Article
Cardiac & Cardiovascular Systems
Weichun Wu, Bingyang Liu, Min Huang, David H. Hsi, LiLi Niu, Yue Tian, Jingru Lin, Jiangtao Wang, Shuai Yang, Hongquan Lu, Changming Xiong, Zhenhui Zhu, Hao Wang
Summary: The 4D auto-RVQ technology shows potential in estimating right ventricular function and some hemodynamic changes in pulmonary hypertension patients with high image quality, while further large-scale studies are needed to evaluate RV function in patients with average image quality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Rong Jiang, Lan Wang, Qin-Hua Zhao, Cheng Wu, Ping Yuan, Shang Wang, Rui Zhang, Su-Gang Gong, Wen-Hui Wu, Jing He, Hong-Ling Qiu, Ci-Jun Luo, Jin-Ming Liu, Zhi-Cheng Jing
Summary: We established and validated a novel nomogram using echocardiographic parameters to predict all-cause death in patients with severe CLD-PH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Franck F. Rahaghi, Nicholas A. Kolaitis, Ayodeji Adegunsoye, Joao A. de Andrade, Kevin R. Flaherty, Lisa H. Lancaster, Joyce S. Lee, Deborah J. Levine, Ioana R. Preston, Zeenat Safdar, Rajan Saggar, Sandeep Sahay, Mary Beth Scholand, Oksana A. Shlobin, David A. Zisman, Steven D. Nathan
Summary: This study identifies triggers and screening tools for pulmonary hypertension (PH) in patients with interstitial lung disease (ILD) through expert consensus. Due to the lack of standardized approaches, this consensus statement aims to aid physicians in the identification of ILD patients with possible PH and provide guidance for timely right heart catheterization.
Article
Medicine, General & Internal
Giulia Elena Mandoli, Federico Landra, Benedetta Chiantini, Carlotta Sciaccaluga, Maria Concetta Pastore, Marta Focardi, Luna Cavigli, Flavio D'Ascenzi, Sonia Bernazzali, Massimo Maccherini, Serafina Valente, Matteo Cameli, Michael Henein
Summary: This study evaluated the predictive accuracy of peak TRV for PH based on the new and old cutoff values for mPAP, and compared it with the mean RV-RA pressure gradient. The results showed that peak TRV performed better than mean RV-RA pressure gradient in predicting PH, regardless of the hemodynamic definitions, and had higher sensitivity and equal positive predictive value.
Article
Medicine, General & Internal
Zhuoyuan Xu, Hongsheng Zhang, Alexandra Arvanitaki, Chen Zhang, Qiangqiang Li, Bradley B. Keller, Hong Gu
Summary: This retrospective study analyzed 591 diagnostic RHC procedures in pediatric PAH patients and found that most patients had low-risk outcomes, with approximately 3% experiencing a pulmonary hypertensive crisis. Therefore, it is recommended to perform RHC procedures in experienced pediatric cardiology centers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Aleksandra Bartnik, Joanna Pepke-Zaba, Stephen P. Hoole, Paul White, Madalina Garbi, John G. Coghlan, Fouad Taghavi, Steven Tsui, Jonathan Weir-McCall
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition that occurs in some patients with prior acute pulmonary embolism, characterized by shortness of breath, persistently elevated pulmonary pressures, and right heart failure. Surgical pulmonary endarterectomy (PEA) is effective for patients with proximal disease distribution, while balloon pulmonary angioplasty (BPA) and medical therapy are options for those with inoperable disease. Current evaluation of pulmonary hemodynamics does not accurately reflect patient symptoms, and further research is needed on how to manage symptomatic patients without pulmonary hypertension.
Article
Critical Care Medicine
Gabor Kovacs, Alexander Avian, Gerhard Bachmaier, Natascha Troester, Adrienn Tornyos, Philipp Douschan, Vasile Foris, Teresa Sassmann, Katarina Zeder, Joerg Lindenmann, Luka Brcic, Michael Fuchsjaeger, Alvar Agusti, Horst Olschewski
Summary: By combining echocardiography, NT-proBNP level, and PA to Ao diameter ratio, severe PH in patients with COPD can be predicted with high sensitivity and specificity. The contribution of severe airflow limitation and severe PH to impaired survival is comparable.
