Article
Oncology
Xindi Ke, Bao Jin, Wen You, Yang Chen, Haifeng Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang, Yilei Mao, Shunda Du
Summary: This study analyzed 450 patients with BTC and found that fibrinogen and INR were the best predictors of overall survival. The developed nomogram and novel stratification model showed satisfactory performance, outperforming the conventional TNM staging system.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Yang, Jia-Yan Huang, Xing Chen, Wen-Wu Ling, Yan Luo, Yu-Jun Shi, Ji-Bin Liu, Qiang Lu, Andrej Lyshchik
Summary: The study evaluated the relationship between CEUS LI-RADS classification of cHCC-CCA and their histopathological component predominance, as well as the prediction of patient survival post-surgical resection. LR-5 category tended to represent HCC-predominant tumors with longer disease-free survival compared to LR-M and LR-TIV categories in cHCC-CCA patients.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Tiemo S. Gerber, Benjamin Goeppert, Anne Hausen, Hagen R. Witzel, Fabian Bartsch, Mario Schindeldecker, Lisa-Katharina Groeger, Dirk A. Ridder, Oscar Cahyadi, Irene Esposito, Matthias M. Gaida, Peter Schirmacher, Peter R. Galle, Hauke Lang, Wilfried Roth, Beate K. Straub
Summary: This study focuses on the differential expression and localization of cell-cell contact proteins E-cadherin and N-cadherin in primary liver cancer and liver metastases of ductal adenocarcinoma of the pancreas. The study demonstrates that N-cadherin positivity can distinguish intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas, improving the accuracy of the diagnosis. The findings suggest that N-cadherin can be a helpful marker for differential diagnosis between these two types of cancers.
Article
Gastroenterology & Hepatology
Sung Chan Kwon, Seungmin Bang, Young Nyun Park, Ji Hoon Park, So Jeong Kim, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eunhyang Park, Hee Seung Lee
Summary: This study found that PD-L1 expression in tumor cells is associated with poor prognosis in BTC patients, while PD-L1 expression in immune cells is beneficial for prognosis. There is a significant correlation between PD-L1 expression in tumor cells and immune cells and overall survival rates of patients.
Review
Gastroenterology & Hepatology
Fredy Nehme, Jeffrey H. Lee
Summary: Pancreatic adenocarcinoma is a leading cause of cancer-related morbidity and mortality with most patients presenting with advanced disease. Preoperative biliary drainage (PBD) has traditionally been used to improve surgical outcomes, but recent data suggests potential increased complications with systematic PBD. Indications for PBD include cholangitis, delayed surgery, and jaundice relief in patients planned to receive neoadjuvant therapy. Endoscopic retrograde cholangiopancreatography is the preferred method for PBD, with self-expanding metal stents shown to be cost-effective and safe compared to plastic stents.
DIGESTIVE ENDOSCOPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changwu Zhou, Yi Wang, Li Ma, Xianling Qian, Chun Yang, Mengsu Zeng
Summary: The study aimed to investigate the correlation between MRI features and biomarkers, as well as prognostic factors for RFS and OS in cHCC-CCA patients. Results showed that cHCC-CCA imaging features were not correlated with AFP or CA19-9 levels. Age, CA19-9 > 37 U/ml, arterial phase peritumoral enhancement, and delayed enhancement were identified as independent predictors of poor RFS. Arterial phase peripheral enhancement was found to be an independent predictor of poor OS.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Joo-Hyun Park, Jung Yong Hong, Minsuk Kwon, Jiyun Lee, Kyungdo Han, In Woong Han, Wonseok Kang, Joo Kyung Park
Summary: The study revealed an association between non-alcoholic fatty liver disease (NAFLD) and biliary tract cancer (BTC), including cholangiocarcinoma and gallbladder cancer. Patients with NAFLD had an increased risk of developing BTC, with the risk further elevated in cases of concomitant NAFLD and diabetes.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changwu Zhou, Xin Lu, Yi Wang, Xianling Qian, Chun Yang, Mengsu Zeng
Summary: The study aimed to distinguish MR features based on different proportions of the HCC component and investigate whether the proportion of HCC component could predict the prognosis of cHCC-CCA patients. The results showed that cHCC-CCAs with an HCC component >70% had a better overall survival prognosis compared to those with an HCC component <=70%.
