Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Cardiac & Cardiovascular Systems
Oliver K. Jawitz, Vignesh Raman, David Becerra, Jacob Klapper, Matthew G. Hartwig
Summary: This study aimed to identify factors associated with survival beyond a decade after lung transplant. The results showed that approximately one-quarter of lung transplant recipients survived 10 years post-transplant. There were different factors associated with 1-year and 10-year survival, and the Lung Allocation Score did not impact long-term survival. Further research is needed to improve patient selection and management strategies to increase long-term survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Respiratory System
Adele Coriati, Jenna Sykes, Lydie Lemonnier, Xiayi Ma, Sanja Stanojevic, Clemence Dehillotte, Nicolas Carlier, Anne L. Stephenson, Pierre-Regis Burgel
Summary: After the implementation of the BELT programme, CF patients in France were more likely to receive lung transplants than die. Post-transplant survival in France did not change significantly in the post-HELT period compared with the pre-HELT period, and was similar to outcomes in Canada.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Critical Care Medicine
Nicholas A. Kolaitis, Hubert Chen, Daniel R. Calabrese, Kerry Kumar, Jill Obata, Carrie Bach, Jeffrey A. Golden, Marc A. Simon, Jasleen Kukreja, Steven R. Hays, Lorriana E. Leard, Jonathan P. Singer, Teresa De Marco
Summary: The 2015 revision of the lung allocation score (LAS) aimed to improve waiting list mortality and transplant rates for patients with pulmonary arterial hypertension (PAH). A study comparing the pre- and post-revision eras found that the revision did achieve its intended goals, providing better transplantation opportunities and reducing the risk of death on the waiting list for patients with PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Max Shin, Amit Iyengar, Mark R. Helmers, John J. Kelly, Cindy Song, David Rekhtman, Marisa Cevasco
Summary: The study found that changing the allocation policy can improve waitlist outcomes for patients undergoing heart-lung transplantation, with no impact on post-transplant survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Carli J. Lehr, Andrew Wey, Melissa A. Skeans, Erika D. Lease, Maryam Valapour
Summary: This study evaluated the factors impacting lung transplant allocation, including queue updates, post-transplant survival time, time-varying effects for non-proportional hazards, and different weights for waitlist and post-transplant area under the curve. The findings suggest that incorporating equally weighted models using 5-year posttransplant survival can improve transplant outcomes under the continuous distribution system.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Immunology
Haytham Elgharably, Kamal S. Ayyat, Toshihiro Okamoto, Lucy Thuita, Shinya Unai, Alejandro C. Bribriesco, James J. Yun, Douglas R. Johnston, Usman Ahmad, Sudish C. Murthy, Marie M. Budev, Gosta B. Pettersson, Kenneth R. McCurry
Summary: Over the past 30 years, lung fibrosis has become the primary indication for lung transplantation, with an increase in recipient age and surgical complexity. In the third era, hypoalbuminemia, thrombocytopenia, and high primary graft dysfunction grade were identified as multivariate predictors of early mortality. The 5-year survival rates in the second and third eras were significantly higher than in the first era.
