Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Article
Multidisciplinary Sciences
Douglas V. N. P. Oliveira, Kira P. Prahm, Ib J. Christensen, Anker Hansen, Claus K. Hogdall, Estrid V. Hogdall
Summary: Gene expression profiling is an effective tool in exploring new molecular markers for ovarian cancer patients, with specific markers still needing further research on their association with patient survival and clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Leonor Drouin, Benedetta Guani, Vincent Balaya, Henri Azais, Sarah Betrian, Pierre-Adrien Bolze, Yohann Dabi, Yohan Kerbage, Claire Sanson, Patrice Mathevet, Fabrice Lecuru, Frederic Guyon, Cherif Akladios, Sofiane Bendifallah, Elise Deluche, Francois Zaccarini
Summary: The study aimed to assess current French practices in managing patients with advanced epithelial ovarian cancer. Results showed that less than 50% of patients were eligible for primary debulking surgery, there was a wide range in the timing of BRCA testing, and the use of bevacizumab varied depending on the presence of residual disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Reproductive Biology
Yi Hu, Kun Fu, Huining Liu, Qiongqiong He, Xiaoqin Qiu, Wenqing Yang, Yu Zhang
Summary: This study aimed to investigate whether ovarian seromucinous carcinoma truly represented a distinct category of ovarian tumors or an analogue of ovarian endometrioid carcinoma. Through the analysis of clinicopathological features and prognosis of 12 patients, it was found that ovarian seromucinous carcinoma and ovarian endometrioid carcinoma had significant differences in clinical characteristics and prognosis, indicating that direct classification of ovarian seromucinous carcinoma as ovarian endometrioid carcinoma is not appropriate.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ying-Cheng Chiang, Po-Han Lin, Tzu-Pin Lu, Kuan-Ting Kuo, Yi-Jou Tai, Heng-Cheng Hsu, Chia-Ying Wu, Chia-Yi Lee, Hung Shen, Chi-An Chen, Wen-Fang Cheng
Summary: Somatic mutations in DNA damage response genes are associated with increased risk of recurrence and tumor-related death in epithelial ovarian cancer patients. The highest percentage of DDR gene mutations was found in serous carcinoma patients, while lower percentages were observed in endometrioid and clear cell carcinoma patients.
Review
Oncology
Delphine Fessart, Jacques Robert, Cecile Hartog, Eric Chevet, Frederic Delom, Guillaume Babin
Summary: Epithelial ovarian cancer (EOC) is the most common gynecologic disorder and despite recent advances made in new therapeutics, it remains the most lethal gynecologic malignancy. The discovery of anterior gradient proteins AGR2 and AGR3, members of the protein disulfide isomerase (PDI) family, has attracted attention for their potential involvement in adenocarcinoma development. Understanding the role of the AGR family may offer new avenues for handling EOC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Marie Metairie, Louise Benoit, Meriem Koual, Enrica Bentivegna, Henri Wohrer, Pierre-Adrien Bolze, Yohan Kerbage, Emilie Raimond, Cherif Akladios, Xavier Carcopino, Geoffroy Canlorbe, Jennifer Uzan, Vincent Lavoue, Camille Mimoun, Cyrille Huchon, Martin Koskas, Helene Costaz, Francois Margueritte, Yohann Dabi, Cyril Touboul, Sofiane Bendifallah, Lobna Ouldamer, Nicolas Delanoy, Huyen-Thu Nguyen-Xuan, Anne-Sophie Bats, Henri Azais
Summary: This retrospective multicenter study assessed the prognostic impact of the FIGO staging classification and the initial metastatic location on survival in patients with ovarian cancer. The study found that patients with FIGO stage IVA had a worse prognosis than those with stage IVB, and initial pleural involvement was a poor prognostic factor. The researchers suggested modifying the current FIGO staging classification.
Article
Medicine, General & Internal
Min Hoan Moon, Hee Sun Park, Young Jun Kim, Mi Hye Yu, Sungeun Park, Sung Il Jung
Summary: This study aimed to determine computed tomography (CT) features in differentiating stage 1 borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs). The results showed that a larger tumor size and a smaller solid component were significantly associated with BOTs. In cases with a solid component, smaller and ill-defined solid component was significantly associated with BOTs.
