Review
Biochemistry & Molecular Biology
Nicolas Nicastro, Umberto Nencha, Pierre R. Burkhard, Valentina Garibotto
Summary: This study summarizes the current evidence on dopaminergic molecular imaging in the diagnostic evaluation of Parkinson's disease (PD), atypical parkinsonian syndromes, and dementia with Lewy bodies (DLB), as well as its potential to distinguish these conditions and estimate disease progression. Dopamine imaging has an outstanding potential for early detection of neurodegeneration.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, Chuantao Zuo, A. Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, John O. Prior, Yan Zhong, Xiaofeng Dou, Congcong Yu, Chentao Jin, Rui Zhou, Fengtao Liu, Xinyi Li, Jiaying Lu, Hong Zhang, Jian Wang
Summary: This article introduces the international consensus and practice guideline, aiming to promote the standardized use of presynaptic dopaminergic PET imaging in parkinsonism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Kaki Tsang, Richard Walker
Summary: This study assessed the impact of DaT Scan imaging on the diagnosis and subsequent clinical management of patients with indeterminate Parkinsonism. The results showed that DaT scanning is useful for confirming the correct diagnosis and guiding the clinical management of Parkinsonism patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Namhun Lee, Se-Jong Oh, Jang-Woo Park, Kyung-Rok Nam, Kyung-Jun Kang, Kyo-Chul Lee, Yong-Jin Lee, June-Seek Choi, Jeong-Ho Seok, Jae-Yong Choi
Summary: Early life stress can lead to behavioral deficits, including anxiety and depressive phenotypes, as well as dysfunction in neurotransmitter systems in animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Article
Clinical Neurology
Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Honglinag Li, Toru Sakurai, Masahide Suzuki, Hong Tai, Shogo Furukawa, Atsuhiko Sugiyama, Yoshitaka Yamanaka, Tatsuya Yamamoto, Takashi Iimori, Hajime Yokota, Hiroki Mukai, Takuro Horikoshi, Takashi Uno, Satoshi Kuwabara
Summary: This study found a correlation between cerebral blood flow (CBF) and dopamine transporter (DAT) in patients with Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Using machine learning, the combination of CBF and DAT was found to be better for distinguishing PD from APS than either modality alone.
MOVEMENT DISORDERS
(2022)
Article
Medicine, General & Internal
Abdurrahim Rahimian, Mahanaz Etehadtavakol, Masoud Moslehi, Eddie Y. K. Ng
Summary: The study evaluated the effectiveness of different filters in improving the quality of myocardial perfusion single-photon emission computed tomography (SPECT) images. Data from 30 patients, consisting of over 900 images, were collected using the Siemens Symbia T2 dual-head SPECT/CT scanner. The results showed that the Wiener filter with a kernel size of 5 x 5 outperformed other filters in denoising the SPECT images.
Article
Multidisciplinary Sciences
Nai-Jie Guo, Song Li, Wei Liu, Yuan-Ze Yang, Xiao-Dong Zeng, Shang Yu, Yu Meng, Zhi-Peng Li, Zhao-An Wang, Lin-Ke Xie, Rong-Chun Ge, Jun-Feng Wang, Qiang Li, Jin-Shi Xu, Yi-Tao Wang, Jian-Shun Tang, Adam Gali, Chuan-Feng Li, Guang-Can Guo
Summary: Optically active defects in hBN have not been coherently controlled yet. Guo et al. isolate a new carbon-related defect and achieve its coherent control by efficiently producing arrays of defects in hBN.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Jun Ikezawa, Fusako Yokochi, Ryoichi Okiyama, Satoko Kumada, Maya Tojima, Tsutomu Kamiyama, Takashi Hanakawa, Hiroshi Matsuda, Fumiaki Tanaka, Yasuhiro Nakata, Eiji Isozaki
Summary: Functional impairments of the dopaminergic system may be involved in the development of generalized and segmental dystonia. Abnormalities in the substantia nigra of patients with dystonia were found to be different from degeneration in Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taisuke Murata, Hajime Yokota, Ryuhei Yamato, Takuro Horikoshi, Masato Tsuneda, Ryuna Kurosawa, Takuma Hashimoto, Joji Ota, Koichi Sawada, Takashi Iimori, Yoshitada Masuda, Yasukuni Mori, Hiroki Suyari, Takashi Uno
Summary: This study developed a deep learning-based approach using NAC images and CTAC images for training to obtain accurate AC images in brain-perfusion SPECT. Experimental results showed that this approach had higher accuracy than conventional Chang's AC method.
Article
Oncology
ShanBing Wang, Jiapei Liu, Kaijian Lei, Yuming Jia, Chunxiu Wang, Xia Zhang, Ting Li
Summary: This study aimed to test the efficacy of SPECT-defined ABMS VMAT in reducing grade 3+ acute HT in locally advanced cervical cancer patients treated with chemoradiotherapy. The results showed that ABMS VMAT significantly reduced the incidence of grade 3+ acute HT and improved chemotherapy delivery. However, there was weak evidence of the effect on distant metastasis.
Article
Optics
Yi Ren, Zhenglu Duan, Bixua Fan, Shengguo Guan, Min Xie, Cunjin Liu
Summary: A coupled Jaynes-Cummings model is proposed for generating strong antibunched single photons and correlated photon pairs, with optimal conditions for conventional/unconventional photon blockade identified. Results reveal an intersection point between conventional and unconventional photon blockade, where single photon performance is enhanced, and strong photon correlation in unconventional blockade conditions.
Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Optics
Kyu-Young Kim, Christopher J. K. Richardson, Edo Waks, Je-Hyung Kim
Summary: Researchers have successfully demonstrated single-photon pulses at a telecom wavelength with a Gaussian-like temporal mode profile from a cavity-coupled single quantum dot. By engineering the exciton dynamics and utilizing cascade recombination, they are able to modify the rise and decay dynamics of single excitons, leading to possible purification of single photons at high excitation power. Additionally, coupling quantum dots into a low Q cavity mode results in a Gaussian-like spatial mode profile, bringing a high collection efficiency.
Article
Primary Health Care
Katharina van Baal, Birgitt Wiese, Gabriele Mueller-Mundt, Stephanie Stiel, Nils Schneider, Kambiz Afshar
Summary: By implementing a clinical decision aid and a public campaign, the quality of end-of-life care provided by general practitioners improved, particularly in the areas of care planning and documentation.