Article
Medicine, General & Internal
Eirini I. Rigopoulou, Marianna Bakarozi, Ioannis Dimas, Konstantinos Galanis, Vasiliki Lygoura, Nikolaos K. Gatselis, Mairi Koulentaki, George N. Dalekos
Summary: This study evaluated the health-related quality of life (HRQoL) in Greek PBC patients for the first time and found that it is associated with clinical and laboratory parameters. The HRQoL of Greek PBC patients is impaired, with fatigue, social and emotional dysfunction exerting the highest impact.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Surain B. Roberts, Gideon M. Hirschfield, Lawrence J. Worobetz, Catherine Vincent, Jennifer A. Flemming, Angela Cheung, Karim Qumosani, Mark Swain, Dusanka Grbic, Hin Hin Ko, Kevork Peltekian, Nazia Selzner, Lusine Abrahamyan, Bishoi Aziz, Ellina Lytvyak, Kattleya Tirona, Aliya F. Gulamhusein, Harry L. A. Janssen, Aldo J. Montano-Loza, Andrew L. Mason, Bettina E. Hansen
Summary: In a diverse Canadian cohort of PBC patients, Indigenous Canadians have poorer liver transplant-free and event-free survival compared to White patients. They are more likely to have a clinical event before diagnosis and present with higher liver function test indicators, which persist during follow-up.
Article
Gastroenterology & Hepatology
Lukas Goosmann, Angela Buchholz, Katrin Bangert, Valentin Fuhrmann, Stefan Kluge, Ansgar W. Lohse, Samuel Huber, Lutz Fischer, Martina Sterneck, Peter Huebener
Summary: Among cirrhosis patients, acute-on-chronic liver failure (ACLF) is associated with reduced post-liver transplantation (LT) survival mainly due to infections. Long-term follow-up revealed comparable graft function and comorbidity burden in ACLF-LT and non-ACLF-LT survivors, but many ACLF-LT recipients experienced significantly impaired health and quality of life.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Jorn C. Goet, Carla F. Murillo Perez, Maren H. Harms, Annarosa Floreani, Nora Cazzagon, Tony Bruns, Florian Prechter, George N. Dalekos, Xavier Verhelst, Nikolaos K. Gatselis, Keith D. Lindor, Willem J. Lammers, Aliya Gulamhusein, Anna Reig, Marco Carbone, Frederik Nevens, Gideon M. Hirschfield, Adriaan J. van der Meer, Henk R. van Buuren, Bettina E. Hansen, Albert Pares
Summary: This study evaluated the prognostic value of Mayo Risk Score (MRS), UK-PBC score, and GLOBE score in patients with primary biliary cholangitis, finding that the GLOBE score had superior discriminatory performance. However, all scores demonstrated comparable prediction accuracy for outcomes such as liver transplantation or death.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ben Barron-Millar, Laura Ogle, George Mells, Steven Flack, Jonathan Badrock, Richard Sandford, John Kirby, Jeremy Palmer, Laura Jopson, John Brain, Graham R. Smith, Steve Rushton, Vinod S. Hegade, Rebecca Jones, Simon Rushbrook, Douglas Thorburn, Steve Ryder, Gideon Hirschfield, Jessica K. Dyson, David E. J. Jones
Summary: The UK-PBC study aimed to explore the biological basis of UDCA nonresponse in primary biliary cholangitis (PBC) and identified a set of serum chemokines potentially related to cellular senescence with significant differential expression between responders and nonresponders. These proteins have the potential to serve as biomarkers for high-risk disease identification and should be further evaluated for their clinical utility in prospective studies.
Article
Medicine, General & Internal
Lu Wang, Keshuai Sun, Ai Tian, Yansheng Liu, Miao Zhang, Xinmin Zhou, Ying Han
Summary: This study found that adding FF to UDCA treatment can significantly reduce serum levels of ALP and improve GLOBE and UK-PBC scores. It also improves or stabilizes disease features, including fibrosis and ductular injury.
