Article
Clinical Neurology
Charlotte Ernstsen, Sarah L. Christensen, Jes Olesen, David M. Kristensen
Summary: The combination of olcegepant and sumatriptan did not show an additive effect compared to single-drug treatment in this mouse model study. Triptan-gepant combinations are unlikely to improve migraine treatment, but further studies are needed and combinations should be examined in patients with migraine.
Article
Clinical Neurology
Marte H. Bjork, Solveig Borkenhagen, Francisco Oteiza, Aud N. Dueland, Frank E. Sorgaard, Erik Magnus Saether, Christoffer Bugge
Summary: The study found a favorable effect of CGRPabs, amitriptyline, and simvastatin compared with beta blockers, while topiramate and clonidine were associated with poorer outcomes. Patients on simvastatin, CGRPabs, and amitriptyline were more likely to achieve a clinically significant reduction in triptan use during the first 90 days of treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Achim Frese, Oliver Summ, Stefan Evers
Summary: The study found that healthy subjects showed a significant increase in alpha-calcitonin-gene related peptide levels only after injection of capsaicin in the forehead, which suggests that this elevation is not specific to primary headache attacks but may be a non-specific effect of first trigeminal branch stimulation following pain activation.
Article
Anesthesiology
David A. C. Messerer, Thomas Datzmann, Anke Baranowsky, Leandra Peschel, Andrea Hoffmann, Michael Groeger, Michael Amling, Martin Wepler, Benedikt L. Nussbaum, Shan Jiang, Paul Knapstein, Antonia Donat, Enrico Calzia, Peter Radermacher, Johannes Keller
Summary: The study found that CGRP receptor antagonism with olcegepant was not beneficial in a porcine model of polymicrobial sepsis, which closely mimics human sepsis.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Luca Giani, Alberto Proietti Cecchini, Alberto Astengo, Giuseppe Lauria, Massimo Leone
Summary: In cluster headache patients with long and frequent attacks, those who do not respond to subcutaneous sumatriptan have longer duration and more frequent attacks compared to responders.
Article
Medicine, Research & Experimental
Linda Harris, Gilbert L'Italien, Thomas O'Connell, Zacharia Hasan, Susan Hutchinson, Sylvia Lucas
Summary: Current standards of care for migraine management may not adequately address the disability associated with the condition. This study aimed to estimate the potential use of new acute therapies for migraine, with findings suggesting that 15-25% of individuals with migraine may be eligible for these new treatments. The development of a conceptual framework offers a tool for assessing the eligible patient population and associated costs of these new therapies.
ADVANCES IN THERAPY
(2021)
Review
Clinical Neurology
Dilara Onan, Samaira Younis, William David Wellsgatnik, Fatemeh Farham, Saulius Andruskevicius, Ana Abashidze, Asel Jusupova, Yuriy Romanenko, Oxana Grosu, Meerimgul Zamirbekovna Moldokulova, Ulkar Mursalova, Saida Saidkhodjaeva, Paolo Martelletti, Sait Ashina
Summary: This article explores the similarities and differences in the pathophysiology, epidemiology, burden and disability, comorbidities, and responses to treatments between tension-type headache (TTH) and migraine. Distinguishing between the two in clinical practice and research is challenging due to the lack of specific diagnostic tests and biomarkers. The article also discusses future research directions to address diagnostic challenges and improve the understanding and management of these conditions.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Gabriel Garate, Maria Toriello, Vicente Gonzalez-Quintanilla, Sara Perez-Pereda, Jorge Madera, Marta Pascual, Jose Manuel Olmos, Julio Pascual
Summary: This study found that COVID-19 patients in the acute phase of the infection often experience headaches. By comparing the serum levels of calcitonin gene-related peptide (CGRP) in 25 COVID-19 inpatients with lung involvement experiencing headache, 15 COVID-19 inpatients without headache, and 25 healthy controls, it was discovered that CGRP levels were increased in COVID-19 patients with headache, supporting the role of trigeminal activation in the pathophysiology of headache in this viral infection.
