Article
Cardiac & Cardiovascular Systems
Peter J. Kennel, Alexandre Yahi, Yoshifumi Naka, Donna M. Mancini, Charles C. Marboe, Klaas Max, Kemal Akat, Thomas Tuschl, Elena-Rodica M. Vasilescu, Emmanuel Zorn, Nicholas P. Tatonetti, Paul Christian Schulze
Summary: This study utilized next-generation small RNA sequencing to analyze circulating miRNAs as potential biomarkers for detecting and predicting allograft rejection after heart transplantation. It found three specific miRNAs with significantly increased levels in patients with cardiac rejection and identified potential predictors for acute cellular rejection (ACR) and antibody-mediated rejection (AMR), with hsa-miR-486-5p being strongly associated with acute rejection episodes. Monitoring allograft rejection using circulating miRNAs may offer an alternative to invasive endomyocardial biopsy.
Article
Biology
Isabell A. Just, Meryem Guelfirat, Laura Leser, Ata Uecertas, Laurenz Kopp Fernandes, Maren Godde, Nicolas Merke, Philipp Stawowy, Felix Hennig, Christoph Knosalla, Volkmar Falk, Jan Knierim, Felix Schoenrath
Summary: This study investigated the diagnostic and prognostic value of using TDI-derived wall motion analysis as a screening modality in OHT aftercare. The results showed that Sm remained stable during the follow-up period, but reductions were associated with acute rejections and cardiac allograft vasculopathy. Lower Sm was linked to a higher all-cause mortality rate.
Article
Health Care Sciences & Services
Silvia Lozano-Edo, Esther Rosello-Lleti, Ignacio Sanchez-Lazaro, Estefania Tarazon, Manuel Portoles, Maryem Ezzitouny, Raquel Lopez-Vilella, Miguel Angel Arnau, Luis Almenar, Luis Martinez-Dolz
Summary: This study found that serum RANGAP1 levels can serve as a non-invasive biomarker for predicting the risk of ACR during the first year after heart transplantation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Qixia Shen, Yucheng Wang, Jiaoyi Chen, Lifeng Ma, Xiaoru Huang, Sydney C. W. Tang, Huiyao Lan, Hong Jiang, Jianghua Chen
Summary: Allograft rejection in renal transplantation is associated with reduced graft survival. Changes in immune cell types, including an increase in specific macrophages and a decrease in other immune cells, may significantly contribute to the transition from acute rejection to chronic rejection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Dandel, Roland Hetzer
Summary: Enhancing acute rejection monitoring and optimizing action strategies can prevent allograft failure and delay the development of cardiac allograft vasculopathy. The combined use of endomyocardial biopsies with non-invasive technologies ensures the best possible surveillance and management of acute rejection.
HEART FAILURE REVIEWS
(2021)
Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Guillaume Coutance, Eva Desire, Jean-Paul Duong Van Huyen
Summary: Despite advances in immunosuppression, allograft rejection remains a significant complication after heart transplantation. The current invasive diagnostic method has limitations, thus innovative strategies are needed to improve the accuracy of diagnosis.
Article
Endocrinology & Metabolism
Agnieszka Bielska, Magdalena Niemira, Witold Bauer, Iwona Sidorkiewicz, Anna Szalkowska, Anna Skwarska, Justyna Raczkowska, Damian Ostrowski, Kamil Gugala, Slawomir Dobrzycki, Adam Kretowski
Summary: The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight the urgent need to identify early biomarkers for IHD development in diabetic individuals. This study suggests that circulating serum-derived micro RNAs (miRNAs) may serve as potential biomarkers for early diagnosis of IHD in T2DM patients. Six miRNAs were significantly upregulated in T2DM IHD patients and were associated with multiple signaling pathways. These miRNAs showed high diagnostic value, indicating their potential as biomarkers for early IHD detection in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karsten Suhre, Darshana M. Dadhania, John Richard Lee, Thangamani Muthukumar, Qiuying Chen, Steven S. Gross, Manikkam Suthanthiran
Summary: Noninvasive biomarkers of kidney allograft status, measured through urine metabolites, can serve as indicators of rejection events; while metabolite profiles are effective for discriminating rejection biopsies, estimated Glomerular Filtration Rate (eGFR) also plays a significant role in the metabolite signal.
Article
Materials Science, Multidisciplinary
Cheng Deng, Chenyuan Wang, Wenpei Fu, Lujuan Wu, Qiaofeng Jin, Li Zhang, Wen Zhang, Wei Li, Mingxing Xie
Summary: This study evaluated the efficacy of a FK506-loaded microneedle (FK506 MN) in treating acute rejection in heart transplantation. The results showed that FK506 MN could successfully alleviate acute rejection and prolong allograft survival. In addition, it also reduced T cell and macrophage infiltration as well as the secretion of certain cytokines.
MATERIALS & DESIGN
(2023)
Article
Agriculture, Dairy & Animal Science
Wen-Bin Zheng, Lang Cai, Yang Zou, Wen-Wei Gao, Qing Liu, Xing-Quan Zhu
Summary: This study examined the expression of miRNAs in the serum of Beagle dogs infected with T. canis using RNA sequencing technology and identified several differently expressed miRNAs. The results indicated that T. canis infection can alter the expression of miRNAs in the serum of Beagle dogs and provided baseline data for further research on the regulatory signaling networks involved in the pathogenesis of toxocariasis.
