Journal
JOURNAL OF HEPATOLOGY
Volume 49, Issue 5, Pages 688-694Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2008.03.028
Keywords
HBV/HCV co-infection; Peginterferon-a2b; Ribavirin; Hepatitis C clearance
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Funding
- Federal Ministry for Education and Research
- Essex -Pharma, Germany
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Background/Aims:The efficacy of pegylated interferon alpha and ribavirin in HBV/HCV co-infected patients is unknown. Methods: Nineteen patients with chronic HBV/HCV co-infection (HBsAg and HCV-RNA positive; 10 HCV-genotype 1;9 HCV-genotype 2 or 3) were included in this prospective multicenter pilot study. Baseline HBV-DNA was negative in 13 individuals. All patients received weight-adjusted PEG-IFN-alpha 2b and ribavirin for 48 weeks. Results: In the intent-to-treat analysis, a biochemical and an HCV-RNA response were observed in 12 and 14 patients, respectively (63 % and 74 %). At the end of the treatment as well as at the end of the follow-up the HCV-RNA response was 93 % (14/15) in patients adherent to therapy (86% in genotype 1 and 100% in genotypes 2 and 3 infection). Two of the five initially HBV-DNA positive patients with follow-up available were HBV-DNA negative at follow-up week 24. In contrast, HBV-DNA became detectable after the clearance of HCV in four initially HBV-DNA negative patients. Conclusions: Combination therapy with PEG-IFN-a2b and ribavirin is highly effective in inducing a virological response concerning HCV in patients with HBV/HCV co-infection. However, HBV replication may increase after the clearance of HCV and thus close monitoring for both the viruses is recommended even in patients with initially undetectable HBV-DNA. (C) 2008 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.
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