Article
Agriculture, Dairy & Animal Science
Lea Middendorf, Marion Schmicke, Kristian Duengelhoef, Erwin Sieverding, Heinrich Windhaus, Dieter Mischok, Dimitri Radko, Christian Visscher
Summary: Hepatic lipidosis (HL) in fattening turkeys is a well-known disease, but the exact cause and pathogenesis remain unclear. A recent study found high levels of iron in liver tissue of turkeys with HL, suggesting potential malnutrition/starvation and severe liver damage.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Medicine, Research & Experimental
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Shao Li, Gongbo Fu, Min Zeng, Yi Gao
Summary: The study utilized a fiber scaffold bioreactor for high-density, 3D culture of porcine hepatocytes to construct a bioartificial liver and evaluated its protective effects in an ALF porcine model. The bioartificial liver treatment enhanced liver regeneration, alleviated systemic inflammatory response, and reduced extrahepatic organ injury, leading to prolonged survival in the ALF model.
Article
Immunology
Ying Yuan, Qin Zhang, Bingfeng Wu, Tianyu Huang, Ping Gong, Lin Xiang
Summary: This study aimed to investigate the influence and mechanisms of Oncostatin M (OSM) on macrophage polarization. The results showed that OSM could inhibit M1 polarization and promote M2 polarization, and it induced the expression of osteogenic-related factors through the Hippo-YAP pathway. Understanding the role and mechanism of OSM in macrophage polarization around dental implants is clinically significant.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macias-Rodriguez, Astrid Ruiz-Margain, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P. A. Ebert, Heike Bantel, Enrico De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding, Hong-Lei Weng
Summary: The study found that the expression of HNF4 alpha in liver progenitor cells (LPCs) is crucial for determining the clinical outcomes of patients with acute liver failure (ALF). Recovered patients with ALF show normal coagulation function, while those requiring liver transplantation demonstrate abnormal activin/follistatin ratio.
Article
Multidisciplinary Sciences
Atsushi Miura, Takashi Hosono, Taiichiro Seki
Summary: Depleting macrophages can suppress tissue remodeling and partially delay cell proliferation during regeneration after acute liver injury. Inhibiting tissue remodeling caused by depleted macrophages can delay the recovery of metabolic functions, indicating that liver injury affects liver metabolism.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Katia Sayaf, Daniela Gabbia, Francesco Paolo Russo, Sara De Martin
Summary: This review provides an update on the recent advances in understanding the molecular basis of gender differences in both acute and chronic liver damage. Experimental studies on animal models and clinical observations were included, investigating acute liver failure such as drug-induced liver injury, and chronic liver diseases including viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver diseases, and hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Medicine, General & Internal
Theoharis C. Theoharides, Irene Tsilioni
Summary: The article points out that mast cells, as a unique tissue immune cell, can orchestrate the immune response by secreting proinflammatory molecules. It highlights the degranulation of mast cells in the lungs of deceased patients with severe Covid-19, as well as the elevated levels of mast cell-derived proteolytic enzymes in patients' serum.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Oncology
Alessandra Caligiuri, Stefano Gitto, Giulia Lori, Fabio Marra, Maurizio Parola, Stefania Cannito, Alessandra Gentilini
Summary: Pro-inflammatory cytokines play a key role in the development of liver cancer, with OSM playing a significant role. IL-6 type cytokines operate through the gp130 and JAK/STAT signaling pathways. Although therapeutic approaches for HCC and CCA have been implemented, there are limited treatment options. We discuss the potential of selectively inhibiting OSM-related pathways for the treatment of liver malignancies.
Article
Cell Biology
Robert Chevreau, Hussein Ghazale, Chantal Ripoll, Chaima Chalfouh, Quentin Delarue, Anne Laure Hemonnot-Girard, Daria Mamaeva, Helene Hirbec, Bernard Rothhut, Shalaka Wahane, Florence Evelyne Perrin, Harun Najib Noristani, Nicolas Guerout, Jean Philippe Hugnot
Summary: Ependymal cells in the adult spinal cord activate multiple signaling pathways after injury, downregulate cilia-associated genes, upregulate various genes including Osmr, and the Osmr receptor Oncostatin may regulate the fate of ependymal cells towards astrocytic differentiation by affecting cell proliferation and differentiation.
Article
Engineering, Biomedical
Chenyue Zhan, Guifang Lin, Yong Huang, Ziqian Wang, Fang Zeng, Shuizhu Wu
Summary: This study demonstrates a diselenide-based nanodrug for the treatment of acute liver failure by inhibiting NLRP3 inflammasome activation and enhancing liver regeneration. The nanodrug accumulates in the liver of ALF mice upon administration and releases beneficial drug components. Multiple contrast agents have been loaded onto the nanodrug for imaging purposes.