EUROPEAN RADIOLOGY
(2022)
Review
Surgery
Kush Savsani, Katrina Hansen-Artache, Anjelica Alfonso, Seung Lee, Bryce Hatfield, Daisuke Imai, Aamir Khan, Amit Sharma, Irfan Saeed, Vinay Kumaran, Adrian Cotterell, Marlon Levy, David A. Bruno
Summary: This report presents a rare case of IPMN-B treated with robotic hepatectomy and cholecystectomy, supplemented with intraoperative imagery. The successful surgery highlights the importance of early diagnosis and intervention in managing IPMN.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Review
Cell Biology
Claudia Mestre-Alagarda, Rajaventhan Srirajaskanthan, Yoh Zen, Mojisila Giwa, Mark Howard, Marc Lucas Ooft
Summary: Multiple studies have shown that recurrent genetic and epigenetic abnormalities are associated with worse prognosis in neuroendocrine tumors (NETs). However, most of these studies are small and only conducted univariate analysis. This review and meta-analysis focus on NETs in the gastrointestinal tract, liver, biliary tract, and pancreas, and found specific genetic and epigenetic alterations that are associated with worse survival outcomes. It also emphasizes the importance of considering NETs from different anatomical locations as distinct biological entities with different molecular prognostic markers.
Article
Multidisciplinary Sciences
Kaide Xia, Dinghua Chen, Shuai Jin, Xinglin Yi, Li Luo
Summary: This study aimed to predict cancer-specific survival in lung papillary adenocarcinoma (LPADC) using ensemble machine learning and classical Cox regression models. The results showed that the unique survival trees, random survival forests, and gradient boosting survival models performed well in predicting long-term survival. The developed models have been implemented as web applications for deployment into clinical practice.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Sandra Pavicevic, Sophie Reichelt, Deniz Uluk, Isabella Lurje, Cornelius Engelmann, Dominik P. Modest, Uwe Pelzer, Felix Krenzien, Nathanael Raschzok, Christian Benzing, Igor M. Sauer, Sebastian Stintzing, Frank Tacke, Wenzel Schoening, Moritz Schmelzle, Johann Pratschke, Georg Lurje
Summary: Cholangiocarcinoma is a rapidly increasing global malignancy of the biliary tract, often presenting with advanced or unresectable disease. Biomarkers obtained from patients' serum or tumor tissue could help guide therapy and identify those at higher risk of recurrence. Genetic aberrations in cholangiocarcinoma have also been linked with improved response to targeted therapies. This review provides an overview of prognostic and predictive biomarkers in cholangiocarcinoma.
Article
Gastroenterology & Hepatology
Thomas Albrecht, Annik Rossberg, Jana Dorothea Albrecht, Jan Peter Nicolay, Beate Katharina Straub, Tiemo Sven Gerber, Michael Albrecht, Fritz Brinkmann, Alphonse Charbel, Constantin Schwab, Johannes Schreck, Alexander Brobeil, Christa Flechtenmacher, Moritz von Winterfeld, Bruno Christian Koehler, Christoph Springfeld, Arianeb Mehrabi, Stephan Singer, Monika Nadja Vogel, Olaf Neumann, Albrecht Stenzinger, Peter Schirmacher, Cleo-Aron Weis, Stephanie Roessler, Jakob Nikolas Kather, Benjamin Goeppert
Summary: We present a deep learning model (HEPNET) that can accurately distinguish intrahepatic cholangiocarcinoma from colorectal liver metastasis using H&E-stained whole-slide images. HEPNET achieved high accuracy on both internal and external test sets, surpassing the performance of pathology experts.