Article
Medicine, General & Internal
Markus Graf, Christian M. Lange, Mona M. Langer, Joern M. Schattenberg, Jessica Seessle, Julia Dietz, Annika Vermehren, Florian A. Michael, Antonia Mondorf, Stefan Zeuzem, Anita Pathil, Christiana Graf, David E. Kaplan, Hideaki Kato
Summary: This study aimed to assess the prevalence, biochemical, and serological features, as well as the clinical course, of AIH-PBC VS. The results showed that the biochemical Paris criteria were rarely detected and should be redefined. Combined therapy of UDCA and IS appeared to be more effective than monotherapy with UDCA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Aaron Wetten, David Emrys Jeffreys Jones, Jessica Katharine Dyson
Summary: This article summarizes the use of generic fibrates as add-in therapy for PBC and evaluates the clinical trial data of seladelpar in terms of liver biochemistry, symptomology, and safety. Results show that seladelpar leads to marked improvement in liver biochemistry and symptoms, and safety concerns have been addressed. Compared to existing off-label fibrates, seladelpar has the potential to be an attractive second-line agent in PBC.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Gastroenterology & Hepatology
Mark R. Pedersen, Garrett Greenan, Sumant Arora, Arvind R. Murali, Marlyn J. Mayo
Summary: UDCA after LT reduces the odds of BC and bile stones and sludge in all-comer LT recipients and reduces or delays the incidence of rPBC in patients transplanted for PBC. UDCA use after LT could be considered in all LT recipients to reduce the odds of BC and may be particularly beneficial for patients transplanted for PBC by reducing the incidence of rPBC.
LIVER TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Christophe Corpechot, Fabrice Carrat, Farid Gaouar, Frederic Chau, Gideon Hirschfield, Aliya Gulamhusein, Aldo J. Montano-Loza, Ellina Lytvyak, Christoph Schramm, Albert Pares, Ignasi Olivas, John E. Eaton, Karim T. Osman, George Dalekos, Nikolaos Gatselis, Frederik Nevens, Nora Cazzagon, Alessandra Zago, Francesco Paolo Russo, Nadir Abbas, Palak Trivedi, Douglas Thorburn, Francesca Saffioti, Laszlo Barkai, Davide Roccarina, Vicenza Calvaruso, Anna Fichera, Adele Delamarre, Esli Medina-Morales, Alan Bonder, Vilas Patwardhan, Cristina Rigamonti, Marco Carbone, Pietro Invernizzi, Laura Cristoferi, Adriaan van der Meer, Rozanne de Veer, Ehud Zigmond, Eyal Yehezkel, Andreas E. Kremer, Ansgar Deibel, Jerome Dumortier, Tony Bruns, Karsten Grosse, Georges-Philippe Pageaux, Aaron Wetten, Jessica Dyson, David Jones, Olivier Chazouilleres, Bettina Hansen, Victor de Ledinghen
Summary: In the largest ever study of LSM in patients with PBC, LSM assessed by VCTE improves prediction of survival beyond biochemical response, established prognostic scores, and age categories, independent of time. LSM can reasonably be regarded as a useful prognostic marker and a potential surrogate endpoint in PBC clinical trials.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ellina Lytvyak, Mina Niazi, Rohit Pai, Daniel He, Guangzhi Zhang, Stefan G. Hubscher, Andrew L. Mason
Summary: Managment of recurrent primary biliary cholangitis with combination antiretroviral therapy has shown successful outcomes, although it can be associated with side effects.