Article
Cardiac & Cardiovascular Systems
Erin M. Schnellinger, Edward Cantu, Douglas E. Schaubel, Stephen E. Kimmel, Alisa J. Stephens-Shields
Summary: This study estimated the clinical impact of replacing the Lung Allocation Score (LAS) with a modified LAS (mLAS) in lung transplant candidates. The results suggest that implementing mLAS can lead to important differences in allocation and possibly improve waitlist survival.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Zhizhou Yang, Melanie P. Subramanian, Yan Yan, Bryan F. Meyers, Benjamin D. Kozower, G. Alexander Patterson, Ruben G. Nava, Ramsey R. Hachem, Chad A. Witt, Michael K. Pasque, Derek E. Byers, Hrishikesh S. Kulkarni, Daniel Kreisel, Akinobu Itoh, Varun Puri
Summary: This study analyzed clinical data of lung transplant patients and found an association between center volume and 1-year survival rate. The optimal threshold for volume was identified as 33 cases per year, as exceeding this number did not provide additional benefits.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jay M. Brahmbhatt, Travis Hee Wai, Christopher H. Goss, Erika D. Lease, Christian A. Merlo, Siddhartha G. Kapnadak, Kathleen J. Ramos
Summary: Improved predictive models are needed for lung transplantation in the United States to accurately predict long-term post-transplant survival and fairly allocate organs. The existing models show poor accuracy in predicting 1-year and 3-year post-transplant mortality, and tend to overestimate the risk of death in patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Immunology
Emmanouil Giorgakis, Tommy Ivanics, Shirin E. Khorsandi, David Wallace, Lyle Burdine, Wayel Jassem, Amit K. Mathur, Nigel Heaton
Summary: There are differences between the United States and the United Kingdom in terms of characteristics and posttransplant survival of patients who received donation after circulatory death (DCD) liver allografts from donors aged >60 years. The utilization of older DCD liver transplants is low in the United States, resulting in worse survival for donors aged >60. However, survival rates for donors aged <= 60 are similar in both countries, supporting an extension to the current US DCD age cutoff.
Article
Oncology
Eloisa Ruiz, Paula Moreno, Francisco Javier Gonzalez, Alba Maria Fernandez, Benito Cantador, Juan Luis Parraga, Angel Salvatierra, Antonio Alvarez
Summary: Lung transplant recipients are at high risk of developing malignancies, with de novo lung cancers being the most lethal, especially in patients with chronic obstructive pulmonary disease receiving single lung transplants. This study emphasizes the importance of considering the prevalence and impact of malignancies on long-term survival in lung transplant recipients.
Article
Surgery
Alexy Tran-Dinh, Imane Tir, Sebastien Tanaka, Enora Atchade, Brice Lortat-Jacob, Sylvain Jean-Baptiste, Nathalie Zappella, Sandrine Boudinet, Yves Castier, Herve Mal, Pierre Mordant, Iannis Ben Abdallah, Vincent Bunel, Jonathan Messika, Laurence Armand-Lefevre, Nathalie Grall, Philippe Montravers
Summary: Culture-positive preservation fluid (PF) after lung transplantation (LT) has a high prevalence and may decrease recipient survival, further studies are required to confirm these results and improve management.
TRANSPLANT INTERNATIONAL
(2023)
Article
Surgery
Carlos Ortiz-Bautista, Javier Muniz, Luis Almenar-Bonet, Maria G. Crespo-Leiro, Jose M. Sobrino-Marquez, Marta Farrero-Torres, Maria D. Garcia-Cosio, Beatriz Diaz-Molina, Isabel Zegri-Reiriz, Francisco Gonzalez-Vilchez, Zorba Blazquez-Bermejo, Amador Lopez Granados, Manuel Gomez-Bueno, Luis de la Fuente-Galan, Teresa Blasco-Peiro, Iris P. Garrido-Bravo, Elena Garcia-Romero, Gregorio Rabago Juan-Aracil, Luis Garcia-Guereta, Juan F. Delgado-Jimenez
Summary: The IMPACT score failed to accurately predict the risk of death after heart transplantation in a contemporary Spanish cohort.