Article
Reproductive Biology
Diederick de Jong, Amudha Thangavelu, Timothy Broadhead, Inga Chen, Dermot Burke, Racheal Johnson, Richard Hutson, Angelika Kaufmann, Peter Lodge, David Nugent, Aaron Quyn, Georgios Theophilou, Alexandros Laios
Summary: Implementation of ERAS and prehabilitation protocols can improve surgical resection rates without increasing perioperative morbidity and delaying adjuvant chemotherapy, leading to better prognosis in advanced EOC patients.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Julian Marschalek, Marlene Hager, Sophie Wanderer, Johannes Ott, Maria Frank, Christian Schneeberger, Detlef Pietrowski
Summary: The aim of this laboratory-based study was to investigate cell death after cryopreservation in ovarian endothelial and epithelial cell lines. Differences in cell viability were found after warming and cultivation for 48 to 72 hours. Using different cryoprotective protocols, varying vitality rates were observed between the cell lines. Additionally, there was a significant difference in the percentage of vital cells immediately after warming and after cultivation, indicating cell type and cryoprotective agent dependency in cryopreservation-induced damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
He An, Yiang Wang, Esther M. F. Wong, Shanshan Lyu, Lujun Han, Jose A. U. Perucho, Peng Cao, Elaine Y. P. Lee
Summary: This study compared the ability of morphological and texture features derived from contrast-enhanced CT in histological subtyping of epithelial ovarian carcinoma (EOC). The study found that HGSC demonstrated higher texture features than non-HGSC, and both models performed well in predicting histological subtypes of EOC. Texture analysis provided objective and quantitative metrics on tumor characteristics and exhibited high classification accuracy for EOC subtypes.
EUROPEAN RADIOLOGY
(2021)
Article
Reproductive Biology
Sigit Purbadi, Tricia Dewi Anggraeni, Angelina Vitria
Summary: This study evaluated the benefit of routine surgical staging for patients with clinical early-stage EOC. The results suggest that routine peritoneal biopsies may not be advantageous for these patients, as further research with a larger cohort is needed to obtain more information.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Cell Biology
Xiaoling Hong, Ning Ma, Danjie Li, Mengwen Zhang, Wenqiuzi Dong, Jie Huang, Xinxin Ci, Songling Zhang
Summary: Dissemination of ovarian cancer cells can lead to poor prognosis. This study identified UBE2E2 as an upregulated protein in ovarian cancer and showed that it is associated with poor prognosis. UBE2E2 was found to promote ovarian cancer cell migration, epithelial-mesenchymal transition (EMT), and metastasis through the activation of the Nrf2-p62-Snail signaling pathway. The deletion of UBE2E2 reduced tumorigenicity and metastasis in mice models. These findings provide novel therapeutic targets for preventing ovarian cancer metastasis.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Kira Philipsen Prahm, Claus Kim Hogdall, Mona Aarenstrup Karlsen, Ib Jarle Christensen, Guy Wayne Novotny, Estrid Hogdall
Summary: The study aimed to investigate differences in microRNA expression according to clinicopathological characteristics and predict cytoreductive outcome in ovarian cancer patients. One microRNA, miR-130a, was associated with serous histology and advanced FIGO stage, while seven other microRNAs were found to be significantly associated with clinicopathological characteristics but need further validation.
Article
Cell Biology
Tong Su, Panpan Zhang, Fujun Zhao, Shu Zhang
Summary: This study investigated the roles of infiltrated immune cells and immune-related genes (IRGs) in epithelial ovarian cancer, and established an immune-based prognostic risk model using nine IRGs. The model classified EOC patients into low-risk and high-risk groups, and revealed different immune landscapes between the two groups, providing insights into the immune status in the tumor microenvironment for prognosis.
