4.6 Article

Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study

Journal

OPTICS LETTERS
Volume 40, Issue 15, Pages 3568-3571

Publisher

OPTICAL SOC AMER
DOI: 10.1364/OL.40.003568

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Funding

  1. Singapore Ministry of Health's National Medical Research Council
  2. Singapore National Research Foundation [NMRC/EDG/1062/2012]

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In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor. (C) 2015 Optical Society of America

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