Article
Cell Biology
Yunzhong Zhang, Ketao Jiang, Guoqing Xie, Jie Ding, Su Peng, Xiaoyu Liu, Cheng Sun, Xin Tang
Summary: FGF21, as a metabolic stress hormone mainly secreted by the liver, has been shown to act as a negative regulator for the myelin development process in the peripheral nervous system (PNS) by activating p38 MAPK/c-Jun signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nur Aziz, Eunji Kim, Yanyan Yang, Han Gyung Kim, Tao Yu, Jae Youl Cho
Summary: Our study found that sodium orthovanadate (SO) suppressed the production of prostaglandin E2 (PGE2) and the expression of COX-2 in LPS-stimulated macrophages. Additionally, SO promoted c-Jun degradation through hyperphosphorylation of p38, which is linked to the suppression of PGE2 secretion in inflammatory responses.
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Cardiac & Cardiovascular Systems
Jing Tan, Wei Gao, Wanchao Yang, Xianzhang Zeng, Linlin Wang, Xiaoguang Cui
Summary: JNK1 exacerbates ischemia-reperfusion injury in lung transplantation, while JNK2 alleviates it. JNK1 silencing attenuates lung graft dysfunction by inhibiting inflammation and apoptosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Lesley Jia Wei Pua, Chun-Wai Mai, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Chee-Onn Leong, Wei-Meng Lim, Ling-Wei Hii
Summary: JNK and p38 MAPK signaling pathways play important roles in nasopharyngeal carcinoma (NPC), promoting tumor processes such as cell proliferation, apoptosis, inflammation, metastasis, and angiogenesis. Although the underlying mechanisms are not fully understood, further research on JNK and p38 MAPK could provide important insights for diagnosis, prognosis, and treatment decision-making in NPC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Biochemistry & Molecular Biology
Masashi Okada, Yurika Nakagawa-Saito, Yuta Mitobe, Asuka Sugai, Keita Togashi, Shuhei Suzuki, Chifumi Kitanaka
Summary: Glioma stem cells (GSCs) play a critical role in the malignancy of glioblastoma multiforme (GBM) by resisting therapy and promoting tumor initiation. This study reveals that phospholipase C (PLC) epsilon is highly expressed in GSCs and maintains their stemness and survival capacity through the activation of JNK pathway. PLC epsilon may serve as a promising therapeutic target for GSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Ping Zhong, Zhongneng Xu, Wei Chen, Kai Peng, Yuping Sun, Xiaopeng Wu, Huiming Sun, Xiaoying Chen, Peng Luo, Chaozheng Li, Huo Li, Wen Huang
Summary: 9C-Jun NH2-terminal kinase (JNK)-interacting protein 4 (JIP4) is identified and characterized in Litopenaeus vannamei, serving as an essential component in organizing and linking the MAPK pathway. Lv-JIP4 is widely expressed in various tissues, with high levels in muscle, and plays a potential role in activating and phosphorylating Lv-p38(MAPK) in response to low-temperature stress.
AQUACULTURE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Hyunwook Cho, Jung-Mi Hah
Summary: JNK3 plays a crucial role in neurodegenerative diseases, and this study summarizes the research on JNK3 inhibitors, focusing on structural and docking insights.
Article
Virology
Shumin Li, Siying Liu, Rui Ai Chen, Mei Huang, To Sing Fung, Ding Xiang Liu
Summary: This study reveals that coronavirus infection induces the expression of ZFP36, an anti-inflammatory protein, and promotes the degradation of transcripts coding for IL-6 and IL-8, as well as other proteins related to inflammation. The p38 MAP kinase and its upstream kinase MKK3, as well as downstream kinase MK2, play a regulatory role in the upregulation of ZFP36 during coronavirus infection. This MKK3-p38-MK2-ZFP36 axis could be a potential therapeutic target for severe coronavirus infections.
JOURNAL OF VIROLOGY
(2022)
Article
Environmental Sciences
Caiyun Lai, Fan Wu, Yan Wang, Wei Wang, Yueqi Li, Gaoqiang Zhang, Jianji Gao, Zhiliang Zhu, Jianhui Yuan, Jianping Yang, Wenjuan Zhang
Summary: TCE exposure can cause DNA hypomethylation and histone hyperacetylation in cells, leading to increased protein levels of tumor-related genes and inhibiting cell growth. These changes could serve as early biomarkers for TCE-associated diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Jake W. Willows, Gilian Gunsch, Emma Paradie, Magdalena Blaszkiewicz, Jeffrey R. Tonniges, Maria F. Pino, Steven R. Smith, Lauren M. Sparks, Kristy L. Townsend
Summary: Peripheral neuropathy, including axonal degeneration and demyelination, affects adipose tissues in obesity, diabetes, and aging. This study investigated the presence of demyelinating neuropathy in adipose tissue and found that adipose tissue contains myelinated and unmyelinated nerves populated by Schwann cells (SCs), which play a role in nerve regeneration. The study also showed that SCs in adipose tissue become dysregulated in diabetic peripheral neuropathy.