Article
Biochemistry & Molecular Biology
Ming Gao, Yuansong Sun, Qi Wang, Shuaiting Ma, Xinwei Guo, Lingling Zhou, Yeng Chen, Kasi Marimuthu, Subash C. B. Gopinath
Summary: The study synthesized zeolite nanoparticles using rice hush ash and utilized them to identify the colon cancer biomarker CCSP-2, confirming the size and composition of the nanoparticles with Field Emission Scanning Electron Microscopy and Field Emission Transmission Electron Microscopy. Precise detection of CCSP-2 was achieved by modifying the electrode surface.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Correction
Integrative & Complementary Medicine
Subramanion L. Jothy, Yeng Chen, Jagat R. Kanwar, Sreenivasan Sasidharan
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yin-Ling Wong, Anand Ramanathan, Kar Mun Yuen, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Zainal Ariff Abdul Rahman, Yeng Chen
Summary: This study identified differentially expressed serum proteins as potential biomarkers for oral squamous cell carcinoma (OSCC) through comparative proteomics profiling. Decreased expression of CLU and HP could serve as complementary biomarkers of OSCC and assist in predicting patient outcomes. Further investigations with larger cohorts are needed for validation.
Article
Chemistry, Analytical
Renyuan Ma, Subash C. B. Gopinath, Thangavel Lakshmipriya, Yeng Chen
Summary: A sandwich aptasensor with high sensitivity was developed for quantitative analysis of CEA, which is important for diagnosing and monitoring cancer.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hu Hui, Subash C. B. Gopinath, Zool H. Ismail, Yeng Chen, K. Pandian, Palaniyandi Velusamy
Summary: Myocardial infarction (MI) is a life-threatening condition that can cause cardiac arrest and organ damage. Current diagnostic techniques are not sensitive enough for early detection, but blood biomarker-based diagnosis, specifically the measurement of cardiac troponin I (cTnI), provides a potential solution. In this study, a sensor based on interdigitated electrodes was developed and used to detect cTnI. The use of aptamer-conjugated gold nanoparticles and detection antibodies in a sandwich pattern significantly improved the sensitivity of the detection. The developed sensor showed promising results for diagnosing MI.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dapeng Qin, Qiuping Gong, Xin Li, Yanping Gao, Subash C. B. Gopinath, Yeng Chen, Zehua Yang
Summary: In this study, a gold nanoparticle-based colorimetric biosensing method was used to accurately and easily detect the specific target DNA for Mycoplasma pneumoniae. The color of the gold nanoparticles changes in the presence of the target DNA, allowing for the diagnosis of Mycoplasma pneumoniae.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Leong Poh Yan, Subash C. B. Gopinath, Sreeramanan Subramaniam, Yeng Chen, Palaniyandi Velusamy, Suresh V. Chinni, Ramachawolran Gobinath, Veeranjaneya Reddy Lebaka
Summary: Green production of nanoscale iron oxide-based nanostructures has great potential and attraction. The utilization of agro-wastes for bio-based synthesis offers a simplified and eco-friendly method, reducing environmental impact and cost. This approach expands the applications of iron oxide nanomaterials in medical and agricultural fields.
FRONTIERS IN CHEMISTRY
(2022)
Review
Engineering, Biomedical
Hong Hui Jing, Fevzi Bardakci, Sinan Akgol, Kevser Kusat, Mohd Adnan, Mohammad Jahoor Alam, Reena Gupta, Sumaira Sahreen, Yeng Chen, Subash C. B. Gopinath, Sreenivasan Sasidharan
Summary: Carbon dots (CDs) are a type of crystalline, quasi-spherical fluorescence nanomaterials with a size between 1 nm to 10 nm. Green CDs are synthesized from renewable biomass and have distinct advantages over physicochemical methods. Green CDs can be synthesized using various plant-based organic resources and have diverse applications in biomedical fields. This review focuses on the synthesis, characterization techniques, properties, and biomedical applications of green CDs.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Engineering, Chemical
Hussaini Adam, Subash C. B. Gopinath, M. K. Md Arshad, Tijjani Adam, Uda Hashim, Zaliman Sauli, Makram A. Fakhri, Sreeramanan Subramaniam, Yeng Chen, Sreenivasan Sasidharan, Yuan Seng Wu
Summary: This study presents an electrochemically-based microfluidic nanobiosensor array for monoplex and multiplex detection of physiologically relevant analytes. The integrated system is portable and serves as a custom electrochemical reader. It has great potential for real-time profiling of immune-mediated treatment responses and as a point-of-care diagnostic device for conducting near-patient tests using biological samples.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Biochemistry & Molecular Biology
Hussaini Adam, Subash C. B. Gopinath, Thirumananseri Kumarevel, M. K. Md Arshad, Tijjani Adam, Zaliman Sauli, Sreeramanan Subramaniam, Uda Hashim, Yeng Chen
Summary: In this study, a novel technique for the selective detection of amyloid fibrils was reported. Using a dipole moment on a dielectrode surface, this technique can sensitively detect the aggregation of alpha-synuclein, which is crucial for diagnosing Parkinson's disease. The stability and detection range of the sensor were confirmed through physical and electrical characterization.
