Article
Critical Care Medicine
Nathaniel Mosley, Joon Y. Chung, Gina Jin, Maria A. Franceschini, Michael J. Whalen, David Y. Chung
Summary: This study found that a lower baseline cerebral blood flow prior to injury may contribute to the occurrence of a cortical spreading depolarization (CSD). Furthermore, a CSD at the time of injury can be associated with worse cognitive outcome under the appropriate experimental conditions in a mouse model of traumatic brain injury (TBI).
NEUROCRITICAL CARE
(2022)
Article
Pharmacology & Pharmacy
P. Kallianezos, X. Sinopidis, C. Petropoulos, D. Gkentzi, P. Plotas, S. Fouzas, A. Karatza, E. Jelastopulu
Summary: The study found that more than half of parents had clinical scores for both anxiety and depression. Factors such as female gender, distant residence, high school education, unstable employment, and low income were determinants for severe anxiety. Fathers were five times more likely to have severe depression compared to mothers.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Review
Plant Sciences
Karol Rojek, Anna Serefko, Ewa Poleszak, Aleksandra Szopa, Andrzej Wrobel, Malgorzata Guz, Jianbo Xiao, Krystyna Skalicka-Wozniak
Summary: Aromatic grasses of Cymbopogon genus are widely used in traditional medicine, and their essential oils and active substances have been studied for potential therapeutic effects, especially in the treatment of neurological and mental disorders. Many scientists suggest that plants from the Cymbopogon genus are ideal candidates for further pharmaceutical research.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Immunology
Akihiro Kanaya, Mu Yang, Charles Emala, Maya Mikami
Summary: The study found that mimicking allergic lung inflammation in mice can lead to significant histological changes in the lungs and behavioral changes consistent with depression and altered spatial memory. The increased levels of certain proteins suggest a link between lung inflammation and brain mast cell activation, which may be responsible for depression-like behavior.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Critical Care Medicine
Kate Karelina, Katarina Schneiderman, Sarthak Shah, Julie Fitzgerald, Ruth Velazquez Cruz, Robin Oliverio, Bailey Whitehead, Jingzhen Yang, Zachary M. Weil
Summary: Despite the common practice of prescribed rest after traumatic brain injury (TBI), research shows little to no benefit of it on patient outcomes, with prolonged rest potentially interfering with patient well-being. In contrast, animal models consistently indicate that exercise is neuroprotective and promotes recovery after brain injury, suggesting carefully titrated physical activity may be a safe and effective approach to promoting recovery.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Multidisciplinary Sciences
Sasigant So O'Neil, Isabel Platt, Divya Vohra, Emma Pendl-Robinson, Eric Dehus, Laurie Zephyrin, Kara Zivin
Summary: This study estimated the cost of maternal morbidity for all pregnancies and births in the United States in 2019, finding that the total cost of nine maternal morbidity conditions was $32.3 billion. However, due to limited data, the actual cost is likely higher. The study highlights the substantial impact of maternal morbidity on society and suggests the need for further investment in maternal health.
Article
Neurosciences
Tory Eisenlohr-Moul, Danielle A. Swales, David R. Rubinow, Lauren Schiff, Crystal E. Schiller
Summary: The hormonal changes during pregnancy and childbirth can affect a person's emotional state, especially for those with a history of postpartum depression. This study aimed to understand how hormone-sensitive individuals can be differentiated from hormone-insensitive controls and which symptoms show the most rapid and consistent response. The results showed that hormone-sensitive participants could be distinguished from controls early on in the study, with symptoms such as anger/irritability, mood swings, and fatigue showing the most significant changes within the first week of hormone manipulation. This study highlights the importance of reproductive hormones in perinatal affective disorders and suggests that anger and irritability may be early indicators of hormone sensitivity.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Pediatrics
Majidreza Akbarizadeh, Mahin Naderi Far, Fereshteh Ghaljaei
Summary: This study investigates the prevalence of depression among children with type 1 and type 2 diabetes, finding a higher prevalence among children with type 1 diabetes, especially among girls. The study also highlights a higher prevalence of depression in lower-middle-income countries.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Environmental Sciences
Yasmina M. Abd-Elhakim, Nabela I. El Sharkawy, Heba S. A. Gharib, Mona A. Hassan, Mohamed M. M. Metwally, Khlood M. Elbohi, Bayan A. Hassan, Amany Tharwat Mohammed
Summary: The study found that exposure to chlorpyrifos and iprodione had effects on the behavior and nervous system of male juvenile rats, such as reducing locomotion and exploration and increasing the severity of depression and anxiety. Additionally, significant biochemical and histological abnormalities were observed in their brain tissues, with the abnormalities being relatively less severe in the co-exposure group.
Article
Critical Care Medicine
Laura M. Heath, M. Rafae Kidwai, Brenda Colella, Georges Monette, Pavel Tselichtchev, Jennifer C. Tomaszczyk, Robin E. Green
Summary: This study examined the long-term trajectories of anxiety and depressive symptoms following moderate-severe traumatic brain injury (TBI), identified predictors of these trajectories, and explored their impact on 1-year return to productivity. The findings showed that there were four distinct trajectories for anxiety and depression, with most individuals experiencing stable or low levels over time. However, a subset of individuals showed rapid worsening of anxiety or depression, and those with worsening symptoms were less likely to return to productivity by 1-year post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Neurosciences
Arun Reddy Ravula, Jose Rodriguez, Daniel Younger, Venkatesan Perumal, Ningning Shao, Kakulavarapu V. Rama Rao, Bryan Pfister, Namas Chandra
Summary: Blast-induced neurotrauma (BINT) is a significant concern for soldiers and civilians, with repeated low-level blast (rLLB) potentially causing chronic neurocognitive changes. The study introduces a rat model of rLLB and finds that it induces acute and chronic anxiety-like symptoms, motor and memory impairments, along with increased microglial activation and reactive astrocytosis, highlighting the cumulative impact of rLLB on brain regions and potential neurobehavioral alterations.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Wolfgang Loescher, Carl E. Stafstrom
Summary: Epilepsy is associated with neurobehavioral comorbidities and a bidirectional relationship. Rodent models provide valuable insights into shared mechanisms and potential treatments for epilepsy and its comorbidities.
Article
Psychology, Multidisciplinary
James R. Hall, Melissa Petersen, Leigh Johnson, Sid E. O'Bryant
Summary: The study found a significant relationship between high plasma tau levels and symptoms of depression, apathy, anxiety, worry, and sleep disturbances in older adults, which may be early indicators of cognitive decline and prodromal Alzheimer's disease.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Felix Koop, Sarah Strauss, Claas-Tido Peck, Thomas Aper, Mathias Wilhelmi, Christian Hartmann, Jan Hegermann, Julia Schipke, Peter M. Vogt, Vesna Bucan
Summary: This study tested a two-composite scaffold made of longitudinally oriented native spider silk containing a Haemocomplettan fibrin sheath to bridge lesions in the spinal cord and enhance axonal sprouting. However, implantation in-vivo resulted in a granulomatous foreign body reaction.
Article
Multidisciplinary Sciences
Mutasim Makeen, Lia M. Farrell, Kelsea R. LaSorda, Yangyang Deng, Valeria Altamirano, Olivia Jarvis, Tanya Kenkre, Grace Lim
Summary: Pain and depression are associated with postpartum depression but may not necessarily improve maternal-infant attachment. Lower pain scores are related to higher maternal-infant attachment, while higher depression scores are related to lower maternal-infant attachment.
SCIENTIFIC REPORTS
(2022)