Review
Biochemistry & Molecular Biology
Jake P. Mann, Dominic Lenz, Zania Stamataki, Deirdre Kelly
Summary: Acute liver failure (ALF) is a rare but potentially fatal disease in children with multifactorial etiology and diverse mechanisms. Understanding the activation and regulation of immune systems and apoptotic pathways can lead to better diagnosis, management, and outcomes in pediatric ALF patients.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yang Chen, Sirong Shi, Bo Li, Tian Lan, Kefei Yuan, Jingsheng Yuan, Yongjie Zhou, Jiulin Song, Tao Lv, Yujun Shi, Bo Xiang, Taoran Tian, Tao Zhang, Jiayin Yang, Yunfeng Lin
Summary: This study explores the effects of tetrahedral framework nucleic acids (TFNAs) on hepatocyte proliferation and liver regeneration. It demonstrates that TFNA can promote hepatocyte proliferation and enhance liver regeneration by activating specific signaling pathways. The results suggest that TFNA shows potential as an effective therapeutic agent for treating acute liver injury, preventing the progression to acute liver failure and reducing mortality rate.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Gastroenterology & Hepatology
Oliver D. Tavabie, Constantine J. Karvellas, Siamak Salehi, Jaime L. Speiser, Christopher F. Rose, Krishna Menon, Andreas Prachalias, Michael A. Heneghan, Kosh Agarwal, William M. Lee, Mark J. W. McPhail, Varuna R. Aluvihare
Summary: The study demonstrates that combining regeneration-linked microRNA signatures with clinical parameters can outperform existing prognostic models for APAP-ALF, improving identification of patients with poor prognosis who may benefit from transplantation.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Eline Geervliet, Leon W. M. M. Terstappen, Ruchi Bansal
Summary: This study investigated the effects of exogenous FGF7 on hepatocyte survival and proliferation, as well as on macrophage-induced inflammation and HSCs activation in acute liver injury. The results showed that exogenous FGF7 can promote hepatocyte survival and proliferation, and reduce inflammation and fibrosis in acute liver injury through paracrine mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Deepanshu Maheshwari, Dhananjay Kumar, Rakesh Kumar Jagdish, Nidhi Nautiyal, Ashinikumar Hidam, Rekha Kumari, Rashi Sehgal, Nirupama Trehanpati, Sukriti Baweja, Guresh Kumar, Swati Sinha, Meenu Bajpai, Viniyendra Pamecha, Chhagan Bihari, Rakhi Maiwall, Shiv Kumar Sarin, Anupam Kumar
Summary: Monocyte dysfunction and bioenergetic failure are observed in acute-on-chronic liver failure (ACLF). Umbilical cord mesenchymal stem cells (ucMSCs) can resuscitate monocyte energy and prevent exhaustion, leading to improved liver injury and regeneration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hui Ye, Chaobo Chen, Hanghang Wu, Kang Zheng, Beatriz Martin-Adrados, Esther Caparros, Ruben Frances, Leonard J. Nelson, Manuel Gomez del Moral, Iris Asensio, Javier Vaquero, Rafael Banares, Matias A. Avila, Raul J. Andrade, M. Isabel Lucena, Maria Luz Martinez-Chantar, Helen L. Reeves, Steven Masson, Richard S. Blumberg, Jordi Gracia-Sancho, Yulia A. Nevzorova, Eduardo Martinez-Naves, Francisco Javier Cubero
Summary: The mechanisms underlying acetaminophen hepatotoxicity-induced endoplasmic reticulum stress are still not fully understood, but inhibiting XBP1 and enhancing autophagy may help ameliorate liver injury.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Jose J. G. Marin, Maria Reviejo, Meraris Soto, Elisa Lozano, Maitane Asensio, Sara Ortiz-Rivero, Carmen Berasain, Matias A. Avila, Elisa Herraez
Summary: This article discusses the impact of alternative splicing on liver carcinogenesis and the development of malignant characteristics of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Understanding these impacts is crucial for developing novel therapeutic approaches that can manipulate the phenotype of cancer cells.
Article
Oncology
Chaobo Chen, Hanghang Wu, Hui Ye, Agustin Tortajada, Sandra Rodriguez-Perales, Raul Torres-Ruiz, August Vidal, Maria Isabel Peligros, Johanna Reissing, Tony Bruns, Mohamed Ramadan Mohamed, Kang Zheng, Amaia Lujambio, Maria J. Iraburu, Leticia Colyn, Maria Ujue Latasa, Maria Arechederra, Maite G. Fernandez-Barrena, Carmen Berasain, Javier Vaquero, Rafael Banares, Leonard J. Nelson, Christian Trautwein, Roger J. Davis, Eduardo Martinez-Naves, Yulia A. Nevzorova, Alberto Villanueva, Matias A. Avila, Francisco Javier Cubero
Summary: This study reveals the contribution of unfolded protein response activation and liver tissue scarring to the development of polycystic liver disease (PLD) and early cancer. The mutant mice used in this study serve as an ideal tool for investigating PLD and early cancer development. The findings suggest that activation of unfolded protein response and fibrosis may trigger the formation of hepatic cysts and early stages of cholangiocarcinoma (CCA).