LIVER INTERNATIONAL
(2021)
Article
Pediatrics
Heping Fang, Zehao Li, Ruoling Xian, Yu Yin, Juan Wang, Hongling Guo, Xiaoke Dai, Mingman Zhang, Yan Hu, Yingcun Li
Summary: This study aimed to clarify the early growth and developmental characteristics of children with biliary atresia (BA) undergoing primary liver transplantation (pLT). A prospective cohort study was conducted and the results showed that BA-pLT children have growth and developmental problems, particularly in motor and language skills.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Mazen Noureddin, Nabil Noureddin, Jason Eccleston, Daniel Woolridge, T. Jake Liang, Michele Tana, David E. Kleiner, Gracia Viana Rodriguez, Christopher Koh, Jay H. Hoofnagle, Theo Heller
Summary: This study evaluated the involvement of bile duct and disease progression in patients with primary biliary cholangitis (PBC) and found that bile duct injury does not follow the same course as fibrosis, and certain indicators are associated with ductopenia progression.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Eric F. Martin
Summary: The number of liver transplantation for primary biliary cholangitis (PBC) has decreased over the years, but it remains an important and curative option for progressive PBC patients. Recent studies from the Global PBC Study Group have provided valuable insights into the changes in PBC before and after liver transplantation.
CLINICS IN LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Hayley Chen, Alexander Johnston, Andrew Palmer, Matthew Mickenbecker, Timothy O'Sullivan, Paul Clark
Summary: The study found that despite the benefits of timely palliative care referral, less than one quarter of patients with decompensated cirrhosis were referred. Referral seemed to be reserved for those facing imminent death, while mortality remained high for non-referred patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marco Carbone, Stephen J. Sharp, Steve Flack, Dimitrios Paximadas, Kelly Spiess, Carolyn Adgey, Laura Griffiths, Reyna Lim, Paul Trembling, Kate Williamson, Nick J. Wareham, Mark Aldersley, Andrew Bathgate, Andrew K. Burroughs, Michael A. Heneghan, James M. Neuberger, Douglas Thorburn, Gideon M. Hirschfield, Heather J. Cordell, Graeme J. Alexander, David E. J. Jones, Richard N. Sandford, George F. Mells
Review
Immunology
Vincenzo Ronca, Marco Carbone, Francesca Bernuzzi, Federica Malinverno, Hani S. Mousa, M. Eric Gershwin, Pietro Invernizzi
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2017)
Article
Gastroenterology & Hepatology
Marco Carbone, Pietro Invernizzi
LIVER INTERNATIONAL
(2017)
Article
Gastroenterology & Hepatology
Elisabeth M. G. de Vries, Martti Farkkila, Piotr Milkiewicz, Johannes R. Hov, Bertus Eksteen, Douglas Thorburn, Olivier Chazouilleres, Albert Pares, Stale Nygard, Odd H. Gilja, Ewa Wunsch, Pietro Invernizzi, Marco Carbone, Francesca Bernuzzi, Kirsten M. Boberg, Helge Rosjo, William Rosenberg, Ulrich H. Beuers, Cyriel Y. Ponsioen, Tom H. Karlsen, Mette Vesterhus
LIVER INTERNATIONAL
(2017)
Article
Cell Biology
E. K. K. Henriksen, M. K. Viken, M. Wittig, K. Holm, T. Folseraas, S. Mucha, E. Melum, J. R. Hov, K. N. Lazaridis, B. D. Juran, O. Chazouilleres, M. Farkkila, D. N. Gotthardt, P. Invernizzi, M. Carbone, G. M. Hirschfield, S. M. Rushbrook, E. Goode, C. Y. Ponsioen, R. K. Weersma, B. Eksteen, K. K. Yimam, S. C. Gordon, D. Goldberg, L. Yu, C. L. Bowlus, A. Franke, B. A. Lie, T. H. Karlsen
