Article
Cardiac & Cardiovascular Systems
Masaki Funamoto, Asishana A. Osho, Selena S. Li, Philicia Moonsamy, Navyatha Mohan, Chin Siang Ong, Serguei Melnitchouk, Thoralf M. Sundt, Todd L. Astor, Mauricio A. Villavicencio
Summary: This study investigated factors associated with improved survival in patients undergoing isolated lung transplantation with a GFR of 30 to 50 mL/min per 1.73 m(2). Outpatient recipients aged less than 60 years with a GFR of 30 to 50 mL/min per 1.73 m(2) were found to have superior survival outcomes. This suggests that lung transplant listing should not be declined based solely on a GFR less than 50 mL/min per 1.73 m(2).
ANNALS OF THORACIC SURGERY
(2021)
Article
Urology & Nephrology
Mersema Abate, Nicholas Jandovitz, Jamie S. Hirsch, Nadine Breslin, Lawrence Lau, Ahmed E. Fahmy, Kenar D. Jhaveri, Safiya Richardson, Yaser Alsalmay, Anthony Baez, Akash Mishra, Siavash Bolourani, Santiago J. Miyara, Aaron Winnick, Gayatri Nair, Madhu C. Bhaskaran, Elliot Grodstein, Adam M. Kressel, Lewis W. Teperman, Ernesto P. Molmenti, Vinay Nair
Summary: This study found that removing race coefficients in GFR estimation formulas may lead to a more equitable distribution of Black candidates listed earlier on a preemptive basis.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Immunology
Pierre Delanaye, Ingrid Masson, Nicolas Maillard, Hans Pottel, Christophe Mariat
Summary: This study compared the predictive performance of the new CKD-EPI equation, classical CKD-EPI equation, and EKFC equation in a French cohort of KTRs. The results showed that the new CKD-EPI equation was less accurate compared to the classical CKD-EPI and EKFC equations. Further validation of the EKFC equation in KTRs with diverse ethnic backgrounds is needed.
Letter
Medicine, General & Internal
Marc Raynaud, Olivier Aubert, Alexandre Loupy
Summary: This letter evaluates a new calculation formula for estimating glomerular filtration rate without considering race. The authors point out that the accuracy of the formula has not been confirmed in diverse subpopulations or countries.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Iwona Zaporowska-Stachowiak, Tomasz Grabowski, Katarzyna Stachowiak-Szymczak, Karolina Gosciniak, Artur Tezyk, Maciej Sopata
Summary: This pilot study identified ten statistically significant correlations related to midazolam pharmacokinetics and physiological factors, proposing two equations with high predictive ability. Limitations of the study include its pilot nature and the need for further validation on a larger population.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Urology & Nephrology
Eman H. Ibrahim, Mostafa G. Aly, Gerhard Opelz, Christian Morath, Martin Zeier, Caner Susal, Douaa M. Sayed, Eman Hassan, Naruemol Ekpoom, Volker Daniel
Summary: Higher counts of CD19+ CD25+ Bregs are independently associated with better renal function and higher absolute Treg counts in renal transplant recipients.
Article
Pharmacology & Pharmacy
Xiao-Jun Cai, Yan Chen, Xiao-Shan Zhang, Yu-Zhen Wang, Wen-Bo Zhou, Chun-Hong Zhang, Bo Wu, Hui-Zhu Song, Hang Yang, Xu-Ben Yu
Summary: This study investigated the population pharmacokinetics of polymyxin B in lung transplant recipients and found that renal function significantly affected the clearance of polymyxin B, suggesting the need for dosage adjustment in patients with renal impairments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiuyan Li, ZeSong Yang, Shiwen Zheng, Yangbiao Wu, Wanghai Cai, Minxiong Hu, Qingguo Zhu, Liefu Ye
Summary: This study compared the applicability of 14 equations for estimating glomerular filtration rate (eGFR) before and after nephron-sparing surgery (NSS) in patients with renal tumors. The results showed that the FAS(Scr-SCysC) equation performed the best in evaluating postoperative GFR.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Medicine, General & Internal
Maria Perticone, Raffaele Maio, Giovanni Tripepi, Domenico Abelardo, Michele Andreucci, Egidio Imbalzano, Alfredo Francesco Toscani, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Francesco Perticone
Summary: Chronic kidney disease is a risk factor for cardiovascular events, and smoking and chronic obstructive pulmonary disease (COPD) are risk factors for renal impairment. This study found that smoking and COPD have a competitive interaction in the decline of renal function, suggesting the need for kidney damage screening in patients with both conditions.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Seiko Nakamichi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
Summary: Subclinical hypothyroidism (SCH) may influence the association between HbA1c and renal function, indicating the importance of thyroid function in influencing kidney function in diabetic patients.
