute kidney injury (AKI) in cirrhosis, including hepatorenal syndrome (HRS), is a common and serious complication leading to significant morbidity and mortality. AKI is categorized into non-HRS AKI and HRS-AKI, with liver transplantation being the ideal treatment option for HRS. Further research is needed to optimize treatment approaches for AKI in cirrhosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Eman Ibrahim El-Desoki Mahmoud, Doaa H. Abdelaziz, Sherief Abd-Elsalam, Noha O. Mansour
Summary: The study compared the efficacy of norepinephrine and midodrine/octreotide in treating patients with hepatorenal syndrome. Results showed that norepinephrine with albumin was significantly more effective in improving renal function compared to midodrine and octreotide with albumin.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Pragyi Shrestha, Saleh Yazdani, Romain R. Vives, Rana El Masri, Wendy Dam, Bart van de Sluis, Jacob van den Born
Summary: Proteinuria induces hypersulfated hepatic heparan sulfate proteoglycans, increasing their affinity to PCSK9 and impairing hepatic triglyceride-rich remnant lipoproteins uptake. Heparan sulfate accumulates in sinusoids of proteinuric rats, potentially serving as a novel target for controlling dyslipidemia.
KIDNEY INTERNATIONAL
(2021)
Review
Urology & Nephrology
Garabed Eknoyan, Murray Epstein
Summary: Hepatorenal syndrome (HRS) is a serious complication of liver decompensation that leads to progressive but potentially reversible deterioration of kidney function. Through advancements in research on the pathogenesis of HRS, as well as treatment options such as dialysis and liver or combined liver-kidney transplantation, the fatal condition of HRS has been transformed into a treatable disorder.
KIDNEY INTERNATIONAL
(2021)
Article
Transplantation
Anthony Bonavia, Gregory Vece, Kunal Karamchandani
Summary: The use of traditional terms in classifying acute kidney injury may limit understanding of the diverse and evolving nature of the condition. Precise terminology plays a significant role in treatment approaches for AKI, affecting the care that patients receive.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Yasunari Hiramine, Hirofumi Uto, Seiichi Mawatari, Shuji Kanmura, Yasushi Imamura, Takuya Hiwaki, Akiko Saishoji, Manei Oku, Koichi Tokushige, Shigeho Maenohara, Akio Ido
Summary: In patients with hepatic ascites, the incidence of AKI is high and is associated with a significantly worse prognosis. The use of tolvaptan (TLV) in combination with diuretics may reduce the risk of AKI and have a synergistic therapeutic effect on hepatic ascites.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ming-Chao Tsai, Kuo-Chin Chang, Yi-Hao Yen, Cheng-Kun Wu, Ming-Tsung Lin, Tsung-Hui Hu
Summary: This study aimed to compare the development of AKI during TDF and entecavir treatment of CHB patients with cirrhotic refractory ascites. The results showed that TDF treatment was a risk factor for the development of AKI and HRS, especially in patients with comorbidity.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Songtao Liu, Qinghua Meng, Yuan Xu, Jianxin Zhou
Summary: This review discusses the association between hepatorenal syndrome and acute-on-chronic liver failure in cirrhotic patients, highlighting the progress and controversies in diagnosis and treatment. The need for more active research on treating difficult diseases is emphasized to improve prognosis.
GASTROENTEROLOGY REPORT
(2021)
Article
Gastroenterology & Hepatology
Lukas Otero Sanchez, Claire Francoz
Summary: AKI complicates the course in patients with chronic liver diseases, especially those with decompensated cirrhosis, and efforts should be made for early diagnosis and tailored therapeutic interventions. Significant progress has been made in understanding the key events and defining prognostic factors for AKI in the cirrhotic population.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Arpan Mohanty, Andres Cardenas
Summary: In this review, we discuss the diagnostic criteria and current treatment paradigms for HRS-AKI, a specific type of kidney injury seen in patients with cirrhosis and ascites. Early diagnosis and treatment of HRS-AKI are crucial for improving renal function and post-transplant outcomes.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ethan M. Weinberg, Florence Wong, Hugo E. Vargas, Michael P. Curry, Khurram Jamil, S. Chris Pappas, Pratima Sharma, K. Rajender Reddy
Summary: Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a serious complication of decompensated cirrhosis with limited therapeutic options. Terlipressin improves renal function in HRS-1 patients, while liver transplantation is a curative treatment for advanced chronic liver disease. Treatment with terlipressin plus albumin can decrease the need for renal replacement therapy in HRS-1 patients pretransplant and posttransplant.
