Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
David Ross Darley, Jin Ma, Ella Huszti, Rasheed Ghany, Michael Hutcheon, Chung-Wai Chow, Jussi Tikkanen, Shaf Keshavjee, Lianne Gail Singer, Tereza Martinu
Summary: This study aims to determine the prognostic significance of D-LCOcor on chronic lung allograft dysfunction (CLAD) and survival. The results show that low baseline D-LCOcor is significantly associated with death, and declines in D-LCOcor are associated with shorter survival. This suggests that D-LCOcor may be a useful marker for predicting poor outcomes after lung transplantation.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Review
Biochemistry & Molecular Biology
Dalila Cavallaro, Marco Guerrieri, Stefano Cattelan, Gaia Fabbri, Sara Croce, Martina Armati, David Bennett, Antonella Fossi, Luca Voltolini, Luca Luzzi, Alberto Salvicchi, Piero Paladini, Adriano Peris, Miriana d'Alessandro, Paolo Cameli, Elena Bargagli, Tuscany Transplant Group, Laura Bergantini
Summary: Bronchiolitis obliterans syndrome is the most common form of CLAD, and its pathogenesis and markers play a crucial role in early diagnosis and treatment.
Article
Medicine, General & Internal
Jesper Romhild Davidsen, Christian B. Laursen, Mikkel Hojlund, Thomas Kromann Lund, Klaus Nielsen Jeschke, Martin Iversen, Anna Kalhauge, Elisabeth Bendstrup, Jorn Carlsen, Michael Perch, Daniel Pilsgaard Henriksen, Hans Henrik Lawaetz Schultz
Summary: This study found that pleural thickening identified by lung ultrasound may serve as a potential surrogate marker to distinguish restrictive allograft syndrome (RAS) from bronchiolitis obliterans syndrome (BOS) in chronic lung allograft dysfunction (CLAD) patients after lung transplant. This discovery provides a new method for clinical diagnosis of CLAD patients post lung transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sudip Das, Eric Bernasconi, Angela Koutsokera, Daniel-Adrien Wurlod, Vishwachi Tripathi, German Bonilla-Rosso, John-David Aubert, Marie-France Derkenne, Louis Mercier, Celine Pattaroni, Alexis Rapin, Christophe von Garnier, Benjamin J. Marsland, Philipp Engel, Laurent P. Nicod
Summary: This study examined the viable bacterial community in bronchoalveolar lavage samples from 64 lung transplant recipients and identified four distinct compositional states, called "pneumotypes," which were associated with immune activity, lung function, and risks of infection and rejection. The findings highlight the link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Miguel M. Leiva-Juarez, Luke Benvenuto, Joseph Costa, John W. Blackett, Meghan Aversa, Hilary Robbins, Lori Shah, Bryan P. Stanifer, Phillippe H. Lemaitre, Daniela Jodorkovsky, Selim Arcasoy, Joshua R. Sonett, Frank D'Ovidio
Summary: This study suggests that undergoing fundoplication after lung transplantation can improve posttransplant survival, especially for younger patients with restrictive diseases and those who receive single or double lung transplants. The method of diagnosing gastroesophageal reflux disease has different impacts on outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Review
Medicine, General & Internal
Anna Astashchanka, Joseph Ryan, Erica Lin, Brandon Nokes, Catriona Jamieson, Seth Kligerman, Atul Malhotra, Jess Mandel, Jisha Joshua
Summary: This review discusses the pulmonary complications post-HSCT, providing essential knowledge for non-pulmonary healthcare providers and emphasizing the importance of early diagnosis, treatment, and prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Cardiac & Cardiovascular Systems
Hakan Yazan, Fathouma Khalif, Lina Al Shadfaan, Sennur Bilgin, Mustafa Nursoy, Fatma Betul Cakir, Zeynep Ebru Cakin, Selcuk Uzuner, Erkan Cakir
Summary: This study evaluated the clinical and radiological findings and treatment outcomes of PIBO patients. The majority of patients showed clinical improvement and significant radiological improvements after treatment.
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Critical Care Medicine
Michael P. Combs, David S. Wheeler, Jenna E. Luth, Nicole R. Falkowski, Natalie M. Walker, John R. Erb-Downward, Vibha N. Lama, Robert P. Dickson
Summary: The characteristics of the respiratory microbiome in healthy lung transplant recipients within the first year of transplantation have a significant impact on subsequent CLAD-free survival, with an increased lung bacterial burden predicting chronic rejection and death. The lung microbiome represents an understudied and potentially modifiable risk factor for lung allograft dysfunction.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Infectious Diseases
Hugo Testaert, Margaux Bouet, Florent Valour, Anne Gigandon, Marie -Edith Lafon, Francois Philit, Agathe Senechal, Jean-Sebastien Casalegno, Elodie Blanchard, Jerome Le Pavec, Florence Ader
Summary: This study analysed the impact of antimicrobial treatments on functional outcomes in adult lung transplant recipients with RSV-confirmed infection. It was found that 28.8% of recipients developed new allograft dysfunction at 3 months post-infection. Ribavirin treatment and azithromycin prophylaxis did not prevent decline in lung function.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Pediatrics
Dimitrios Moutafidis, Maria Gavra, Sotirios Golfinopoulos, Antonios Kattamis, George Chrousos, Christina Kanaka-Gantenbein, Athanasios G. Kaditis
Summary: This study investigated age effects on lung attenuation and low- and high-attenuation thresholds in pediatric quantitative chest CT scans. It found that age was inversely associated with mean lung attenuation, and there were correlations between low- and high-attenuation percentages with age and total lung capacity. The findings suggest that quantitative analysis of chest CT scans in children without lung disease can help define age-specific thresholds for evaluating pediatric lung disease severity.