PROCESS BIOCHEMISTRY
(2023)
Review
Green & Sustainable Science & Technology
Wan Yuen Tan, Subash C. B. Gopinath, Periasamy Anbu, Ahmad Radi Wan Yaakub, Sreeramanan Subramaniam, Yeng Chen, Sreenivasan Sasidharan
Summary: With the development of bionanotechnology, the field of nanobiocatalysts has grown rapidly and transformed various nanomaterials into novel nanocarriers for enzyme immobilization. Nanotubes, nanofibers, nanopores, nanoparticles, and nanocomposites have been successfully used as nanocarriers. The combination of enzymes and nanocarriers through different immobilization techniques has attracted attention due to their exceptional catalytic performance, stability, and reusability. The review discusses enzyme immobilization on nanocarriers and highlights the techniques, properties, preparations, and applications of nanoimmobilized enzymes.
Article
Infectious Diseases
Valiappan Ranjutha, Yeng Chen, Lamya Ahmed Al-Keridis, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen, Subash C. B. Gopinath, Sreenivasan Sasidharan
Summary: Polyalthia longifolia is a medicinal plant used in traditional medicine for skin diseases. This study confirms the synergistic antimicrobial activity of Polyalthia longifolia methanol leaf extract (MEPL) and ceftriaxone against methicillin-resistant Staphylococcus aureus (MRSA) bacteria. The combination of MEPL and ceftriaxone significantly reduces the minimum inhibitory concentration of ceftriaxone and inhibits the expression of the resistant mecA gene in MRSA.
Review
Engineering, Biomedical
Kai Zheng, Jiaxiang Bai, Huilin Yang, Yaozeng Xu, Guoqing Pan, Huaiyu Wang, Dechun Geng
Summary: This review summarizes the current advanced nanomaterials for the diagnosis and therapy of bone-related diseases. First, the potential utility of nanomaterials for biological imaging and biomarker detection is discussed. Second, the special functions of nanomaterials as therapeutic delivery platforms for bone homeostasis regulation and cellular modulation are highlighted. Finally, perspectives in this field are offered, including current key bottlenecks and future directions, which may help in exploiting nanomaterials with novel properties and unique functions. This review provides scientific guidance to enhance the development of advanced nanomaterials for the diagnosis and therapy of bone-related diseases.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Qinyi Zhang, Jun Yao Teow, Jesinda Pauline Kerishnan, Adyani Azizah Abd Halim, Yeng Chen
Summary: Oral squamous cell carcinoma (OSCC) is a common type of head and neck cancer with a high mortality rate. Early detection using biomarkers, such as Clusterin (CLU), can greatly improve the survival rate. However, the exact roles of CLU and its isoforms in OSCC carcinogenesis have not been fully explored. This article provides a comprehensive review of CLU's structure, genetics, and correlation with OSCC tumorigenesis, as well as its potential diagnostic and prognostic biomarker development.
Article
Engineering, Electrical & Electronic
Huijuan Geng, Subash Cb Gopinath, Yeng Chen, Wenyan Niu
Summary: This study successfully detected HBsAg and lowered the detection limit to 0.1 ng/mL using an interdigitated gold electrode sensor assisted by HBsAg-specific aptamer and antibody interactions. The sandwich assay showed high accuracy and specificity in HBsAg detection, indicating its potential for interference-free detection in real-life samples.
JOURNAL OF NANOELECTRONICS AND OPTOELECTRONICS
(2022)
