Article
Surgery
Kelly T. Wagner, Jason Zimmermann, Lila Brody, Fred Brody
Summary: Management of symptomatic pancreatic pseudocysts sometimes requires laparoendoscopic techniques when endoscopic management is not available or fails. This approach can provide patients with the same clinical benefits as an endoscopic approach.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Patrick L. Quinn, Shefali Bansal, Ashley Gallagher, Ravi J. Chokshi
Summary: The study suggests that endoscopic drainage should be considered as the first-line therapy for the treatment of symptomatic pancreatic pseudocysts, as it provides better effectiveness and cost savings.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Gastroenterology & Hepatology
Wenzhen Hao, Yunli Chen, Yu Jiang, Aiming Yang
Summary: The study compared the efficacy and safety of endoscopic treatment and laparoscopic treatment for pancreatic pseudocysts (PPCs) in 301 participants. Results showed that there were no significant differences in treatment success rate, adverse events, or recurrence between the two treatments. However, the endoscopic group had shorter operation time, less intraoperative blood loss, and shorter hospital stay compared to the laparoscopic group.
Review
Gastroenterology & Hepatology
Wenzhen Hao, Yunli Chen, Yu Jiang, Aiming Yang
Summary: The study found that there was no significant difference in treatment success, adverse events, and recurrence rates between endoscopic and laparoscopic treatment for pancreatic pseudocysts (PPCs). However, the endoscopic treatment group had significantly shorter operation time, less intraoperative blood loss, and shorter hospital stay.
Article
Gastroenterology & Hepatology
Dora Czapari, Alex Varadi, Nelli Farkas, Gergely Nyari, Katalin Marta, Szilard Vancsa, Rita Nagy, Brigitta Teutsch, Stefania Bunduc, Balint Eross, Laszlo Czako, Aron Vincze, Ferenc Izbeki, Maria Papp, Bela Merkely, Peter Hegy
Summary: Patients discharged after acute pancreatitis (AP) face a significant risk of mortality and morbidity. Age, comorbidities, and severity are the most significant independent risk factors for death after AP. Cardiac failure and AP-related sepsis are the main causes of death in the first 90-day period after discharge.
Article
Medicine, Research & Experimental
Xiaobing Cui, Wen Xu, Yingchun Zhang, Fang Wang, Pei Guo, Wei Gong
Summary: Autoimmune pancreatitis (AIP) is a unique form of pancreatitis characterized by infiltration of immunoglobulin G4-positive cells, pancreatic duct narrowing, and swollen pancreas. While AIP typically responds well to steroid treatment, complications such as pseudocysts and pancreatic calculi are rare but should be carefully monitored, especially in cases of disease relapse.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Emergency Medicine
Pujitha Kudaravalli, Nikita Garg, Venkata Satish Pendela, Harvir Singh Gambhir
Summary: Pancreatic pseudocysts are common complications in both acute and chronic pancreatitis, with a higher prevalence in chronic pancreatitis, especially in alcoholic patients. Hemorrhagic pseudocyst is a rare but potentially lethal complication of pancreatic pseudocysts, requiring various diagnostic modalities for diagnosis and treatment. Early recognition and treatment are crucial due to a mortality rate of up to 40%.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Nian-Jun Xiao, Ting-Ting Cui, Fang Liu, Wen Li
Summary: Pancreatic and peripancreatic collections are common local complications of acute pancreatitis, which can develop into pancreatic pseudocyst or walled-off necrosis. Minimally invasive treatments, especially endoscopic techniques, have become the standard for severe complications, although complications such as pancreatic fistulae or stent-related issues should not be overlooked.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Medicine, Research & Experimental
Jonathan Hartanto Tan, Wenjie Chin, Abdul Lateef Shaikh, Shusen Zheng
Summary: Advances in radiological techniques have led to an increase in the diagnosis of pancreatic pseudocysts. Historically, management of pancreatic pseudocyst has been achieved through conservative treatments and surgery, but due to complications and recurrence rate, management of pancreatic pseudocyst is challenging. Surgeons and gastroenterologists are currently attempting to determine the optimal management technique to reduce complications and recurrence rate.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Medicine, General & Internal
Kittane Vishnupriya, Arjun Chanmugam
Summary: Management of acute pancreatitis and its complications has undergone rapid evolution, with a shift from prolonged bowel rest, empiric IV antibiotics, and early surgical intervention to early feeding, judicious antibiotic use, and delayed invasive interventions. Minimally invasive techniques are preferred even in complex cases.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Mohim Thakur, Ajay K. Dhiman
Summary: Pancreatic pseudocyst (PPC) and walled-off necrosis (WON)are late complications of acute pancreatitis that historically require surgical management. With advancements in endoscopic equipment, transmural endoscopic drainage has become a preferred method for treating PPC. Limited studies have compared laparoscopic and endoscopic drainage, often including PPC and WON together. There is a lack of specific recommendations and well-designed clinical trials comparing these two modalities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Anna C. Lilly, Igor Astsaturov, Erica A. Golemis
Summary: Pancreatic cancer is difficult to detect and treat, resulting in poor survival outcomes. The increasing incidence of this cancer is related to aging populations, obesity, and pancreatitis. Risk factors for pancreatic cancer include signaling from fat cells, elevated levels of intrapancreatic adipocytes, inflammation from immune cells, and fibrosis caused by pancreatic obstruction and cell lysis. Further studies are needed to understand the role of adipocytes in the pre-cancerous niche and their implications in mouse models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jingxin Yan, Zheheng Zhang, Zhixin Wang, Wenhao Yu, Xiaolei Xu, Yaxuan Wang, Haining Fan
Summary: Pancreatic divisum is a condition caused by the lack of fusion of the pancreatic duct during embryonic development. Clinicians may lack understanding of the disease due to its asymptomatic nature. Diagnosis typically involves magnetic resonance cholangiopancreatography, with treatment options including endoscopic retrograde cholangiopancreatography and stent implantation.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Surgery
Muhammad Bassel Darwish, Shankar Logarajah, Patrick James McLaren, Beatrice Campilan, Annie Laurie Benzie, Edward Cho, Houssam Osman, D. Rohan Jeyarajah
Summary: Background: Pancreatic-enteric drainage procedures are commonly used for the treatment of pancreatic pseudocysts and walled-off pancreatic necrosis. However, the need for pancreatic resection after cyst-enteric drainage procedure in case of recurrence is not well studied. This study aimed to determine the percentage of patients requiring resection due to recurrence after surgical cystogastrostomy and identify predictors of drainage failure. Methods: A retrospective review was conducted on patients who underwent surgical cystogastrostomy between 2012 and 2020. The characteristics of patients, their diseases, and treatment were identified. Failure of surgical drainage was defined as the need for subsequent pancreatic resection due to recurrence. Results: Out of the 24 cystogastrostomies performed, 3 patients (12.5%) required a subsequent distal pancreatectomy after surgical drainage. There was no significant difference in comorbidities between the drainage alone group and the failure of drainage group. However, there seemed to be a trend suggesting that smaller cyst size may be associated with cystgastrostomy failure. Conclusion: Surgical pancreatic drainage was successful in managing pancreatic fluid collections initially. The study did not identify any predictors of failure of initial drainage. Resection with distal pancreatectomy for walled-off pancreatic necrosis and pancreatic pseudocysts should be reserved for cases of drainage failure.