Article
Oncology
Seckin Akgul, Bryan A. Chan, Peter M. Manders
Summary: Carboplatin dosage varies depending on the equation used, with the CKD-EPI formula providing the most accurate estimation. Implementing CKD-EPI as the new standard of care for carboplatin dosing internationally is recommended.
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Udoamaka Ezuruike, Alexander Blenkinsop, Amita Pansari, Khaled Abduljalil
Summary: Accurate prediction of fetal exposure to drugs excreted by the kidney requires considering the time-varying renal function parameters. This study collected and integrated data on fetal urinary production rate (FUPR) and creatinine measured at different gestational ages, and compared the predicted fetal glomerular filtration rate (GFR) with neonatal values. The results showed that 3D ultrasound methods yielded higher estimates of FUPR compared to 2D methods, and a power law function accurately captured the change in FUPR with fetal age. The predicted FUPR based on 3D data showed a strong linear relationship with amniotic creatinine concentration, and the predicted fetal GFR values were in good agreement with neonatal values at birth.
FRONTIERS IN PEDIATRICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. M. Zheng, Y. C. Zhu, L. M. Shang, C. K. Du, L. Zhang, W. Sun, Z. P. Wang, Y. Q. Zhao, X. S. Li, Y. Tian
Summary: The study developed a split glomerular filtration rate (sGFR) prediction model based on renal volume parameters, which could be used to estimate renal function of healthy donors and patients with hydronephrosis to some extent. Further studies are needed to evaluate and correct the model.
CLINICAL RADIOLOGY
(2022)
Article
Oncology
Jongpil Lee, Cheryn Song, Donghyun Lee, Jong Keun Kim, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn
Summary: This study analyzed the long-term effects on ipsilateral renal function after partial nephrectomy, revealing that parenchymal volume reduction was the major determinant while factors such as diabetes and proteinuria gained significance over time. Ischemic time affected early GFR reduction with diminishing impact over time.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Cynthia L. Green, Brian C. Gulack, Shaf Keshavjee, Lianne G. Singer, Kenneth McCurry, Marie M. Budev, Tammy L. Reece, Anne O. Lidor, Scott M. Palmer, R. Duane Davis
Summary: A multicenter retrospective study found limited benefits of fundoplication for preventing bronchiolitis obliterans syndrome and improving survival compared to reflux disease without surgery after lung transplantation. However, the study had limitations in terms of sample size, follow-up duration, and potential selection bias, highlighting the need for a randomized, prospective study.
ANNALS OF THORACIC SURGERY
(2023)
Article
Surgery
Carmen Lefaucheur, Kevin Louis, Anna B. Morris, Jean-Luc Taupin, Peter Nickerson, Anat R. Tambur, Howard M. Gebel, Elaine F. Reed
Summary: This consensus report provides clinical practice recommendations in kidney, heart, lung, and liver transplantation based on expert assessment of quality and strength of evidence regarding the relationship between anti-HLA donor-specific antibodies and transplant outcome. The recommendations address major clinical problems in transplantation, including the clinical implications of positive posttransplant DSA detection, the relevance of posttransplant DSA assessment for diagnosis and treatment management, and the relevance of posttransplant DSA for allograft prognosis and risk stratification.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Correction
Cardiac & Cardiovascular Systems
Emily S. Clausen, Jeremy M. Weber, Megan L. Neely, Kathleen J. Ramos, Laurie D. Snyder
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jamie L. Todd, Jeremy M. Weber, Francine L. Kelly, Megan L. Neely, Andrew Nagler, Dylan Carmack, Courtney W. Frankel, David M. Brass, John A. Belperio, Marie M. Budev, Matthew G. Hartwig, Tereza Martinu, John M. Reynolds, Pali D. Shah, Lianne G. Singer, Laurie D. Snyder, S. Sam Weigt, Scott M. Palmer
Summary: This study found an association between reduced levels of club cell secretory protein (CCSP) in bronchoalveolar lavage fluid (BALF) and the development of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. Decreased CCSP in early post-transplant BALF may indicate an increased risk of later CLAD.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Virology
Lorenzo Zaffiri, Joshua E. Messinger, Erika J. Bush, Janet S. Staats, Prekshaben Patel, Scott M. Palmer, Kent J. Weinhold, Laurie D. Snyder, Micah A. Luftig
Summary: Reactivation of Epstein-Barr virus (EBV) is often seen in lung transplant recipients (LTRs), but the cellular immune responses to EBV in adult LTRs have not been fully described. In this study, we found significant changes in CD4/CD8 ratio, EBV-specific CD8(+)CD69(+) T cell responses, and NK cell phenotypic changes in adult LTRs with EBV-associated diseases. These findings provide valuable insights into the immune responses to EBV in adult LTRs and may contribute to improved management of EBV-related complications.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Critical Care Medicine
Aparna C. Swaminathan, Laurie D. Snyder, Hwanhee Hong, Susanna R. Stevens, Alexander S. Long, Eric Yanchenko, Ying Qiu, Rong Liu, Hongtao Zhang, Aryeh Fischer, Leah Burns, Lisa M. Wruck, Scott M. Palmer
Summary: This study aimed to develop IPF ECs using fit-for-purpose data standards and evaluate their endpoint comparability with the BMS-986020 phase II RCT. The results showed that IPF ECs generated from historical RCT placebo arms had comparable primary treatment effects to that of the original clinical trial, while ECs from real-world data sources did not.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Asishana Osho, Marcelo F. F. Fernandes, Ram Poudel, James de Lemos, Haoyun Hong, Juan Zhao, Shen Li, Kathie Thomas, Daniel S. S. Kikuchi, Jessica Zegre-Hemsey, Nasrien Ibrahim, Nilay S. S. Shah, Lori Hollowell, Jacqueline Tamis-Holland, Christopher B. B. Granger, Mauricio Cohen, Timothy Henry, Alice K. K. Jacobs, James G. G. Jollis, Clyde W. W. Yancy, Abhinav Goyal
Summary: This study analyzed data from the American Heart Association registry and found that contemporary systems of care for ST-segment-elevation myocardial infarction (STEMI) in the United States may not effectively reduce racial and ethnic disparities in treatment goals and mortality.
