Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Betul Tas Ozyurtseven, Istemi Serin, Ayse Feyda Nursal, Sacide Pehlivan, Mustafa Pehlivan
Summary: This study investigated the pathogenesis of MRONJ in MM patients, revealing the association between eNOS gene polymorphisms and clinical effects. While there was no significant difference in genotypes and alleles between the patient group and healthy controls, different genotypes were found to potentially impact clinical parameters. These findings suggest the importance of genetic factors in the development of MRONJ in MM patients and highlight the need for further research in this area.
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Health Care Sciences & Services
Jin-Woo Kim, Jeong Yee, Sang-Hyeon Oh, Sun-Hyun Kim, Sun-Jong Kim, Jee-Eun Chung, Hye-Sun Gwak
Summary: The study identified a significant association between VEGFA polymorphisms and BRONJ occurrence, with age and duration of bisphosphonate exposure as important risk factors. Machine learning algorithms showed high predictive performance for assessing BRONJ risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Jiao Huang, Lin Wang, Weidong Tian
Summary: The study showed that small extracellular vesicles derived from adipose tissue (sEV-AT) can promote soft tissue healing, reduce necrotic bones and empty osteocyte lacunae, increase the number of osteoclasts, collagen fibers, and blood vessels, and enhance angiogenesis in BRONJ-like lesions. These findings suggest that sEV-AT has potential for preventing BRONJ.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kumarendran Balachandran, Roszalina Ramli, Saiful Anuar Karsani, Mariati Abdul Rahman
Summary: This study identified potential molecular mechanisms and therapeutic targets for BRONJ by analyzing a microarray dataset of multiple myeloma patients with BRONJ. Differentially expressed genes were found to be associated with apoptosis, RNA splicing, signaling pathways, and lipid metabolism. Seven hub genes were identified and a potential drug treatment and prognostic marker for BRONJ was also identified. The findings provide valuable molecular insights for biomarker validation and drug development for BRONJ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dileep Sharma, Stephen Hamlet, Cedryck Vaquette, Eugen Bogdan Petcu, Poornima Ramamurthy, Saso Ivanovski
Summary: The study demonstrated that a gelatine-hyaluronic acid hydrogel loaded with the angiogenic growth factor VEGF can significantly improve vascularity and reduce osteonecrosis in bisphosphonate-treated rodent maxillary extraction defects. Locally delivered VEGF assists bone healing and prevents medication-related osteonecrosis of the jaw by promoting angiogenesis and immunomodulation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xian Dong, Linhai He, Xiaolong Zang, Yang He, Jingang An, Baoping Wu, Xinhua Liu, Hongsen Bi, Yi Zhang, E. Xiao
Summary: This study found that local transplantation of ADSCs can effectively promote bone healing in BRONJ. The mechanism involves ADSCs promoting bone coupling through TGF-beta 1 activation, significantly rescuing necrotic jawbones in BRONJ and animal model jawbone samples.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jong-Eun Kim, Su-Jin Kim, Dong-Ho Kwon, June-Sung Shim, Jee-Hwan Kim
Summary: This proposed technique uses a patient's CBCT data to reproduce the occlusal plane in relation to digital articulator scan data, align the patient's gypsum cast or intraoral scan data on the reproduced plane, and then transfer the data to a mechanical articulator. It aims to improve the accuracy and comfort of the facebow transfer procedure by utilizing digital technology.
JOURNAL OF PROSTHETIC DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jiayi Li, Hong Seok Moon, Jee-Hwan Kim, Hyung-In Yoon, Kyung Chul Oh
Summary: This study aimed to evaluate the accuracy of eight impression-making methods for edentulous arches and determine the effects of using a 3-dimensionally printed polyetheretherketone (PEEK) scanning aid on the accuracy of intraoral scanners. The results showed that intraoral scanners demonstrated accuracy comparable with that of conventional impression materials, and the PEEK-based scanning aid improved the accuracy of the intraoral scanners compared to conventional impression materials.
JOURNAL OF PROSTHETIC DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hag-Young Lee, Seung-Won Yang, You-Jung Kang, Kyung Chul Oh, Jee-Hwan Kim
Summary: The study investigated the impact of shoulder coverage of the abutment on stress distribution and abutment screw stability in tissue-level internal connection implants. Results showed that complete shoulder coverage improved screw stability, with the no coverage group exhibiting the highest stress and lowest removal torque values. The findings suggest that shoulder coverage plays a crucial role in maintaining the stability of abutment screws in dental implants.
JOURNAL OF PROSTHETIC DENTISTRY
(2021)
Article
Chemistry, Physical
Min-Ho Jang, Young-Bum Park, Jae-Sung Kwon, Yeun-Ju Kim, Jae-Hoon Lee
Summary: The study indicated that non-thermal atmospheric pressure plasma jet treatment can enhance osseointegration of titanium implants in both dental and medical fields. At 4 weeks, the NTAPPJ group showed higher bone volume and bone-to-implant contact ratio compared to the control group. However, by 8 weeks, the differences between the control and experimental groups were no longer significant as the control group had caught up with the experimental group.
