Article
Cardiac & Cardiovascular Systems
Max Shin, Amit Iyengar, Mark R. Helmers, William L. Patrick, William Cohen, Noah Weingarten, David Rekhtman, Cindy Song, Pavan Atluri, Marisa Cevasco
Summary: This study assessed the effect of extended criteria donor (ECD) hearts in patients undergoing simultaneous heart-kidney transplantation (SHKT) vs isolated heart transplants (IHT). The results showed that SHKT patients receiving ECD hearts face greater risks of mortality and graft failure compared to IHT patients receiving ECD hearts.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Sunit-Preet Chaudhry, Varun Sundaram, Samer Najjar
Summary: Heart transplantation in the United States is commonly performed using donors after brain death. Brain death accounts for 2% of adult inhospital deaths in the country and can cause physiological and hemodynamic changes that may negatively affect the donor heart.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yimou Lin, Haitao Huang, Lifeng Chen, Ruihan Chen, Jimin Liu, Shusen Zheng, Qi Ling
Summary: Liver transplantation is the final treatment option for end-stage liver disease. The usage of grafts from extended criteria donors has increased due to donor shortage. However, the use of such grafts carries a higher risk of post-transplant complications. Accurate and comprehensive assessment systems for donor liver quality are lacking. Recent advances in biochemical technologies and bioinformatic analysis have provided valuable insights into graft injury and potential ways to restore graft function.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ian G. Christie, Ernest G. Chan, John P. Ryan, Takashi Harano, Matthew Morrell, James D. Luketich, Pablo G. Sanchez
Summary: This study examined trends in the use of extended criteria donor lungs for lung transplantation and found that the use of extended criteria lungs has increased over time. However, the use of extended criteria donor lungs did not compromise recipient survival outcomes, with both ECD and standard criteria organs showing similar 1-year survival rates.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Noah Weingarten, Amit Iyengar, David Alan Herbst, Mark Helmers, Danika Meldrum, Sara Guevara-Plunkett, Jessica Dominic, Pavan Atluri
Summary: Based on the analysis of data from heart-lung transplantation recipients, it is found that using Extended Criteria Donor (ECD) hearts and/or lungs for transplantation is not associated with increased mortality, providing a safe strategy to increase donor organ supply.
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Review
Immunology
Kentaro Noda, Masashi Furukawa, Ernest G. Chan, Pablo G. Sanchez
Summary: The existing donor shortage in lung transplantation has not been improved by only using brain-dead donors with standard criteria. Clinically, efforts have been made to explore the potential contribution of untapped donors and technological advancements, such as ex vivo lung perfusion techniques, to expand the donor pool and improve posttransplant outcomes.
Article
Surgery
Taylor Nordan, Shant H. Mahrokhian, Caroline J. Liang, Jamel P. Ortoleva, Andre C. Critsinelis, Frederick Y. Chen, Gregory S. Couper, Masashi Kawabori
Summary: Under the new heart transplant allocation system, longer ischemic time has a negative impact on post-transplant survival, especially for younger donors. However, this effect is attenuated when the donor age is 39 years or older.
CLINICAL TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Selena S. Li, Asishana Osho, Philicia Moonsamy, David A. D'Alessandro, Gregory D. Lewis, Mauricio A. Villavicencio, Thoralf M. Sundt, Masaki Funamoto
Summary: Heart transplantation from HCV viremic donors has increased but varies significantly across regions and individual centers. Short-term outcomes are comparable, but the effects of seroconversion and long-term outcomes remain unclear.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Mohammed Quader, Renee Cholyway, Oluwatoyin Akande, Jennifer Bradley, Eleonora Mezzaroma, Stefano Toldo
Summary: The objective of this protocol is to establish a rat heterotopic heart transplantation model using DCD donor hearts. The protocol consists of heart donor setup and recipient setup. In the heart donor setup, the heart is procured after stopping ventilation and flushing with UW solution. In the recipient setup, the donor heart is transplanted into the recipient and reperfusion is initiated. Successful establishment of this model allows further research on cardioprotective approaches for improving heart transplantation outcomes from DCD donors.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Surgery
Vladimir J. Lozanovski, Pascal Probst, Ali Ramouz, Alireza Arefidoust, Omid Ghamarnejad, Ehsan Aminizadeh, Elias Khajeh, Arianeb Mehrabi
Summary: The study found that extended right lobe liver transplantation (ERLT) had lower graft survival rates at 3 months, 1 year, and 3 years compared to whole liver transplantation (WLT), while WLT was less associated with retransplantation, vascular complications, and biliary complications.
