Editorial Material
Cell Biology
Lucia Morgado-Palacin
Summary: Gina DeNicola is researching the metabolism of cancer cells and its relation to NRF2 and the tumor microenvironment.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Shyang Jeng, I-Shyan Sheen, Shu-Sheng Lin, Chuen-Miin Leu, Chiung-Fang Chang
Summary: Endoglin (CD105) is a vital protein associated with angiogenesis in hepatocellular carcinoma (HCC), potentially serving as a diagnostic or prognostic factor. Combining TRC105, an antibody against endoglin, with sorafenib can achieve partial response. While antiangiogenic therapy carries risks, combination therapy with endoglin inhibitors or other targeted therapies shows promise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Fan Pan, Xinrong Lin, Liping Hao, Ting Wang, Haizhu Song, Rui Wang
Summary: This review summarizes the roles of several typical molecules and radiotherapy in regulating the ferroptosis process in hepatocellular carcinoma (HCC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Article
Cell Biology
Yun-Hsin Cheng, Ying-Chieh Ko, Hsiang-Ju Ku, Ching-Chun Huang, Yu-Ching Yao, Yi-Tzu Liao, Ying-Tsong Chen, Shiu-Feng Huang, Li-Rung Huang
Summary: The paper describes two HCC cell lines with distinct features of lipid metabolism related to cancer stemness and differential interplay with the immune system. The authors present this syngeneic HCC mouse model as a practical tool for studying cancer stemness and discovering new therapies targeting liver cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huijie Zhao, Yiming Zhang, Yanting Zhang, Chaoran Chen, Huiyang Liu, Yihan Yang, Honggang Wang
Summary: Inflammasomes are important in innate immunity, dealing with pathogens and cellular products related to stress and injury. The NLRP3 inflammasome, consisting of NLRP3, ASC, and procaspase-1, is the best studied and most characteristic inflammasome. Activation of the NLRP3 inflammasome leads to caspase-1 activation, interleukin (IL)-1 beta and IL-18 maturation, and pyroptosis. While the NLRP3 inflammasome is involved in tumorigenesis, it also plays a protective role in some cancers. This article focuses on the role of the NLRP3 inflammasome in hepatocellular carcinoma (HCC) and analyzes the underlying mechanisms, aiming to provide insights for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biology
Alec J. Davidson, Delaney Beckner, Xavier Bonnefont
Summary: Most organisms on Earth have biological clocks to cope with day-night cycles. Scientists from various fields have been deciphering the mechanisms of 24-hour clocks. The location of the master circadian clock in mammals makes it difficult to study, but in vivo imaging offers opportunities for research.
Article
Genetics & Heredity
Omnia Nasser Abd ElAziz, Asmaa M. Elfiky, Mohamed A. Yassin, Fatma El-Zahraa Abd El-Hakam, Eman M. Saleh, Mahmoud El-Hefnawi, Rania Hassan Mohamed
Summary: This study demonstrates the oncogenic role of miR-181c-5p in hepatocellular carcinoma (HCC) progression through bioinformatics analysis and in vivo experiments.
Review
Pharmacology & Pharmacy
Kai Zhang, Anna E. Barry, Ryan Lamm, Keyur Patel, Michelle Schafer, Hien Dang
Summary: This review summarizes the roles of RNA-binding proteins (RBPs) in the development and progression of hepatocellular carcinoma (HCC). RBPs play a crucial role in promoting HCC progression and may have potential diagnostic and therapeutic implications for early diagnosis and prognosis of the disease.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Qiang Feng, Dongxu Wang, Tianyi Xue, Chao Lin, Yongjian Gao, Liqun Sun, Ye Jin, Dianfeng Liu
Summary: This review focuses on the important roles of RNA modifications, such as m6A, m7G, m5C, in hepatocellular carcinoma (HCC) and their regulatory mechanisms. These modifications and their regulators play crucial regulatory roles in the progression and maintenance of HCC, and may serve as potential novel biomarkers for HCC diagnosis and treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Christos Damaskos, Nikolaos Garmpis, Dimitrios Dimitroulis, Anna Garmpi, Evangelos Diamantis, Panagiotis Sarantis, Vasiliki E. Georgakopoulou, Alexandros Patsouras, Markos Despotidis, Dionysios Prevezanos, Athanasios Syllaios, Georgios Marinos, Evangelos Koustas, Christos Vallilas, Efstathios A. Antoniou, Konstantinos Kontzoglou, Spyridon Savvanis, Gregory Kouraklis
Summary: SNHG15, a lncRNA, has been found to play a role in the development and prognosis of HCC. Current research indicates that over-expression of SNHG15 is associated with the occurrence of HCC and affects patient survival. However, further studies are needed to clarify the potential role of SNHG15 as a prognostic tool and therapeutic target in HCC.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Immunology
Zhijie Xiao, Charlie Lot Sum Yeung, Judy Wai Ping Yam, Xiaowen Mao
Summary: The complement system, as a main producer in the liver, plays a significant role in tumour initiation and progression, particularly in hepatocellular carcinoma (HCC). Understanding the molecular targets involved in complement-mediated tumour development is crucial for developing better treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Smriti Verma, Bidya Dhar Sahu, Madhav Nilakanth Mugale
Summary: Hepatocellular carcinoma (HCC) is a deadly form of primary liver cancer, and the molecular mechanisms underlying its pathogenesis are poorly understood. Long non-coding RNAs (lncRNAs) play a crucial role in HCC, promoting tumor cell autophagy, proliferation, and migration by targeting and modulating downstream genes in cancer-related signaling pathways. Understanding lncRNAs may lead to improved knowledge of HCC etiology.
Article
Health Care Sciences & Services
Chun-Wei Huang, Tsung-Han Wu, Heng-Yuan Hsu, Kuang-Tse Pan, Chao-Wei Lee, Sio-Wai Chong, Song-Fong Huang, Sey-En Lin, Ming-Chin Yu, Shen-Ming Chen
Summary: This study analyzed the genetic expression of alkaline phosphatase (ALP) isoforms and perioperative changes in ALP in patients with hepatocellular carcinoma (HCC) after partial hepatectomy. The results showed that ALP elevation was associated with liver function, HCC recurrence, and liver regeneration capacity. This suggests that ALP could be a functional biomarker for the liver and an independent prognostic factor for HCC after surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
