Journal
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Volume 32, Issue 7, Pages 693-700Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.healun.2013.04.005
Keywords
lung transplant; pretransplant malnutrition; complications; death
Funding
- Slosburg Family Charitable Trust
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BACKGROUND: When high-risk lung transplant candidates are evaluated, nutritional state is often neglected. We evaluated the prevalence of markers reflecting pre-transplant malnutrition and their association with post-operative complications and death. METHODS: From January 2005 to July 2010, 453 patients underwent primary lung transplantation at our institution. Pre-operative nutrition-related variables, including body mass index and weight/height ratio, reflecting cachexia, and albumin, total protein, immunoglobulins, and absolute lymphocyte count were considered in identifying risk factors for time-related major post-operative complications (renal failure requiring dialysis, respiratory failure requiring tracheostomy), pulmonary or bloodstream infections, and death. RESULTS: Forty-eight patients had BMI <18.5 kg/m(2), 41 had a weight/height ratio <= 0.3, 102 had albumin <3.5 g/dl, 110 had total protein <6 g/dl, and 112 had an absolute lymphocyte count <1,000/mu l, indicative of a malnourished state. At 6 months, 30% had experienced pulmonary infection, with lower total serum protein concentration an important risk (p = 0.02). One-year actuarial mortality was 15%; risk factors included lower serum albumin (p = 0.004), particularly when <3 g/dl. In contrast, variables reflecting nutritional state were not statistically significantly correlated with dialysis, respiratory failure requiring tracheostomy, or bloodstream infections. CONCLUSION: Although malnutrition is uncommon in lung transplant patients, those at extremes of low serum albumin and total protein have worse survival and increased risk of post-operative infection. Strategies to improve nutrition of these high-risk candidates awaiting lung transplantation should be developed. J Heart Lung Transplant 2013;32:693-700 (C) 2013 International Society for Heart and Lung Transplantation. All rights reserved.
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