TRANSPLANT INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Sheng Fu, Chakradhari Inampudi, Bhavadharini Ramu, Mathew J. Gregoski, Jessica Atkins, Gregory R. Jackson, Amanda Celia, Jan M. Griffin, Daniel N. Silverman, Daniel P. Judge, Adrian B. van Bakel, Lucas J. Witer, Arman Kilic, Brian A. Houston, Andrew J. Sauer, Michelle M. Kittleson, Kelly H. Schlendorf, Rebecca J. Cogswell, Ryan J. Tedford
Summary: The impact of donor hemodynamics obtained via right-heart catheterization on recipient survival remains unclear. Donors with abnormal hemodynamics may represent an opportunity to expand the pool of viable donor hearts.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Medicine, General & Internal
Anna B. Roehl, Anne Andert, Karsten Junge, Ulf P. Neumann, Marc Hein, Felix Kork
Summary: The number of patients awaiting liver transplantation still exceeds the number of donated organs available, and patients receiving liver transplants who are treated with aprotinin are more likely to experience early allograft dysfunction (EAD).
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Luke J. DeRoos, Elliot B. Tapper, Mariel S. Lavieri, David W. Hutton, Neehar D. Parikh
Summary: In the study, evaluation of ineligible donor use from 2008 to 2020 by OPO and its association with graft and recipient survival was conducted. Differences in graft and patient survival were found between eligible and ineligible recipients for kidney and liver transplants. Eligibility was associated with kidney, liver, and lung graft survival, while there were no significant differences for heart, lung, and pancreas donations.
Article
Cardiac & Cardiovascular Systems
Katrien Vandendriessche, Vincent Tchana-Sato, Didier Ledoux, Karlien Degezelle, Steffen Rex, Arne Neyrinck, Ina Jochmans, Diethard Monbaliu, Christophe Vandenbriele, Johan Van Cleemput, Bart Meyns, Filip Rega
Summary: This study investigates the safety and feasibility of heart transplantation after circulatory death using thoraco-abdominal normothermic regional perfusion and subsequent cold storage. The results show a 100% survival rate and good cardiac function in four procedures.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Julia Riebandt, Dominik Wiedemann, Sigrid Sandner, Philipp Angleitner, Andreas Zuckermann, Thomas Schloeglhofer, Guenther Laufer, Daniel Zimpfer
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
P. H. I. L. I. P. P. ANGLEITNER, T. H. O. M. A. S. SCHLOEGLHOFER, D. O. M. I. N. I. K. WIEDEMANN, J. U. L. I. A. RIEBANDT, A. N. D. R. E. A. S. STRASSL, J. U. L. I. A. MASCHERBAUER, M. A. T. T. H. I. A. S. KAINZ, G. U. E. N. T. H. E. R. LAUFER, A. N. D. R. E. A. S. ZUCKERMANN, D. A. N. I. E. L. ZIMPFER
Summary: In this case report, we present a patient with apical hypertrophic cardiomyopathy and severe fixed pulmonary hypertension. To make the patient eligible for heart transplantation, continuous left-ventricular unloading with a left-ventricular assist device was performed, and the reversal of pulmonary hypertension was assessed using a cardiac pressure sensor.