Article
Cardiac & Cardiovascular Systems
Yan Xiao, Chenglei Su, Guozhen Zhang, Lian Liang, Tao Jin, Jennifer Bradley, Joseph P. Ornato, Wanchun Tang
Summary: Vitamin C improves the recovery of myocardial and cerebral functions, reduces post-resuscitation inflammatory response and oxidative stress, and protects the integrity of the vascular endothelium.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Zhigang Fang, Hyeong-Geug Kim, Menghao Huang, Kushan Chowdhury, Ming O. Li, Suthat Liangpunsakul, X. Charlie Dong
Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Moli Zhu, Qianqian Niu, Jie Zhang, Yanan Yu, Huanhuan Wang, Tiantian Zhu, Ge Wang, Lin Yang, Yaling Yin, Peng Li
Summary: This study found that amorphous selenium nanodots (A SeNDs) can alleviate non-alcoholic fatty liver disease (NAFLD) by reducing hepatocyte steatosis and maintaining liver tissue structure through relieving oxidative stress and inflammatory reactions. The mechanism involves the inhibition of JNK/p38 MAPK pathways after activating VEGFR1 in the liver of rats with NAFLD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Surgery
Jordan N. Robinson, Joshua M. K. Davis, Ryan C. Pickens, Allyson R. Cochran, Lacey King, Patrick Salibi, David A. Iannitti, John B. Martinie, Erin H. Baker, Lee M. Ocuin, Dionisios Vrochides
Summary: Advances in perioperative care have increased the frequency of surgical intervention in patients aged 80 and above. This study investigates the impact of Enhanced Recovery After Surgery (ERAS) on octogenarians undergoing major hepatopancreatobiliary (HPB) surgery. The findings suggest that ERAS implementation in HPB surgery for patients aged 80 and above is safe and may lead to reduced readmissions, with no significant difference in postoperative complications, mortality, and length of stay compared to pre-ERAS cases.
Article
Oncology
Lauren F. Huang, Augustine Hong, Gino Cioffi, Asrar Alahmadi, Tin-Yun Tang, Lee M. Ocuin, Nirav Patil, David L. Bajor, Joel N. Saltzman, Amr Mohamed, Eva Selfridge, Monica Webb Hooper, Jill Barnholtz-Sloan, Richard T. Lee
Summary: This study revealed that Hispanic patients with high-risk BTC are significantly less likely to receive NCCN-concordant treatment compared to White patients. Disparities were observed in insurance coverage and treatment facility utilization among Hispanic patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mohamedraed Elshami, Richard Hoehn, Jonathan J. Hue, Luke Rothermel, Kenneth D. Chavin, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
Summary: The study found that Medicaid expansion (ME) is associated with the diagnosis, treatment, and survival of patients with hepatocellular carcinoma (HCC). Prior to ME, there was no association between future ME status and diagnosis or treatment of early HCC, but patients in future ME states had a lower risk of death. After ME, patients in ME states were more likely to be diagnosed with early HCC and undergo resection or transplantation, resulting in a further decrease in the hazard of death.
Article
Gastroenterology & Hepatology
Mohamedraed Elshami, Jonathan J. Hue, Fasih Ali Ahmed, Hanna Kakish, Richard S. Hoehn, Luke D. Rothermel, Jeffrey M. Hardacre, John B. Ammori, Jordan M. Winter, Lee M. Ocuin
Summary: This study found that a minimum threshold of at least seven resections per year in medical facilities has a significant impact on the outcomes of patients undergoing resection for perihilar cholangiocarcinoma. Patients treated in facilities meeting or exceeding this threshold had lower 90-day mortality, shorter length of stay, lower rate of positive surgical resection margins, and higher lymph node yields. However, there was no impact on lymph node positivity, 30-day mortality, or re-admission.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Christina S. Boutros, Jonathan J. Hue, Mohamedraed Elshami, Luke D. Rothermel, Richard S. Hoehn, John B. Ammori, Jordan M. Winter, Lee M. Ocuin, Jeffrey M. Hardacre
Summary: Age is a key factor in determining the management of adenocarcinoma of the pancreatic tail. Surgical resection plays an important role in managing this cancer, but there is a substantial risk. Shared decision making is needed to balance the chance for long-term survival with the risk of early mortality.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kelly Hoerger, Jonathan J. Hue, Mohamedraed Elshami, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
Summary: The study determined the optimal volume threshold for postoperative mortality after hepatectomy to be at least 46 liver operations per year. Regionalization of surgical care among patients with primary liver malignancies to high-volume centers may result in improved outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Editorial Material
Surgery
Lee M. Ocuin
Article
Surgery
Mohamedraed Elshami, Fasih Ali Ahmed, Jonathan J. Hue, Hanna Kakish, Richard S. Hoehn, Luke D. Rothermel, David Bajor, Amr Mohamed, J. Eva Selfridge, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
Summary: This study examined the impact of total institutional volume on survival outcomes of patients with nonresected hepatobiliary malignancies. It found that nonoperatively managed patients with hepatocellular carcinoma or biliary tract cancer treated at higher-volume facilities had improved survival outcomes, suggesting regionalization of care to high-volume centers may improve survival.