Review
Radiology, Nuclear Medicine & Medical Imaging
Tae Yeon Jeon, Moon Hyung Choi, Seung Bae Yoon, Jae Seung Soh, Sung-Hoon Moon
Summary: This systematic review and meta-analysis evaluated the diagnostic performance of percutaneous transluminal forceps biopsy (PTFB) for differentiating malignant from benign biliary strictures. The results showed that PTFB had high sensitivity and specificity for diagnosing malignant biliary strictures. It had higher sensitivity for intrinsic biliary strictures compared to extrinsic ones. The rate of complications was 10.3%, with a 3.1% rate of major complications.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Xunhao Zhu, Qingqiang Ni, Qianchang Wang, Chaoqun Ma, Faji Yang, Hengjun Gao, Huaqiang Zhu, Xu Zhou, Hong Chang, Jun Lu, Fangfeng Liu
Summary: A 65-year-old woman with recurrent right upper abdominal pain was diagnosed with a rare intraductal papillary mucinous neoplasm of the caudate lobe of the liver; this article reviews studies on intraductal papillary neoplasms of the biliary tract, providing valuable information on the pathology, diagnosis, and treatment of this disease for hepatobiliary surgeons.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
So-Woon Kim, Young Il Kim, Bilal Mustafa, Mi-Ju Kim, Gowun Jeong, Sung-Min Ahn, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim, Seung-Mo Hong, In Ja Park
Summary: TILs have a strong prognostic value in ARMM, with quantification of TILs and analysis of TIL phenotype and infiltration pattern essential for guiding treatment strategies and accurate prognosis in ARMM. Patients with inflamed or brisk-infiltration type tumors show significantly better overall survival outcomes compared to patients with immune-desert/excluded and absent/non-brisk type tumors.
Article
Oncology
Eunhae Cho, Sung Woo Jung, In Ja Park, Jong Keon Jang, Seong Ho Park, Seung-Mo Hong, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Summary: Preoperative chemoradiotherapy is essential for treating locally advanced rectal cancer, accurate prediction of patients' response to chemoradiation can help in choosing the best surgical option and predicting oncologic outcomes. Combining genetic biomarkers and MRI can improve the assessment of response in post-CRT patients with locally advanced rectal cancer.
Article
Gastroenterology & Hepatology
Jung Min Youn, Shin Hwang, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Seung-Mo Hong
Summary: This study retrospectively evaluated the clinicopathological features and long-term outcomes of 146 patients with intraductal papillary neoplasm of the bile duct (IPNB) of the liver. The study found that surgical curability is the most important prognostic factor for IPNB.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Cell Biology
Gaetano Paolino, Irene Esposito, Seung-Mo Hong, Olca Basturk, Paola Mattiolo, Takuma Kaneko, Nicola Veronese, Aldo Scarpa, Volkan Adsay, Claudio Luchini
Summary: Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a distinct pancreatic tumor entity with specific clinicopathological and molecular characteristics. This study provides a comprehensive analysis of ITPN and compares its features with those of pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN). The findings contribute to the understanding of ITPN and have clinical implications for its diagnosis and treatment.
Article
Pathology
Sung Joo Kim, Se Jin Choi, Junmo Yang, Deokhoon Kim, Dong Wook Kim, Jae Ho Byun, Seung-Mo Hong
Summary: The clinical significance of pancreatic ductal adenocarcinomas (PDACs) with a large duct pattern (PLDP) has not been systematically evaluated. This study compared the clinicopathological, immunohistochemical, and mutational characteristics of PDACs with PLDP with conventional PDACs, and found that PLDP PDACs have unique histologic features, longer survival, and better prognosis.
Article
Gastroenterology & Hepatology
Sun-Young Jun, Jihyun Chun, Sung Joo Kim, Dongwook Oh, Jin Hee Kim, Myung-Hwan Kim, Seung-Mo Hong
Summary: This study evaluated granulocytic epithelial lesions (GEL) and related clinicopathologic factors in heterotopic pancreata. The results showed that GELs were detected in a subset of pancreata without clinical evidence of autoimmune pancreatitis (AIP), highlighting the importance of interpreting GEL findings in the context of other histologic, clinical, and radiologic findings for diagnosing AIP.
