Journal
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Volume 29, Issue 3, Pages 261-264Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.healun.2009.07.004
Keywords
cardiac cachexia; mechanical support; heart failure; outcome
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Cardiac cachexia, associated with excessive activation of the sympathetic nervous system together with immune activation, is an important prognostic indicator in heart failure. Anecdotally, the prevalence of cardiac cachexia appears to be falling, perhaps due to the increased use of beta-blockers. However, chronic heart failure is so common that many patients continue to lose weight and continue to deteriorate to a point where transplantation or mechanical support is considered. The origin of cachexia remains elusive and further research is needed to explore the relation between weight, sympathetic activation, and the response to cardiac surgery or transplantation. J Heart Lung Transplant 2010;29:261-4 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.
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