Article
Cardiac & Cardiovascular Systems
Philip F. Halloran, Katelynn Madill-Thomsen, Arezu Z. Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Gokler, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann
Summary: This study extended the MMDx system to classify heart transplant endomyocardial biopsies into a new Minor category characterized by low-level inflammation and ABMR-related gene expression. The results suggest that low-level ABMR-related molecular stress may be operating in more hearts than previously estimated.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Anesthesiology
Caroline Holaubek, Fabian Winter, Anita Lesjak, Arezu Aliabadi-Zuckermann, Philipp Opfermann, Bernhard Urbanek, Christine Schloemmer, Mohamed Mouhieddine, Andreas Zuckermann, Barbara Steinlechner
Summary: The study aimed to identify perioperative risk factors for intensive care unit readmission and in-hospital death after cardiac surgery. Preoperative risk factors such as end-stage renal failure, arrhythmia, chronic obstructive pulmonary disease, age over 80, and high European System for Cardiac Operative Risk Evaluation II score were associated with ICU readmission. Readmitted patients had a higher mortality rate compared to nonreadmitted patients.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Review
Cardiac & Cardiovascular Systems
Maria Generosa Crespo-Leiro, Maria Rosa Costanzo, Finn Gustafsson, Kiran K. Khush, Peter S. Macdonald, Luciano Potena, Josef Stehlik, Andreas Zuckermann, Mandeep R. Mehra
Summary: Heart transplantation faces challenges including limited organ pool, personalized immunosuppressive therapy, and minimizing late complications. Advances such as using hepatitis C-infected donors, expanding donor source, and new preservation techniques have increased organ availability. Mechanical circulatory support has helped patients with advanced heart failure maintain organ function while waiting for a suitable donor match.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Are Martin Holm, Andrew Courtwright, Anne Olland, Andreas Zuckermann, Dirk Van Raemdonck
Summary: This document outlines the International Society for Heart and Lung Transplantation's position on thoracic organ transplantation using Controlled organ donation after circulatory determination of death, and includes a position on methods to ensure the viability of organs after certification of death.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Philipp Opfermann, Alessia Felli, Christine Schloemmer, Martin Dworschak, Michele Bevilacqua, Mohamed Mouhieddine, Daniel Zimpfer, Andreas Zuckermann, Barbara Steinlechner
Summary: This study found that preoperative Multiplate(R) and ROTEM(R) measurements can serve as indicators for assessing the risk of postoperative bleeding in LVAD patients, providing guidance for perioperative clinical management.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Maria Laggner, Felicitas Oberndorfer, Bahar Golabi, Jonas Bauer, Andreas Zuckermann, Philipp Hacker, Irene Lang, Nika Skoro-Sajer, Christian Gerges, Shahrokh Taghavi, Peter Jaksch, Michael Mildner, Hendrik Jan Ankersmit, Bernhard Moser
Summary: This study investigated the gene expression profiles of hypertrophic and regenerated right hearts of two subtypes of pulmonary hypertension (PH) patients. The findings revealed unique gene alteration signatures in different PH subtypes, as well as the identification of a profibrotic factor, early growth response 1 (EGR1), in both subtypes. These findings may contribute to the identification of therapeutic candidates for PH patients who are not eligible for surgical treatment.
Review
Biology
Markus J. Barten, Fausto Baldanti, Alexander Staus, Christian M. Hueber, Kyriaki Glynou, Andreas Zuckermann
Summary: This meta-analysis suggests that prophylactic CMVIG treatment in solid organ transplantation patients can reduce the risk of CMV infection. This is particularly beneficial for patients at high risk of CMV infection or disease.
Article
Cardiac & Cardiovascular Systems
Dana P. McGlothlin, John Granton, Walter Klepetko, Maurice Beghetti, Erika B. Rosenzweig, Paul A. Corris, Evelyn Horn, Manreet K. Kanwar, Karen Mcrae, Antonio Roman, Ryan Tedford, Roberto Badagliacca, Sonja Bartolome, Raymond Benza, Marco Caccamo, Rebecca Cogswell, Celine Dewachter, Laura Donahoe, Elie Fadel, Harrison W. Farber, Jeffrey Feinstein, Veronica Franco, Robert Frantz, Michael Gatzoulis, Choon Hwa (Anne) Goh, Marco Guazzi, Georg Hansmann, Stuart Hastings, Paul M. Heerdt, Anna Hemnes, Antoine Herpain, Chih-Hsin Hsu, Kim Kerr, Nicholas A. Kolaitis, Jasleen Kukreja, Michael Madani, Stuart McCluskey, Michael McCulloch, Bernhard Moser, Manchula Navaratnam, Goran Radegran, Cara Reimer, Laurent Savale, Oksana A. Shlobin, Jana Svetlichnaya, Keith Swetz, Jessica Tashjian, Thenappan Thenappan, Carmine Dario Vizza, Shawn West, Warren Zuckerman, Andreas Zuckermann, Teresa De Marco