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2023)
Article
Surgery
Amrita Chawla, Faiz Afridi, Vishnu Prasath, Ravi Chokshi, Sushil Ahlawat
Summary: This study compared the outcomes of laparoscopic, percutaneous, and endoscopic drainage for pancreatic pseudocysts in inpatient stays. It found that endoscopic and laparoscopic drainage were associated with less short term complications and more favorable in-hospital outcomes compared to percutaneous drainage, which was the most commonly performed method in the 2017 NIS database.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Yazan S. Khaled, Deep J. Malde, Jessica Packer, Nicola De Liguori Carino, Rahul Deshpande, Derek A. O'Reilly, David J. Sherlock, Basil J. Ammori
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2015)
Article
Gastroenterology & Hepatology
Yazan S. Khaled, Muhammed Mohsin, Kavi Fatania, Ada Yee, Robert Adair, Maria Sheridan, Christian Macutkiewicz, Amer Aldouri, Andrew M. Smith
Review
Oncology
Belal Chaudhary, Yazan S. Khaled, Basil J. Ammori, Eyad Elkord
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2014)
Review
Cell Biology
Yazan S. Khaled, Basil J. Ammori, Eyad Elkord
IMMUNOLOGY AND CELL BIOLOGY
(2013)
Article
Orthopedics
Mohamed Abdulla, Yazan S. Khaled, Harish Kapoor
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2014)
Article
Orthopedics
Mohamed Abdulla, Sari S. Khaled, Yazan S. Khaled, Harish Kapoor
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2014)
Letter
Surgery
Yazan S. Khaled, Basil J. Ammori
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2014)
Article
Immunology
Yazan S. Khaled, Basil J. Ammori, Eyad Elkord
JOURNAL OF IMMUNOLOGY RESEARCH
(2014)
Article
Surgery
S. Lof, A. L. Moekotte, B. AlSarireh, B. Ammori, S. Aroori, D. Durkin, G. K. Fusai, J. J. French, D. Gomez, G. Marangoni, R. Marudanayagam, Z. Soonawalla, R. Sutcliffe, S. A. White, M. Abu Hilal, G. Spolentini, N. van Der Heijde, A. Kanwar, A. Schlegel, N. G. Mowbray, S. Rahman, I Kabir, M. Deakin, K. Bowling, Y. Khaled
BRITISH JOURNAL OF SURGERY
(2019)
Article
Nanoscience & Nanotechnology
Arindam Pramanik, Zexi Xu, Shazana H. Shamsuddin, Yazan S. Khaled, Nicola Ingram, Thomas Maisey, Darren Tomlinson, P. Louise Coletta, David Jayne, Thomas A. Hughes, Arwen I. I. Tyler, Paul A. Millner
Summary: Scientists have developed a targeted drug delivery system based on lyotropic liquid crystalline nanoparticles and demonstrated its high specificity and therapeutic efficacy for colorectal cancer through preclinical studies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Oncology
Nicole Lintern, Andrew M. Smith, David G. Jayne, Yazan S. Khaled
Summary: Pancreatic cancer is highly lethal with low survival rate. The resistance to current therapies is largely attributed to the dense tissue surrounding the cancer cells. Photodynamic therapy (PDT) has shown potential in killing pancreatic cancer cells and altering the surrounding tissue.
Article
Medicine, General & Internal
Michael Azzopardi, Tom Wallace, Yazan S. Khaled
Summary: Iliac artery-enteric fistula is a rare but life-threatening cause of lower GI bleeding, especially in patients with previous aortic surgery. This case study reports on the successful endovascular treatment of massive hemorrhage in a patient with aortoiliac graft-enteric fistula, followed by second-stage dacron graft explant and autologous vein reconstruction. Early recognition and multidisciplinary intervention are crucial in managing this condition.
CLINICAL CASE REPORTS
(2023)
Article
Oncology
May Abd Al Samid, Belal Chaudhary, Yazan S. Khaled, Basil J. Ammori, Eyad Elkord
Article
Surgery
Yazan S. Khaled, Basil J. Ammori
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2014)