LIVER TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Cristina Ripoll, Stephanie Platzer, Philipp Franken, Rene Aschenbach, Andreas Wienke, Ulrike Schuhmacher, Ulf Teichgraeber, Andreas Stallmach, Joerg Steighardt, Alexander Zipprich
Summary: Patients with cirrhosis and ascites are at risk of developing hepatorenal AKI (HRS-AKI), which has a high mortality rate. The standard treatment is terlipressin and albumin, but it is not always effective. TIPS, although controversial, is hypothesized to be superior to the standard of care in HRS-AKI patients.
Review
Gastroenterology & Hepatology
Gabriel Mezzano, Adria Juanola, Andres Cardenas, Esteban Mezey, James P. Hamilton, Elisa Pose, Isabel Graupera, Pere Gines, Elsa Sola, Ruben Hernaez
Summary: The study revealed high global prevalence and mortality rates of ACLF, with regional variations possibly explained by triggers/aetiology of CLD or grade.
Review
Medicine, General & Internal
Tom H. Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J. Hutchinson, Bruno Sangro, Natasha K. Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y. Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J. Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Jarvinen, Chris D. Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y. Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Nuria Fabrellas, Ann T. Ma, Juan M. Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey Lazarus, Pere Gines, Maria Buti, Philip N. Newsome, Patrizia Burra, Michael P. Manns
Review
Gastroenterology & Hepatology
Paolo Caraceni, Alastair O'Brien, Pere Gines
Summary: Long-term administration of albumin may be effective and safe for treating patients with cirrhosis and ascites, but further research is needed to determine the target population, optimal dose and frequency of treatment, stopping rules, and cost-effectiveness in different healthcare systems.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Elisa Pose, Pere Gines
MAYO CLINIC PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Marta Carol, Martina Perez-Guasch, Elsa Sola, Marta Cervera, Sara Martinez, Adria Juanola, Ann T. Ma, Emma Avitabile, Laura Napoleone, Elisa Pose, Isabel Graupera, Maria Honrubia, Marko Korenjak, Ferran Torres, Pere Gines, Nuria Fabrellas
Summary: Perceived stigma is common in patients with NAFLD regardless of disease stage, and is associated with impaired quality-of-life. This issue may affect the human and social rights of affected patients.
Correction
Public, Environmental & Occupational Health
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Nuria Fabrellas, Llorenc Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Joern M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernandez, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adria Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Soenke Detlefsen, Pere Toran, Guillem Pera, Celine Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falco, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Gines
Review
Gastroenterology & Hepatology
Adria Juanola, Neha Tiwari, Cristina Sole, Danielle Adebayo, Florence Wong, Pere Gines
Summary: Acute-on-chronic liver failure (ACLF) is a complex syndrome associated with different organ failures in patients with chronic liver disease, mainly cirrhosis. Various definitions have been proposed, with differences in the severity of underlying liver disease, precipitating factors, and organs considered. Regardless of the definition, ACLF is characterized by hyperactive immune response, profound hemodynamic disturbances, and metabolic alterations leading to organ dysfunction. The triggers include bacterial infections, alcoholic hepatitis, gastrointestinal bleeding, and hepatitis B virus flare. Prompt recognition and treatment of the trigger event, as well as specific organ support, are crucial to improve short-term mortality. Liver transplantation may be considered in carefully selected patients.
LIVER INTERNATIONAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Adria Juanola, Ann T. Ma, Koos De Wit, Kohilan Gananandan, Olivier Roux, Giacomo Zaccherini, Cesar Jimenez, Marta Tonon, Cristina Sole, Clara Villaseca, Frank Erhard Uschner, Isabel Graupera, Elisa Pose, Elsa Sola, Ulrich Beuers, Rajeshwar P. Mookerjee, Claire Francoz, Victor Vargas, Salvatore Piano, Sonia Alonso, Jonel Trebicka, Wim Laleman, Sumeet K. Asrani, German Soriano Pastor, Miquel Serra-Burriel, Manuel Morales-Ruiz, Ferran Torres, Andrew S. Allegretti, Aleksander Krag, Paolo Caraceni, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Pere Gines, Ruben Hernaez
Article
Gastroenterology & Hepatology
Jesus Rivera-Esteban, Ramiro Manzano-Nunez, Teresa Broquetas, Isabel Serra-Matamala, Octavi Bassegoda, Agnes Soriano-Varela, Gemma Espin, Joaquin Castillo, Juan Banares, Jose A. Carrion, Pere Gines, Isabel Graupera, Juan M. Pericas
Summary: The study evaluated the impact of the COVID-19 pandemic on outcomes of NAFLD cirrhosis patients, finding that although metabolic control worsened during the pandemic, it was mainly due to non-liver causes, namely COVID-19 itself.
