Review
Medicine, General & Internal
Sharon Bruoha, Chaim Yosefy, Louay Taha, Danny Dvir, Mony Shuvy, Rami Jubeh, Shemy Carasso, Michael Glikson, Elad Asher
Summary: Cardiogenic shock complicating acute myocardial infarction is a complex clinical condition with poor prognosis. Early target vessel revascularization is the most effective treatment, but mortality remains high. Temporary circulatory support devices aim to enhance cardiac unloading and improve organ perfusion, but there is a lack of quality evidence to guide device selection and management, highlighting the importance of multidisciplinary expert care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Ileana Pirozzi, Ali Kight, Amy Kyungwon Han, Mark R. Cutkosky, Seraina A. Dual
Summary: Artificial muscles allow for the design of soft implantable devices that will revolutionize the way we mechanically support the heart. This review examines the prior research on artificial muscles and evaluates their applicability in the short and long term. The challenges and future perspectives for attachment, physiological responsiveness, durability, and biodegradability are discussed.
ADVANCED MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Astrid Kassner, Cenk Oezpeker, Jan Gummert, Armin Zittermann, Anna Gaertner, Jens Tiesmeier, Henrik Fox, Michiel Morshuis, Hendrik Milting
Summary: This study revealed that cardiac fibrosis was significantly increased in heart failure patients and even continued to increase after mechanical unloading. The mRNAs of collagens I and III are independently regulated from the collagen protein.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
David A. Baran, Abhishek Jaiswal, Felix Hennig, Evgenij Potapov
Summary: Clinicians and regulators are struggling to develop allocation systems that balance waitlist mortality and donor availability in the face of a chronic donor shortage. This article discusses the characteristics and limitations of current devices used for temporary mechanical circulatory support (tMCS) as a bridging strategy, as well as the evolving outcomes of transplantation following device support. It also reviews and compares heart transplantation allocation schemas in different countries. The article proposes key principles to guide changes in the next generation of donor allocation systems, including calculated scores, time limits on high urgency statuses, emphasis on durable mechanical support therapies, and peer review of exceptions to organ allocation policy.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Cardiac & Cardiovascular Systems
Danilo Obradovic, Anne Freund, Hans-Josef Feistritzer, Dmitry Sulimov, Goran Loncar, Mohamed Abdel-Wahab, Uwe Zeymer, Steffen Desch, Holger Thiele
Summary: CS is a major concern in acute cardiovascular medicine, with high mortality despite advancements in treatment. Temporary MCS devices may improve clinical outcomes in selected CS patients, but large-scale randomized controlled trials are needed to confirm mortality reduction and further research is necessary to understand the clinical value of MCS in CS.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Benjamin S. Salter, Caroline R. Gross, Menachem M. Weiner, Srinivas R. Dukkipati, Gregory W. Serrao, Noah Moss, Anelechi C. Anyanwu, Daniel Burkhoff, Anuradha Lala
Summary: This Review discusses the functionality, indications, management, and complications of temporary mechanical circulatory support devices in specific clinical scenarios. It also explores the expanding use of these devices in various clinical settings and the ongoing development of MCS device design and technology.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cara Wrigley, Sean Peel, Kimmi Keum Hee Ko, Karla Straker
Summary: By analyzing the names patients give to their MCS devices, emotional relationships can be inferred, focusing on humor, coping, improving acceptance for family and friends, and reclaiming agency. Deliberately considering these factors in future research and development can help improve patient wellbeing.
Article
Cardiac & Cardiovascular Systems
Palak Shah, Mitchell Psotka, Iosif Taleb, Rami Alharethi, Mortada A. Shams, Omar Wever-Pinzon, Michael Yin, Federica Latta, Josef Stehlik, James C. Fang, Guoqing Diao, Ramesh Singh, Naila Ijaz, Christos P. Kyriakopoulos, Wei Zhu, Christopher W. May, Lauren B. Cooper, Shashank S. Desai, Craig H. Selzman, Abdallah G. Kfoury, Stavros G. Drakos
Summary: Evaluating the continuum of reverse cardiac remodeling following LVAD implantation, this study defined three stages and highlighted the importance of individualized clinical management and advancing research in myocardial plasticity.