Article
Surgery
Naofumi Miyahara, Alberto Benazzo, Felicitas Oberndorfer, Akinori Iwasaki, Viktoria Laszlo, Balasz Dome, Mir Ali Hoda, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
Summary: miR-21 expression was higher in restrictive allograft syndrome (RAS) than in bronchiolitis obliterans syndrome (BOS) specimens, with a significant increase in serum concentration over time in RAS patients. Vimentin, NICD, and p-SMAD 2/3 were positive in a higher proportion of BOS patients compared to RAS cases.
TRANSPLANT INTERNATIONAL
(2022)
Editorial Material
Critical Care Medicine
J. Michael Wells, Amit Gaggar, Laurent P. Nicod
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2015)
Article
Critical Care Medicine
Koshika Yadava, Celine Pattaroni, Anke K. Sichelstiel, Aurelien Trompette, Eva S. Gollwitzer, Olawale Salami, Christophe von Garnier, Laurent P. Nicod, Benjamin J. Marsland
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Article
Critical Care Medicine
Eric Bernasconi, Celine Pattaroni, Angela Koutsokera, Christophe Pison, Romain Kessler, Christian Benden, Paola M. Soccal, Antoine Magnan, John-David Aubert, Benjamin J. Marsland, Laurent P. Nicod
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Antonio Valenti, Alessio Casutt, Angela Koutsokera, Jasmine Noetzli, Jean Yannis Perentes, Thorsten Krueger, Marco Pons, Laurent P. Nicod, Alban Lovis
ANNALS OF THORACIC SURGERY
(2016)
Article
Cell Biology
Romain Laurent, Aurelie Nallet, Benoit de Billy, Laurent Obert, Laurence Nicod, Christophe Meyer, Pierre Layrolle, Narcisse Zwetyenga, Florelle Gindraux
CELL AND TISSUE BANKING
(2017)
Article
Respiratory System
Meriem Benmerad, Remy Slama, Karine Botturi, Johanna Claustre, Antoine Roux, Edouard Sage, Martine Reynaud-Gaubert, Carine Gomez, Romain Kessler, Olivier Brugiere, Jean-Francois Mornex, Sacha Mussot, Marcel Dahan, Veronique Boussaud, Isabelle Danner-Boucher, Claire Dromer, Christiane Knoop, Annick Auffray, Johanna Lepeule, Laure Malherbe, Frederik Meleux, Laurent Nicod, Antoine Magnan, Christophe Pison, Valerie Siroux
EUROPEAN RESPIRATORY JOURNAL
(2017)
Article
Respiratory System
Maurizio Bernasconi, Alessio Casutt, Angela Koutsokera, Igor Letovanec, Frederic Tissot, Laurent P. Nicod, Alban Lovis
Article
Respiratory System
Lisa Bretagne, Ibrahima-Dina Diatta, Mohamed Faouzi, Antoine Nobile, Massimo Bongiovanni, Laurent P. Nicod, Romain Lazor
Review
Immunology
Pierre-Joseph Royer, Gustavo Olivera-Botello, Angela Koutsokera, John-David Aubert, Eric Bernasconi, Adrien Tissot, Christophe Pison, Laurent Nicod, Jean-Pierre Boissel, Antoine Magnan
Article
Respiratory System
Christian F. Clarenbach, Laurent P. Nicod, Malcolm Kohler
JOURNAL OF THORACIC DISEASE
(2016)
Article
Dentistry, Oral Surgery & Medicine
A. Louvrier, E. Euvrard, L. Nicod, G. Rolin, F. Gindraux, L. Pazart, C. Houdayer, P. Y. Risold, F. Meyer, C. Meyer
INTERNATIONAL ENDODONTIC JOURNAL
(2018)
Article
Respiratory System
Manuela Funke-Chambour, Andrea Azzola, Dan Adler, Constance Barazzone-Argiroffo, Christian Benden, Annette Boehler, Pierre-Olivier Bridevaux, Martin Brutsche, Christian F. Clarenbach, Katrin Hostettler, Rebekka Kleiner-Finger, Laurent P. Nicod, Paola M. Soccal, Michael Tamm, Thomas Geiser, Romain Lazor
Editorial Material
Respiratory System
Laurent Pierre Nicod
Letter
Critical Care Medicine
Adam Ogna, Maurizio Bernasconi, Bastien Belmondo, Olivier Long, Julien Simons, Nicolas Peguret, Raphael Heinzer, Laurent P. Nicod, Jean Bourhis, Alban Lovis
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Review
Medicine, General & Internal
Celia von Siebenthal, John-David Aubert, Periklis Mitsakis, Patrick Yerly, John O. Prior, Laurent Pierre Nicod
FRONTIERS IN MEDICINE
(2016)