Article
Gastroenterology & Hepatology
Octavi Bassegoda, Jesus Rivera-Esteban, Isabel Serra, Rosa Morillas, Teresa Broquetas, Mercedes Vergara, Adria Rodriguez, Carles Aracil, Silvia Viroles, Jose A. Carrion, Albert Pardo, Sergio Rodriguez-Tajes, Miquel Serra-Burriel, Juan M. Pericas, Salvador Augustin, Pere Gines, Isabel Graupera
Summary: The aim of this study was to assess the incidence and risk factors of acute decompensation of cirrhosis, hepatocellular carcinoma, and extrahepatic cancers in patients with compensated cirrhosis due to nonalcoholic fatty liver disease. The results showed that these patients are at high risk of severe liver complications, such as the development of acute decompensation, in a relative short follow-up time, and they are also at high risk of hepatic and extrahepatic cancers.
HEPATOLOGY COMMUNICATIONS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Marta Cervera, Marta Carol, Ana Belen Rubio, Martina Perez, Carlota Riba, Rosario Hernandez, Ann Ma, Emma Avitabile, Anna Soria, Octavi Bassegoda, Sara Martinez, Jordi Gratacos-Gines, Adria Juanola, Laura Napoleone, Elisa Pose, Isabel Graupera, Pere Gines, Nuria Fabrellas
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Maria Del Barrio Azaceta, Paula Iruzubieta, Rocio Aller de la Fuente, Jesus Maria Banales, Alvaro Santos-Laso, Jose Luis Calleja Panero, Luis Ibanez, Maria Teresa Arias Loste, Manuel Romero Gomez, Carmelo Garcia-Monzon, Judith Gomez-Camarero, Pere Gines, Rosa M. Morillas, Juan Manuel Pericas, Patricia Aspichueta, Rosa Martin-Mateos, Rocio Gallego-Duran, Mercedes De La Torre Sanchez, Desamparados Escudero-Garcia, Vanesa Bernal Monterde, Salvador Benlloch, Juan Turnes, Javier Crespo
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Maria Del Barrio Azaceta, Paula Iruzubieta, Rocio Aller De La Fuente, Jesus Maria Banales, Alvaro Santos-Laso, Jose Luis Calleja Panero, Luis Ibanez, Maria Teresa Arias Loste, Manuel Romero Gomez, Carmelo Garcia-Monzon, Judith Gomez-Camarero, Pere Gines, Rosa M. Morillas, Juan Manuel Pericas, Patricia Aspichueta, Rosa Martin-Mateos, Rocio Gallego-Duran, Mercedes De La Torre Sanchez, Desamparados Escudero-Garcia, Vanesa Bernal Monterde, Salvador Benlloch, Juan Turnes, Javier Crespo
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Raquel A. Martinez Garcia de la Torre, Julia Vallverdu, Silvia Arino Mons, Beatriz Aguilar-Bravo, Mikel Azkargorta, Felix Elortza, Laura Zanatto, Paula Cantallops Vila, Juanjo Lozano, Benedicte Antoine, Isabel Graupera, Pere Gines, Pau Sancho-Bru
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Elisa Pose, Elsa Sola, Juan J. Lozano, Adria Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit, Frank Uschner, Marta Tonon, Konstantin Kazankow, Cesar Jimenez, Daniela Campion, Laura Napoleone, Ann T. Ma, Marta Carol, Manuel Morales-Ruiz, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, Francois Durand, Rajeshwar P. Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Mark M. Davis, Pere Gines
Summary: This study investigated the effects of simvastatin and rifaximin on plasma metabolites in patients with decompensated cirrhosis and ACLF, identifying specific metabolic changes associated with ACLF and noting alterations in key pathways with treatment. The findings suggest a potential for targeted therapies in cirrhosis to prevent ACLF development.
HEPATOLOGY COMMUNICATIONS
(2022)