Article
Gastroenterology & Hepatology
Min Kyu Sung, Hosub Park, Guisuk Park, Seo Young Park, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Dae Wook Hwang, Seung Mo Hong
Summary: This study investigated the prognostic implications of extranodal extension (ENE) in patients with surgically resected pancreatic cancer. The results showed that patients with ENE had lower disease-free survival rates, especially those with nodal metastasis. Therefore, ENE should be considered a prognostic factor in the staging system of pancreatic cancer.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Pathology
Andrea Mafficini, Michele Simbolo, Tatsuhiro Shibata, Seung-Mo Hong, Antonio Pea, Lodewijk A. Brosens, Liang Cheng, Davide Antonello, Concetta Sciammarella, Cinzia Cantu, Paola Mattiolo, Sergio Taormina, Giuseppe Malleo, Giovanni Marchegiani, Elisabetta Sereni, Vincenzo Corbo, Gaetano Paolino, Chiara Ciaparrone, Nobuyoshi Hiraoka, Daniel Pallaoro, Casper Jansen, Michele Milella, Roberto Salvia, Rita T. Lawlor, Volkan Adsay, Aldo Scarpa, Claudio Luchini
Summary: This study provides important insights into the clinicopathologic and molecular features of pancreatic intraductal tubulopapillary neoplasm (ITPN). It confirms ITPN as the origin of invasive pancreatic adenocarcinoma and identifies novel genetic alterations associated with this disease. The study also highlights the potential use of TP53 mutation status as a prognostic biomarker.
Article
Gastroenterology & Hepatology
Yuri Kim, Bokyung Ahn, Kee Don Choi, Beom-Su Kim, Jeong-Hwan Yook, Gin Hyug Lee, Seung-Mo Hong, Jeong Hoon Lee
Summary: This study systematically evaluated the clinical and pathologic characteristics of gastric neuroendocrine tumors (NETs) based on the 2019 WHO classification. The results showed that grade 2 and grade 3 gastric NETs are associated with larger size, deeper invasion, and extragastric recurrence, requiring active treatment.
Article
Pathology
Jihyun Chun, Yeon Wook Kim, Seo-rin Jeong, Hyung Jun Cho, Kyu-Pyo Kim, Dae Wook Hwang, Seung-Mo Hong
Summary: Although nodal metastasis is an important prognostic factor in ampullary adenocarcinoma, the prognostic significance of extranodal extension (ENE) is not well defined. This study investigated the presence of nodal metastasis with ENE in 279 surgically resected patients and compared it with other clinicopathological factors, including overall survival and recurrence-free survival. The results showed that ENE was associated with poorly differentiated tumors and had worse overall survival and recurrence-free survival rates. Evaluation of ENE can provide additional survival information for patients with surgically resected ampullary carcinoma.
Review
Pathology
Paola Mattiolo, Huamin Wang, Olca Basturk, Lodewijk A. A. Brosens, Seung-Mo Hong, Volkan Adsay, Aldo Scarpa, Claudio Luchini
Summary: This study aimed to conduct a systematic review on acinar cystic transformation (ACT) of the pancreas. The findings showed that ACT is a benign entity and does not require surgical resection except for symptomatic cases. Intracystic pancreatic intraepithelial neoplasia (PanIN) and driver mutations were rare, suggesting the need for preoperative diagnosis and long-term follow-up of ACT.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Medicine, General & Internal
Sang-Woo Ha, Shin Hwang, Hyejin Han, Song Ie Han, Seung-Mo Hong
Summary: This case report presents a patient with mucinous cystic neoplasm of the liver who had a successful outcome after surgical resection.
JOURNAL OF YEUNGNAM MEDICAL SCIENCE
(2022)
Article
Surgery
Jin Uk Choi, Shin Hwang, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Jae Seung Kim, Seung-Mo Hong
Summary: IPNB-L is a rare type of biliary neoplasm ranging from benign disease to invasive carcinoma. FDG-PET SUVmax cutoff of 3.0 effectively discerns high-grade neoplasia/carcinoma from low-grade neoplasia, assisting in surgical strategy for these cases.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)
Article
Surgery
Minjae Kim, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Seung-Mo Hong
Summary: This study investigated the effects of cHCC-CC histology, according to the 2010 WHO classification, on patient prognosis. The results showed that postresection outcomes are better in patients with SC-type cHCC-CC compared to those with classical-type cHCC-CC.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Surgery
Byeong-Gon Na, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Seung-Mo Hong, Sung-Gyu Lee
Summary: This study evaluated the outcomes of hepatic resection in patients with epithelioid hemangioendothelioma (EHE), a rare primary liver tumor often misdiagnosed as a metastatic tumor. The results showed that tumor size >_ 4 cm was significantly associated with tumor recurrence.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