CLINICAL TRANSPLANTATION
(2022)
Article
Oncology
Jordan J. Baechle, Paula Marincola Smith, Carmen C. Solorzano, Thuy B. Tran, Lauren M. Postlewait, Shishir K. Maithel, Jason Prescott, Timothy Pawlik, Tracy S. Wang, Jason Glenn, Ioannis Hatzaras, Rivfka Shenoy, John E. Phay, Lawrence A. Shirley, Ryan C. Fields, Linda Jin, Daniel E. Abbott, Sean Ronnekleiv-Kelly, Jason K. Sicklick, Adam Yopp, John Mansour, Quan-Yang Duh, Natalie Seiser, Konstantinos Votanopoulos, Edward A. Levine, George Poultsides, Colleen M. Kiernan
Summary: The study demonstrated that the cumulative GRAS score effectively stratifies overall survival (OS) and disease-free survival (DFS) after index resection for ACC patients. Further prospective analysis is needed to validate its prognostic value in clinical practice.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Joshua C. Grimm, Vicente Valero, Arman Kilic, Todd C. Crawford, John V. Conte, Christian A. Merlo, Pali D. Shah, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Joshua C. Grimm, Cecillia Lui, Arman Kilic, Vicente Valero, Christopher M. Sciortino, Glenn J. R. Whitman, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2015)
Editorial Material
Surgery
S. C. Sweet, A. S. Shah
AMERICAN JOURNAL OF TRANSPLANTATION
(2014)
Article
Anesthesiology
Charles H. Brown, Maura Grega, Ola A. Selnes, Guy M. McKhann, Ashish S. Shah, Andrew LaFlam, William J. Savage, Steven M. Frank, Charles W. Hogue, Rebecca F. Gottesman
ANESTHESIA AND ANALGESIA
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, John V. Conte, William A. Baumgartner, Stuart D. Russell, Christian A. Merlo, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2014)
Letter
Cardiac & Cardiovascular Systems
R. Scott Stephens, Ashish S. Shah, Glenn J. R. Whitman
ANNALS OF THORACIC SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Vasileios Karantalis, Darcy L. DiFede, Gary Gerstenblith, Si Pham, James Symes, Juan Pablo Zambrano, Joel Fishman, Pradip Pattany, Ian McNiece, John Conte, Steven Schulman, Katherine Wu, Ashish Shah, Elayne Breton, Janice Davis-Sproul, Richard Schwarz, Gary Feigenbaum, Muzammil Mushtaq, Viky Y. Suncion, Albert C. Lardo, Ivan Borrello, Adam Mendizabal, Tomer Z. Karas, John Byrnes, Maureen Lowery, Alan W. Heldman, Joshua M. Hare
CIRCULATION RESEARCH
(2014)
Editorial Material
Cardiac & Cardiovascular Systems
Ashish S. Shah
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2013)
Article
Cardiac & Cardiovascular Systems
Josef Stehlik, Lynne W. Stevenson, Leah B. Edwards, Maria G. Crespo-Leiro, Juan F. Delgado, Richard Dorent, Maria Frigerio, Peter Macdonald, Guy A. MacGowan, Alessandro Nanni Costa, Joseph G. Rogers, Ashish S. Shah, Rhiannon Taylor, Rajaiyer V. Venkateswaran, Mandeep R. Mehra
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Jason O. Robertson, Maria V. Grau-Sepulveda, Shoichi Okada, Sean M. O'Brien, J. Matthew Brennan, Ashish S. Shah, Akinobu Itoh, Ralph J. Damiano, Sunil Prasad, Scott C. Silvestry
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Ryan J. Tedford, Claude A. Beaty, Stephen C. Mathai, Todd M. Kolb, Rachel Damico, Paul M. Hassoun, Peter J. Leary, David A. Kass, Ashish S. Shah
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Ashish S. Shah, John V. Conte, Kaushik Mandal, William A. Baumgartner, Duke E. Cameron, Glenn J. R. Whitman
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Joshua C. Grimm, Ashish S. Shah, John V. Conte, Glenn J. R. Whitman, Christopher M. Sciortino
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Ashish S. Shah, James H. Black, Glenn J. R. Whitman, David D. Yuh, Duke E. Cameron, John V. Conte
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Surgery
George J. Arnaoutakis, Gregory J. Bittle, Jeremiah G. Allen, Eric S. Weiss, Jennifer Alejo, William A. Baumgartner, Ashish S. Shah, Christopher L. Wolfgang, David T. Efron, John V. Conte
WORLD JOURNAL OF SURGERY
(2014)