CIRCULATION-HEART FAILURE
(2021)
Review
Cardiac & Cardiovascular Systems
Taiyo Kuroda, Chihiro Miyagi, Kiyotaka Fukamachi, Jamshid H. Karimov
Summary: The importance of treating right heart failure has become increasingly significant due to the higher risk of mortality. However, the multifactorial root and pathophysiological mechanisms of this condition make the choice of appropriate therapeutic targets complex. Mechanical circulatory support devices play a crucial role in the treatment of right heart failure, and the success of treatment relies on the timing of intervention and accurately predicting the duration of support required.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Clinical Neurology
Aaron Shoskes, Glenn Whitman, Sung-Min Cho
Summary: Mechanical circulatory support devices have shown improved survival outcomes in cardiopulmonary failure but are associated with significant neurologic morbidity and mortality. Despite the common occurrence of acute brain injury in short-term and durable MCS devices, there is a lack of guidelines for neurocritical care. Standardized neurological monitoring and management algorithms may potentially improve outcomes for patients with MCS device-associated brain injury.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Ron Waksman, Mohit Pahuja, Sean van Diepen, Alastair G. Proudfoot, David Morrow, Ernest Spitzer, Graham Nichol, Myron L. Weisfeldt, Mauro Moscucci, Patrick R. Lawler, Alexandre Mebazaa, Eddy Fan, Neal W. Dickert, Marc Samsky, Robert Kormos, Ileana L. Pina, Bram Zuckerman, Andrew Farb, John S. Sapirstein, Charles Simonton, Nick E. J. West, Abdulla A. Damluji, Ian C. Gilchrist, Uwe Zeymer, Holger Thiele, Donald E. Cutlip, Mitchell Krucoff, William T. Abraham
Summary: This article discusses the establishment and objectives of the Shock Academic Research Consortium, which aims to develop practical consensus definitions to evaluate the efficacy and safety of mechanical circulatory support devices in clinical trials for cardiogenic shock patients.
Review
Cardiac & Cardiovascular Systems
Varinder Kaur Randhawa, Abdulrahman Al-Fares, Michael Z. Y. Tong, Edward G. Soltesz, Jaime Hernandez-Montfort, Ziad Taimeh, Aaron J. Weiss, Venu Menon, Joseph Campbell, Paul Cremer, Jerry D. Estep
Summary: Temporary mechanical circulatory support (TMCS) plays a crucial role in refractory cardiogenic shock, but strategies for device weaning and explantation are still poorly defined. The revised heart allocation policy includes demonstrating TMCS dependency for heart transplant listing, yet standardized weaning and explant protocols are lacking. Further research is needed to establish optimal timing and implementation of protocols for successful TMCS weaning and explant.
JACC-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Ryan J. Tedford, Marzia Leacche, Angela Lorts, Stavros G. Drakos, Francis D. Pagani, Jennifer Cowger
Summary: Durable left ventricular assist device (dLVAD) support is an important treatment option for patients with advanced heart failure. Innovations in dLVAD technology have improved survival rates and reduced adverse events. However, there are challenges in promoting wider adoption of this therapy, including delayed patient referral, limited clinician knowledge, and deprioritization of patients waiting for heart transplantation. Novel devices with smaller size and less invasive implantation methods are being developed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Meryem Ezzitouny, Esther Rosello-Lleti, Manuel Portoles, Ignacio Sanchez-Lazaro, Miguel Angel Arnau-Vives, Estefania Tarazon, Carolina Gil-Cayuela, Silvia Lozano-Edo, Raquel Lopez-Vilella, Luis Almenar-Bonet, Luis Martinez-Dolz
Summary: This study suggests that patients with advanced HF requiring mechanical circulatory support have significantly lower levels of SERCA2a compared to stable patients without a need for MCS prior to heart transplantation. Larger studies are needed to further confirm and validate these findings.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Benedikt N. Beer, Gianluigi Savarese, Salim Dabboura, Isabell Yan, Jonas Sundermeyer, Peter M. Becher, Hanno Grahn, Moritz Seiffert, Alexander Bernhardt, Holger Thiele, Jacob E. Moller, Stefan Kluge, Hermann Reichenspurner, Paulus Kirchhof, Stefan Blankenberg, Dirk Westermann
Summary: This study retrospectively applied pragmatic enrolment criteria from several RCTs to a real-world CS population, revealing that only about a third of patients were eligible for these trials. The findings suggest a need for more diverse trial populations to improve generalizability of results.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