Summary: This document is the first international consensus statement on the perioperative management of patients with pulmonary hypertension and right heart failure. It provides recommendations for managing patients with pulmonary hypertension being considered for surgery, including preoperative risk assessment, planning, intra- and postoperative monitoring and management strategies that can improve outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Tajinder P. Singh, Wida S. Cherikh, Eileen Hsich, Michael O. Harhay, Don Hayes, Michael Perch, Luciano Potena, Aparna Sadavarte, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Eileen Hsich, Tajinder P. Singh, Wida S. Cherikh, Michael O. Harhay, Don Hayes, Michael Perch, Luciano Potena, Aparna Sadavarte, Kelsi Lindblad, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Hannah Copeland, Ivan Knezevic, David A. Baran, Vivek Rao, Michael Pham, Finn Gustafsson, Sean Pinney, Brian Lima, Marco Masetti, Agnieszka Ciarka, Navin Rajagopalan, Adriana Torres, Eileen Hsich, Jignesh K. Patel, Livia Adams Goldraich, Monica Colvin, Javier Segovia, Heather Ross, Mahazarin Ginwalla, Babak Sharif-Kashani, MaryJane A. Farr, Luciano Potena, Jon Kobashigawa, Maria G. Crespo-Leiro, Natasha Altman, Florian Wagner, Jennifer Cook, Valentina Stosor, Paolo A. Grossi, Kiran Khush, Tahir Yagdi, Susan Restaino, Steven Tsui, Daniel Absi, George Sokos, Andreas Zuckermann, Brian Wayda, Joost Felius, Shelley A. Hall
Summary: The proposed guidelines for donor heart selection are evidence-based and expert-consensus recommendations that were compiled by an international panel of experts after an extensive literature review.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Immunology
Katelynn S. Madill-Thomsen, Jeff Reeve, Arezu Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Goekler, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann, Philip F. Halloran
Summary: Using genome-wide microarray measurements, a molecular classification of parenchymal injury in heart transplants was developed. T cell-mediated rejection and antibody-mediated rejection have differential impacts on the parenchyma, with the latter contributing significantly to late dysfunction. This classification provides new insights into dysfunction and outcomes in heart transplants.
Article
Cardiac & Cardiovascular Systems
Christoph Sinning, Elvin Zengin, Gerhard-Paul Diller, Francesco Onorati, Maria-Angeles Castel, Thibault Petit, Yih-Sharng Chen, Mauro Lo Rito, Carmelina Chiarello, Romain Guillemain, Karine Nubret-Le Coniat, Christina Magnussen, Dorit Knappe, Peter Moritz Becher, Benedikt Schrage, Jacqueline M. Smits, Andreas Metzner, Christoph Knosalla, Felix Schoenrath, Oliver Miera, Mi-Young Cho, Alexander Bernhardt, Jessica Weimann, Alina Gossling, Amedeo Terzi, Antonio Amodeo, Sara Alfieri, Emanuela Angeli, Luca Ragni, Carlo Pace Napoleone, Gino Gerosa, Nicola Pradegan, Inez Rodrigus, Julia Dumfarth, Michel de Pauw, Katrien Francois, Olivier Van Caenegem, Arnaut Ancion, Johan Van Cleemput, Davor Milicic, Ajay Moza, Peter Schenker, Josef Thul, Michael Steinmetz, Gregor Warnecke, Fabio Ius, Susanne Freyt, Murat Avsar, Tim Sandhaus, Assad Haneya, Sandra Eifert, Diyar Saeed, Michael Borger, Henryk Welp, Laszlo Ablonczy, Bastian Schmack, Arjang Ruhparwar, Shiho Naito, Xiaoqin Hua, Nina Fluschnik, Moritz Nies, Laura Keil, Juliana Senftinger, Djemail Ismaili, Shinwan Kany, Dora Csengeri, Massimo Cardillo, Alessandra Oliveti, Giuseppe Faggian, Richard Dorent, Carine Jasseron, Alicia Perez Blanco, Jose Manuel Sobrino Marquez, Raquel Lopez-Vilella, Ana Garcia-Alvarez, Maria Luz Polo Lopez, Alvaro Gonzalez Rocafort, Oscar Gonzalez Fernandez, Raquel Prieto-Arevalo, Eduardo Zatarain-Nicolas, Katrien Blanchart, Aude Boignard, Pascal Battistella, Soulef Guendouz, Lucile Houyel, Marylou Para, Erwan Flecher, Arnaud Gay, Eric Epailly, Camille Dambrin, Kaitlyn Lam, Cally Ho Ka-lai, Yang Hyun Cho, Jin-Oh Choi, Jae-Joong Kim, Louise Coats, David Steven Crossland, Lisa Mumford, Samer Hakmi, Cumaraswamy Sivathasan, Larissa Fabritz, Stephan Schubert, Jan Gummert, Michael Huebler, Peter Jacksch, Andreas Zuckermann, Gunther Laufer, Helmut Baumgartner, Alessandro Giamberti, Hermann Reichenspurner, Paulus Kirchhof
Summary: The ARTORIA-R study plans to collect retrospective data from 1989-2020 and include prospective patients to provide robust information on current management and outcomes of adults with congenital heart disease suffering from advanced heart failure.