Article
Surgery
Georgina Rowe, George Gill, M. Mujeeb Zubair, Qiudong Chen, Jason Thomas, Shrishiv A. A. Timbalia, Asishana A. A. Osho, Dominic Emerson, Richard Kim, Michael E. E. Bowdish, Joanna Chikwe, Joseph W. W. Turek
Summary: This study aimed to evaluate the characteristics and outcomes of children undergoing repeat heart transplantation in the United States based on the underlying diagnosis. The long-term outcomes remain poor for patients undergoing repeat heart transplantation, particularly those with an inter-transplant interval <3.6 years. The underlying diagnosis does not impact outcomes after repeat transplantation, after accounting for other risk factors.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
George Gill, Georgina Rowe, M. Mujeeb Zubair, Qiudong Chen, Jason Thomas, Peter Chiu, Asishana Osho, Vikram Sood, Kurt R. Schumacher, Dominic Emerson, Michael E. Bowdish, Joanna Chikwe, Francis Fynn-Thompson
Summary: The age difference between donors and recipients has an impact on the survival rate after adolescent heart transplantation. An age difference greater than 11 years is associated with higher long-term mortality.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jason Thomas, Qiudong Chen, Amy Roach, Stanley Wolfe, Asishana A. Osho, Vinay Sundaram, Steven A. Wisel, Dominick Megna, Dominic Emerson, Lawrence Czer, Fardad Esmailian, Joanna Chikwe, Irene Kim, Pedro Catarino
Summary: The utilization and outcomes of concurrently procured DCD livers and kidneys were evaluated in this study. It was found that in-situ thoracoabdominal normothermic regional perfusion was associated with increased utilization of DCD livers and a lower incidence of delayed graft function in concurrently procured DCD kidneys.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
W. M. Tsuang, Ml Neely, S. M. Palmer, LG. Singer, M. Budev, P. Shah, J. A. Belperio, J. M. Reynolds, L. D. Snyder
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Joao A. de Andrade, Megan L. Neely, Anne S. Hellkamp, Daniel A. Culver, Hyun J. Kim, Timothy Liesching, Leonard J. Lobo, Murali Ramaswamy, Zeenat Safdar, Shaun Bender, Craig S. Conoscenti, Thomas B. Leonard, Scott M. Palmer, Laurie D. Snyder
Summary: This study investigated the impact of antifibrotic therapy on mortality and other outcomes in patients with idiopathic pulmonary fibrosis (IPF) using causal inference methodology. The results suggest that patients with IPF who receive antifibrotic therapy have improved survival but may also have increased risks of respiratory-related hospitalizations and acute worsening of IPF.
CLINICAL THERAPEUTICS
(2023)
Article
Respiratory System
Todd L. L. Astor, Hilary J. J. Goldberg, Laurie D. D. Snyder, Andrew Courtwright, Ramsey Hachem, Tahuanty Pena, Lorenzo Zaffiri, Gerard J. J. Criner, Marie M. M. Budev, Tany Thaniyavarn, Thomas B. B. Leonard, Shaun Bender, Aliaa Barakat, Janis L. L. Breeze, Peter LaCamera
Summary: In patients with idiopathic pulmonary fibrosis, discontinuing anti-fibrotic therapy < 5 medication half-lives before lung transplant may increase the risk of anastomotic and sternal dehiscence, while there were no differences in other intra-operative and post-transplant complications based on the timing of discontinuation of anti-fibrotic therapy.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)