Review
Clinical Neurology
Monica Chan, Alison Thaler
Summary: This review discusses the epidemiology, presentation, and pathophysiology of persistent post-stroke headache (PPSH), as well as the acute and preventive treatment options. The 2018 International Classification of Headache Disorders, 3rd edition (ICHD-3) includes criteria for diagnosing PPSH. Further investigation is needed to understand the burden of PPSH and to explore the efficacy and safety of potential treatment options.
CURRENT PAIN AND HEADACHE REPORTS
(2023)
Article
Clinical Neurology
Chunyan Li, Timothy G. White, Kevin A. Shah, Wayne Chaung, Keren Powell, Ping Wang, Henry H. Woo, Raj K. Narayan
Summary: This study demonstrates that percutaneous electrical stimulation of the infraorbital branch of the trigeminal nerve (pTNS) can increase brain CGRP concentrations in a dose-dependent manner, producing controllable cerebral vasodilation. This vasodilatory response appears to be independent of the pressor response induced by pTNS, and can be maintained even after transection of the spinal cord or specific nerve administration.
Article
Clinical Neurology
Judit Rosta, Mate Toth, Nadine Friedrich, Peter Santha, Gabor Jancso, Maria Dux
Summary: This study found that insulin can stimulate meningeal nociceptor functions by activating TRPV1 receptors and increasing dural blood flow. Insulin also sensitizes neural and vascular TRPV1 receptors to stimulation. Insulin receptors colocalize with TRPV1 receptors and CGRP in trigeminal ganglion neurons. These findings suggest a potential link between insulin and susceptibility to migraine headaches.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Medicine, Research & Experimental
Li Liao, Yan Tang, Bo Li, Jing Tang, Hong Xu, Ke Zhao, Xiaochun Zhang
Summary: Cardiovascular disease (CVD) is a leading cause of death worldwide and effective medical treatment is still a challenge. Leonurus japonicus Houtt, a traditional Chinese herb, has been widely used in China for the treatment of obstetrical and gynecological disorders as well as CVD. The main alkaloid component, stachydrine, has shown various biological activities and unique advantages in the prevention and treatment of CVD. This review aims to explore the pharmacological effects and molecular mechanisms of stachydrine in treating cardiovascular and cerebrovascular diseases, providing a scientific basis for the development of new CVD drug formulations.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Anesthesiology
Kuan-Po Peng, Arne May
Summary: Noninvasive vagus nerve stimulation (nVNS) is effective in several types of headache disorders, and this study provides functional evidence of a long hypothesized functional trigemino-vagal system in humans.
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Aida Maddahi, Karin Warfvinge, Anja Holm, Jacob C. A. Edvinsson, Philip Victor Reducha, Spyridoula Kazantzi, Kristian A. Haanes, Lars Edvinsson
Summary: This study investigated the distribution of progesterone in the trigeminovascular system and its role in modulating sensory neurotransmission. The results suggest that progesterone may modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further research is needed to fully understand the underlying mechanisms and physiological implications of these findings.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Isabella Mai Christiansen, Jacob C. A. Edvinsson, Philip Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: The present study demonstrates that ACEA alone does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Physiology
Jacob C. A. Edvinsson, Kristian A. Haanes, Lars Edvinsson
Summary: This review focuses on the trigeminovascular system (TGV) and discusses the signaling between fibers, as well as the potential role of neuropeptides and their receptors in migraine pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Maryam Mostajeran, Lars Edvinsson, Hilda Ahnstedt, Kajsa Arkelius, Saema Ansar
Summary: This study aimed to evaluate spontaneous recovery and molecular mechanisms involved in the recovery phase two weeks after stroke in female rats. The results showed that there were differences in the expression of specific proteins in different brain regions of female rats after stroke, which may be important for future therapeutic strategies.
Review
Medicine, General & Internal
Lars Edvinsson
Summary: Migraine is a common neurovascular disorder, affecting over 15% of the global population. Women are three times more likely to suffer from migraine compared to men. The underlying mechanisms of migraine are still largely unknown, but molecules such as CGRP play a crucial role in its pathophysiology.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Lars Edvinsson, Jacob C. A. Edvinsson, Kristian A. Haanes
Summary: The paper presents an analysis of mRNA expression in human and mouse trigeminal ganglia at single-nucleus resolution. It suggests new targets for pain therapies, but the findings should be interpreted in the context of available protein data and warrant functional verification.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Physiology
Andre Erdling, Sara Ellinor Johansson, Aneta Radziwon-Balicka, Saema Ansar, Lars Edvinsson
Summary: Ischemia causes upregulation of vasoconstrictive receptor systems in the cerebral vasculature. Focal ischemic stroke increases vascular sensitivity to UDP-beta-S, while subarachnoid hemorrhage does not.