Article
Immunology
Jung-Woo Seo, Yu Ho Lee, Dong Hyun Tae, Seon Hwa Park, Ju-Young Moon, Kyung Hwan Jeong, Chan-Duck Kim, Byung Ha Chung, Jae Berm Park, Yeong Hoon Kim, Junhee Seok, Sun Hyung Joo, Seung Hwan Lee, Jong Soo Lee, Sang-Ho Lee
Summary: Urinary mRNA could reflect the extent of allograft injury, serving as a non-invasive monitoring tool for acute rejection and aiding in decision-making for performing biopsies on recipients with elevated creatinine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Lenka Krupickova, Martina Fialova, Marek Novotny, Veronika Svachova, Kristyna Mezerova, Eva Cecrdlova, Ondrej Viklicky, Ilja Striz
Summary: Kidney allograft transplantation improves the prognosis of patients with end-stage renal diseases, but acute rejection is a limitation. Our study of 138 patients found higher pretransplant levels of certain chemokines in patients with acute rejection, and in vitro models showed complex interactions between renal epithelial cells and immune cells.
MEDIATORS OF INFLAMMATION
(2021)
Review
Medicine, Research & Experimental
Prathab Balaji Saravanan, Jagan Kalivarathan, Faizaan Khan, Rashi Shah, Marlon F. Levy, Mazhar A. Kanak
Summary: Exosomes secreted by cells can transfer signals and communicate with other cells, and the proteins, lipids, and genetic materials they contain can serve as potential biomarkers for assessing graft function and rejection status. Using exosomes to deliver therapeutic agonists/antagonists to the grafts can prevent rejection and reduce the side effects of immunosuppressive drugs. Exosomes play a critical role in the recognition and cross-presentation of donor organ-specific antigens during allograft rejection, and they have potential as biomarkers for monitoring graft function and damage, as well as therapeutic applications in mitigating allograft rejection.
Article
Urology & Nephrology
Michelle L. Lubetzky, Thalia Salinas, Joseph E. Schwartz, Manikkam Suthanthiran
Summary: Immune monitoring and personalized therapeutics can aid in achieving the goal of "one transplant for life." Using methods such as urinary cell mRNA profiling, accurate diagnosis and prediction of kidney transplant rejection can be achieved, guiding post-transplant treatment.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Physiology
Olof Gidlof, Ramasri Sathanoori, Marco Magistri, Mohammad Ali Faghihi, Claes Wahlestedt, Bjorn Olde, David Erlinge
JOURNAL OF VASCULAR RESEARCH
(2015)
Article
Hematology
Olof Gidlof, Marcel van der Brug, Jenny Ohman, Patrik Gilje, Bjorn Olde, Claes Wahlestedt, David Erlinge
Article
Cardiac & Cardiovascular Systems
Olof Gidlof, J. Gustav Smith, Kazuma Miyazu, Patrik Gilje, Anna Spencer, Sten Blomquist, David Erlinge
BMC CARDIOVASCULAR DISORDERS
(2013)
Article
Immunology
Johanna Sall, Martin Carlsson, Olof Gidlof, Anders Holm, Johan Humlen, Jenny Ohman, Daniel Svensson, Bengt-Olof Nilsson, Daniel Jonsson
JOURNAL OF INNATE IMMUNITY
(2013)
Article
Biochemical Research Methods
Melinda Rezeli, Akos Vegvari, Fabrizio Donnarumma, Olof Gidlof, J. Gustav Smith, David Erlinge, Gyorgy Marko-Varga
JOURNAL OF PROTEOMICS
(2013)
Article
Physiology
Daniel Svensson, Olof Gidlof, Karolina M. Turczynska, David Erlinge, Sebastian Albinsson, Bengt-Olof Nilsson
JOURNAL OF VASCULAR RESEARCH
(2014)
Article
Multidisciplinary Sciences
Olof Gidlof, J. Gustav Smith, Olle Melander, Hakan Lovkvist, Bo Hedblad, Gunnar Engstrom, Peter Nilsson, Joyce Carlson, Goran Berglund, Sandra Olsson, Katarina Jood, Christina Jern, Bo Norrving, Arne Lindgren, David Erlinge
Article
Critical Care Medicine
Patrik Andersson, Olof Gidlof, Oscar O. Braun, Matthias Gotberg, Jesper van der Pals, Bjorn Olde, David Erlinge
Article
Multidisciplinary Sciences
Olof Gidlof, Mikael Evander, Melinda Rezeli, Gyorgy Marko-Varga, Thomas Laurell, David Erlinge
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Selvi Celik, Mardjaneh Karbalaei-Sadegh, Goran Radegran, J. Gustav Smith, Olof Gidlof
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Anna Egerstedt, John Berntsson, Maya Landenhed Smith, Olof Gidlof, Roland Nilsson, Mark Benson, Quinn S. Wells, Selvi Celik, Carl Lejonberg, Laurie Farrell, Sumita Sinha, Dongxiao Shen, Jakob Lundgren, Goran Radegran, Debby Ngo, Gunnar Engstrom, Qiong Yang, Thomas J. Wang, Robert E. Gerszten, J. Gustav Smith
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Olof Gidloef, Kerstin Bader, Selvi Celik, Mario Grossi, Shinichi Nakagawa, Tetsuro Hirose, Bernhard Metzler, Bjoern Olde, David Erlinge
CELL DEATH & DISEASE
(2020)
Article
Medicine, Research & Experimental
Seivi Celik, Mardjaneh Karbalaei Sadegh, Michael Morley, Carolina Roselli, Patrick T. Ellinor, Thomas Cappola, J. Gustav Smith, Olof Gidlof
Article
Critical Care Medicine
Patrik Gilje, Olof Gidlof, Malin Rundgren, Tobias Cronberg, Mariam Al-Mashat, Bjorn Olde, Hans Friberg, David Erlinge