Article
Polymer Science
Enkhjargal Bayarsaikhan, Jung-Hwa Lim, Seung-Ho Shin, Kyu-Hyung Park, Young-Bum Park, Jae-Hoon Lee, Jong-Eun Kim
Summary: The study demonstrates that increasing the postcuring temperature significantly improves the flexural strength and cell viability of 3D printed resin, but also increases cell cytotoxicity. Parts cured at 80 degrees Celsius for 120 minutes show the best performance in terms of mechanical and biological properties.
Article
Dentistry, Oral Surgery & Medicine
Bada Choi, Ye Chan Lee, Kyung Chul Oh, Jae Hoon Lee
Summary: This study found that ultraviolet surface treatment on implants can increase the initial stability in the region of the maxilla with poor bone quality, especially in group III, while the effects were more pronounced in group II.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yoo-Yeon Kim, Young Woo Song, Myong Ji Kim, Jae-Kook Cha, Ji-Man Park, Jee-Hwan Kim, Ui-Won Jung
Summary: Immediate loading of fixed partial prostheses over tapered implants (TIs) and straight implants (SIs) in the posterior region showed reliable outcomes at 1-year follow-up, with TIs demonstrating superior initial mechanical stability compared to SIs.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Cell Biology
Hyun Jung Jung, Won Lee, Jin-Su Shin, Sang-Kyou Lee, Jae Hoon Lee
Summary: The study aimed to investigate whether suppression of NF-kB complex function by p65-TMD-linked PTD could reduce inflammation and bone resorption at peri-implantitis sites in rats. Results showed that the treatment successfully inhibited NF-kB functions and decreased both inflammation and bone resorption, suggesting a potential effective method for treating peri-implantitis.
Article
Dentistry, Oral Surgery & Medicine
Kyung Chul Oh, Byoung Soo Yun, Jee-Hwan Kim
Summary: The accuracy of metal 3D printed frameworks for removable partial dentures was evaluated and compared to conventional frameworks and resin printing/casting workflows. The results showed that metal 3D printed frameworks have similar internal discrepancies as conventional frameworks and meet clinical standards.
Article
Dentistry, Oral Surgery & Medicine
Kyung Chul Oh, Jeongho Jeon, Jee-Hwan Kim
Summary: A novel design of removable partial dentures (RPDs) incorporates custom abutments into the RPD framework using computer-aided design and 3D printing technology. This workflow enables a top-down approach for prioritizing the shape and arrangement of artificial teeth and facilitates their replacement.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hyejin Choi, Kwanghwan Lee, Donghyo Kim, Sanguk Kim, Jae Hoon Lee
Summary: This study used whole-exome sequencing and bioinformatics analysis to comprehensively characterize genetic variants of amelogenesis imperfecta in a Korean family. The research identified a missense mutation in the HCCS gene, which is potentially associated with mitochondria function and the pathogenesis of amelogenesis imperfecta.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yun-Ju Lee, Hayeon Pak, Chung-Ju Hwang, Yoon Jeong Choi, Jae-Hoon Lee, Ji Hyun Lee, Jung-Yul Cha
Summary: The study investigated the genetics of External Apical Root Resorption (EARR) in 118 Korean orthodontic patients using targeted next-generation sequencing. Results showed that variations in SPP1 rs9138 and SFRP2 rs3810765 may be related to EARR during orthodontic treatment, indicating a potential genetic influence on this orthodontic outcome.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Pediatrics
Nayoung Kim, Hoon Kim, Ik-Hwan Kim, Jiho Lee, Ko Eun Lee, Hyo-Seol Lee, Jee-Hwan Kim, Je Seon Song, Yooseok Shin
Summary: This study evaluated the fracture resistance, biaxial flexural strength, and dynamic mechanical analysis of 3D printing resins for the esthetic restoration of primary molars. The results showed that both resins exhibited good performance in terms of fracture resistance and could be alternative options for fixed prostheses of primary teeth in children.
Article
Polymer Science
You-Jung Kang, Yeseul Park, Yooseok Shin, Jee-Hwan Kim
Summary: This study evaluated the effect of surface treatments and adhesion conditions on the long-term use of 3D printing polymers in bonding with resin cements. The optimal adhesion condition for UDMA was achieved with APA and SBU treatments followed by the use of U200 cement, while the adhesion conditions had no significant effect on Bis-EMA. After thermocycling, the SBS significantly decreased in UDMA without APA treatment and in the entire Bis-EMA group. Surface porosity and increased roughness were observed on both material surfaces after APA.
Article
Genetics & Heredity
Shinyeop Lee, Hyunsoo Ahn, Hyeonhye Kim, Kwanghwan Lee, Sanguk Kim, Jae Hoon Lee
Summary: This study aimed to identify genetic variants associated with non-syndromic bilateral mandibular second premolar hypodontia in a Korean population. Through whole-exome sequencing, several candidate genes related to tooth development were identified and functional enrichment analysis revealed enriched terms in a protein-protein interaction network. Known variants for oligodontia were also found in patients with hypodontia, supporting the possibility of synergistic effects in other genes.
FRONTIERS IN GENETICS
(2023)