Article
Veterinary Sciences
Tomoya Morita, Kensuke Nakamura, Tatsuyuki Osuga, Sei Kawamoto, Shingo Miki, Mitsuyoshi Takiguchi
Summary: This study validated the relationship between echocardiographic indices and right heart catheterization variables in dogs with acute pulmonary embolism, and identified a useful echocardiographic index for diagnosing acute pulmonary embolism.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Giulia Manguso, Anthony Vignone, Manuela Merli, Cristiano Miotti, Annalisa Caputo, Carmine Dario Vizza, Roberto Badagliacca
Summary: Liver cirrhosis is the fourth leading cause of death in Europe, with a high mortality rate and the need for liver transplantation. Transjugular intrahepatic portosystemic shunt (TIPS) is a common treatment strategy to reverse portal hypertension in these patients. However, the coexistence of pulmonary hypertension or heart failure is considered a contraindication to TIPS, but the definition of heart failure has not been clearly specified. There is limited and controversial data regarding the development of heart failure and pulmonary hypertension after TIPS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Julien Grynblat, Sophie-Guiti Malekzadeh-Milani, Mathilde Meot, Frederic Perros, Isabelle Szezepanski, Stephane Morisset, Caroline Ovaert, Caroline Bonnet, Pascale Maragnes, Julien Ranchoup, Marc Humbert, I. David Montani, Marilyne Levy, Damien Bonnet
Summary: This study aims to define the goals of repeated right heart catheterization (RHC) and evaluate the correlation between noninvasive criteria and hemodynamic parameters. The results showed that pulmonary vascular resistance index, pulmonary artery compliance index, and right atrial pressure were associated with adverse outcomes in pediatric pulmonary arterial hypertension. Noninvasive criteria accurately predicted the evolution of hemodynamic parameters, but some patients still had at least one at-risk hemodynamic parameter at second RHC.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Respiratory System
Stanislav Keranov, Oliver Doerr, Leili Jafari, Christian Troidl, Christoph Liebetrau, Steffen Kriechbaum, Till Keller, Sandra Voss, Timm Bauer, Jakob Lorenz, Manuel J. Richter, Khodr Tello, Henning Gall, Hossein A. Ghofrani, Eckhard Mayer, Christoph B. Wiedenroth, Stefan Guth, Holger Loerchner, Jochen Poeling, Prakash Chelladurai, Soni Savai Pullamsetti, Thomas Braun, Werner Seeger, Christian W. Hamm, Holger Nef
Summary: The study revealed that CILP1 is a novel biomarker associated with maladaptive RV function and PH, with significant differences in its concentrations among different cardiac pathology groups, showing potential in predicting maladaptive RV function.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Chao Li, Ge-Fei Chen, Ci-Jun Luo, Hong-Ling Qiu, Jin-Ming Liu, Lan Wang, Rui Zhang
Summary: The study showed that echocardiographic ARHR is an independent determinant of prognosis in IPAH at long-term follow-up, and may help indicate RV morphologic and functional improvement associated with better prognostic likelihood.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dilia Giuggioli, Valeria Riccieri, Edoardo Cipolletta, Nicoletta Del Papa, Francesca Ingegnoli, Amelia Spinella, Greta Pellegrino, Anna Maria Risa, Marco de Pinto, Silvia Papa, Giuseppe Armentaro, Rossella De Angelis
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by immune-system alterations, fibrosis, and microangiopathy. Pulmonary arterial hypertension (PAH) is a severe complication affecting about 10-15% of SSc patients, and appropriate screening programs are necessary. Nail fold videocapillaroscopy (NVC) studies show more severe microvascular dysfunction in SSc patients with PAH, suggesting a correlation with pulmonary microangiopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Timothy E. Thayer, Rebecca T. Levinson, Shi Huang, Tufik Assad, Eric Farber-Eger, Quinn S. Wells, Jonathan D. Mosley, Evan L. Brittain
Summary: This study found a positive association between BMI and pulmonary arterial pressure, but not with markers of pulmonary vascular remodeling. Mendelian randomization analyses supported that higher BMI causes higher systolic pulmonary artery pressure. BMI is a modifier of pulmonary hypertension severity in both PAH and PVH, with involvement primarily in the pathogenesis of PVH.