Editorial Material
Gastroenterology & Hepatology
Alex Claveria-Cabello, Maite G. Fernandez-Barrena, MATiAS A. Avila
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Ruben Hernaez, Matias A. Avila
Review
Gastroenterology & Hepatology
Rocio I. R. Macias, Vincenzo Cardinale, Timothy J. Kendall, Matias A. Avila, Maria Guido, Cedric Coulouarn, Chiara Braconi, Adam E. Frampton, John Bridgewater, Diletta Overi, Stephen P. Pereira, Marco Rengo, Jakob N. Kather, Angela Lamarca, Federica Pedica, Alejandro Forner, Juan W. Valle, Eugenio Gaudio, Domenico Alvaro, Jesus M. Banales, Guido Carpino
Summary: This paper discusses the clinical role of tissue biomarkers in cholangiocarcinoma (CCA) and provides an update on recent advances and future research directions in this field.
Article
Medicine, Research & Experimental
Mandy Schott, Melanie Kappelmann-Fenzl, Stefan Fischer, Maite G. Fernandez-Barrena, Antonio Pineda-Lucena, Matias A. avila, Silke Kuphal, Anja-Katrin Bosserhoff
Summary: The tumor suppressive function of CYLD has been identified in melanoma, but the precise molecular mechanism remains unclear. This study generated a novel melanoma mouse model and found that CYLD plays a role in chromatin structure formation through histone methylation. These findings reveal a new role of CYLD in melanoma progression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Immunology
Simon Melderis, Matthias T. Warkotsch, Julien Dang, Julia Hagenstein, Laura-Isabell Ehnold, Georg R. Herrnstadt, Christoph B. Niehus, Frederic C. Feindt, Dominik Kylies, Victor G. Puelles, Carmen Berasain, Matias A. Avila, Katrin Neumann, Gisa Tiegs, Tobias B. Huber, Pierre-Louis Tharaux, Oliver M. Steinmetz
Summary: Systemic lupus erythematosus (SLE) is a common autoimmune disorder, with lupus nephritis (LN) being a frequent and difficult to treat complication. This study identified the multifunctional cytokine AREG as an anti-inflammatory mediator in LN, suppressing pathogenic T cell immunity. These findings highlight the potential of the AREG/EGFR axis as a therapeutic target.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Oncology
Miriam Recalde, Maria Garate-Rascon, Jose Maria Herranz, Maria Elizalde, Maria Azkona, Juan P. Unfried, Loreto Boix, Maria Reig, Bruno Sangro, Maite G. Fernandez-Barrena, Puri Fortes, Matias A. Avila, Carmen Berasain, Maria Arechederra
Summary: This study identifies a set of lncRNAs that are significantly downregulated in hepatocellular carcinoma (HCC) and are related to tumor dedifferentiation and patients' prognosis. Mechanistically, these lncRNAs are involved in hepatic differentiation and their expression is silenced by DNA methylation in HCC. These findings provide insights into the progression of liver cancer and potential new biomarkers.
Review
Biochemistry & Molecular Biology
Maria Garate-Rascon, Miriam Recalde, Carla Rojo, Maite G. Fernandez-Barrena, Matias A. Avila, Maria Arechederra, Carmen Berasain
Summary: SLU7 is a splicing factor that affects the diversity of gene transcripts and serves as an integrative hub for gene expression regulation. It plays critical roles in liver differentiation, genome integrity, and cell cycle progression. Aberrant expression of SLU7 may be associated with human diseases including cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Carmen Berasain, Maria Arechederra, Josepmaria Argemi, Maite G. Fernandez-Barrena, Matias A. Avila
Summary: The identity of adult hepatocytes is established during embryonic development and regulated after birth. Transcription factors and pre-mRNA splicing regulators play a crucial role in defining the transcriptome, which determines the complex functions of the liver. Persistent downregulation of key identity genes is a major factor in chronic liver disease and organ dysfunction. Therefore, understanding the disruption of core transcription factors and splicing regulators in diseased hepatocytes is clinically important.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Matias A. Avila
Editorial Material
Gastroenterology & Hepatology
Francisco Javier Cubero, Pablo Sarobe, Gisa Tiegs
Editorial Material
Biochemistry & Molecular Biology
Maite G. Fernandez-Barrena, Matias A. Avila
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)