Journal
OPTICS LETTERS
Volume 40, Issue 20, Pages 4803-4806Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.40.004803
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Funding
- ImPACT Program of the Council for Science, Technology and Innovation
- Noguchi Shitagau Research Grant, New Technology Development Foundation
- Konica Minolta Imaging Science Encouragement Award, JSPS KAKENHI [2572024, 25560190]
- JGC-S Scholarship Foundation
- Mitsubishi Foundation
- TOBIRA Award
- Burroughs Wellcome Foundation
- China Postdoctoral Council
- Grants-in-Aid for Scientific Research [25560190] Funding Source: KAKEN
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We present a method for high-throughput optofluidic particle analysis that provides both the morphological and chemical profiles of individual particles in a large heterogeneous population. This method is based on an integration of a time-stretch optical microscope with a submicrometer spatial resolution of 780 nm and a three-color fluorescence analyzer on top of an inertial-focusing microfluidic device. The integrated system can perform image-and fluorescence-based screening of particles with a high throughput of 10,000 particles/s, exceeding previously demonstrated imaging particle analyzers in terms of specificity without sacrificing throughput. (C) 2015 Optical Society of America
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