Article
Hematology
Ryo Kurosawa, Kimio Satoh, Takashi Nakata, Tomohiko Shindo, Nobuhiro Kikuchi, Taijyu Satoh, Mohammad A. H. Siddique, Junichi Omura, Shinichiro Sunamura, Masamichi Nogi, Yutaro Takeuchi, Satoshi Miyata, Hiroaki Shimokawa
Summary: Pulmonary arterial hypertension is characterized by abnormal proliferation of pulmonary artery smooth muscle cells and vascular remodeling, leading to right ventricular failure. Bsg and CyPA play crucial roles in exacerbating RV dysfunction, while celastrol has potential as a novel drug for PH and RV failure by suppressing Bsg and CyPA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Surgery
Jacqueline M. Smits, George Nossent, Patrick Evrard, Gyoergy Lang, Christiane Knoop, Johanna M. Kwakkel-van Erp, Frank Langer, Rene Schramm, Ed van de Graaf, Robin Vos, Geert Verleden, Benoit Rondelet, Daniel Hoefer, Rogier Hoek, Konrad Hoetzenecker, Tobias Deuse, Agita Strelniece, Dave Green, Erwin de Vries, Undine Samuel, Guenther Laufer, Roland Buhl, Christian Witt, Jens Gottlieb
TRANSPLANT INTERNATIONAL
(2018)
Article
Surgery
Remco B. Grobben, Cynthia Frima, Hendrik M. Nathoe, Tim Leiner, Johanna M. Kwakkel-van Erp, Wilton A. van Klei, Linda M. Peelen, Joost A. van Herwaarden
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2019)
Article
Immunology
Kevin Budding, Jessica van Setten, Eduard A. van de Graaf, Oliver A. van Rossum, Tineke Kardol-Hoefnagel, Johanna M. Kwakkel-van Erp, Erik-Jan D. Oudijk, C. Erik Hack, Henderikus G. Otten
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Transplantation
Inge Schreurs, Bob Meek, Danielle Hijdra, Maria Rodriguez Gomez, Coline H. M. van Moorsel, H. D. Luijk, Johanna M. Kwakkel-van Erp, Erik-Jan Oudijk, Diana A. van Kessel, Jan C. Grutters
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2020)
Article
Immunology
I. Schreurs, B. Meek, D. Hijdra, C. H. M. van Moorsel, H. D. Luijk, J. M. Kwakkel-van Erp, E. Oudijk, D. A. van Kessel, J. C. Grutters
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Nursing
Marion J. Wessels-Bakker, Eduard A. van de Graaf, Johanna M. Kwakkel-van Erp, Harry G. Heijerman, Wiepke Cahn, Renske Schappin
Summary: The study aimed to explore the prevalence of psychological distress and its correlation with medication adherence in lung transplant patients. Results showed high levels of post-traumatic stress symptoms in recipients and a positive relationship between anxiety symptoms and medication adherence. More research on anxiety and dyspnoea in lung transplant recipients is recommended.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Geriatrics & Gerontology
M. T. H. M. Henkens, A. G. Raafs, J. A. J. Verdonschot, M. Linschoten, M. van Smeden, P. Wang, B. H. M. van der Hooft, R. Tieleman, M. L. F. Janssen, R. M. A. ter Bekke, M. R. Hazebroek, I. C. C. van der Horst, F. W. Asselbergs, F. J. H. Magdelijns, S. R. B. Heymans
Summary: Age is the main determinant of COVID-19 related in-hospital mortality, with negligible mediation effect of pre-existing comorbidities.