Article
Gastroenterology & Hepatology
Mohamedraed Elshami, Fasih A. Ahmed, Hanna Kakish, Jonathan J. Hue, Richard S. Hoehn, Luke D. Rothermel, David Bajor, Amr Mohamed, Jennifer E. Selfridge, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
Summary: This study examined the utilization of systemic chemotherapy in patients with metastatic hepatocellular carcinoma (HCC), biliary tract cancers (BTC), and pancreatic adenocarcinoma (PDAC). The results showed that age and Charlson-Deyo score were associated with lower likelihood of receiving chemotherapy, while private health insurance and treatment at high-volume facilities increased the chances of receiving chemotherapy.
Article
Biotechnology & Applied Microbiology
Kevin P. Labadie, Shannon A. Kreuser, Katherine J. Brempelis, Sara K. Daniel, Xiuyun Jiang, Kevin M. Sullivan, Alan F. Utria, Heidi L. Kenerson, Teresa S. Kim, Courtney A. Crane, Venu G. Pillarisetty
Summary: Although IL-10 can promote effector T-cell function, its overall effect in the tumor microenvironment appears to be suppressive. Thus, blocking IL-10 has therapeutic potential for enhancing antitumor immune function. Using genetically engineered macrophages (GEMs) as delivery vehicles, researchers created IL-10-blocking antibodies and demonstrated their efficacy in tumor models. The GEMs produced sustained levels of the antibody and led to a significantly higher rate of tumor cell apoptosis.
CANCER GENE THERAPY
(2023)
Editorial Material
Surgery
Lee M. Ocuin
Article
Oncology
Kristin G. Anderson, David A. Braun, Aitziber Buque, Sarah B. Gitto, Jennifer L. Guerriero, Brendan Horton, Bridget P. Keenan, Teresa S. Kim, Abigail Overacre-Delgoffe, Marco Ruella, Todd A. Triplett, Omkara Veeranki, Vivek Verma, Fan Zhang
Summary: Anticancer immunotherapies have shown improved outcomes in patients with various malignancies, but many patients do not respond or have durable responses due to immune resistance mechanisms. These mechanisms vary among patients with the same cancer type and involve multiple cell types. Advanced tumor profiling technologies can define immune resistance pathways, which can be used to categorize cancers into immune resistance archetypes. Targeted therapies addressing multiple cell axes and suppressive mechanisms based on these archetypes may improve efficacy and outcomes for individual patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Amr Mohamed, Sylvia Asa, Thomas S. McCormick, Hilmi Al-Shakhshir, Arvind Dasari, Mauricio Retuerto, Iman Salem, Lee Ocuin, David Bajor, Richard Lee, Eva Selfridge, Arash Kardan, Lee Zhenghong, Norbert Avril, Shelby Kopp, Jordan Winter, Jeffrey Hardacre, John Ammori, Mahmoud Ghannoum
Article
Biochemistry & Molecular Biology
Amr Mohamed, Sylvia L. Asa, Thomas McCormick, Hilmi Al-Shakhshir, Arvind Dasari, Retuerto Mauricio, Iman Salem, Lee M. Ocuin, David Bajor, Richard T. Lee, J. Eva Selfridge, Arash Kardan, Zhenghong Lee, Norbert Avril, Shelby Kopp, Jordan M. Winter, Jeffrey M. Hardacre, John B. Ammori, Mahmoud A. Ghannoum
Summary: The balance of gut microbiome is crucial for human health and the integrity of the gut barrier. Dysbiosis, characterized by impaired gut microbiome, is associated with various diseases, including cancers, through modulation of inflammation. However, limited research has been conducted on the gut microbiome in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we analyzed the gut microbiome, including both bacterial and fungal communities, in patients with metastatic GEP-NENs. We found significant differences in the gut microbiome between GEP-NENs and control samples, as well as between different subtypes of GEP-NENs. The results also showed associations between the gut microbiome and behavioral, dietary, and tumor features. This study highlights the importance of the gut microbiome in GEP-NENs and provides insights into the pathogenesis of these diseases.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Meeting Abstract
Oncology
Henry J. Stitzel, Jonathan J. Hue, Mohamedraed Elshami, Richard Hoehn, Luke Rothermel, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter, Lee M. Ocuin
ANNALS OF SURGICAL ONCOLOGY
(2022)