Article
Immunology
Sarah J. Fitzsimons, Jonathan D. W. Evans, Doris M. Rassl, Kuan Ken Lee, Fiona E. Strachan, Jayan Parameshwar, Nicholas L. Mills, Stephen J. Pettit
Summary: This study aimed to investigate whether a new high-sensitivity cardiac troponin I (hs-cTnI) assay could be used as a rule-out test for acute cellular rejection (ACR) after heart transplantation. The results showed no association between hs-cTnI concentration and the presence of significant ACR on surveillance endomyocardial biopsy, indicating that measurement of hs-cTnI may not be a useful technique for diagnosis or exclusion of ACR after heart transplantation.
Article
Immunology
Zhe Yang, Fei Han, Tao Liao, Haofeng Zheng, Zihuan Luo, Maolin Ma, Jiannan He, Lei Li, Yongrong Ye, Rui Zhang, Zhengyu Huang, Yannan Zhang, Qiquan Sun
Summary: Artemisinin demonstrates significant immunosuppressive effects in rat cardiac transplantation model, attenuating rejection reactions and prolonging allograft survival. By targeting multiple effector cells, artemisinin effectively reduces T cell-mediated rejection and antibody-mediated rejection, showing potential for clinical use in transplant rejection prevention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Peripheral Vascular Disease
Carlos M. Ferrario, Seethalakshmi R. Iyer, John C. Burnett, Sarfaraz Ahmad, Kendra N. Wright, Jessica L. VonCannon, Amit Saha, Leanne Groban
Summary: The study identified the presence of Ang (1-12) in the blood of both normotensive subjects and patients with hypertension, regardless of age or sex, suggesting its role as a potential source for Ang II production in the blood. Higher plasma Ang (1-12) concentrations in hypertensive patients were correlated with certain indicators.
Article
Immunology
Xiangyu Fan, Jini Qiu, Tianjie Yuan, Jing Zhang, Jianjiang Xu
Summary: The study demonstrates that Piperlongumine (PL) can exhibit both anti-angiogenic and anti-inflammatory effects in preventing corneal allograft rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jinwen Lin, Ying Chen, Huijuan Zhu, Kai Cheng, Huiping Wang, Xianping Yu, Mengmeng Tang, Jianghua Chen
Summary: This study demonstrates that remodeling of lymphatic vessels plays a key role in antigen presentation and lymph node activation after kidney transplantation. Higher density of lymphatic vessels is associated with renal dysfunction and pathological changes post-transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marco Alfonso Perrone, Alberto Aimo, Sergio Bernardini, Aldo Clerico
Summary: The term inflammageing was introduced in 2000 to describe the chronic inflammatory state of elderly individuals, which is characterized by elevated levels of inflammatory biomarkers, comorbidities, disability, frailty, and premature death. Inflammageing is linked to various cardiovascular diseases and early detection and counteraction of inflammageing can prevent cardiovascular disease and slow down age-related health decline. Early interventions require reliable and cost-effective biomarkers, such as cardiac-specific biomarkers, for diagnosis and further clinical studies are needed to assess their usefulness and cost/benefit ratio.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study identified and validated a urinary proteomic signature for the surveillance of cardiac allograft vasculopathy (CAV). The proteins in the signature may offer insights into CAV pathological processes and warrant further investigation into personalized treatment targets.
Article
Urology & Nephrology
Rajil B. Mehta, Ivy Melgarejo, Vignesh Viswanathan, Xingyu Zhang, Matthew Pittappilly, Parmjeet Randhawa, Chethan Puttarajappa, Puneet Sood, Christine Wu, Akhil Sharma, Michele Molinari, Sundaram Hariharan
Summary: This study demonstrates that subclinical inflammation (SCI) detected through surveillance biopsy in the first year post-transplantation is associated with subsequent immunological events, including clinical biopsy proven acute rejection (C-BPAR) and death-censored graft loss.