Article
Medicine, General & Internal
Stijn E. Verleden, Peter Braubach, Christopher Werlein, Edith Plucinski, Mark P. Kuhnel, Annemiek Snoeckx, Haroun El Addouli, Tobias Welte, Axel Haverich, Florian P. Laenger, Sabine Dettmer, Patrick Pauwels, Veronique Verplancke, Paul E. Van Schil, Therese Lapperre, Johanna M. Kwakkel-Van-Erp, Maximilian Ackermann, Jeroen M. H. Hendriks, Danny Jonigk
Summary: Pathology and radiology are complementary tools in diagnosing non-neoplastic pulmonary diseases. The innovative technique of inflating whole lung specimens and subjecting them to CT allows for an accurate matching of CT imaging and histopathology data. This technique enables targeted assessment of localized disease extent and investigation of early mechanisms of lung diseases on a morphological and molecular level.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Stijn E. Verleden, Jeroen M. H. Hendriks, Patrick Lauwers, Suresh Krishan Yogeswaran, Veronique Verplancke, Johanna M. Kwakkel-Van-Erp
Summary: Chronic lung allograft dysfunction (CLAD) is a major obstacle in lung transplant outcomes. The search for biomarkers to assist in earlier detection, differential diagnosis, and prognosis of CLAD phenotypes is increasing. This article discusses the current status and state-of-the-art of biomarker research in CLAD, with a focus on radiological biomarkers and those found in peripheral tissue, bronchoalveolar lavage, and circulating blood. The future of biomarker research lies in combining clinical information with findings in tissue, bronchoalveolar lavage, or blood to achieve the ultimate goal of earlier CLAD identification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Stijn E. Verleden, Arno Vanstapel, Joseph Jacob, Tinne Goos, Jeroen Hendriks, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Laurens De Sadeleer, Robin Vos, Johanna M. Kwakkel-van Erp, Arne P. Neyrinck, Geert M. Verleden, Matthieu N. Boone, Wim Janssens, Els Wauters, Birgit Weynand, Danny D. Jonigk, Johny Verschakelen, Wim A. Wuyts
Summary: This study determined the correlation between radiologic findings and histopathologic results in CT-defined interstitial lung abnormalities (ILAs) in human lung explants.
Proceedings Paper
Optics
Joy Willemse, Reinier R. Wener, Fabio Feroldi, Margherita Vaselli, Johanna M. Kwakkel-van Erp, Eduard A. van de Graaf, Erik Thunnissen, Johannes F. de Boer
Summary: Polarization-sensitive optical coherence tomography was used to image healthy and diseased lungs ex vivo, revealing differences in alveoli size and airway smooth muscle thickness.
OPTICAL COHERENCE IMAGING TECHNIQUES AND IMAGING IN SCATTERING MEDIA IV
(2021)
Article
Transplantation
T. Antychin, J. A. Zarowski, V. Verplancke, J. M. H. Hendriks, S. K. Yogeswaran, P. Lauwers, K. Lamote, J. M. Kwakkel-van Erp
Summary: Calcineurin inhibitors (CNIs) are commonly used in immunosuppressive therapy after solid organ transplantation, but can cause neurotoxicity. This case report describes a patient who developed severe motor and sensory neuron dysfunction related to CNIs after lung transplantation, with symptoms improving after switching to a mammalian Target of Rapamycin-inhibitor.
INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tjomme van der Bruggen, Anna Kolecka, Bart Theelen, Johanna M. Kwakkel-van Erp, Bert Arets, Teun Boekhout
MEDICAL MYCOLOGY CASE REPORTS
(2018)
Article
Surgery
A. Shahabeddin Parizi, P. F. M. Krabbe, E. A. M. Verschuuren, R. A. S. Hoek, J. M. Kwakkel-van Erp, M. E. Erasmus, W. van der Bij, K. M. Vermeulen
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Article
Respiratory System
Firdaus A. Mohamed Hoesein, Mareye Voortman, Johanna M. Kwakkel-van Erp, Bart Luijk, Pim A. de Jong
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2017)