Article
Biochemistry & Molecular Biology
Marco Carbone, Laura Cristoferi, Paolo Angelo Cortesi, Matteo Rota, Antonio Ciaccioa, Stefano Okolicsanyi, Marta Gemma, Luciana Scalone, Giancarlo Cesana, Luca Fabris, Michele Colledan, Stefano Fagiuoli, Gaetano Ideo, Luca Saverio Belli, Luca Maria Munari, Lorenzo Mantovani, Mario Strazzabosco
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Gastroenterology & Hepatology
Paolo Muratori, Marco Carbone, Giorgia Stangos, Lisa Perini, Claudine Lalanne, Vincenzo Ronca, Nora Cazzagon, Giampaolo Bianchi, Marco Lenzi, Annarosa Floreani, Pietro Invernizzi, Luigi Muratori
DIGESTIVE AND LIVER DISEASE
(2018)
Editorial Material
Gastroenterology & Hepatology
Marco Carbone, Giulia Bonato, Pietro Invernizzi
Article
Gastroenterology & Hepatology
Carla F. Murillo Perez, Jorn C. Goet, Willem J. Lammers, Aliya Gulamhusein, Henk R. van Buuren, Cyriel Y. Ponsioen, Marco Carbone, Andrew Mason, Christophe Corpechot, Pietro Invernizzi, Marlyn J. Mayo, Pier Maria Battezzati, Annarosa Floreani, Albert Pares, Frederik Nevens, Kris V. Kowdley, Tony Bruns, George N. Dalekos, Douglas Thorburn, Gideon Hirschfield, Nicholas F. LaRusso, Keith D. Lindor, Kalliopi Zachou, Raoul Poupon, Palak J. Trivedi, Xavier Verhelst, Harry L. A. Janssen, Bettina E. Hansen
Article
Gastroenterology & Hepatology
Gianluca Rompianesi, Reena Ravikumar, Sophie Jose, Michael Allison, Anuja Athale, Felicity Creamer, Bridget Gunson, Derek Manas, Andrea Monaco, Darius Mirza, Nicola Owen, Keith Roberts, Gourab Sen, Parthi Srinivasan, Stephen Wigmore, Giuseppe Fusai, Bimbi Fernando, Andrew Burroughs, Emmanuel Tsochatzis
LIVER INTERNATIONAL
(2019)
Article
Immunology
Andrea Monaco, Tommaso Maria Manzia, Roberta Angelico, Giuseppe Iaria, Carlo Gazia, Yousef Al Alawi, Konstantinos Fourtounas, Giuseppe Tisone, Roberto Cacciola
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Surgery
Tommaso Maria Manzia, Carlo Gazia, Ilaria Lenci, Roberta Angelico, Luca Toti, Andrea Monaco, Alessandro Anselmo, Leonardo Baiocchi, Paolo Grossi, Giuseppe Tisone
Summary: This case report describes the first successful liver transplantation using a liver procured from a SARS-CoV-2 positive donor, with the recipient clearing the infection and recovering normal liver function after the surgery. The findings suggest that the prompt use of SARS-CoV-2 infected liver donors could offer a life-saving opportunity for SARS-CoV-2 positive patients who have developed neutralizing antibodies.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Transplantation
Evaldo Favi, Carmelo Puliatti, Samuele Iesari, Andrea Monaco, Mariano Ferraresso, Roberto Cacciola
TRANSPLANTATION DIRECT
(2018)
Article
Allergy
Benedetta Terziroli Beretta-Piccoli, Guido Stirnimann, Andreas Cerny, David Semela, Roxane Hessler, Beat Helbling, Felix Stickel, Carolina Kalid-de Bakker, Florian Bihl, Emiliano Giostra, Magdalena Filipowicz Sinnreich, Carl Oneta, Adriana Baserga, Pietro Invernizzi, Marco Carbone, Joachim Mertens
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2018)
Article
Gastroenterology & Hepatology
Pietro Invernizzi, Annarosa Floreani, Marco Carbone, Marco Marzioni, Antonio Craxi, Luigi Muratori, Umberto Vespasiani Gentilucci, Ivan Gardini, Antonio Gasbarrini, Paola Kruger, Francesco Saverio Mennini, Virginia Ronco, Elena Lanati, Pier Luigi Canonico, Domenico Alvaro
DIGESTIVE AND LIVER DISEASE
(2017)