KIDNEY INTERNATIONAL
(2022)
Article
Cell Biology
Davis A. Englund, Ayumi E. Sakamoto, Chad M. Fritsche, Amanda A. Heeren, Xu Zhang, Brian R. Kotajarvi, Denise R. Lecy, Matthew J. Yousefzadeh, Marissa J. Schafer, Thomas A. White, Elizabeth J. Atkinson, Nathan K. LeBrasseur
Summary: This study demonstrates that a 12-week structured exercise program significantly improves physical function in older adults, while reducing the expression of key markers of the senescence program and circulating concentrations of senescence-related proteins. Levels of senescence-related proteins at baseline are predictive of changes in physical function in response to the exercise intervention.
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
Article
Materials Science, Multidisciplinary
Cheng Deng, Chenyuan Wang, Wenpei Fu, Lujuan Wu, Qiaofeng Jin, Li Zhang, Wen Zhang, Wei Li, Mingxing Xie
Summary: This study evaluated the efficacy of a FK506-loaded microneedle (FK506 MN) in treating acute rejection in heart transplantation. The results showed that FK506 MN could successfully alleviate acute rejection and prolong allograft survival. In addition, it also reduced T cell and macrophage infiltration as well as the secretion of certain cytokines.
MATERIALS & DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Guillaume Coutance, Eva Desire, Jean-Paul Duong Van Huyen
Summary: Despite advances in immunosuppression, allograft rejection remains a significant complication after heart transplantation. The current invasive diagnostic method has limitations, thus innovative strategies are needed to improve the accuracy of diagnosis.
Review
Cardiac & Cardiovascular Systems
Jordan S. Pober, Sharon Chih, Jon Kobashigawa, Joren C. Madsen, George Tellides
Summary: This article discusses the incidence and diagnosis, the nature of the vascular remodelling, immune and non-immune contributions to pathogenesis, current therapies, and future areas of research in cardiac allograft vasculopathy (CAV).
CARDIOVASCULAR RESEARCH
(2021)
Article
Urology & Nephrology
Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
Summary: This study found that resident macrophages in the donor kidney rapidly expanded during the early stages of kidney transplantation and were induced to express high levels of Ccl8. This led to the infiltration of recipient monocytes, their differentiation into resident macrophages, and subsequent expression of Ccl8. Enhanced infiltration of recipient T cells followed. Targeting the CCL8-CCR8 axis shows promise for reducing early kidney allograft inflammation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Cassandra Roeske, Amy Martinuk, Asna Choudhry, Geoffrey N. Hendy, Michael Gollob, Qiuji Li, Tina Georgalis, Adolfo J. de Bold
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2015)
Editorial Material
Cardiac & Cardiovascular Systems
Adolfo J. de Bold
JACC-HEART FAILURE
(2015)
Review
Endocrinology & Metabolism
Hugo R. Ramos, Andreas L. Birkenfeld, Adolfo J. de Bold
ENDOCRINE CONNECTIONS
(2015)
Article
Cardiac & Cardiovascular Systems
Monica Forero McGrath, Tsuneo Ogawa, Adolfo J. de Bold
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Astra I. Chang, Monica Forero McGrath, Adolfo J. de Bold
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Tsuneo Ogawa, Adolfo J. de Bold
Review
Pharmacology & Pharmacy
Adolfo J. de Bold
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Mercedes L. Kuroski de Bold, Alejandra Etchepare, Amy Martinuk, Adolfo J. de Bold
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2010)
Article
Endocrinology & Metabolism
Mercedes Kuroski de Bold, William P. Sheffield, Amy Martinuk, Varsha Bhakta, Louise Eltringham-Smith, Adolfo J. de Bold
REGULATORY PEPTIDES
(2012)
Review
Endocrinology & Metabolism
Tsuneo Ogawa, Adolfo J. de Bold
ENDOCRINE CONNECTIONS
(2014)
Review
Cardiac & Cardiovascular Systems
Jens P. Goetze, Benoit G. Bruneau, Hugo R. Ramos, Tsuneo Ogawa, Mercedes Kuroski de Bold, Adolfo J. de Bold
NATURE REVIEWS CARDIOLOGY
(2020)
Letter
Medicine, General & Internal
Adolfo J. de Bold
MEDICINA-BUENOS AIRES
(2014)
Article
Medicine, General & Internal
Tsuneo Ogawa, Adolfo J. De Bold
MEDICINA-BUENOS AIRES
(2013)