PHYSIOLOGICAL REPORTS
(2022)
Review
Cell Biology
Philip Victor Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: Migraines are a common neurological disorder characterized by inflammation and sensitization mechanisms, with intracranial meningeal inflammation playing a key role. Animal models have provided valuable insights into these mechanisms.
Article
Clinical Neurology
Aida Maddahi, Lars Edvinsson, Karin Warfvinge
Summary: The expression of vasopressin and its receptors in the brain and trigeminovascular system, particularly in migraine-related regions, was identified. No differences in CGRP and vasopressin expression were found between male and female rats in the trigeminal ganglion. However, the number of RAMP1, oxytocin, oxytocin receptor, and vasopressin receptors immunoreactive cells were higher in females. Vasopressin and its receptors were expressed in both hypothalamus and trigeminal ganglion, with higher levels of vasopressin mRNA in the hypothalamus. Vasopressin and closely related oxytocin may play important roles in migraine pathophysiology.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Chemistry, Medicinal
Jesper Peter Bomers, Anne-Sofie Grell, Lars Edvinsson, Sara Ellinor Johansson, Kristian Agmund Haanes
Summary: This study investigated the effects of trametinib treatment on female rats with induced subarachnoid haemorrhage. The results showed that trametinib treatment significantly improved arterial contractility, reduced subacute increases in intracranial pressure, and improved sensorimotor and neurological outcomes in female rats.
Article
Clinical Neurology
Philip V. Reducha, Jesper P. Boemers, Lars Edvinsson, Kristian A. Haanes
Summary: This study aimed to investigate the behavioral changes similar to migraine caused by CFA application on the skull in rats, and the potential mitigating effects of the CGRP specific antibody fremanezumab after CFA application. The results showed that surgical application of CFA to the dura caused periorbital allodynia and increased CGRP positive fibers in the trigeminal ganglion. However, fremanezumab did not alleviate periorbital allodynia, although it reduced the amount of CGRP positive fibers.
FRONTIERS IN NEUROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Kristian A. Haanes, Lars Edvinsson
Article
Clinical Neurology
Aida Maddahi, Karin Warfvinge, Anja Holm, Jacob C. A. Edvinsson, Philip Victor Reducha, Spyridoula Kazantzi, Kristian A. Haanes, Lars Edvinsson
Summary: This study investigated the distribution of progesterone in the trigeminovascular system and its role in modulating sensory neurotransmission. The results suggest that progesterone may modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further research is needed to fully understand the underlying mechanisms and physiological implications of these findings.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Multidisciplinary Sciences
Lena Erlandsson, Lena Ohlsson, Zahra Masoumi, Mimmi Rehnstrom, Tina Cronqvist, Lars Edvinsson, Stefan R. Hansson
Summary: Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and organ damage. This study found that placenta-derived extracellular vesicles (STBEVs) in PE patients have negative effects on vascular contractility and cause structural damage to blood vessels. These effects can be reduced by blocking vesicle uptake. This discovery provides a new therapeutic strategy for preventing cardiovascular risks caused by PE.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Anette Sams, Kristian Agmund Haanes, Anja Holm, Spyridoula Kazantzi, Lars Friis Mikkelsen, Lars Edvinsson, Susan Brain, Majid Sheykhzade
Summary: This study characterized the vasomotor responses of isolated coronary, cerebral, and mesenteric arteries in Gottingen Minipigs (GM), and compared the responses to those obtained from parallel studies using other artery types. The results showed that different arterial sources had different responses to selected agonists of endothelial, sympathetic, parasympathetic, and sensory pathways. The study also demonstrated the robust nature of the vasomotor responses after 24 hours of cold storage of vascular tissue.
VASCULAR PHARMACOLOGY
(2023)
